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1. 发明申请

WO1995013132A1 METHOD OF FORMING PARTICLES USING A SUPERCRITICAL FLUID, AEROGEL PARTICLES FORMED THEREBY, AND ANTIPERSPIRANTS CONTAINING AEROGEL PARTICLES 审中-公开
标题翻译：使用超临界流体形成颗粒的方法，形成的空气颗粒和含有空气颗粒的抗生素
公开(公告)号：WO1995013132A1
公开(公告)日：1995-05-18
申请号：PCT/US1994012669
申请日：1994-11-07
申请人： THE GILLETTE COMPANY , CF TECHNOLOGIES, INC. , ROUANET, Stephane, Fabrice , MCGOVERN, William, Edward , CAO, Wanqing , KLOTZ, Irving, M. , CARRILLO, Angel, L. , MOSES, John, M.
发明人： THE GILLETTE COMPANY , CF TECHNOLOGIES, INC.
IPC分类号： B01J13/00
CPC分类号： A61Q15/00 , A61K8/042 , A61K8/26 , B01J13/0091
摘要： A method for providing aerogels, and aerogels produced according to the method, is described. As one aspect, antiperspirant compounds that are in aerogel form, and antiperspirant and deodorant compositions including such salts, are described. The method involves contacting a solution containing material to be processed with a species selected to precipitate the material and selected so as to be miscible with the solvent system of the solution. After the material is precipitated, the material may be washed with the precipitating species until it is substantially free of solvent system. Then, the precipitating species containing the material precipitate is taken above its critical point, and the supercritical fluid is exhausted above its critical temperature. Alternately, a separate isolating species is introduced to displace the precipitating species, or the precipitating species/solvent system mixture. The isolating species then is taken above its critical point, and exhausted above its critical temperature. The invention provides for batch or continuous processes.
摘要翻译：描述了一种提供气凝胶和根据该方法生产的气凝胶的方法。一方面，描述了气凝胶形式的止汗化合物，以及包含这些盐的止汗剂和除臭剂组合物。该方法包括将待处理材料的溶液与选择的物质接触以沉淀材料并选择以便与溶液的溶剂体系混溶。材料沉淀后，材料可以用沉淀物质洗涤，直到其基本上不含溶剂体系。然后，将含有物质沉淀物的沉淀物质高于其临界点，超临界流体在其临界温度以上耗尽。或者，引入单独的隔离物质以置换沉淀物质或沉淀物质/溶剂体系混合物。然后将隔离物质置于其临界点以上，并在其临界温度以上耗尽。本发明提供批量或连续方法。

2. 发明申请

WO1996014052A1 METHOD OF MAKING POLYHYDRIC ALCOHOL SOLUTIONS OF ENHANCED EFFICACY ANTIPERSPIRANT ACTIVES 审中-公开
标题翻译：制备高效抗菌活性多糖醇溶液的方法
公开(公告)号：WO1996014052A1
公开(公告)日：1996-05-17
申请号：PCT/US1995014073
申请日：1995-10-30
申请人： THE GILLETTE COMPANY , PROVANCAL, Stephen, J. , CARRILLO, Angel, L. , FLUHLER, Thomas, J. , ORYSZCZAK, Richard , SANE, Jayant, N.
发明人： THE GILLETTE COMPANY
IPC分类号： A61K07/38
CPC分类号： A61Q15/00 , A61K8/26 , A61K8/28 , A61K8/345 , A61K8/44
摘要： The present invention comprises a process of preparing a solution of an enhanced efficacy aluminum antiperspirant salt in a polyhydric alcohol by (a) providing an aqueous solution consisting essentially of about 5 % to about 18 % by weight of an enhanced efficacy aluminum antiperspirant salt in water, the enhanced efficacy aluminum antiperspirant salt having been prepared in situ without having been dried to a solid powder; (b) mixing the aqueous solution with a sufficient amount of a liquid polyhydric alcohol to provide a mixed solution which has an antiperspirant salt to polyhydric alcohol ratio of about 1:4 to about 1.2:1; and (c) rapidly evaporating the water from the mixed solution under vacuum to provide a final liquid polyhydric alcohol solution containing about 20 to 50 % enhanced efficacy aluminum antiperspirant salt and about 2 to 16 % water, with the balance being polyhydric alcohol. An alkaline glycinate salt, such as sodium, potassium or zinc glycinate, may be added to the polyhydric alcohol prior to the addition of the antiperspirant salt solution in order to raise the pH of the recovered product to about 4.1 to 5.0.
摘要翻译：本发明包括通过（a）提供基本上由约5重量％至约18重量％的增强的功效铝止汗药盐在水中组成的水溶液来制备增强的功效性铝止汗药盐在多元醇中的溶液的方法已经在原位制备了不再干燥成固体粉末的增强效力的铝止汗盐; （b）将水溶液与足量的液体多元醇混合，得到具有止汗剂盐与多元醇比为约1:4至约1.2:1的混合溶液; 和（c）在真空下从混合溶液中快速蒸发水，得到含有约20至50％增强效力的铝止汗塞盐和约2至16％水的最终液体多元醇溶液，余量为多元醇。在加入止汗盐溶液之前，可以向多元醇中加入碱性甘氨酸盐，例如甘氨酸钠，钾或锌，以便将回收产物的pH提高至约4.1至5.0。

3. 发明申请

WO1994028866A1 PROCESS FOR MANUFACTURING AN ANTIPERSPIRANT STICK 审中-公开
标题翻译：制造抗刺激性胶囊的方法
公开(公告)号：WO1994028866A1
公开(公告)日：1994-12-22
申请号：PCT/US1994005960
申请日：1994-05-26
申请人： THE GILLETTE COMPANY , CARLSON, Jeffrey, R., Sr. , COE, Craig, M. , CARRILLO, Angel, L. , SMITH, David, W. , KARASSIK, Nancy, M.
发明人： THE GILLETTE COMPANY
IPC分类号： A61K07/34
CPC分类号： A61K8/26 , A61K8/0229 , A61K8/39 , A61K8/585 , A61Q15/00 , Y10S424/05
摘要： The present invention provides a process for making a solid antiperspirant stick comprising a particulate aluminum antiperspirant salt suspended in an anhydrous carrier vehicle, wherein said carrier vehicle comprises a high melting component which melts at 70 DEG C or higher. This process includes heating the carrier vehicle in a closed mixing vessel to a temperature in excess of 70 DEG C, preferably in excess of 75 DEG C, to melt the high melting component, adding the antiperspirant salt to the carrier vehicle, and cooling the carrier vehicle to form a solid antiperspirant stick. The improvement of the present invention comprises cooling the carrier vehicle below 70 DEG C, preferably to about 65 DEG C or less, but above the solidification point prior to adding the antiperspirant salt and maintaining the carrier vehicle below 70 DEG C, preferably at about 65 DEG C or less, during and after the antiperspirant salt addition, thereby substantially preventing agglomeration of the antiperspirant salt into large particles, especially particles in excess of 60 microns.
摘要翻译：本发明提供一种制备固体止汗棒的方法，所述固体止汗棒包含悬浮在无水载体载体中的颗粒状铝止汗剂盐，其中所述载体载体包含熔点在70℃或更高的高熔点组分。该方法包括将封闭混合容器中的载体载体加热至超过70℃，优选超过75℃的温度，以熔化高熔点组分，将止汗剂盐加入到载体载体中，并冷却载体车辆形成固体止汗棒。本发明的改进包括将载体载体冷却至低于70℃，优选至约65℃或更低，但高于固化点，然后加入止汗盐，并将载体载体保持在70℃以下，优选约65℃ 在加入止汗盐期间和之后，从而基本上防止止汗剂盐结合成大颗粒，特别是超过60微米的颗粒。

4. 发明申请

WO0234223A3 ALUMINUM-ZIRCONIUM ANTIPERSPIRANT SALTS 审中-公开
标题翻译：铝 - ZIRCONIUM抗菌剂
公开(公告)号：WO0234223A3
公开(公告)日：2003-04-03
申请号：PCT/US0146112
申请日：2001-10-24
申请人： GILLETTE CO , CARRILLO ANGEL L , ORYSZCZAK RICHARD , SHEN YAN-FEI
发明人： CARRILLO ANGEL L , ORYSZCZAK RICHARD , SHEN YAN-FEI
IPC分类号： A61K8/28 , A61Q15/00 , C01F7/00 , C01F7/16 , C01F7/48 , C01F7/56 , C01F7/66 , C01G25/00 , A61K7/38
CPC分类号： A61Q15/00 , A61K8/28 , C01G25/006 , C01P2002/87 , Y10S424/05
摘要： Disclosed are enhanced efficacy aluminum-zirocnium antiperspirant salt compositions which exhiit an HPLC peak 5 area content of about 33 % or more, preferably at least 45 %, more preferably at least 50 %, most preferably at least 55 %. Especially preferred are aluminum-zirconium antiperspirant salt composition which, in addition to the aforementioned high peak 5 content, also exhibit an HPLC peak 4 to peak 3 area ratio of at least 0.4, preferably at least 0.7. The aforementioned salt compositions will preferably have a metal (Al + Zr) to chloride (or anion) ratio of about 0.90 to about 1.00. Also disclosed are methods of making such antiperspirant salt compositions and aqueous solutions of such antiperspirant sald compositions. Further disclosed are topical compositions comprising a dermatologically acceptable carrier vehicle and a perspiration reducing effective amount of an aluminium-zirconium antiperspirant salt composition as described above.
摘要翻译：公开了增强的功效性铝 - 锑止汗剂盐组合物，其具有约33％或更高，优选至少45％，更优选至少50％，最优选至少55％的HPLC峰5面积含量。特别优选的是铝 - 锆止汗剂盐组合物，除了上述高峰5含量之外，还显示HPLC峰4至峰3面积比至少为0.4，优选至少0.7。上述盐组合物优选具有约0.90至约1.00的金属（Al + Zr）与氯化物（或阴离子）的比例。还公开了制备这种止汗剂盐组合物和这种止汗剂组合物的水溶液的方法。进一步公开的是包含皮肤病学可接受的载体载体和减少有效量的如上所述的铝 - 锆止汗剂盐组合物的汗液的局部组合物。

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