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1. 发明申请

WO2014150894A1 LOCKING GASTRIC OBSTRUCTION DEVICE AND METHOD OF USE 审中-公开
标题翻译：锁定气体阻挡装置及其使用方法
公开(公告)号：WO2014150894A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/024475
申请日：2014-03-12
申请人： BARONOVA, INC.
发明人： NEEDLEMAN, David , ROTH, Alex , BURNETT, Daniel Rogers , VAN WESTENBERG, Jimmy , IKI, Kobi
IPC分类号： A61B5/03 , A61B17/08 , A61B17/12 , A61F2/04 , A61M29/00
CPC分类号： A61F5/0079 , A61F5/0089
摘要： The present invention relates to a device for intermittently obstructing a bodily opening, such as a gastric opening, and includes a proximal member connected to a distal member by a tether. The proximal member is formable from an elongated and narrower configuration to a contracted or expanded but wider configuration. When employed in the stomach, the device may be arranged transluminally with the distal member disposed in the duodenum and the proximal member disposed against the pyloric valve, intermittently occluding the pyloric valve and preventing or delaying the flow of gastric contents through the pyloric valve.
摘要翻译：本发明涉及一种用于间歇地阻塞诸如胃开口的身体开口的装置，并且包括通过系绳连接到远端构件的近端构件。近端构件可从细长且较窄的构造形成为收缩或扩展但更宽的构型。当在胃中使用时，装置可以平行地布置，其中远端构件设置在十二指肠中，并且近端构件设置在幽门阀上，间歇地闭塞幽门阀并防止或延迟通过幽门阀的胃内容物流。

2. 发明申请

WO2018169805A1 INGESTIBLE AND EXPANDABLE DEVICES AND ASSEMBLIES FOR WEIGHT-LOSS AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2018169805A1
公开(公告)日：2018-09-20
申请号：PCT/US2018/021868
申请日：2018-03-09
申请人： BARONOVA, INC.
发明人： QI, Wenkang , BREWER, Tracy
IPC分类号： A61F5/00 , A61M29/02 , A61N2/06 , A61N2/10
CPC分类号： A61F5/0013 , A61F5/00 , A61F5/0026 , A61F5/0036
摘要： Disclosed are devices, assemblies, and methods for treating obesity. In one embodiment, an ingestible intragastric device is disclosed comprising an expandable frame, a device covering encompassing the expandable frame, and multiple magnetic components wherein at least one of the magnetic components is configured to be magnetized remotely by a portable electronic device. In another embodiment, an intragastric assembly is disclosed comprising a plurality of intragastric space-filling devices each having an electropermanent magnet configured to be magnetized remotely by a portable electronic device. The intragastric space-filling devices are configured to magnetically join together into an intragastric space-filling agglomeration. In another embodiment, an intragastric assembly is disclosed comprising a plurality of intragastric space-filling vessels configured to join together to form an intragastric vessel agglomeration. Each intragastric space-filling vessel comprises a magnet and a filling material configured to expand upon contact with stomach acid.

3. 发明申请

WO2007092501A2 GASTRO-INTESTINAL DEVICE AND METHOD FOR TREATING ADDICTION 审中-公开
标题翻译：胃肠道装置及治疗方法
公开(公告)号：WO2007092501A2
公开(公告)日：2007-08-16
申请号：PCT/US2007003260
申请日：2007-02-05
申请人： BARONOVA INC , BURNETT DANIEL R
发明人： BURNETT DANIEL R
CPC分类号： A61F5/0079 , A61B5/14539 , A61B5/42 , A61B5/4839 , A61B5/6882 , A61F5/003 , A61F5/0036 , A61N1/0558 , A61N1/36007
摘要： A device and a method for treating a medical condition include a reversible member disposed in a patient's gastro-intestinal tract, and a dispensing member coupled to the reversible member that delivers a drug and/or a noxious when a predetermined substance is detected. In a different embodiment, the device and method of the present invention include a polymer infused with a drug and disposed into a preformed shell inside the gastric space, where it expands and hardens, releasing the drug over time. Both the casing and the polymer may be biocompatible. The present invention enables the slow-release of anti-addictive agents without patient tampering and with the appropriate dosage. Ancillary systems such as sensors, actuators, refill and recharge ports, and communication and data processing units may also be included.
摘要翻译：用于治疗医疗状况的装置和方法包括设置在患者胃肠道中的可逆构件，以及耦合到可逆构件的分配构件，其在检测到预定物质时递送药物和/或有害物质。在不同的实施方案中，本发明的装置和方法包括注射药物的聚合物，并且放置在胃空间内的预先形成的壳体中，其中其膨胀和硬化，随着时间的推移释放药物。套管和聚合物都可以是生物相容的。本发明能够缓慢释放抗上瘾剂而无需患者篡改和适当的剂量。还可以包括诸如传感器，执行器，补充和再充电端口的辅助系统，以及通信和数据处理单元。

4. 发明申请

WO2018136967A1 GASTRIC OBSTRUCTION DEVICE DEPLOYMENT ASSEMBLY AND METHODS OF DELIVERING AND DEPLOYING A GASTRIC OBSTRUCTION DEVICE 审中-公开
公开(公告)号：WO2018136967A1
公开(公告)日：2018-07-26
申请号：PCT/US2018/014913
申请日：2018-01-23
申请人： BARONOVA, INC.
发明人： NEEDLEMAN, David , ROTH, Alex , BURNETT, Daniel R. , VAN WESTENBERG, Jimmy , IKI, Kobi
IPC分类号： A61B17/12 , A61F2/04 , A61M29/00
CPC分类号： A61F5/0089 , A61F5/003 , A61F5/004 , A61F5/0079
摘要： The present invention relates to gastric obstruction device deployment systems and a device for intermittently obstructing a bodily opening, such as a gastric opening, and includes a proximal occluding member connected to a distal occluding member by a tether. The proximal occluding member is formable from an elongated and narrower configuration to a contracted or expanded but wider configuration. When employed in the stomach, the gastric obstruction device may be arranged transluminally with the distal occluding member disposed in the duodenum and the proximal occluding member disposed against the pyloric valve, intermittently occluding the pyloric valve and preventing or delaying the flow of gastric contents through the pyloric valve.

5. 发明申请

WO2006020370A3 DEVICES AND METHODS FOR PYLORIC ANCHORING 审中-公开
标题翻译：用于垂直锚定的装置和方法
公开(公告)号：WO2006020370A3
公开(公告)日：2008-12-24
申请号：PCT/US2005026370
申请日：2005-07-25
申请人： BARONOVA INC , BURNETT DANIEL R , HALL GREGORY W , CAMPBELL-WHITE ANNETTE , BAJOR JORDAN T
发明人： BURNETT DANIEL R , HALL GREGORY W , CAMPBELL-WHITE ANNETTE , BAJOR JORDAN T
IPC分类号： A61B18/18 , A61B5/03 , A61B5/07 , A61B17/04 , A61B17/08 , A61B17/12 , A61F20060101 , A61F2/04 , A61F5/00
CPC分类号： A61F5/0079 , A61B5/036 , A61B5/073 , A61B5/145 , A61B5/14539 , A61B5/14546 , A61B5/4238 , A61B17/12022 , A61B17/12036 , A61B17/12099 , A61B17/12136 , A61B17/12172 , A61B17/1219 , A61B2017/00876 , A61B2017/12054 , A61B2017/12086 , A61F2/24 , A61F5/003 , A61F5/0036 , A61F2002/044 , A61N1/06 , A61N1/40
摘要： A device for performing one or more functions in a gastrointestinal tract of a patient includes an anchoring member and at least one actuator, sensor, or combination of both coupled with the anchoring device. The anchoring device (80) is adapted to maintain at least part of the device within a pyloric portion of the patient's stomach and to intermittently engage, without directly attaching to, stomach tissue. Actuators perform any suitable function, such as transmitting energy to tissue, acting as a sleeve to reduce nutrient absorption, occupying space in the stomach, eluting a drug and/or the like. Sensors may be adapted to sense any suitable patient characteristic within the patient's gastrointestinal tract, such as pH, temperature, bile content, nutrient content, fats, sugars, alcohol, opiates, drugs, analytes, electrolytes and/or hemoglobin.
摘要翻译：用于在患者的胃肠道中执行一个或多个功能的装置包括锚定构件和至少一个致动器，传感器或两者的组合，其与锚定装置联接。锚固装置（80）适于将装置的至少一部分保持在患者胃的幽门部分内并间歇地接合，而不直接附着于胃组织。致动器执行任何合适的功能，例如将能量传递到组织，用作套筒以减少营养吸收，占据胃中的空间，洗脱药物等。传感器可以适于感测患者胃肠道内的任何合适的患者特征，例如pH，温度，胆汁含量，营养成分，脂肪，糖，酒精，阿片剂，药物，分析物，电解质和/或血红蛋白。

6. 发明申请

WO2006047708A3 MEDICAL DEVICE DELIVERY CATHETER 审中-公开
标题翻译：医疗器械输送管
公开(公告)号：WO2006047708A3
公开(公告)日：2009-04-16
申请号：PCT/US2005038842
申请日：2005-10-25
申请人： BARONOVA INC , BURNETT DANIEL R , HALL GREGORY W , BAJOR JORDAN T , FISHER WINFIELD SCOTT , HITES TIBOR LASZLO
发明人： BURNETT DANIEL R , HALL GREGORY W , BAJOR JORDAN T , FISHER WINFIELD SCOTT , HITES TIBOR LASZLO
IPC分类号： A61B17/00 , A61B7/04 , A61F2/04
CPC分类号： A61F2/95 , A61B17/12099 , A61B17/12159 , A61B2017/12054 , A61B2017/12059 , A61B2017/12081 , A61B2090/037 , A61F2/88 , A61F2/97 , A61F5/0079 , A61F2002/044 , A61F2002/9511
摘要： Apparatus for delivering a medical device to a location in a patient's body includes an elongate catheter body having a proximal end and a distal end, a pod coupled with the distal end of the catheter body and adapted to house the medical device during delivery to the location and to open to release the medical device, and at least one distal actuator coupled with at least one of the pod and the medical device. The distal actuator is adapted to promote opening of the pod. A method involves advancing a pod at the distal end of an elongate catheter to the location within the body and activating an actuator coupled with the pod and/or the medical device to cause the pod to open. Opening the pod releases the medical device.
摘要翻译：用于将医疗装置递送到患者体内的位置的装置包括具有近端和远端的细长导管主体，与导管主体的远端联接的适配器，用于在输送到位置期间容纳医疗装置并且打开以释放所述医疗装置，以及至少一个与所述容器和所述医疗装置中的至少一个联接的远端致动器。远侧致动器适于促进荚的打开。一种方法包括将细长导管的远端处的囊推进到体内的位置，并启动与荚和/或医疗装置连接的致动器以使荚打开。打开荚释放医疗器械。

7. 发明申请

WO2007092390A3 DEVICES AND METHODS FOR GASTROINTESTINAL STIMULATION 审中-公开
标题翻译：胃肠道刺激的装置和方法
公开(公告)号：WO2007092390A3
公开(公告)日：2008-02-21
申请号：PCT/US2007003052
申请日：2007-02-05
申请人： BARONOVA INC , BURNETT DANIEL R
发明人： BURNETT DANIEL R
IPC分类号： A61B17/08
CPC分类号： A61F5/0079 , A61B5/14539 , A61B5/42 , A61B5/4839 , A61B5/6882 , A61F5/003 , A61F5/0036 , A61N1/0558 , A61N1/36007
摘要： Devices and methods for applying gastrointestinal stimulation include implanting a stimulation device including a body with at least one expandable portion and a bridging portion and at least one stimulation member in the gastrointestinal tract. The at least one stimulation member includes one or more energy delivery members, one or more sensors, or a combination of both. The body maintains the device within the gastrointestinal space, and preferentially within the pyloric portion of the patient's stomach, and prevents passage of the device from the gastrointestinal space, but is not rigidly anchored or affixed to the gastrointestinal wall tissue.
摘要翻译：用于施加胃肠刺激的装置和方法包括将包括身体的刺激装置植入到具有至少一个可膨胀部分和桥接部分以及至少一个刺激部件的胃肠道中。所述至少一个刺激构件包括一个或多个能量传递构件，一个或多个传感器或两者的组合。身体将该装置保持在胃肠空间内，优选地在患者胃的幽门部分内保持，并且防止装置从胃肠空间通过，而不是刚性地锚固或固定在胃肠壁组织上。

8. 发明申请

WO2007027812A3 GASTRIC RETAINING DEVICES AND METHODS 审中-公开
公开(公告)号：WO2007027812A3
公开(公告)日：2007-03-08
申请号：PCT/US2006/033923
申请日：2006-08-29
申请人： BARONOVA, INC. , BURNETT, Daniel, R. , HALL, Greg , GALLUP, David, A.
发明人： BURNETT, Daniel, R. , HALL, Greg , GALLUP, David, A.
IPC分类号： A61F2/04 , A61B17/08 , A61F2/00
摘要： Devices and methods are disclosed that facilitate gastric retention. In one embodiment of the present invention, a gastric device includes a support portion for preventing the device from passing through the pyloric valve or esophagus, and an optional retaining member for maintaining a position in the stomach. The device may be deliverable into the stomach through the esophagus, either by swallowing or through a delivery tube or catheter, and may be fully reversible. In another embodiments, a gastric device according to the present invention self-expands within the stomach, while in still another embodiments a gastric device is inflatable or otherwise expandable.

9. 发明申请

WO2009033049A1 DEVICE FOR INTERMITTENTLY OBSTRUCTING A GASTRIC OPENING AND METHOD OF USE 审中-公开
标题翻译：用于间断打开气门开启的装置和使用方法
公开(公告)号：WO2009033049A1
公开(公告)日：2009-03-12
申请号：PCT/US2008/075439
申请日：2008-09-05
申请人： BARONOVA, INC. , BURNETT, Daniel Rogers , NARCISO, Hugh , PASPA, Paul , WISER, David , MEADE, Stephen L.
发明人： BURNETT, Daniel Rogers , NARCISO, Hugh , PASPA, Paul , WISER, David , MEADE, Stephen L.
IPC分类号： A61B17/08
CPC分类号： A61F5/0079 , A61B5/065 , A61B17/12022 , A61B17/1204 , A61B17/12099 , A61B17/12136 , A61B17/12159 , A61B17/12163 , A61B17/12172 , A61B17/1219 , A61B2017/00119 , A61B2017/00221 , A61B2017/22069 , A61M5/14276 , A61M5/1723 , A61M31/002
摘要： The present invention relates to a device for intermittently obstructing a bodily opening, such as a gastric opening, and includes a proximal member connected to a distal member by a tether. The proximal member includes an apron member surrounding a first occluding member, which is formable from an elongated and narrower configuration to a contracted or expanded but wider configuration. When employed in the stomach, the device of the present invention is arranged transluminally, with the distal member disposed in the duodenum and the proximal member disposed against the pyloric valve, intermittently occluding the pyloric valve and preventing or delaying the flow of gastric contents through the pyloric valve. In certain embodiments, a reservoir may be included for releasing a substance of interest, for example for releasing insulin from a reservoir disposed in the distal member. Sensors, actuators, and data transmission devices may also be included.
摘要翻译：本发明涉及一种用于间歇地阻塞诸如胃开口的身体开口的装置，并且包括通过系绳连接到远端构件的近端构件。近端构件包括围绕第一闭塞构件的围裙构件，其可从细长且较窄的构造形成为收缩或扩展但更宽的构造。当在胃中使用时，本发明的装置是平行布置的，其中远端构件设置在十二指肠中，并且近端构件设置在幽门瓣上，间歇地闭塞幽门瓣膜，并且通过所述胃内容物阻止或延迟胃液的流动幽门阀在某些实施方案中，可以包括储存器以释放感兴趣的物质，例如用于从设置在远端构件中的储存器释放胰岛素。还可以包括传感器，致动器和数据传输装置。

10. 发明申请

WO2007092501A3 GASTRO-INTESTINAL DEVICE AND METHOD FOR TREATING ADDICTION 审中-公开
公开(公告)号：WO2007092501A3
公开(公告)日：2007-08-16
申请号：PCT/US2007/003260
申请日：2007-02-05
申请人： BARONOVA, INC. , BURNETT, Daniel, R.
发明人： BURNETT, Daniel, R.
IPC分类号： A61B17/08
摘要： A device and a method for treating a medical condition include a reversible member disposed in a patient's gastro-intestinal tract, and a dispensing member coupled to the reversible member that delivers a drug and/or a noxious when a predetermined substance is detected. In a different embodiment, the device and method of the present invention include a polymer infused with a drug and disposed into a preformed shell inside the gastric space, where it expands and hardens, releasing the drug over time. Both the casing and the polymer may be biocompatible. The present invention enables the slow-release of anti-addictive agents without patient tampering and with the appropriate dosage. Ancillary systems such as sensors, actuators, refill and recharge ports, and communication and data processing units may also be included.

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