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    • 1. 发明申请
    • CORONARY INFUSION CATHETER AND INTRA-CORONARY DRUG ADMINISTRATION METHODS
    • 冠状动脉灌注导管和冠状动脉介入治疗方法
    • WO0029056A3
    • 2001-01-04
    • PCT/US9927605
    • 1999-11-18
    • CORVASCULAR INCDUHAYLONGSOD FRANCIS GNARCISO HUGH JRMILLER JOHNPASPA PAULIKI KOBIMORALES STEPHEN
    • DUHAYLONGSOD FRANCIS GNARCISO HUGH JRMILLER JOHNPASPA PAULIKI KOBIMORALES STEPHEN
    • A61M25/00A61M25/06A61M29/02
    • A61M25/0041A61M25/0662A61M2025/1097A61M2210/127
    • An infusion/guide catheter which is adapted to be introduced into a coronary ostium of a coronary artery of the heart of a patient through an opening in an aorta of the patient, permitting blood perfusion from the aorta into the ostium. Preferably, the catheters can be placed without the use of fluoroscopy. In one embodiment, the infusion catheter generally comprises a tube having at least one lumen, a proximal end, and a distal end, the tube having at least one bend to facilitate placement of the distal end of the tube into the ostium of the coronary artery when the proximal end of the tube extends from the opening in the aorta, wherein the distal end of the tube is configured to fit within the coronary ostium while still permitting blood perfusion from the aorta into the ostium. The catheter, can be used to deliver a fluid, more locally in the heart to enhance the efficiency of fluid or drug administration. Several embodiments include a light delivery portion capable of illuminating a distal end of the catheter for visualization thereof through the vasculature. A guidewire having a light delivery portion is also capable of illuminating a distal end of a catheter for placement of the catheter in a coronary vessel without the use of fluoroscopy.
    • 输液/引导导管,其适于通过患者主动脉中的开口引入患者心脏的冠状动脉的冠状口,允许从主动脉进入口腔的血液灌注。 优选地,可以在不使用荧光透视的情况下放置导管。 在一个实施例中,输注导管通常包括具有至少一个内腔,近端和远端的管,该管具有至少一个弯曲部,以便于将管的远端放置在冠状动脉的口中 当管的近端从主动脉中的开口延伸时,其中管的远端构造成适合于冠状口中,同时仍然允许从主动脉进入口腔的血液灌注。 导管可用于在心脏中更局部地输送流体,以提高流体或药物施用的效率。 几个实施例包括能够照射导管的远端的光输送部分,用于通过脉管系统使其可视化。 具有光输送部分的导丝还能够照射导管的远端,以将导管放置在冠状血管中而不使用透视。
    • 2. 发明申请
    • COVERED STENT WITH CONTROLLED THERAPEUTIC AGENT DIFFUSION
    • 具有控制治疗药物扩散的涵盖性
    • WO2006031284A3
    • 2006-04-13
    • PCT/US2005024183
    • 2005-07-11
    • VASCULAR ARCHITECTS INCIKI KOBITSURUDA MARSHALL
    • IKI KOBITSURUDA MARSHALL
    • A61F2/06A61K9/22A61K9/52A61K31/74
    • A61F2/91A61F2/88A61F2250/0068
    • A covered stent (18) includes a generally tubular stent body (16) having inner and outer stent body surfaces (26, 24). A sleeve of porous material (20) encloses the stent body and has inner and outer portions (40, 42) opposed to the inner and outer stent body surfaces. A therapeutic agent is located along the stent body, the agent being diffusible through the material. A diffusion barrier (30) is located between the inner material portion and the agent along the stent. The diffusion barrier prevents passage of at least a significant amount the agent through the inner portion of the sleeve of porous material. A diffusion restrictor (32) is located between the outer portion of the sleeve of porous material and the agent along the stent. The diffusion restrictor permits passage of the agent through the inner material portion at a therapeutic level.
    • 被覆盖的支架(18)包括具有内部和外部支架体表面(26,24)的大体上管状的支架体(16)。 多孔材料(20)的套管包围支架主体并且具有与内部和外部支架体表面相对的内部和外部部分(40,42)。 治疗剂沿着支架体定位,该药剂通过该材料可扩散。 扩散阻挡层(30)沿着支架位于内部材料部分和试剂之间。 扩散阻挡层防止至少大量的试剂穿过多孔材料套筒的内部。 扩散限制器(32)位于多孔材料套筒的外部部分和沿着支架的试剂之间。 扩散限制器允许药剂以治疗水平通过内部材料部分。