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1. 发明申请

WO03041690A2 PRINTING OR DISPENSING A SUSPENSION SUCH AS THREE-DIMENSIONAL PRINTING OF DOSAGE FORMS 审中-公开
标题翻译：打印或分配暂停作为剂量形式的三维打印
公开(公告)号：WO03041690A2
公开(公告)日：2003-05-22
申请号：PCT/US0143722
申请日：2001-11-21
申请人： THERICS INC , ROWE CHARLES W , PRYCE LEWIS WENDY E , CIMA MICHAEL J , BORNANCINI ESTEBAN R N , SHERWOOD JILL K , WANG CHEN-CHAO , GAYLO CHRISTOPHER M , FAIRWEATHER JAMES A
发明人： ROWE CHARLES W , PRYCE LEWIS WENDY E , CIMA MICHAEL J , BORNANCINI ESTEBAN R N , SHERWOOD JILL K , WANG CHEN-CHAO , GAYLO CHRISTOPHER M , FAIRWEATHER JAMES A
IPC分类号： A61K9/44 , A61J3/10 , A61K9/20 , A61K9/24 , A61K9/26 , A61K9/28 , A61K31/4745 , A61K47/44 , A61K47/46 , A61L27/00
CPC分类号： A61J3/10 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/209 , A61K9/2095 , A61K9/2893 , B33Y10/00 , B33Y70/00 , B33Y80/00
摘要： The invention includes dispensing a suspension containing solid particles for use in manufacturing a dosage form or other biomedical article by 3DP. The suspension contains solid particles suspended in a liquid. The solid particles may be one or more Active Pharmaceutical Ingredients. The solid particles may be particles of material that are insoluble in the liquid, or they may be particles of a substance that have already dissolved in the liquid up to the saturation level and are present in a concentration beyond what can be dissolved. In addition to solid particles, the liquid may also contain other substances dissolved in it, either substances containing Active Pharmaceutical Ingredients (API) or substances without API. One aspect of the invention includes prevention of agglomeration by adding one or more of several categories of additives to the suspending liquid. Another aspect of the invention includes manipulating the surface charge of the particles in an API suspension to prevent particles from agglomerating. A further aspect of the invention includes an amorphous API that has a greater bioavailability than the corresponding crystalline material. Yet another aspect of the present invention includes a system for providing continuous circulation of the suspension such that the solid particles remain dispersed in the suspension.
摘要翻译：本发明包括分配含有固体颗粒的悬浮液，用于通过3DP制造剂型或其它生物医学制品。悬浮液含有悬浮在液体中的固体颗粒。固体颗粒可以是一种或多种活性药物成分。固体颗粒可以是不溶于液体的材料颗粒，或者它们可以是已经溶解在液体中的物质的颗粒直到饱和水平并且以超过可溶解的浓度存在。除了固体颗粒外，液体还可能含有溶解在其中的其他物质，含有活性药物成分（API）的物质或不含API的物质。本发明的一个方面包括通过向悬浮液中加入几种类型的添加剂中的一种或多种来防止附聚。本发明的另一方面包括操作API悬浮液中颗粒的表面电荷以防止颗粒附聚。本发明的另一方面包括具有比相应的结晶材料更大的生物利用度的无定形API。本发明的另一方面包括一种用于提供悬浮液的连续循环使得固体颗粒保持分散在悬浮液中的系统。

2. 发明申请

WO1995029642A1 POWER-ASSISTED OBTURATOR 审中-公开
标题翻译：功率辅助器
公开(公告)号：WO1995029642A1
公开(公告)日：1995-11-09
申请号：PCT/US1995005382
申请日：1995-04-28
申请人： ABRAMS, Andrew, L. , GAYLO, Christopher, M.
IPC分类号： A61B17/34
CPC分类号： A61B17/3476 , A61B17/320068 , A61B17/3494 , A61B2017/320044
摘要： A power-assisted obturator system for penetrating a body cavity wall is provided. The system comprises an obturator having main shank (1) with a tip (4) on its distal end (3). The tip has relatively blung dull cutting edges which are incapable of readily cutting through bodily tissue except when the tip is vibrated at ultrasonic or near-ultrasonic frequencies. The proximal end (2) of themain shank (1) is connectable to a power source (12), which provides power to vibrate the obturator tip at ultrasonic or near-ultrasonic frequencies thereby transforming the relatively blunt edges into cutting edges which simultaneously cut and coagulate tissue. In a preferred embodiment, the obturator system includes vibration feedback and control (11) which terminates dilivery of energy to the tip when penetration is sensed.
摘要翻译：提供一种用于穿透体腔壁的动力辅助闭孔器。该系统包括具有在其远端（3）上具有尖端（4）的主柄（1）的闭塞器。尖端具有相对平坦的钝的切割边缘，除了当尖端在超声波或接近超声频率处振动之外，它们不能容易地切穿身体组织。主杆（1）的近端（2）可连接到电源（12），该电源（12）提供功率以使振动器尖端以超声波或近超声频率振动，从而将相对钝的边缘转变成同时切割的切割边缘凝固组织。在优选实施例中，闭孔器系统包括振动反馈和控制（11），当感测到穿透时，该反馈和控制（11）终止对尖端的能量的束缚。

3. 发明申请

WO2005007390A1 THREE-DIMENSIONAL PRINTING APPARATUS AND METHODS OF MANUFACTURE INCLUDING STERILIZATION OR DISINFECTION, FOR EXAMPLE, USING ULTRAVIOLET LIGHT 审中-公开
标题翻译：三维印刷装置及其制造方法，包括灭菌或消毒，例如使用紫外线灯
公开(公告)号：WO2005007390A1
公开(公告)日：2005-01-27
申请号：PCT/US2004/022462
申请日：2004-07-14
申请人： THERICS, INC. , WEST, Thomas, George , LIU, Qing , MATERNA, Peter, A. , LITWAK, Alfred, Anthony , GAYLO, Christopher, M.
发明人： WEST, Thomas, George , LIU, Qing , MATERNA, Peter, A. , LITWAK, Alfred, Anthony , GAYLO, Christopher, M.
IPC分类号： B29C67/00
CPC分类号： A61L2/208 , A61L2/10 , A61L2/206 , B29C64/165 , B29C2035/0827 , B29C2791/005 , B33Y10/00 , B33Y30/00 , B33Y40/00
摘要： The invention includes a three-dimensional printing (3DP) machine that has at least one ultraviolet (UV) light source directed at powder or slurry being processed by the 3DP machine and/or directed at any of various surfaces or machine components, in a manner suitable to kill or damage microorganisms to a desired extent. The UV light sources may be either stationary or movable, and may be either pulsed or substantially continuous, and may operate in any desired sequence and timing with respect to other operations performed by the machine. The invention may include ultraviolet illumination in such a way as to interact with powder to sterilize or disinfect powder either while the powder is stationary or, alternatively, as powder is being moved from one place to another within the 3DP machine, or both. The invention also includes methods of performing three-dimensional printing using such illumination. The invention also includes the combination of other methods of sterilization or disinfection with the use of ultraviolet light. The invention also includes the use of ultraviolet light sources for a combination of polymerization/cross-linking in addition to sterilization/disinfection.
摘要翻译：本发明包括三维打印（3DP）机器，其具有至少一个紫外线（UV）光源，其以粉末或浆料为由3DP机器处理和/或以各种表面或机器部件中的任何一种或多种方式被引导适合杀死或损害微生物至所需程度。 UV光源可以是静止的或可移动的，并且可以是脉冲的或基本上连续的，并且可以相对于由机器执行的其它操作以任何期望的顺序和定时操作。本发明可以包括紫外线照射，以便与粉末相互作用以在粉末静止时或者当粉末在3DP机器内从一个位置移动到另一个位置时消除粉末或二者兼而有之。本发明还包括使用这种照明进行三维打印的方法。本发明还包括灭菌或消毒的其它方法与紫外线的组合。本发明还包括除灭菌/消毒之外使用紫外光源用于聚合/交联的组合。

4. 发明申请

WO2003041690A3 THREE-DIMENSIONAL SUSPENSION PRINTING OF DOSAGE FORMS 审中-公开
公开(公告)号：WO2003041690A3
公开(公告)日：2003-05-22
申请号：PCT/US2001/043722
申请日：2001-11-21
申请人： THERICS, INC. , ROWE, Charles, W. , PRYCE LEWIS, Wendy, E. , CIMA, Michael, J. , BORNANCINI, Esteban, R., N. , SHERWOOD, Jill, K. , WANG, Chen-Chao , GAYLO, Christopher, M. , FAIRWEATHER, James, A.
发明人： ROWE, Charles, W. , PRYCE LEWIS, Wendy, E. , CIMA, Michael, J. , BORNANCINI, Esteban, R., N. , SHERWOOD, Jill, K. , WANG, Chen-Chao , GAYLO, Christopher, M. , FAIRWEATHER, James, A.
IPC分类号： A61K9/20
摘要： The invention includes dispensing a suspension containing solid particles for use in manufacturing a dosage form or other biomedical article by 3DP. The suspension contains solid particles suspended in a liquid. The solid particles may be one or more Active Pharmaceutical Ingredients. The solid particles may be particles of material that are insoluble in the liquid, or they may be particles of a substance that have already dissolved in the liquid up to the saturation level and are present in a concentration beyond what can be dissolved. In addition to solid particles, the liquid may also contain other substances dissolved in it, either substances containing Active Pharmaceutical Ingredients (API) or substances without API. One aspect of the invention includes prevention of agglomeration by adding one or more of several categories of additives to the suspending liquid. Another aspect of the invention includes manipulating the surface charge of the particles in an API suspension to prevent particles from agglomerating. A further aspect of the invention includes an amorphous API that has a greater bioavailability than the corresponding crystalline material. Yet another aspect of the present invention includes a system for providing continuous circulation of the suspension such that the solid particles remain dispersed in the suspension.

5. 发明申请

WO2003030787A1 SYSTEM AND METHOD FOR RAPIDLY CUSTOMIZING DESIGN, MANUFACTURE AND/OR SELECTION OF BIOMEDICAL DEVICES 审中-公开
标题翻译：用于快速自定义生物医学设备的设计，制造和/或选择的系统和方法
公开(公告)号：WO2003030787A1
公开(公告)日：2003-04-17
申请号：PCT/US2001/042496
申请日：2001-10-05
申请人： THERICS, INC. , BRADBURY, Thomas, J. , GAYLO, Christopher, M. , FAIRWEATHER, James , CHESMEL, Kathleen, D. , MATERNA, Peter , YOUSSEF, Adolphe
发明人： BRADBURY, Thomas, J. , GAYLO, Christopher, M. , FAIRWEATHER, James , CHESMEL, Kathleen, D. , MATERNA, Peter , YOUSSEF, Adolphe
IPC分类号： A61F2/30
CPC分类号： A61F2/30942 , A61F2/186 , A61F2/2803 , A61F2/2875 , A61F2002/2878 , A61F2002/30062 , A61F2002/30677 , A61F2002/30678 , A61F2002/30948 , A61F2002/30952 , A61F2002/30953 , A61F2002/30962 , A61F2002/30968 , A61F2210/0004 , A61F2240/002 , A61F2310/00293 , B33Y50/00 , B33Y80/00 , G05B2219/45172 , G06F19/00 , G16H50/50
摘要： The rapid design and manufacture of biomedical devices such as implants, oral dosage pills and implantable pharmaceuticals employs electronic data and modeling transmissions via a computer network. Patient information and patient-specific radiological data is captured and transmitted via a computer network to a design and/or manufacturing site. A multi-dimensional digital model is created based on the radiological data and patient information. Communications interchanges between a clinical/diagnostic site and a design/manufacturing site permit modification of the digital model until approved. The approved digital model is converted into machine instructions to construct the biomedical device. Alternatively, the digital model is employed in a best fit selection of a biomedical device from a pre-existing set of biomedical devices or machine-instructions. Transmittal of data over computer networks is further directed to the use of a Website to perform various client-interaction and follow-up tasks.
摘要翻译：生物医学装置如植入物，口服药丸和可植入药物的快速设计和制造采用电子数据和通过计算机网络建模传输。患者信息和患者特定放射学数据被捕获并通过计算机网络传输到设计和/或制造现场。基于放射学数据和患者信息创建多维数字模型。临床/诊断现场与设计/生产现场之间的通信交换允许修改数字模型，直到获得批准。将批准的数字模型转换为机器指令以构建生物医学装置。或者，数字模型被用于从预先存在的一组生物医学装置或机器指令的生物医学装置的最佳拟合选择。通过计算机网络传输数据进一步涉及使用网站执行各种客户端交互和后续任务。

6. 发明申请

WO2002083194A1 METHOD AND APPARATUS FOR ENGINEERED REGENERATIVE BIOSTRUCTURES 审中-公开
标题翻译：用于工程化再生生物结构的方法和装置
公开(公告)号：WO2002083194A1
公开(公告)日：2002-10-24
申请号：PCT/US2002/011515
申请日：2002-04-12
申请人： THERICS, INC. , BEAM, Heather, Ann , CHESMEL, Kathleen, D. , BRADBURY, Thomas, J. , GAYLO, Christopher, M. , LITWAK, Alfred, Anthony , LIU, Qing , MATERNA, Peter, Albert , MONKHOUSE, Donald , PATTERSON, Jennifer , PRYOR, Timothy, J. , SAINI, Sunil , SURPRENANT, Henry, Leon , WANG, Chen-Chau , WEST, Thomas, George , YOO, Jaedeok
发明人： BEAM, Heather, Ann , CHESMEL, Kathleen, D. , BRADBURY, Thomas, J. , GAYLO, Christopher, M. , LITWAK, Alfred, Anthony , LIU, Qing , MATERNA, Peter, Albert , MONKHOUSE, Donald , PATTERSON, Jennifer , PRYOR, Timothy, J. , SAINI, Sunil , SURPRENANT, Henry, Leon , WANG, Chen-Chau , WEST, Thomas, George , YOO, Jaedeok
IPC分类号： A61L27/12
CPC分类号： A61L27/46 , A61F2/28 , A61F2002/30034 , A61F2002/30059 , A61F2002/30062 , A61F2002/30225 , A61F2002/30271 , A61F2002/30971 , A61F2210/0004 , A61F2230/0069 , A61F2230/0082 , A61F2250/0031 , A61F2310/00293 , A61L27/12 , A61L27/50 , A61L27/56 , A61L2430/02 , B33Y30/00 , B33Y80/00 , C04B28/34 , C04B35/447 , C04B35/634 , C04B35/638 , C04B38/06 , C04B2111/00181 , C04B2111/00836 , C04B2235/3212 , C04B2235/447 , C04B2235/5436 , C04B2235/6026 , C04B2235/616 , C04B2235/6567 , C04B2235/80 , C04B2235/96 , C04B35/00 , C04B38/0054 , C04B38/0074
摘要： An engineered regenerative biostructure (erb) for implantation into a human body as a bone substitute, which includes an internal microstructure, mesostructure and/or macrostructure to provide improved bone in-growth, and methods for making the erb. Under one aspect of the invention, the biostructure has resorbable and nonresorbable regions. Under another aspect of the invention, the biostructure is constructed of hydroxyapatite, tricalcium phosphate and/or demineralized bone. Under yet another aspect of the invention, the porous biostructure is partially or fully infused with a resorbable, nonresorbable or dissolvable material.
摘要翻译：用于作为骨替代物植入人体的工程再生生物结构（erb），其包括内部微观结构，介观结构和/或宏观结构以提供改善的骨生长，以及用于制备所述erb的方法。在本发明的一个方面，生物结构具有可再吸收和不可再吸收的区域。在本发明的另一方面，生物结构由羟基磷灰石，磷酸三钙和/或脱矿质骨构成。在本发明的另一方面，多孔生物结构部分或全部注入可再吸收的，不可再吸收或可溶解的材料。

7. 发明申请

WO0177988A3 SYSTEM AND METHOD FOR RAPIDLY CUSTOMIZING A DESIGN AND REMOTELY MANUFACTURING BIOMEDICAL DEVICES USING A COMPUTER SYSTEM 审中-公开
标题翻译：使用计算机系统快速自定义设计和远程制造生物医学设备的系统和方法
公开(公告)号：WO0177988A3
公开(公告)日：2003-03-06
申请号：PCT/US0111415
申请日：2001-04-05
申请人： THERICS INC , BRADBURY THOMAS J , GAYLO CHRISTOPHER M , FAIRWEATHER JAMES , CHESMEL KATHLEEN D , MATERNA PETER
发明人： BRADBURY THOMAS J , GAYLO CHRISTOPHER M , FAIRWEATHER JAMES , CHESMEL KATHLEEN D , MATERNA PETER
IPC分类号： A61C8/00 , A61C13/00 , A61F2/00 , A61F2/02 , A61F2/28 , A61F2/30 , A61K9/00 , A61K9/20 , G05B19/4099 , G06F19/00 , G06Q10/06 , G06Q50/22 , G06F17/50 , G06T17/00
CPC分类号： G06Q10/00 , A61C8/0006 , A61C13/0004 , A61F2/2803 , A61F2/30942 , A61F2002/2817 , A61F2002/2835 , A61F2002/2878 , A61F2002/30062 , A61F2002/3008 , A61F2002/30616 , A61F2002/30677 , A61F2002/30948 , A61F2002/30952 , A61F2002/30953 , A61F2002/30968 , A61F2210/0004 , A61F2250/0098 , A61F2310/00293 , A61K9/2095 , B33Y80/00 , B65G2207/14 , G05B19/4099 , G05B2219/35008 , G05B2219/35053 , G05B2219/35054 , G05B2219/35219 , G05B2219/35223 , G05B2219/45166 , G05B2219/45168 , G05B2219/49023 , G06F19/3418 , G06F19/3456 , G06F19/3481 , G06Q10/06 , G06Q50/22 , G16H10/60 , G16H15/00 , G16H50/50
摘要： A method of rapid design and manufacture of biomedical devices (160) using electronic data and modeling transmissions, wherein such transmissions are transferred via a computer network. The method includes capturing patient-specific diagnostic imaged data (100), converting the data to a digital computer file (110), transmitting the converted data (110) via the computer network to a remote manufacturing site, converting the computer file (110) into a multi-dimensional model (120) and then into machine instructions (130), and constructing (140) the biomedical implant (160). The present invention is further directed to the preparation of rapid-prototyped pharmaceutical forms, including oral dosage pills and implantable pharmaceuticals, with transmittal of such data over computer networks being used to significantly increase the cost effectiveness and responsiveness, and is further directed to the use of a website to perform various client-interaction and follow-up tasks.
摘要翻译：使用电子数据和建模传输来快速设计和制造生物医学装置（160）的方法，其中这样的传输通过计算机网络传送。该方法包括捕获患者特定的诊断成像数据（100），将数据转换为数字计算机文件（110），经由计算机网络将转换的数据（110）传送到远程制造站点，将计算机文件（110）进入多维模型（120），然后进入机器指令（130），以及构建（140）生物医学植入物（160）。本发明进一步涉及快速成型的药物形式的制备，包括口服剂量药片和可植入药物，通过计算机网络传送这些数据用于显着提高成本效益和响应性，并进一步涉及使用的网站执行各种客户端交互和后续任务。

8. 发明申请

WO0187272A2 METHOD AND FORM OF A DRUG DELIVERY DEVICE, SUCH AS ENCAPSULATING A TOXIC CORE WITHIN A NON-TOXIC REGION IN AN ORAL DOSAGE FORM 审中-公开
标题翻译：药物递送装置的方法和形式，如在口服剂型中的非毒性区域中包埋毒性核心
公开(公告)号：WO0187272A2
公开(公告)日：2001-11-22
申请号：PCT/US0140763
申请日：2001-05-18
申请人： THERICS INC , MASSACHUSETTS INST TECHNOLOGY , PAYUMO FRANCIS C , WANG CHEN CHAO , SHERWOOD JILL K , CIMA MICHAEL J , GAYLO CHRISTOPHER M , MONKHOUSE DONALD C , YOO JAEDEOK
发明人： PAYUMO FRANCIS C , WANG CHEN-CHAO , SHERWOOD JILL K , CIMA MICHAEL J , GAYLO CHRISTOPHER M , MONKHOUSE DONALD C , YOO JAEDEOK
IPC分类号： A61K9/20 , A61K9/28 , A61K31/198 , A61K31/4375 , A61K45/00 , A61K47/38 , A61K47/42 , A61P35/00 , A61P43/00
CPC分类号： A61K9/2893 , A61K9/209 , A61K9/2886 , B33Y10/00 , B33Y70/00 , B33Y80/00
摘要： A drug delivery device such as an oral dosage form (ODF) with a toxic or potent core encapsulated by a non-toxic region. The non-toxic region may be a region including multiple layers, coatings, shells, and combinations thereof, which provides protection to and isolation from the toxic or potent core. The drug in the toxic or potent core is incorporated into the dosage form via, for example, three-dimensional printing, as a solution, solubilization or suspension of solid particles in liquid, rather than by the more conventional handling and compressing of dry powder. This minimizes the likelihood of creating airborne particles of the toxic drug during manufacturing, hence controlling and minimizing the exposure of manufacturing personnel to the hazardous substance. Wet dispensing of the toxic or potent drug further provides greater bioavailability of the drug to the patient.
摘要翻译：药物递送装置，例如具有由无毒区域包封的毒性或有效核心的口服剂型（ODF）。无毒区域可以是包括多层，涂层，壳及其组合的区域，其提供对有毒或有效的核心的保护和分离。毒性或有效核心中的药物通过例如三维印刷作为溶液，固体颗粒在液体中的溶解或悬浮而不是通过更常规的干粉处理和压缩而引入剂型中。这最小化在制造过程中产生毒性药物的空气中颗粒的可能性，从而控制和最小化制造人员对有害物质的暴露。有毒或有效的药物的湿分配进一步提供药物对患者更大的生物利用度。

9. 发明申请

WO1996008654A1 PUMP FOR SHEAR SENSITIVE FLUIDS 审中-公开
标题翻译：用于剪切敏感流体的PUMP
公开(公告)号：WO1996008654A1
公开(公告)日：1996-03-21
申请号：PCT/US1995011632
申请日：1995-09-14
申请人： ABRAMS, Andrew, L. , GAYLO, Christopher, M.
IPC分类号： F04D29/18
CPC分类号： F04D29/2244 , A61M1/101 , A61M1/1012 , A61M1/1013 , A61M1/1029 , F04D5/00 , F04D29/242 , Y10S415/90
摘要： A centrifugal pump for shear sensitive fluids includes a pump housing (10) defining an interior volume. An impeller comprising at least two vanes (40) is rotatably mounted in the housing (10). The impeller vanes (40), which preferably are airfoil-shaped, are spaced from the interior housing of the pump whereby to leave a gap (50) between the vanes and the pump housing so as to permit a portion of the fluid in the spacing to flow smoothly over the top contour (46) of the impeller vanes.
摘要翻译：用于剪切敏感流体的离心泵包括限定内部容积的泵壳体（10）。包括至少两个叶片（40）的叶轮可旋转地安装在壳体（10）中。优选翼型的叶轮叶片（40）与泵的内部壳体间隔开，从而在叶片和泵壳体之间留出间隙（50），从而允许一部分流体在间隔以顺利地流过叶轮叶片的顶部轮廓（46）。

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