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1. 发明申请

WO1996014052A1 METHOD OF MAKING POLYHYDRIC ALCOHOL SOLUTIONS OF ENHANCED EFFICACY ANTIPERSPIRANT ACTIVES 审中-公开
标题翻译：制备高效抗菌活性多糖醇溶液的方法
公开(公告)号：WO1996014052A1
公开(公告)日：1996-05-17
申请号：PCT/US1995014073
申请日：1995-10-30
申请人： THE GILLETTE COMPANY , PROVANCAL, Stephen, J. , CARRILLO, Angel, L. , FLUHLER, Thomas, J. , ORYSZCZAK, Richard , SANE, Jayant, N.
发明人： THE GILLETTE COMPANY
IPC分类号： A61K07/38
CPC分类号： A61Q15/00 , A61K8/26 , A61K8/28 , A61K8/345 , A61K8/44
摘要： The present invention comprises a process of preparing a solution of an enhanced efficacy aluminum antiperspirant salt in a polyhydric alcohol by (a) providing an aqueous solution consisting essentially of about 5 % to about 18 % by weight of an enhanced efficacy aluminum antiperspirant salt in water, the enhanced efficacy aluminum antiperspirant salt having been prepared in situ without having been dried to a solid powder; (b) mixing the aqueous solution with a sufficient amount of a liquid polyhydric alcohol to provide a mixed solution which has an antiperspirant salt to polyhydric alcohol ratio of about 1:4 to about 1.2:1; and (c) rapidly evaporating the water from the mixed solution under vacuum to provide a final liquid polyhydric alcohol solution containing about 20 to 50 % enhanced efficacy aluminum antiperspirant salt and about 2 to 16 % water, with the balance being polyhydric alcohol. An alkaline glycinate salt, such as sodium, potassium or zinc glycinate, may be added to the polyhydric alcohol prior to the addition of the antiperspirant salt solution in order to raise the pH of the recovered product to about 4.1 to 5.0.
摘要翻译：本发明包括通过（a）提供基本上由约5重量％至约18重量％的增强的功效铝止汗药盐在水中组成的水溶液来制备增强的功效性铝止汗药盐在多元醇中的溶液的方法已经在原位制备了不再干燥成固体粉末的增强效力的铝止汗盐; （b）将水溶液与足量的液体多元醇混合，得到具有止汗剂盐与多元醇比为约1:4至约1.2:1的混合溶液; 和（c）在真空下从混合溶液中快速蒸发水，得到含有约20至50％增强效力的铝止汗塞盐和约2至16％水的最终液体多元醇溶液，余量为多元醇。在加入止汗盐溶液之前，可以向多元醇中加入碱性甘氨酸盐，例如甘氨酸钠，钾或锌，以便将回收产物的pH提高至约4.1至5.0。

2. 发明申请

WO2007004163A1 PARTICULATE ENHANCED EFFICACY ANTIPERSPIRANT SALT WITH RAISED PH 审中-公开
标题翻译：具有增效效果的增效抗菌剂
公开(公告)号：WO2007004163A1
公开(公告)日：2007-01-11
申请号：PCT/IB2006/052188
申请日：2006-06-29
申请人： THE GILLETTE COMPANY , SHEN, Yanfei , PROVANCAL, Stephen, J. , ORYSZCZAK, Richard
发明人： SHEN, Yanfei , PROVANCAL, Stephen, J. , ORYSZCZAK, Richard
IPC分类号： A61Q15/00 , A61K8/02 , A61K8/04 , A61K8/26 , A61K8/28 , A61K8/44 , A61K8/36 , A61K8/362 , A61K8/365 , C01G25/00
CPC分类号： A61Q15/00 , A61K8/0229 , A61K8/0241 , A61K8/28 , A61K8/44 , A61K8/585 , A61K2800/58 , A61K2800/651 , C01G25/006
摘要： Disclosed is a solid particulate antiperspirant salt comprising a mixture (or complex) of an enhanced efficacy aluminum-zirconium chlorohydrex-amino acid and a neutralizing salt. The particulate antiperspirant salt, when measured as an aqueous solution at a concentration of 15% by weight at 25°C, has a pH greater than 4.5, preferably about 4.6 to about 5.3. Also disclosed is a topical antiperspirant composition comprising the aforementioned particulate antiperspirant salt and a method of reducing perspiration from human skin by applying the aforementioned antiperspirant composition. In addition, there is disclosed a method of preparing the aforementioned particulate antiperspirant salt.
摘要翻译：公开了一种固体颗粒止汗盐，其包含增强的效力的铝 - 锆氯水氨基酸和中和盐的混合物（或络合物）。当在25℃下以15重量％的浓度测量水溶液时，颗粒状止汗剂的pH值大于4.5，优选约4.6至约5.3。还公开了包含上述颗粒止汗剂的局部止汗组合物和通过应用上述止汗组合物来减少人皮肤出汗的方法。此外，公开了制备上述粒状止汗剂盐的方法。

3. 发明申请

WO0234223A3 ALUMINUM-ZIRCONIUM ANTIPERSPIRANT SALTS 审中-公开
标题翻译：铝 - ZIRCONIUM抗菌剂
公开(公告)号：WO0234223A3
公开(公告)日：2003-04-03
申请号：PCT/US0146112
申请日：2001-10-24
申请人： GILLETTE CO , CARRILLO ANGEL L , ORYSZCZAK RICHARD , SHEN YAN-FEI
发明人： CARRILLO ANGEL L , ORYSZCZAK RICHARD , SHEN YAN-FEI
IPC分类号： A61K8/28 , A61Q15/00 , C01F7/00 , C01F7/16 , C01F7/48 , C01F7/56 , C01F7/66 , C01G25/00 , A61K7/38
CPC分类号： A61Q15/00 , A61K8/28 , C01G25/006 , C01P2002/87 , Y10S424/05
摘要： Disclosed are enhanced efficacy aluminum-zirocnium antiperspirant salt compositions which exhiit an HPLC peak 5 area content of about 33 % or more, preferably at least 45 %, more preferably at least 50 %, most preferably at least 55 %. Especially preferred are aluminum-zirconium antiperspirant salt composition which, in addition to the aforementioned high peak 5 content, also exhibit an HPLC peak 4 to peak 3 area ratio of at least 0.4, preferably at least 0.7. The aforementioned salt compositions will preferably have a metal (Al + Zr) to chloride (or anion) ratio of about 0.90 to about 1.00. Also disclosed are methods of making such antiperspirant salt compositions and aqueous solutions of such antiperspirant sald compositions. Further disclosed are topical compositions comprising a dermatologically acceptable carrier vehicle and a perspiration reducing effective amount of an aluminium-zirconium antiperspirant salt composition as described above.
摘要翻译：公开了增强的功效性铝 - 锑止汗剂盐组合物，其具有约33％或更高，优选至少45％，更优选至少50％，最优选至少55％的HPLC峰5面积含量。特别优选的是铝 - 锆止汗剂盐组合物，除了上述高峰5含量之外，还显示HPLC峰4至峰3面积比至少为0.4，优选至少0.7。上述盐组合物优选具有约0.90至约1.00的金属（Al + Zr）与氯化物（或阴离子）的比例。还公开了制备这种止汗剂盐组合物和这种止汗剂组合物的水溶液的方法。进一步公开的是包含皮肤病学可接受的载体载体和减少有效量的如上所述的铝 - 锆止汗剂盐组合物的汗液的局部组合物。

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