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1. 发明申请

WO2017048224A1 CARTRIDGES AND SYSTEMS FOR OUTSIDE-IN FLOW IN MEMBRANE-BASED THERAPIES 审中-公开
标题翻译：基于膜的治疗外部流入的药物和系统
公开(公告)号：WO2017048224A1
公开(公告)日：2017-03-23
申请号：PCT/US2015/050004
申请日：2015-09-14
申请人： LABIB, Mohamed, E. , DUKHIN, Stanislav, S. , KELLY, Thomas , MATERNA, Peter
发明人： LABIB, Mohamed, E. , DUKHIN, Stanislav, S. , KELLY, Thomas , MATERNA, Peter
IPC分类号： B01D61/28 , B01D63/02 , A61M1/16
CPC分类号： A61M1/1625 , B01D61/28 , B01D63/02 , B01D2313/08
摘要： Embodiments of the invention pertain to cartridges, systems and methods for performing hemodialysis and related extracorporeal blood treatment modalities and therapies, in which blood flows in the inter fiber space and dialysate flows in the lumens of hollow fibers. Appropriate connectors and fitting orientations may be provided. There may be provided orbital distributors, fanning of fibers, and features to promote uniformity of fiber spacing in the fiber bundle. Orbital distributors may contain contoured surfaces, flow redirectors, non-uniform-conductance flow elements, through-wall distributors, and other features. There may be subdivision of the fiber bundle into two groups of fibers with separate control fluid to each group. Appropriate systems may be provided for various therapies. Flow past the fibers may be parallel, transverse or other configuration. These various features may enable long-term application to all dialysis and ultrafiltration related therapies, and also to other therapies and to applications including implantables, portables and wearables.
摘要翻译：本发明的实施例涉及用于进行血液透析和相关的体外血液处理模式和疗法的药筒，系统和方法，其中血液在纤维间隙中流动并且透析液在中空纤维内腔中流动。可以提供适当的连接器和配合方向。可以提供轨道分配器，纤维的扇形和特征，以促进纤维束中的纤维间隔的均匀性。轨道分配器可以包含轮廓表面，流动重定向器，非均匀电导流动元件，通孔分配器和其他特征。可以将纤维束分成两组纤维，每组具有单独的控制流体。可以为各种疗法提供适当的系统。通过纤维的流动可以是平行的，横向的或其它构型。这些各种特征可以使得能够长期应用于所有透析和超滤相关疗法，以及其它疗法以及包括植入物，便携式和可穿戴物在内的应用。

2. 发明申请

WO0238280A3 A WETTING-RESISTANT NOZZLE FOR DISPENSING SMALL VOLUMES OF LIQUID AND A METHOD FOR MANUFACTURING A WETTING-RESISTANT NOZZLE 审中-公开
标题翻译：用于分配液体小容量的耐湿喷嘴和制造耐湿喷嘴的方法
公开(公告)号：WO0238280A3
公开(公告)日：2003-10-09
申请号：PCT/US0147041
申请日：2001-11-13
申请人： THERICS INC , MATERNA PETER A
发明人： MATERNA PETER A
IPC分类号： B01L3/02 , B05B1/00 , B05B13/02 , B05C5/02 , B05C13/02 , B41J2/14
CPC分类号： B01L3/0241 , B01L2300/166 , B05B1/00 , B05B13/0228 , B05C5/0212 , B05C13/025 , B41J2/14
摘要： A wetting-resistant nozzle for accurately and precisely dispensing small volumes of liquids. The nozzle comprises an internal flowpath, and an external surface that recedes from the discharge point at an angle greater than 90 degrees, and an exceptionally low surface energy for the external surface. The low surface energy material may exist as a coating on top of a shaped substrate. A flat land region may be included and may have sharp edges, one of which may define the boundary of the low surface energy region. Another embodiment includes the low surface energy material as a bulk material through which a hole is drilled. The internal flowpath inside the nozzle may be smoothly tapered. Liquid being dispensed tends not to advance past the edge of the low surface energy region, which may coincide with a geometrically sharp edge. Such nozzles provide improved dispensing of liquids that have both low surface tension and low viscosity, such as organic solvents.
摘要翻译：一种防湿喷嘴，用于精确和精确地分配少量液体。喷嘴包括内部流路，以及以大于90度的角度从排出点后退的外表面，以及外表面的极低的表面能。低表面能材料可以作为成形基底顶部的涂层存在。可以包括平坦的区域区域并且可以具有尖锐的边缘，其中一个可以限定低表面能区域的边界。另一个实施例包括作为大量材料的低表面能材料，通过该材料钻出孔。喷嘴内的内部流路可以平滑地渐缩。分配的液体往往不会超过低表面能区域的边缘，这可能与几何锋利的边缘重合。这种喷嘴提供了具有低表面张力和低粘度的液体的改进分配，例如有机溶剂。

3. 发明申请

WO0177988A3 SYSTEM AND METHOD FOR RAPIDLY CUSTOMIZING A DESIGN AND REMOTELY MANUFACTURING BIOMEDICAL DEVICES USING A COMPUTER SYSTEM 审中-公开
标题翻译：使用计算机系统快速自定义设计和远程制造生物医学设备的系统和方法
公开(公告)号：WO0177988A3
公开(公告)日：2003-03-06
申请号：PCT/US0111415
申请日：2001-04-05
申请人： THERICS INC , BRADBURY THOMAS J , GAYLO CHRISTOPHER M , FAIRWEATHER JAMES , CHESMEL KATHLEEN D , MATERNA PETER
发明人： BRADBURY THOMAS J , GAYLO CHRISTOPHER M , FAIRWEATHER JAMES , CHESMEL KATHLEEN D , MATERNA PETER
IPC分类号： A61C8/00 , A61C13/00 , A61F2/00 , A61F2/02 , A61F2/28 , A61F2/30 , A61K9/00 , A61K9/20 , G05B19/4099 , G06F19/00 , G06Q10/06 , G06Q50/22 , G06F17/50 , G06T17/00
CPC分类号： G06Q10/00 , A61C8/0006 , A61C13/0004 , A61F2/2803 , A61F2/30942 , A61F2002/2817 , A61F2002/2835 , A61F2002/2878 , A61F2002/30062 , A61F2002/3008 , A61F2002/30616 , A61F2002/30677 , A61F2002/30948 , A61F2002/30952 , A61F2002/30953 , A61F2002/30968 , A61F2210/0004 , A61F2250/0098 , A61F2310/00293 , A61K9/2095 , B33Y80/00 , B65G2207/14 , G05B19/4099 , G05B2219/35008 , G05B2219/35053 , G05B2219/35054 , G05B2219/35219 , G05B2219/35223 , G05B2219/45166 , G05B2219/45168 , G05B2219/49023 , G06F19/3418 , G06F19/3456 , G06F19/3481 , G06Q10/06 , G06Q50/22 , G16H10/60 , G16H15/00 , G16H50/50
摘要： A method of rapid design and manufacture of biomedical devices (160) using electronic data and modeling transmissions, wherein such transmissions are transferred via a computer network. The method includes capturing patient-specific diagnostic imaged data (100), converting the data to a digital computer file (110), transmitting the converted data (110) via the computer network to a remote manufacturing site, converting the computer file (110) into a multi-dimensional model (120) and then into machine instructions (130), and constructing (140) the biomedical implant (160). The present invention is further directed to the preparation of rapid-prototyped pharmaceutical forms, including oral dosage pills and implantable pharmaceuticals, with transmittal of such data over computer networks being used to significantly increase the cost effectiveness and responsiveness, and is further directed to the use of a website to perform various client-interaction and follow-up tasks.
摘要翻译：使用电子数据和建模传输来快速设计和制造生物医学装置（160）的方法，其中这样的传输通过计算机网络传送。该方法包括捕获患者特定的诊断成像数据（100），将数据转换为数字计算机文件（110），经由计算机网络将转换的数据（110）传送到远程制造站点，将计算机文件（110）进入多维模型（120），然后进入机器指令（130），以及构建（140）生物医学植入物（160）。本发明进一步涉及快速成型的药物形式的制备，包括口服剂量药片和可植入药物，通过计算机网络传送这些数据用于显着提高成本效益和响应性，并进一步涉及使用的网站执行各种客户端交互和后续任务。

4. 发明申请

WO2011112748A3 SPINAL SURGICAL APPARATUS AND METHOD OF TREATING AN ABNORMALLY SHAPED SPINE 审中-公开
公开(公告)号：WO2011112748A3
公开(公告)日：2011-09-15
申请号：PCT/US2011/027789
申请日：2011-03-09
申请人： KIM, Saechin , MATERNA, Peter, A.
发明人： KIM, Saechin , MATERNA, Peter, A.
IPC分类号： A61B17/70
摘要： A spinal surgical apparatus is described. The spinal surgical apparatus may include a first member having an adjustable length, wherein the first member allows increase in the length thereof but prevents decrease in the length thereof. Optionally, the spinal surgical apparatus may also include a second member allowing rotation in a first rotational direction but preventing rotation in a second rotational direction opposed to the first rotational direction. A method of treating an abnormally shaped spine is also described.

5. 发明申请

WO2005037137A2 SPINAL CAGE INSERT, FILLER PIECE AND METHOD OF MANUFACTURING 审中-公开
标题翻译：脊椎笼插入物，填充物片和制造方法
公开(公告)号：WO2005037137A2
公开(公告)日：2005-04-28
申请号：PCT/US2004/034092
申请日：2004-10-18
申请人： THERICS, INC. , SHAPPLEY, Ben, R. , HATCHER, Thomas, James , BEER, Charles , PRYOR, Timothy, J. , BLUM, John , BRADBURY, Thomas, J. , MATERNA, Peter, A. , MCGLOHORN, Jonathan , WEST, Thomas, George , SAINI, Sunil , RECBER, Ali, Cem
发明人： SHAPPLEY, Ben, R. , HATCHER, Thomas, James , BEER, Charles , PRYOR, Timothy, J. , BLUM, John , BRADBURY, Thomas, J. , MATERNA, Peter, A. , MCGLOHORN, Jonathan , WEST, Thomas, George , SAINI, Sunil , RECBER, Ali, Cem
IPC分类号： A61F
CPC分类号： A61F2/28 , A61F2/30744 , A61F2/4455 , A61F2002/2835 , A61F2002/30059 , A61F2002/30062 , A61F2002/30153 , A61F2002/30154 , A61F2002/30224 , A61F2002/30225 , A61F2002/30235 , A61F2002/30263 , A61F2002/30271 , A61F2002/30354 , A61F2002/30403 , A61F2002/30599 , A61F2002/30772 , A61F2002/30785 , A61F2002/30807 , A61F2002/30813 , A61F2002/30815 , A61F2002/30822 , A61F2002/30957 , A61F2002/30985 , A61F2210/0004 , A61F2220/0025 , A61F2220/0033 , A61F2230/0019 , A61F2230/0021 , A61F2230/0069 , A61F2230/0082 , A61F2230/0084 , A61F2250/0063 , A61F2310/00293
摘要： A spinal cage insert for a spinal cage is provided. The spinal cage insert has a shape suitable to be inserted into and fit closely in an interior of the spinal cage. The insert may comprise a member of the calcium phosphate family. The spinal cage insert may be made to a desired shape of porous ceramic, and it may include channels and/or surface features. Various shapes of filler pieces are also provided, wherein the filler pieces may be suitable to augment external regions of vertebrae which have been fused to each other so as to promote build-up of bone. The spinal cage insert and/or the filler pieces may be osteoconductive and may also contain osteoinductive substances or material. The articles may also contain cavities suitable for containing particles of demineralized bone matrix (DBM). Methods of use and methods of manufacturing the spinal cage insert and filler pieces are also provided.
摘要翻译：提供了一种用于脊柱笼的脊柱笼插入物。该脊柱笼插入物具有适合插入并紧密配合在脊柱笼内部的形状。插入物可以包含磷酸钙家族的成员。脊柱笼插入物可以制成所需形状的多孔陶瓷，并且其可以包括通道和/或表面特征。还提供了各种形状的填充片，其中填充片可以适合于增加彼此融合的椎骨的外部区域以促进骨的积聚。脊椎骨架插入物和/或填充物片可以是骨传导性的并且还可以包含骨诱导物质或材料。这些制品还可以含有适于容纳脱矿质骨基质（DBM）颗粒的空腔。还提供使用方法和制造脊柱笼插入件和填充件的方法。

6. 发明申请

WO2004005014A3 THREE-DIMENSIONAL PRINTING METHOD AND APPARATUS 审中-公开
标题翻译：三维打印方法和设备
公开(公告)号：WO2004005014A3
公开(公告)日：2004-07-08
申请号：PCT/US0320447
申请日：2003-06-26
申请人： THERICS INC , PRYOR TIMOTHY J , GAYLO CHISTOPHER M , ISKRA JAMES P , IMIOLEK IRENEUSZ J , FEDOR JEFFREY A , FAIRWEATHER JAMES A , FAGERQUIST RANDY LEE , WEITZEL DOUGLAS E , MATERNA PETER A
发明人： PRYOR TIMOTHY J , GAYLO CHISTOPHER M , ISKRA JAMES P , IMIOLEK IRENEUSZ J , FEDOR JEFFREY A , FAIRWEATHER JAMES A , FAGERQUIST RANDY LEE , WEITZEL DOUGLAS E , MATERNA PETER A
IPC分类号： B27N3/02 , B29C31/04 , B29C35/02 , B29C35/08 , B29C41/36 , B29C41/46 , B29C41/52 , B29C67/00 , B41F1/34 , B41J3/407 , B41L5/16 , H05B6/00 , B41J2/045 , B41J29/377 , F16C27/02 , F16C29/02 , G01F1/34
CPC分类号： B41J3/4073 , B22F3/1055 , B22F2003/1057 , B29C35/0288 , B29C41/36 , B29C41/46 , B29C41/52 , B29C43/34 , B29C64/165 , B29C2035/0822 , B29C2043/3494 , B33Y10/00 , B33Y30/00 , B33Y40/00 , B33Y50/00 , Y02P10/295
摘要： Apparatus, systems and methods for use in three-dimensional printing are shown and described. Various embodiments of the invention allow for more precise and controlled delivery of heat to achieve interlayer drying; isolation of the working region from the outside for reasons of cleanliness and in connection with the vapors of organic solvents; better control of the temperature of the working region; better accuracy in the flowrates of binder fluid dispensed; matching of delivered flowrates for multiple dispensers; verification of delivered flowrate or drops; provision for easier changeover of the machine from one powder to another; cleanability; and other needs.
摘要翻译：显示和描述了用于三维打印的装置，系统和方法。本发明的各种实施方案允许更精确和可控的热传递以实现层间干燥; 由于清洁的原因并与有机溶剂的蒸气有关，将工作区域从外部隔离; 更好地控制工作区域的温度; 粘合剂流体分配精度更高; 匹配多个分配器的输送流量; 验证所提供的流量或液滴; 提供更容易将机器从一种粉末切换到另一种粉末; 清洁性; 和其他需求。

7. 发明申请

WO2005114323A3 MANUFACTURING PROCESS OF THREE DIMENSIONAL PRINTING 审中-公开
标题翻译：三维印刷的制造工艺
公开(公告)号：WO2005114323A3
公开(公告)日：2006-12-21
申请号：PCT/US2005016734
申请日：2005-05-12
申请人： THERICS INC , MASSACHUSETTS INST TECHNOLOGY , SERDY JAMES , SACHS EMANUEL , WEST THOMAS GEORGE , SAINI SUNIL , CAI JIE , CARUSO ANDREA B , SHAROBIEM JOHN F , MATERNA PETER A
发明人： SERDY JAMES , SACHS EMANUEL , WEST THOMAS GEORGE , SAINI SUNIL , CAI JIE , CARUSO ANDREA B , SHAROBIEM JOHN F , MATERNA PETER A
IPC分类号： A61F2/00 , A61F2/02 , A61F2/28 , A61F2/30 , A61F13/00 , G03C1/00
CPC分类号： A61L27/56 , A61F2/28 , A61F2002/30062 , A61F2002/30224 , A61F2002/30225 , A61F2002/30785 , A61F2002/30985 , A61F2210/0004 , A61F2230/0069 , A61F2310/00293 , A61F2310/00353 , A61L27/54 , A61L2300/412 , A61L2300/434 , A61L2300/602 , B33Y10/00 , B33Y70/00 , B33Y80/00 , Y10T428/15 , Y10T428/24273 , Y10T428/31504
摘要： The invention includes biostructures which may be characterized as having substantially all of the organic-solvent-soluble material in the form of a network of irregularly shaped perforated films. The biostructure may further include particles of a substantially-insoluble material, which may be a member of the calcium phosphate family. The biostructure may be osteoconductive. The biostructure may further contain an Active Pharmaceutical Ingredient or other bioactive substance. The API may be a substance which stimulates the production of bone morphogenetic protein, such as Lovastatin or related substances, thereby making the biostructure effectively osteoinductive. One or more of the polymers may have a resorption rate in the human body such as to control the release of the API. Methods of manufacture are also disclosed.
摘要翻译：本发明包括生物结构，其可以被表征为具有基本上所有有机溶剂可溶性材料形式的不规则形状的穿孔膜的网络。生物结构可以进一步包括可以是磷酸钙家族成员的基本不溶物质的颗粒。生物结构可能是骨传导的。生物结构还可以含有活性药物成分或其他生物活性物质。 API可以是刺激骨形态发生蛋白（例如洛伐他汀或相关物质）生产的物质，从而使生物结构有效地成骨诱导。一种或多种聚合物可能在人体内具有吸收速率，以便控制API的释放。还公开了制造方法。

8. 发明申请

WO2005007390A1 THREE-DIMENSIONAL PRINTING APPARATUS AND METHODS OF MANUFACTURE INCLUDING STERILIZATION OR DISINFECTION, FOR EXAMPLE, USING ULTRAVIOLET LIGHT 审中-公开
标题翻译：三维印刷装置及其制造方法，包括灭菌或消毒，例如使用紫外线灯
公开(公告)号：WO2005007390A1
公开(公告)日：2005-01-27
申请号：PCT/US2004/022462
申请日：2004-07-14
申请人： THERICS, INC. , WEST, Thomas, George , LIU, Qing , MATERNA, Peter, A. , LITWAK, Alfred, Anthony , GAYLO, Christopher, M.
发明人： WEST, Thomas, George , LIU, Qing , MATERNA, Peter, A. , LITWAK, Alfred, Anthony , GAYLO, Christopher, M.
IPC分类号： B29C67/00
CPC分类号： A61L2/208 , A61L2/10 , A61L2/206 , B29C64/165 , B29C2035/0827 , B29C2791/005 , B33Y10/00 , B33Y30/00 , B33Y40/00
摘要： The invention includes a three-dimensional printing (3DP) machine that has at least one ultraviolet (UV) light source directed at powder or slurry being processed by the 3DP machine and/or directed at any of various surfaces or machine components, in a manner suitable to kill or damage microorganisms to a desired extent. The UV light sources may be either stationary or movable, and may be either pulsed or substantially continuous, and may operate in any desired sequence and timing with respect to other operations performed by the machine. The invention may include ultraviolet illumination in such a way as to interact with powder to sterilize or disinfect powder either while the powder is stationary or, alternatively, as powder is being moved from one place to another within the 3DP machine, or both. The invention also includes methods of performing three-dimensional printing using such illumination. The invention also includes the combination of other methods of sterilization or disinfection with the use of ultraviolet light. The invention also includes the use of ultraviolet light sources for a combination of polymerization/cross-linking in addition to sterilization/disinfection.
摘要翻译：本发明包括三维打印（3DP）机器，其具有至少一个紫外线（UV）光源，其以粉末或浆料为由3DP机器处理和/或以各种表面或机器部件中的任何一种或多种方式被引导适合杀死或损害微生物至所需程度。 UV光源可以是静止的或可移动的，并且可以是脉冲的或基本上连续的，并且可以相对于由机器执行的其它操作以任何期望的顺序和定时操作。本发明可以包括紫外线照射，以便与粉末相互作用以在粉末静止时或者当粉末在3DP机器内从一个位置移动到另一个位置时消除粉末或二者兼而有之。本发明还包括使用这种照明进行三维打印的方法。本发明还包括灭菌或消毒的其它方法与紫外线的组合。本发明还包括除灭菌/消毒之外使用紫外光源用于聚合/交联的组合。

9. 发明申请

WO2003037607A1 A SYSTEM AND METHOD FOR UNIAXIAL COMPRESSION OF AN ARTICLE, SUCH AS A THREE-DIMENSIONALLY PRINTED DOSAGE FORM 审中-公开
标题翻译：用于单一压缩的系统和方法，例如三维打印剂量形式
公开(公告)号：WO2003037607A1
公开(公告)日：2003-05-08
申请号：PCT/US2002/034836
申请日：2002-10-29
申请人： THERICS, INC. , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , PRYCE LEWIS, Wendy, E. , ROWE, Charles, William , CIMA, Michael, J. , MATERNA, Peter, A.
发明人： PRYCE LEWIS, Wendy, E. , ROWE, Charles, William , CIMA, Michael, J. , MATERNA, Peter, A.
IPC分类号： B29C67/00
CPC分类号： A61K9/20 , A61J3/10 , A61K9/2095 , B29C64/00 , B29C64/165 , B29C67/0051 , B29C67/0081 , B29L2031/753 , B33Y70/00 , B33Y80/00
摘要： A uniaxially compressed dosage form manufactured by three-dimensional printing that preserves the predetermined internal architecture of the dosage form while producing an improved surface finish. The compression compacts the dosage form, eliminating at least some of the void space that remains at the end of conventional three-dimensional printing. Surface finish obtained as a result of the uniaxial compression process can be essentially equal to that obtained from conventional tablet pressing. Additionally, the internal structure or spatial variation of composition of the dosage form is preserved during the pressing operation, with geometric shrinkage occurring mostly in the direction of the axis of pressing. Further, as a result of compression, a greater quantity of API can be packed into a given final volume of dosage form.
摘要翻译：通过三维印刷制造的单轴压缩剂型，其保持了剂型的预定内部结构，同时产生改进的表面光洁度。压缩压缩剂型，消除了在传统三维印刷结束时保留的至少一些空隙空间。作为单轴压缩方法的结果获得的表面光洁度基本上等于由常规压片法获得的表面光洁度。此外，在压制操作期间保留了剂型的组成的内部结构或空间变化，几何收缩主要发生在按压轴的方向上。此外，作为压缩的结果，可以将更大量的API包装在给定的最终体积的剂型中。

10. 发明申请

WO2021248028A1 HOLLOW FIBERS FOR OUTSIDE-IN DIALYSIS APPLICATIONS 审中-公开
公开(公告)号：WO2021248028A1
公开(公告)日：2021-12-09
申请号：PCT/US2021/035945
申请日：2021-06-04
申请人： NOVAFLUX, INC. , GEREMIA, Ilaria , STAMATIALIS, Dimitrios , LABIB, Mohamed , MATERNA, Peter
发明人： GEREMIA, Ilaria , STAMATIALIS, Dimitrios , LABIB, Mohamed , MATERNA, Peter
IPC分类号： B01D69/08 , B01D67/00 , B01D69/14 , B01D71/68 , A61M1/1625 , A61M2202/0421 , A61M2205/7527 , B01D2323/08 , B01D2323/22 , B01D2325/025 , B01D2325/20 , B01D67/0016 , B01D69/085 , B01D69/087 , B01D69/141 , D01D5/06 , D01D5/24 , D01F8/16 , D10B2331/06 , D10B2401/022 , D10B2401/10 , D10B2509/00
摘要： Disclosed are hollow fibers suitable for use in dialysis in an outside-in configuration. For such fibers, it is desirable that the fiber have a low albumin sieving coefficient and have a permeability high enough to be considered a High Flux dialyzer, and it is desirable that the outer (blood-facing) surface have a sufficiently small roughness and be hydrophilic. It is desirable that there be a selective layer on the outer surface and, interiorly of that, a porous structurally supportive region, which may contain elongated macrovoids. Such a fiber may be spun through a triple-concentric spinneret that produces a bore liquid surrounded by dope surrounded by a shower. The shower and the coagulation bath may be pure water, which is a non-solvent. The process may be performed at room temperature. Spinning parameters are discussed.

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