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    • 2. 发明申请
    • ALUMINUM-ZIRCONIUM ANTIPERSPIRANT SALTS WITH HIGH PEAK 5 Al CONTENT
    • 具有高峰值5铝含量的铝 - 锆 - 抗真菌剂
    • WO02034223A2
    • 2002-05-02
    • PCT/US2001/046112
    • 2001-10-24
    • A61K8/28A61Q15/00C01F7/00C01F7/16C01F7/48C01F7/56C01F7/66C01G25/00A61K7/38
    • A61Q15/00A61K8/28C01G25/006C01P2002/87Y10S424/05
    • Disclosed are enhanced efficacy aluminum-zirocnium antiperspirant salt compositions which exhiit an HPLC peak 5 area content of about 33 % or more, preferably at least 45 %, more preferably at least 50 %, most preferably at least 55 %. Especially preferred are aluminum-zirconium antiperspirant salt composition which, in addition to the aforementioned high peak 5 content, also exhibit an HPLC peak 4 to peak 3 area ratio of at least 0.4, preferably at least 0.7. The aforementioned salt compositions will preferably have a metal (Al + Zr) to chloride (or anion) ratio of about 0.90 to about 1.00. Also disclosed are methods of making such antiperspirant salt compositions and aqueous solutions of such antiperspirant sald compositions. Further disclosed are topical compositions comprising a dermatologically acceptable carrier vehicle and a perspiration reducing effective amount of an aluminium-zirconium antiperspirant salt composition as described above.
    • 公开了增强的功效性铝 - 锑止汗剂盐组合物,其具有约33%或更高,优选至少45%,更优选至少50%,最优选至少55%的HPLC峰5面积含量。 特别优选的是铝 - 锆止汗剂盐组合物,除了上述高峰5含量之外,还显示HPLC峰4至峰3面积比至少为0.4,优选至少0.7。 上述盐组合物优选具有约0.90至约1.00的金属(Al + Zr)与氯化物(或阴离子)的比例。 还公开了制备这种止汗剂盐组合物和这种止汗剂组合物的水溶液的方法。 进一步公开的是包含皮肤病学可接受的载体载体和减少有效量的如上所述的铝 - 锆止汗剂盐组合物的汗液的局部组合物。
    • 4. 发明申请
    • POLYHYDRIC ALCOHOL STABILIZED ANTIPERSPIRANT SALT SOLUTIONS
    • POLYHYDRIC ALCOHOL稳定的抗菌盐溶液
    • WO98058626A1
    • 1998-12-30
    • PCT/US1998/012953
    • 1998-06-22
    • A61K8/26A61K8/28A61K8/34A61K8/44A61Q15/00C01F7/48C01F7/56C01F7/64C01F7/66A61K7/38
    • C01F7/66A61K8/26A61K8/28A61K8/34A61K8/345A61K8/44A61Q15/00C01F7/48C01F7/56
    • The present invention relates to methods of making enhanced efficacy antiperspirant salts and particularly stabilized aqueous polyhydric alcohol solutions of such salts. One such method involves stabilizing an aqueous solution of an enhanced efficacy antiperspirant salt by adding an effective amount of a polyhydric alcohol having from 3 to 6 carbon atoms and from 3 to 6 hydroxyl groups. A second disclosed method involves preparing an enhanced efficacy aluminum antiperspirant salt by heating an aqueous solution of an aluminum antiperspirant salt in the presence of a polyhydric alcohol having from 3 to 6 carbon atoms and from 3 to 6 hydroxyl groups at a temperature of at least 50 DEG C for a time sufficient to convert the salt to an enhanced salt. A third disclosed method is an improvement in the method of making an aluminum hydroxy halide or an aluminum hydroxy nitrate by reacting aluminum with an aqueous solution of aluminum halide or aluminum nitrate (or with aqueous hydrogen halide or nitric acid), wherein the improvement comprises including a polyhydric alcohol having from 3 to 6 carbon atoms and from 3 to 6 hydroxyl groups in the reaction mixture. Also disclosed are compositions produced by the foregoing methods.
    • 本发明涉及制备增效功效止汗盐和特别稳定的这些盐的多羟基水溶液。 一种这样的方法包括通过加入有效量的具有3至6个碳原子和3至6个羟基的多元醇来稳定增强的功效止汗剂盐的水溶液。 第二个公开的方法包括通过在至少50℃的温度下,在具有3至6个碳原子的多元醇和3至6个羟基的存在下加热铝止汗剂盐水溶液来制备增强的功效性的铝止汗剂盐 DEG一段时间足以将盐转化为增强的盐。 第三个公开的方法是通过使铝与卤化铝或硝酸铝(或与卤化氢或硝酸水溶液)的水溶液反应制备铝羟基卤化物或羟基硝酸铝的方法的改进,其中改进包括 在反应混合物中具有3至6个碳原子和3至6个羟基的多元醇。 还公开了通过前述方法制备的组合物。
    • 5. 发明申请
    • ALUMINUM-ZIRCONIUM ANTIPERSPIRANT SALTS
    • 铝 - ZIRCONIUM抗菌剂
    • WO0234223A3
    • 2003-04-03
    • PCT/US0146112
    • 2001-10-24
    • GILLETTE COCARRILLO ANGEL LORYSZCZAK RICHARDSHEN YAN-FEI
    • CARRILLO ANGEL LORYSZCZAK RICHARDSHEN YAN-FEI
    • A61K8/28A61Q15/00C01F7/00C01F7/16C01F7/48C01F7/56C01F7/66C01G25/00A61K7/38
    • A61Q15/00A61K8/28C01G25/006C01P2002/87Y10S424/05
    • Disclosed are enhanced efficacy aluminum-zirocnium antiperspirant salt compositions which exhiit an HPLC peak 5 area content of about 33 % or more, preferably at least 45 %, more preferably at least 50 %, most preferably at least 55 %. Especially preferred are aluminum-zirconium antiperspirant salt composition which, in addition to the aforementioned high peak 5 content, also exhibit an HPLC peak 4 to peak 3 area ratio of at least 0.4, preferably at least 0.7. The aforementioned salt compositions will preferably have a metal (Al + Zr) to chloride (or anion) ratio of about 0.90 to about 1.00. Also disclosed are methods of making such antiperspirant salt compositions and aqueous solutions of such antiperspirant sald compositions. Further disclosed are topical compositions comprising a dermatologically acceptable carrier vehicle and a perspiration reducing effective amount of an aluminium-zirconium antiperspirant salt composition as described above.
    • 公开了增强的功效性铝 - 锑止汗剂盐组合物,其具有约33%或更高,优选至少45%,更优选至少50%,最优选至少55%的HPLC峰5面积含量。 特别优选的是铝 - 锆止汗剂盐组合物,除了上述高峰5含量之外,还显示HPLC峰4至峰3面积比至少为0.4,优选至少0.7。 上述盐组合物优选具有约0.90至约1.00的金属(Al + Zr)与氯化物(或阴离子)的比例。 还公开了制备这种止汗剂盐组合物和这种止汗剂组合物的水溶液的方法。 进一步公开的是包含皮肤病学可接受的载体载体和减少有效量的如上所述的铝 - 锆止汗剂盐组合物的汗液的局部组合物。