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    • 1. 发明申请
    • CARTRIDGES AND SYSTEMS FOR OUTSIDE-IN FLOW IN MEMBRANE-BASED THERAPIES
    • 基于膜的治疗外部流入的药物和系统
    • WO2017048224A1
    • 2017-03-23
    • PCT/US2015/050004
    • 2015-09-14
    • LABIB, Mohamed, E.DUKHIN, Stanislav, S.KELLY, ThomasMATERNA, Peter
    • LABIB, Mohamed, E.DUKHIN, Stanislav, S.KELLY, ThomasMATERNA, Peter
    • B01D61/28B01D63/02A61M1/16
    • A61M1/1625B01D61/28B01D63/02B01D2313/08
    • Embodiments of the invention pertain to cartridges, systems and methods for performing hemodialysis and related extracorporeal blood treatment modalities and therapies, in which blood flows in the inter fiber space and dialysate flows in the lumens of hollow fibers. Appropriate connectors and fitting orientations may be provided. There may be provided orbital distributors, fanning of fibers, and features to promote uniformity of fiber spacing in the fiber bundle. Orbital distributors may contain contoured surfaces, flow redirectors, non-uniform-conductance flow elements, through-wall distributors, and other features. There may be subdivision of the fiber bundle into two groups of fibers with separate control fluid to each group. Appropriate systems may be provided for various therapies. Flow past the fibers may be parallel, transverse or other configuration. These various features may enable long-term application to all dialysis and ultrafiltration related therapies, and also to other therapies and to applications including implantables, portables and wearables.
    • 本发明的实施例涉及用于进行血液透析和相关的体外血液处理模式和疗法的药筒,系统和方法,其中血液在纤维间隙中流动并且透析液在中空纤维内腔中流动。 可以提供适当的连接器和配合方向。 可以提供轨道分配器,纤维的扇形和特征,以促进纤维束中的纤维间隔的均匀性。 轨道分配器可以包含轮廓表面,流动重定向器,非均匀电导流动元件,通孔分配器和其他特征。 可以将纤维束分成两组纤维,每组具有单独的控制流体。 可以为各种疗法提供适当的系统。 通过纤维的流动可以是平行的,横向的或其它构型。 这些各种特征可以使得能够长期应用于所有透析和超滤相关疗法,以及其它疗法以及包括植入物,便携式和可穿戴物在内的应用。