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1. 发明申请

WO0234223A3 ALUMINUM-ZIRCONIUM ANTIPERSPIRANT SALTS 审中-公开
标题翻译：铝 - ZIRCONIUM抗菌剂
公开(公告)号：WO0234223A3
公开(公告)日：2003-04-03
申请号：PCT/US0146112
申请日：2001-10-24
申请人： GILLETTE CO , CARRILLO ANGEL L , ORYSZCZAK RICHARD , SHEN YAN-FEI
发明人： CARRILLO ANGEL L , ORYSZCZAK RICHARD , SHEN YAN-FEI
IPC分类号： A61K8/28 , A61Q15/00 , C01F7/00 , C01F7/16 , C01F7/48 , C01F7/56 , C01F7/66 , C01G25/00 , A61K7/38
CPC分类号： A61Q15/00 , A61K8/28 , C01G25/006 , C01P2002/87 , Y10S424/05
摘要： Disclosed are enhanced efficacy aluminum-zirocnium antiperspirant salt compositions which exhiit an HPLC peak 5 area content of about 33 % or more, preferably at least 45 %, more preferably at least 50 %, most preferably at least 55 %. Especially preferred are aluminum-zirconium antiperspirant salt composition which, in addition to the aforementioned high peak 5 content, also exhibit an HPLC peak 4 to peak 3 area ratio of at least 0.4, preferably at least 0.7. The aforementioned salt compositions will preferably have a metal (Al + Zr) to chloride (or anion) ratio of about 0.90 to about 1.00. Also disclosed are methods of making such antiperspirant salt compositions and aqueous solutions of such antiperspirant sald compositions. Further disclosed are topical compositions comprising a dermatologically acceptable carrier vehicle and a perspiration reducing effective amount of an aluminium-zirconium antiperspirant salt composition as described above.
摘要翻译：公开了增强的功效性铝 - 锑止汗剂盐组合物，其具有约33％或更高，优选至少45％，更优选至少50％，最优选至少55％的HPLC峰5面积含量。特别优选的是铝 - 锆止汗剂盐组合物，除了上述高峰5含量之外，还显示HPLC峰4至峰3面积比至少为0.4，优选至少0.7。上述盐组合物优选具有约0.90至约1.00的金属（Al + Zr）与氯化物（或阴离子）的比例。还公开了制备这种止汗剂盐组合物和这种止汗剂组合物的水溶液的方法。进一步公开的是包含皮肤病学可接受的载体载体和减少有效量的如上所述的铝 - 锆止汗剂盐组合物的汗液的局部组合物。

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