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1. 发明申请

WO2006026704A2 DEVICES AND METHODS FOR GYNECOLOGIC HORMONE MODULATION IN MAMMALS 审中-公开
标题翻译：乳腺肿瘤细胞调节的装置和方法
公开(公告)号：WO2006026704A2
公开(公告)日：2006-03-09
申请号：PCT/US2005/031102
申请日：2005-08-31
申请人： LEPTOS BIOMEDICAL, INC. , NARCISO, Hugh, Louis, Jr.
发明人： NARCISO, Hugh, Louis, Jr.
IPC分类号： A61N1/32
CPC分类号： A61N1/0558 , A61N1/0556 , A61N1/326 , A61N1/36107
摘要： Methods and devices for electrically stimulating nerves and organs to induce and modulate the production of hormones according to desired hormone production patterns and hormone level patterns to treat gynecological conditions. Such methods and devices may be used to treat menopause or to alleviate the symptoms of menopause. In addition, such methods and devices may be used for birth control.
摘要翻译：用于电刺激神经和器官以诱导和调节激素生成的方法和装置根据所需的激素生成模式和激素水平模式来治疗妇科病症。这些方法和装置可用于治疗绝经或减轻绝经症状。此外，这种方法和装置可以用于避孕。

2. 发明申请

WO2004082736A2 LIGHT GENERATING DEVICE TO INTRAVASCULAR USE 审中-公开
标题翻译：光生成装置用于静脉内使用
公开(公告)号：WO2004082736A2
公开(公告)日：2004-09-30
申请号：PCT/US2004/007563
申请日：2004-03-12
申请人： LIGHT SCIENCES CORPORATION , NARCISO, Hugh , BURWELL, Phillip , GUO, Zihong , MATSON, Jennifer , DALY, Steven , SHINE, David , LICHTTENEGGER, Gary , BISHOP, Jean , YEO, Nick
发明人： BURWELL, Phillip , GUO, Zihong , MATSON, Jennifer , DALY, Steven , SHINE, David , LICHTTENEGGER, Gary , BISHOP, Jean , YEO, Nick
IPC分类号： A61M
CPC分类号： A61N5/0601 , A61B2018/2261 , A61N5/062 , A61N2005/0602 , A61N2005/0652 , A61N2005/1003
摘要： Light generating devices for illuminating portions of vascular tissue, to render photodynamic therapy. In one embodiment, a light source array preferably including a plurality of light emitting diodes, a focusing lens, and a light diffusing element are included in a distal end of a catheter. A balloon is optionally provided to interrupt blood flow that can block the transmission of light, and to center the apparatus in a blood vessel. Optical fibers optionally direct light from the light source to the diffusing element. The light source array can have a radial or linear configuration and can produce more than one wavelength of light for activating different photoreactive agents. Linear light source elements are particularly useful to treat elongate portions of tissue in a vessel. One embodiment intended for use with a conventional balloon catheter integrates light sources into a guidewire.
摘要翻译：用于照射血管组织部分的光产生装置，以进行光动力疗法。在一个实施例中，优选地包括多个发光二极管的光源阵列，聚焦透镜和光漫射元件被包括在导管的远端中。可选地提供气球来中断可阻挡光的传播的血流，并使装置居中在血管中。光纤可选地将来自光源的光引导到漫射元件。光源阵列可以具有径向或线性配置并且可以产生多于一个波长的光以激活不同的光反应剂。线性光源元件特别适用于处理容器中组织的细长部分。旨在用于常规气囊导管的一个实施例将光源集成到导丝中。

3. 发明申请

WO0029056A3 CORONARY INFUSION CATHETER AND INTRA-CORONARY DRUG ADMINISTRATION METHODS 审中-公开
标题翻译：冠状动脉灌注导管和冠状动脉介入治疗方法
公开(公告)号：WO0029056A3
公开(公告)日：2001-01-04
申请号：PCT/US9927605
申请日：1999-11-18
申请人： CORVASCULAR INC , DUHAYLONGSOD FRANCIS G , NARCISO HUGH JR , MILLER JOHN , PASPA PAUL , IKI KOBI , MORALES STEPHEN
发明人： DUHAYLONGSOD FRANCIS G , NARCISO HUGH JR , MILLER JOHN , PASPA PAUL , IKI KOBI , MORALES STEPHEN
IPC分类号： A61M25/00 , A61M25/06 , A61M29/02
CPC分类号： A61M25/0041 , A61M25/0662 , A61M2025/1097 , A61M2210/127
摘要： An infusion/guide catheter which is adapted to be introduced into a coronary ostium of a coronary artery of the heart of a patient through an opening in an aorta of the patient, permitting blood perfusion from the aorta into the ostium. Preferably, the catheters can be placed without the use of fluoroscopy. In one embodiment, the infusion catheter generally comprises a tube having at least one lumen, a proximal end, and a distal end, the tube having at least one bend to facilitate placement of the distal end of the tube into the ostium of the coronary artery when the proximal end of the tube extends from the opening in the aorta, wherein the distal end of the tube is configured to fit within the coronary ostium while still permitting blood perfusion from the aorta into the ostium. The catheter, can be used to deliver a fluid, more locally in the heart to enhance the efficiency of fluid or drug administration. Several embodiments include a light delivery portion capable of illuminating a distal end of the catheter for visualization thereof through the vasculature. A guidewire having a light delivery portion is also capable of illuminating a distal end of a catheter for placement of the catheter in a coronary vessel without the use of fluoroscopy.
摘要翻译：输液/引导导管，其适于通过患者主动脉中的开口引入患者心脏的冠状动脉的冠状口，允许从主动脉进入口腔的血液灌注。优选地，可以在不使用荧光透视的情况下放置导管。在一个实施例中，输注导管通常包括具有至少一个内腔，近端和远端的管，该管具有至少一个弯曲部，以便于将管的远端放置在冠状动脉的口中当管的近端从主动脉中的开口延伸时，其中管的远端构造成适合于冠状口中，同时仍然允许从主动脉进入口腔的血液灌注。导管可用于在心脏中更局部地输送流体，以提高流体或药物施用的效率。几个实施例包括能够照射导管的远端的光输送部分，用于通过脉管系统使其可视化。具有光输送部分的导丝还能够照射导管的远端，以将导管放置在冠状血管中而不使用透视。

4. 发明申请

WO2004082736A3 LIGHT GENERATING DEVICE TO INTRAVASCULAR USE 审中-公开
标题翻译：光生成装置用于静脉内使用
公开(公告)号：WO2004082736A3
公开(公告)日：2005-10-27
申请号：PCT/US2004007563
申请日：2004-03-12
申请人： LIGHT SCIENCES CORP , BURWELL PHILLIP , GUO ZIHONG , MATSON JENNIFER , DALY STEVEN , SHINE DAVID , LICHTTENEGGER GARY , BISHOP JEAN , YEO NICK , NARCISO HUGH
发明人： BURWELL PHILLIP , GUO ZIHONG , MATSON JENNIFER , DALY STEVEN , SHINE DAVID , LICHTTENEGGER GARY , BISHOP JEAN , YEO NICK
IPC分类号： A61B18/22 , A61M20060101 , A61N1/00 , A61N5/00 , A61N5/06 , A61N5/10
CPC分类号： A61N5/0601 , A61B2018/2261 , A61N5/062 , A61N2005/0602 , A61N2005/0652 , A61N2005/1003
摘要： Light generating devices for illuminating portions of vascular tissue, to render photodynamic therapy. In one embodiment, a light source array preferably including a plurality of light emitting diodes, a focusing lens, and a light diffusing element are included in a distal end of a catheter. A balloon is optionally provided to interrupt blood flow that can block the transmission of light, and to center the apparatus in a blood vessel. Optical fibers optionally direct light from the light source to the diffusing element. The light source array can have a radial or linear configuration and can produce more than one wavelength of light for activating different photoreactive agents. Linear light source elements are particularly useful to treat elongate portions of tissue in a vessel. One embodiment intended for use with a conventional balloon catheter integrates light sources into a guidewire.
摘要翻译：用于照射血管组织部分的光产生装置，以进行光动力疗法。在一个实施例中，优选地包括多个发光二极管的光源阵列，聚焦透镜和光漫射元件被包括在导管的远端中。可选地提供气球来中断可阻挡光的传播的血流，并使装置居中在血管中。光纤可选地将来自光源的光引导到漫射元件。光源阵列可以具有径向或线性配置并且可以产生多于一个波长的光以激活不同的光反应剂。线性光源元件特别适用于处理容器中组织的细长部分。旨在用于常规气囊导管的一个实施例将光源集成到导丝中。

5. 发明申请

WO1997005127A1 PHOTOACTIVATABLE COMPOUNDS FOR THE PREVENTION OF INTIMAL HYPERPLASIA AND OTHER DISEASES 审中-公开
标题翻译：用于预防原发性高血压和其他疾病的光敏化合物
公开(公告)号：WO1997005127A1
公开(公告)日：1997-02-13
申请号：PCT/US1996012128
申请日：1996-07-23
申请人： PDT SYSTEMS, INC. , ROBINSON, Byron , MORGAN, Alan, R. , NARCISO, Hugh, L.
发明人： PDT SYSTEMS, INC.
IPC分类号： C07D309/38
CPC分类号： C07D493/04 , A61K41/0066 , A61K41/0071
摘要： A broad class of photosensitive compounds having enhanced in vivo target tissue selectivity and versatility in photodynamic therapy. Many furocoumarin compounds, such as psoralens, exhibit cytostatic activity when photoactivated but exhibit little in vivo specificity for selectively accumulating in any particular target tissue such as atheromatous plaques. Reactive Oxygen Producing Photosensitizers ("ROPPs") are photoactivatable compounds having an affinity for hyperproliferating cells (such as atheromatous plaque cells), which when photoactivated, produce cytotoxic reaction products. The photoactivity of a ROPP, such as a porphyrin, may be reduced by metalating the porphyrin while the selective affinity of the metalized ROPP for hyperproliferating tissue remains substantially unchanged. By linking a furocoumarin compound to a ROPP to form a F-ROPP, the cytostatic properties of the furocoumarin portion of the F-ROPP can be exploited while the selective affinity of the ROPP portion of the compound for hyperproliferating cells such as atheromatous plaque provides enhanced tissue selectivity without cytotoxicity. In vivo, certain F-ROPPs may be forced to selectively accumulate in a target tissue by illuminating only the target tissue with light having a wavelength operable for photoactivating the F portion of the F-ROPP thereby causing the F-ROPP to either form a monoadduct with or cross-link the cellular DNA in the target tissue. Light of a second wavelength can then be delivered to the target tissue to photoactivate the ROPP portion causing further interference with cellular activity.
摘要翻译：广泛的光敏化合物具有增强的体内靶组织选择性和光动力疗法的多功能性。许多呋喃香豆素化合物，如补骨脂素，当光活化时表现出细胞抑制活性，但是在任何特定靶组织如动脉粥样硬化斑块中选择性积累，但体内特异性较小。活性氧生产光敏剂（“ROPP”）是具有对过度增殖细胞（如动脉粥样硬化斑块细胞）的亲和力的光活化化合物，其在光活化时产生细胞毒性反应产物。可以通过金属化卟啉来减少ROPP如卟啉的光活性，同时金属化ROPP对过度增殖组织的选择性亲和性基本上保持不变。通过将呋喃香豆素化合物与ROPP连接以形成F-ROPP，可以利用F-ROPP的呋喃香豆素部分的细胞生长抑制性能，而化合物的ROPP部分对过度增殖细胞如动脉粥样硬化斑块的选择性亲和性提高组织选择性没有细胞毒性。在体内，某些F-ROPP可能被迫通过用具有可激活F-ROPP的F部分的光波长的光照射目标组织而选择性地累积在靶组织中，从而使F-ROPP形成单加合物与靶组织中的细胞DNA连接或交联。然后可以将第二波长的光递送到目标组织以激活ROPP部分，导致进一步干扰细胞活性。

6. 发明申请

WO2009033049A1 DEVICE FOR INTERMITTENTLY OBSTRUCTING A GASTRIC OPENING AND METHOD OF USE 审中-公开
标题翻译：用于间断打开气门开启的装置和使用方法
公开(公告)号：WO2009033049A1
公开(公告)日：2009-03-12
申请号：PCT/US2008/075439
申请日：2008-09-05
申请人： BARONOVA, INC. , BURNETT, Daniel Rogers , NARCISO, Hugh , PASPA, Paul , WISER, David , MEADE, Stephen L.
发明人： BURNETT, Daniel Rogers , NARCISO, Hugh , PASPA, Paul , WISER, David , MEADE, Stephen L.
IPC分类号： A61B17/08
CPC分类号： A61F5/0079 , A61B5/065 , A61B17/12022 , A61B17/1204 , A61B17/12099 , A61B17/12136 , A61B17/12159 , A61B17/12163 , A61B17/12172 , A61B17/1219 , A61B2017/00119 , A61B2017/00221 , A61B2017/22069 , A61M5/14276 , A61M5/1723 , A61M31/002
摘要： The present invention relates to a device for intermittently obstructing a bodily opening, such as a gastric opening, and includes a proximal member connected to a distal member by a tether. The proximal member includes an apron member surrounding a first occluding member, which is formable from an elongated and narrower configuration to a contracted or expanded but wider configuration. When employed in the stomach, the device of the present invention is arranged transluminally, with the distal member disposed in the duodenum and the proximal member disposed against the pyloric valve, intermittently occluding the pyloric valve and preventing or delaying the flow of gastric contents through the pyloric valve. In certain embodiments, a reservoir may be included for releasing a substance of interest, for example for releasing insulin from a reservoir disposed in the distal member. Sensors, actuators, and data transmission devices may also be included.
摘要翻译：本发明涉及一种用于间歇地阻塞诸如胃开口的身体开口的装置，并且包括通过系绳连接到远端构件的近端构件。近端构件包括围绕第一闭塞构件的围裙构件，其可从细长且较窄的构造形成为收缩或扩展但更宽的构造。当在胃中使用时，本发明的装置是平行布置的，其中远端构件设置在十二指肠中，并且近端构件设置在幽门瓣上，间歇地闭塞幽门瓣膜，并且通过所述胃内容物阻止或延迟胃液的流动幽门阀在某些实施方案中，可以包括储存器以释放感兴趣的物质，例如用于从设置在远端构件中的储存器释放胰岛素。还可以包括传感器，致动器和数据传输装置。

7. 发明申请

WO2006026704A3 DEVICES AND METHODS FOR GYNECOLOGIC HORMONE MODULATION IN MAMMALS 审中-公开
标题翻译：乳腺肿瘤细胞调节的装置和方法
公开(公告)号：WO2006026704A3
公开(公告)日：2007-05-10
申请号：PCT/US2005031102
申请日：2005-08-31
申请人： LEPTOS BIOMEDICAL INC , NARCISO HUGH LOUIS JR
发明人： NARCISO HUGH LOUIS JR
IPC分类号： A61N1/36
CPC分类号： A61N1/0558 , A61N1/0556 , A61N1/326 , A61N1/36107
摘要： Methods and devices for electrically stimulating nerves and organs to induce and modulate the production of hormones according to desired hormone production patterns and hormone level patterns to treat gynecological conditions. Such methods and devices may be used to treat menopause or to alleviate the symptoms of menopause. In addition, such methods and devices may be used for birth control.
摘要翻译：用于电刺激神经和器官以诱导和调节激素生成的方法和装置根据所需的激素生成模式和激素水平模式来治疗妇科病症。这些方法和装置可用于治疗绝经或减轻绝经症状。此外，这种方法和装置可以用于避孕。

8. 发明申请

WO9945852A3 ANASTOMOSIS DEVICE AND METHOD 审中-公开
标题翻译： ANASTOMOSIS装置和方法
公开(公告)号：WO9945852A3
公开(公告)日：1999-12-23
申请号：PCT/US9904714
申请日：1999-03-03
申请人： CORVASCULAR INC , DUHAYLONGSOD FRANCIS G , FRENCH FRITZ , CHAPMAN TROY , NARCISO HUGH L JR
发明人： DUHAYLONGSOD FRANCIS G , FRENCH FRITZ , CHAPMAN TROY , NARCISO HUGH L JR
IPC分类号： A61B17/00 , A61B17/11
CPC分类号： A61B17/11 , A61B2017/00004 , A61B2017/1135
摘要： A method for coupling a first vessel and a second vessel in an anastomosis. The method includes providing a first vessel with a fastener coupled thereto, inserting at least a portion of the device into the second vessel with an end portion of the fastener extending generally longitudinally through the second vessel, and radially expanding at least a portion of the fastener to sealingly secure the first vessel to an inner wall of the second vessel. An anastomosis fastener for use in coupling the first and second vessels together is also disclosed. The second vessel has an opening formed in a side wall thereof for insertion of the device. The device includes a tubular member at least a portion thereof being radially expandable. The tubular member is preformed with a bend along its central longitudinal axis so that a portion of the tubular member extends out from the side wall of the second vessel while an end portion of the tubular member extends generally coaxially with the second vessel when the tubular member is inserted in the second vessel. The tubular member is sufficiently rigid to substantially retain the tubular member in its preformed configuration after the tubular member is expanded.
摘要翻译：一种用于在吻合中连接第一血管和第二血管的方法。所述方法包括提供第一容器和与其连接的紧固件，将所述装置的至少一部分插入第二容器中，其中紧固件的端部大致纵向延伸穿过第二容器，并且径向扩张至少一部分紧固件以将第一容器密封地固定到第二容器的内壁。还公开了用于将第一容器和第二容器联接在一起的吻合紧固件。第二容器在其侧壁上具有用于插入装置的开口。该装置包括管状部件，其至少一部分可径向膨胀。管状构件沿其中心纵向轴线弯曲成预定形状，从而管状构件的一部分从第二容器的侧壁延伸出去，同时管状构件的端部与第二容器大致同轴地延伸，当管状构件插入第二个容器中。管状构件具有足够的刚性以在管状构件膨胀之后将管状构件基本保持在其预成型构造中。

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