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1. 发明申请

WO2020117626A1 4-AMINO OR 4-ALKOXY-SUBSTITUTED ARYL SULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS 审中-公开
公开(公告)号：WO2020117626A1
公开(公告)日：2020-06-11
申请号：PCT/US2019/063909
申请日：2019-12-02
申请人： MERCK SHARP & DOHME CORP. , BUNGARD, Christopher J. , CHEN, Helen Y. , COX, Jason M. , GUO, Liangqin , KELLY, Michael J. III , KIM, Ronald M. , LAYTON, Mark E. , LIU, Hong , LIU, Jian , PATEL, Mehul F. , PERKINS, James J. , WANG, Deping , WON, Walter , YU, Younong , ZHANG, Ting
发明人： BUNGARD, Christopher J. , CHEN, Helen Y. , COX, Jason M. , GUO, Liangqin , KELLY, Michael J. III , KIM, Ronald M. , LAYTON, Mark E. , LIU, Hong , LIU, Jian , PATEL, Mehul F. , PERKINS, James J. , WANG, Deping , WON, Walter , YU, Younong , ZHANG, Ting
IPC分类号： C07D495/04 , C12Q1/26
摘要： Disclosed are compounds of Formula (I), Formula (II), or a salt thereof: Formula (I) Formula (II) which compounds have properties for inhibiting Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula (I), Formula (II) or their salts, and methods of treating pain disorders, cough, and itch using the same.

2. 发明申请

WO2020092187A1 2-AMINO-N-PHENYL-NICOTINAMIDES AS NAV1.8 INHIBITORS 审中-公开
公开(公告)号：WO2020092187A1
公开(公告)日：2020-05-07
申请号：PCT/US2019/058251
申请日：2019-10-28
申请人： MERCK SHARP & DOHME CORP. , BRESLIN, Michael, J. , BUNGARD, Christopher James , CHOBANIAN, Harry, R. , JONES, Kristen, L. G. , LAYTON, Mark, E. , LIU, Jian , PERKINS, James, J. , SCHUBERT, Jeffrey William , STACHEL, Shawn, J. , SUEN-LAI, Linda, M. , WU, Zhe
发明人： BRESLIN, Michael, J. , BUNGARD, Christopher James , CHOBANIAN, Harry, R. , JONES, Kristen, L. G. , LAYTON, Mark, E. , LIU, Jian , PERKINS, James, J. , SCHUBERT, Jeffrey William , STACHEL, Shawn, J. , SUEN-LAI, Linda, M. , WU, Zhe
IPC分类号： A61K31/4425 , A61K31/167 , A61K31/44 , C07D213/06 , C07D213/20
摘要： Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Na v 1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Na v 1.8 channel activity. The compounds of the present invention may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders.

3. 发明申请

WO2015143597A9 COAXIAL FILTER AND METHOD FOR MANUFACTURING THE SAME 审中-公开
标题翻译：同轴过滤器及其制造方法
公开(公告)号：WO2015143597A9
公开(公告)日：2015-11-19
申请号：PCT/CN2014073935
申请日：2014-03-24
申请人： ERICSSON TELEFON AB L M , LIU JIAN
发明人： LIU JIAN , GAO XIANG , ZHOU BO
IPC分类号： H01P1/202
CPC分类号： H01P1/202 , G06F17/11 , G06F17/5009 , G06F2217/12 , H01P11/007
摘要： Embodiments of the present invention provide a coaxial filter (20). The coaxial filter (20) comprises a first port (21), a second port (22), at least two capacitor segments (231; 232; 233; 234; 235) each having two metal layers (2311, 2313; 2313, 2323; 2323, 2333; 2333, 2343; 2343, 2353) and a dielectric layer (2312; 2322; 2332; 2342; 2352) between them, and at least one grounded inductor stub (241; 242; 243; 244) connected to a metal layer of the at least two capacitor segments (231; 232; 233; 234; 235). The at least two capacitor segments (231; 232; 233; 234; 235) are coaxially connected in series between the first port (21) and the second port (22). An axis (VAX1; VAX2; VAX3; VAX4) of the at least one grounded inductor stub (241; 242; 243; 244) is vertical to an axis (HAXl) of the at least two capacitor segments (231, 232, 233, 234, 235).
摘要翻译：本发明的实施例提供一种同轴过滤器（20）。同轴滤波器（20）包括第一端口（21），第二端口（22），至少两个电容器段（231; 232; 233; 234; 235），每个具有两个金属层（2311,2313; 2313,2323 ; 2323,2333; 2333,2343; 2343,253）和它们之间的电介质层（2312; 2322; 2332; 2342; 2352），以及至少一个接地电感器短截线（241; 242; 243; 244）所述至少两个电容器段（231; 232; 233; 234; 235）的金属层。所述至少两个电容器段（231; 232; 233; 234; 235）串联在第一端口（21）和第二端口（22）之间。所述至少一个接地电感器短截线（241; 242; 243; 244）的轴线（VAX1; VAX2; VAX3; VAX4）垂直于所述至少两个电容器段（231,232,233,244）的轴线（HAX1） 234,235）。

4. 发明申请

WO2014116504A1 BTK INHIBITORS 审中-公开
标题翻译： BTK抑制剂
公开(公告)号：WO2014116504A1
公开(公告)日：2014-07-31
申请号：PCT/US2014/011950
申请日：2014-01-17
申请人： MERCK SHARP & DOHME CORP. , WU, Hao , KIM, Ronald, M. , LIU, Jian , LIU, Shilan , YANG, Chundao , ZHENG, Shuling
发明人： WU, Hao , KIM, Ronald, M. , LIU, Jian , LIU, Shilan , YANG, Chundao , ZHENG, Shuling
IPC分类号： C07D213/75
CPC分类号： A61K45/06 , A61K31/4985 , A61K31/519 , C07D473/34 , C07D487/04 , C07D519/00
摘要： The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I or pharmaceutically acceptable salts thereof. Formula I or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds in the treatment of Btk mediated disorders.
摘要翻译：本发明提供根据式I的布鲁顿氏酪氨酸激酶（Btk）抑制剂化合物或其药学上可接受的盐。式I或其药学上可接受的盐或包含这些化合物的药物组合物及其在治疗中的用途。具体而言，本发明涉及Btk抑制剂化合物在治疗Btk介导的疾病中的用途。

5. 发明申请

WO2013063217A1 FUSED BICYCLIC OXAZOLIDINONE CETP INHIBITOR 审中-公开
标题翻译：熔融双相氧化硅酮CETP抑制剂
公开(公告)号：WO2013063217A1
公开(公告)日：2013-05-02
申请号：PCT/US2012/061842
申请日：2012-10-25
申请人： MERCK SHARP & DOHME CORP. , SHAO, Pengcheng Patrick , YE, Feng , VACHAL, Petr , SHA, Deyou , KATIPALLY, Revathi Reddy , LIU, Jian , SUN, Wanying
发明人： SHAO, Pengcheng Patrick , YE, Feng , VACHAL, Petr , SHA, Deyou , KATIPALLY, Revathi Reddy , LIU, Jian , SUN, Wanying
IPC分类号： C07D498/04 , A61K31/4188 , A61P9/10
CPC分类号： C07D498/04 , A61K31/424 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/506 , A61K45/06
摘要： Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis.
摘要翻译：具有式I结构的化合物，包括化合物的药学上可接受的盐，是CETP抑制剂，可用于培养HDL-胆固醇，降低LDL-胆固醇，以及用于治疗或预防动脉粥样硬化。

6. 发明申请

WO2013020589A1 ADJUSTABLE MASK 审中-公开
标题翻译：可调面膜
公开(公告)号：WO2013020589A1
公开(公告)日：2013-02-14
申请号：PCT/EP2011/063714
申请日：2011-08-09
申请人： APPLIED MATERIALS, INC. , SCHEER, Evelyn , HANIKA, Markus , LINDENBERG, Ralph , BENDER, Marcus , LOPP, Andreas , SCHWANITZ, Konrad , PIERALISI, Fabio , LIU, Jian
发明人： SCHEER, Evelyn , HANIKA, Markus , LINDENBERG, Ralph , BENDER, Marcus , LOPP, Andreas , SCHWANITZ, Konrad , PIERALISI, Fabio , LIU, Jian
IPC分类号： C23C14/04 , C23C16/04
CPC分类号： C23C14/042 , C23C16/042
摘要： An deposition apparatus for forming a deposition material layer on a substrate is described. The deposition apparatus includes a substrate support adapted for holding a substrate; and an edge (660) exclusion mask (640) for covering a periphery of the substrate (610) during layer deposition. The mask has at least one frame portion defining an aperture. The at least one frame portion of the mask is adapted for being moved (670,680) with respect to the substrate depending on the amount of deposition material deposited on the at least one frame portion of the mask. Further, a method for depositing a deposition material layer on a substrate using an edge exclusion mask is described.
摘要翻译：描述了用于在基板上形成沉积材料层的沉积装置。沉积设备包括适于保持衬底的衬底支撑件; 以及用于在层沉积期间覆盖衬底（610）的周边的边缘（660）排除掩模（640）。掩模具有限定孔的至少一个框架部分。掩模的至少一个框架部分适于相对于基板移动（670,680），这取决于沉积在掩模的至少一个框架部分上的沉积材料的量。此外，描述了使用边缘排除掩模在基板上沉积沉积材料层的方法。

7. 发明申请

WO2012145531A8 ION CONDUCTIVE MULTILAYER STRUCTURE 审中-公开
标题翻译：离子导体多层结构
公开(公告)号：WO2012145531A8
公开(公告)日：2012-12-20
申请号：PCT/US2012034285
申请日：2012-04-19
申请人： UNIV TEXAS , CHEN CHONGLIN , LIU JIAN , COLLINS GREGORY ROY
发明人： CHEN CHONGLIN , LIU JIAN , COLLINS GREGORY ROY
IPC分类号： H01M6/18
CPC分类号： H01M8/1213 , H01M4/8867 , H01M4/8871 , H01M4/9025 , H01M4/9033 , H01M4/9066 , H01M8/1253 , H01M8/126 , H01M8/1286 , Y02E60/525 , Y02P70/56
摘要： A novel ion conductive material may be formed as a thin-film multilayered structure. The thin-film multilayered structure may be formed using multiple ion conductive sublayers of an electronic insulator and an ionic conductor. A nanometer-range thickness of the electronic insulator may be selected to provide desirable ion conductive properties that may be different from bulk material properties due to quantum size effects. The thin-film multilayered structure may behave in aggregate as an electronic insulator while behaving as an ion conductor at relatively low temperatures. The thin-film multilayered structure may be used as an electrolyte in a solid-oxide fuel cell (SOFC) for conduction of oxygen ions at relatively low temperatures, for example, less than about 600°C.
摘要翻译：新颖的离子导电材料可以形成为薄膜多层结构。薄膜多层结构可以使用电子绝缘体和离子导体的多个离子导电子层来形成。可以选择纳米级厚度的电子绝缘体以提供由于量子尺寸效应而可能不同于块体材料性质的期望的离子导电性质。薄膜多层结构可以作为电子绝缘体聚集，同时在相对较低的温度下作为离子导体起作用。该薄膜多层结构可以用作固体氧化物燃料电池（SOFC）中的电解质，用于在相对低的温度例如小于约600℃下传导氧离子。

8. 发明申请

WO2012044567A3 IMIDAZOLE DERIVATIVES 审中-公开
公开(公告)号：WO2012044567A3
公开(公告)日：2012-04-05
申请号：PCT/US2011/053213
申请日：2011-09-26
申请人： MERCK SHARP & DOHME CORP. , LIU, Jian , BALKOVEC, James, M. , KRIKORIAN, Arto, D. , GUIADEEN, Deodial , YANG, Ginger, Xu-Qiang , JIAN, Tianying , WU, Zhicai , YU, Yang , NARGUND, Ravi, P. , VACHAL, Petr
发明人： LIU, Jian , BALKOVEC, James, M. , KRIKORIAN, Arto, D. , GUIADEEN, Deodial , YANG, Ginger, Xu-Qiang , JIAN, Tianying , WU, Zhicai , YU, Yang , NARGUND, Ravi, P. , VACHAL, Petr
IPC分类号： A01N43/52
摘要： Described herein are compounds of Formula (I). The compounds of Formula (I) act as DGAT1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for hyperlipidemia, diabetes mellitus and obesity.

9. 发明申请

WO2012044567A2 IMIDAZOLE DERIVATIVES 审中-公开
标题翻译：咪唑衍生物
公开(公告)号：WO2012044567A2
公开(公告)日：2012-04-05
申请号：PCT/US2011053213
申请日：2011-09-26
申请人： MERCK SHARP & DOHME , LIU JIAN , BALKOVEC JAMES M , KRIKORIAN ARTO D , GUIADEEN DEODIAL , YANG GINGER XU-QIANG , JIAN TIANYING , WU ZHICAI , YU YANG , NARGUND RAVI P , VACHAL PETR
发明人： LIU JIAN , BALKOVEC JAMES M , KRIKORIAN ARTO D , GUIADEEN DEODIAL , YANG GINGER XU-QIANG , JIAN TIANYING , WU ZHICAI , YU YANG , NARGUND RAVI P , VACHAL PETR
IPC分类号： A61K31/497 , A61K31/4439
CPC分类号： C07D403/04 , C07D235/18 , C07D401/04 , C07D401/14 , C07D403/10 , C07D417/10 , C07D471/04
摘要： Described herein are compounds of Formula (I). The compounds of Formula (I) act as DGAT1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for hyperlipidemia, diabetes mellitus and obesity.
摘要翻译：本文描述的是式（I）的化合物。式（I）化合物作为DGAT1抑制剂，可用于预防，治疗或作为高脂血症，糖尿病和肥胖症的补救剂。

10. 发明申请

WO2011031857A3 SUBSTRATE SURFACE MODIFICATION UTILIZING A DENSIFIED FLUID AND A SURFACE MODIFIER 审中-公开
标题翻译：使用致密流体和表面改性剂进行基底表面改性
公开(公告)号：WO2011031857A3
公开(公告)日：2011-09-29
申请号：PCT/US2010048268
申请日：2010-09-09
申请人： SABIN CORP , LIU JIAN-LIN , DEMARS BRUCE J
发明人： LIU JIAN-LIN , DEMARS BRUCE J
IPC分类号： A61L29/14 , A61L29/16
CPC分类号： A61M25/0009 , A61L29/04 , A61L29/085 , A61L29/14 , A61L2400/10
摘要： Described are methods for modifying the surface properties of a polymer substrate by exposing the substrate to a densified fluid and a surface modifying agent. The densified fluid may be densified carbon dioxide and the surface modifying agent may be one which reduces the surface tension of the polymer substrate, for example as incorporated into a medical device such as a catheter.
摘要翻译：描述了通过将基材暴露于致密流体和表面改性剂来改变聚合物基材的表面性质的方法。致密化的流体可以是致密化的二氧化碳，并且表面改性剂可以是降低聚合物基材表面张力的表面改性剂，例如掺入诸如导管的医疗装置中。

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