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1. 发明申请

WO1996014052A1 METHOD OF MAKING POLYHYDRIC ALCOHOL SOLUTIONS OF ENHANCED EFFICACY ANTIPERSPIRANT ACTIVES 审中-公开
标题翻译：制备高效抗菌活性多糖醇溶液的方法
公开(公告)号：WO1996014052A1
公开(公告)日：1996-05-17
申请号：PCT/US1995014073
申请日：1995-10-30
申请人： THE GILLETTE COMPANY , PROVANCAL, Stephen, J. , CARRILLO, Angel, L. , FLUHLER, Thomas, J. , ORYSZCZAK, Richard , SANE, Jayant, N.
发明人： THE GILLETTE COMPANY
IPC分类号： A61K07/38
CPC分类号： A61Q15/00 , A61K8/26 , A61K8/28 , A61K8/345 , A61K8/44
摘要： The present invention comprises a process of preparing a solution of an enhanced efficacy aluminum antiperspirant salt in a polyhydric alcohol by (a) providing an aqueous solution consisting essentially of about 5 % to about 18 % by weight of an enhanced efficacy aluminum antiperspirant salt in water, the enhanced efficacy aluminum antiperspirant salt having been prepared in situ without having been dried to a solid powder; (b) mixing the aqueous solution with a sufficient amount of a liquid polyhydric alcohol to provide a mixed solution which has an antiperspirant salt to polyhydric alcohol ratio of about 1:4 to about 1.2:1; and (c) rapidly evaporating the water from the mixed solution under vacuum to provide a final liquid polyhydric alcohol solution containing about 20 to 50 % enhanced efficacy aluminum antiperspirant salt and about 2 to 16 % water, with the balance being polyhydric alcohol. An alkaline glycinate salt, such as sodium, potassium or zinc glycinate, may be added to the polyhydric alcohol prior to the addition of the antiperspirant salt solution in order to raise the pH of the recovered product to about 4.1 to 5.0.
摘要翻译：本发明包括通过（a）提供基本上由约5重量％至约18重量％的增强的功效铝止汗药盐在水中组成的水溶液来制备增强的功效性铝止汗药盐在多元醇中的溶液的方法已经在原位制备了不再干燥成固体粉末的增强效力的铝止汗盐; （b）将水溶液与足量的液体多元醇混合，得到具有止汗剂盐与多元醇比为约1:4至约1.2:1的混合溶液; 和（c）在真空下从混合溶液中快速蒸发水，得到含有约20至50％增强效力的铝止汗塞盐和约2至16％水的最终液体多元醇溶液，余量为多元醇。在加入止汗盐溶液之前，可以向多元醇中加入碱性甘氨酸盐，例如甘氨酸钠，钾或锌，以便将回收产物的pH提高至约4.1至5.0。

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