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1. 发明申请

WO2011031857A3 SUBSTRATE SURFACE MODIFICATION UTILIZING A DENSIFIED FLUID AND A SURFACE MODIFIER 审中-公开
标题翻译：使用致密流体和表面改性剂进行基底表面改性
公开(公告)号：WO2011031857A3
公开(公告)日：2011-09-29
申请号：PCT/US2010048268
申请日：2010-09-09
申请人： SABIN CORP , LIU JIAN-LIN , DEMARS BRUCE J
发明人： LIU JIAN-LIN , DEMARS BRUCE J
IPC分类号： A61L29/14 , A61L29/16
CPC分类号： A61M25/0009 , A61L29/04 , A61L29/085 , A61L29/14 , A61L2400/10
摘要： Described are methods for modifying the surface properties of a polymer substrate by exposing the substrate to a densified fluid and a surface modifying agent. The densified fluid may be densified carbon dioxide and the surface modifying agent may be one which reduces the surface tension of the polymer substrate, for example as incorporated into a medical device such as a catheter.
摘要翻译：描述了通过将基材暴露于致密流体和表面改性剂来改变聚合物基材的表面性质的方法。致密化的流体可以是致密化的二氧化碳，并且表面改性剂可以是降低聚合物基材表面张力的表面改性剂，例如掺入诸如导管的医疗装置中。

2. 发明申请

WO2011031857A2 SUBSTRATE SURFACE MODIFICATION UTILIZING A DENSIFIED FLUID AND A SURFACE MODIFIER 审中-公开
标题翻译：使用透明液体和表面改性剂的基材表面改性
公开(公告)号：WO2011031857A2
公开(公告)日：2011-03-17
申请号：PCT/US2010/048268
申请日：2010-09-09
申请人： SABIN CORPORATION , LIU, Jian-Lin , DEMARS, Bruce, J.
发明人： LIU, Jian-Lin , DEMARS, Bruce, J.
IPC分类号： A61L29/08
CPC分类号： A61M25/0009 , A61L29/04 , A61L29/085 , A61L29/14 , A61L2400/10
摘要： Described are methods for modifying the surface properties of a polymer substrate by exposing the substrate to a densified fluid and a surface modifying agent. The densified fluid may be densified carbon dioxide and the surface modifying agent may be one which reduces the surface tension of the polymer substrate, for example as incorporated into a medical device such as a catheter.
摘要翻译：描述了通过将基底暴露于致密化流体和表面改性剂来改变聚合物基材的表面性质的方法。致密化的流体可以是致密化的二氧化碳，并且表面改性剂可以是降低聚合物基材的表面张力的表面改性剂，例如结合到诸如导管的医疗装置中。

3. 发明申请

WO1993024570A1 BLEND OF FLEXIBLE COIL POLYMER AND THERMOTROPIC LIQUID CRYSTALLINE OLIGOMER 审中-公开
标题翻译：柔性线圈聚合物和热液体液晶低聚物的混合物
公开(公告)号：WO1993024570A1
公开(公告)日：1993-12-09
申请号：PCT/US1993005074
申请日：1993-05-27
申请人： AKZO N.V. , KIM, Ki-Soo , DASHEVSKY, Sophia , LIU, Jian-Lin , PALMAKA, Stanley, Walter
发明人： AKZO N.V.
IPC分类号： C08L67/00
CPC分类号： C08L67/02 , C08L67/025 , C08L77/00 , C08L101/00 , C08L67/00 , C08L2666/18
摘要： Blends can be formed which comprise a flexible coil polymer substrate, e.g., of a poly(alkylene terephthalate), and a thermotropic, essentially liquid crystalline oligomer which comprises aromatic units and at least one linear polyalkylene spacer. These blends can be used to form fibers or molded articles.
摘要翻译：可以形成包含柔性线圈聚合物基质（例如聚对苯二甲酸亚烷基酯）和包含芳族单元和至少一个直链聚亚烷基间隔基的热致变基本上液晶低聚物的共混物。这些共混物可用于形成纤维或模塑制品。

4. 发明申请

WO2011031882A3 METHODS OF MANUFACTURING DRUG-LOADED SUBSTRATES 审中-公开
标题翻译：制造药物负载的基质的方法
公开(公告)号：WO2011031882A3
公开(公告)日：2011-03-17
申请号：PCT/US2010/048300
申请日：2010-09-09
申请人： SABIN CORPORATION , LIU, Jian-lin , DEMARS, Bruce, J.
发明人： LIU, Jian-lin , DEMARS, Bruce, J.
IPC分类号： A61L29/14 , A61L29/16
摘要： Described are methods for modifying a substrate by exposing the substrate to a densified fluid. The substrate may be a polymer or a metal alloy, and the densified fluid may be carbon dioxide. Uses of such substrate modification include impregnation of the substrate with one or more drugs, impregnation of microcellular particles, and formation of microcellular compositions.
摘要翻译：描述了通过将衬底暴露于致密流体来改变衬底的方法。衬底可以是聚合物或金属合金，并且致密流体可以是二氧化碳。这种底物修饰的用途包括用一种或多种药物浸渍底物，浸渍微孔细胞颗粒和形成微孔组合物。

5. 发明申请

WO1994020552A1 ENHANCED PROCESSING OF ULTRAHIGH MOLECULAR WEIGHT POLYMERS 审中-公开
标题翻译：超高分子量聚合物的增强加工
公开(公告)号：WO1994020552A1
公开(公告)日：1994-09-15
申请号：PCT/US1994001423
申请日：1994-02-08
申请人： AKZO N.V. , VLEGGAAR, Jan , KIM, Ki-Soo , DASHEVSKY, Sophia , LIU, Jian-Lin , PALMAKA, Stanley, W. , JUIJN, Johannes, A.
发明人： AKZO N.V.
IPC分类号： C08F20/00
CPC分类号： C08L67/02 , C08L67/00 , C08L77/00
摘要： Polymer blends of an ultrahigh molecular weight polymer, such as ultrahigh molecular weight polyester, for example, polyethylene terephthalate, or polyamide, and a liquid crystalline polymer, oligomer, or mixture thereof have improved melt processing characteristics due to the presence of the liquid crystalline additive.
摘要翻译：超高分子量聚合物如超高分子量聚酯，例如聚对苯二甲酸乙二醇酯或聚酰胺，以及液晶聚合物，低聚物或其混合物的聚合物共混物由于存在液晶添加剂而具有改善的熔融加工特性。

6. 发明申请

WO1994003520A1 SYNTHESIS OF BLOCK LIQUID CRYSTAL COPOLYMER 审中-公开
标题翻译：块状液晶共聚物的合成
公开(公告)号：WO1994003520A1
公开(公告)日：1994-02-17
申请号：PCT/US1993006846
申请日：1993-07-21
申请人： AKZO N.V. , KIM, Ki-Soo , DASHEVSKY, Sophia , LIU, Jian-Lin , PALMAKA, Stanley, W.
发明人： AKZO N.V.
IPC分类号： C08G63/06
CPC分类号： C08G63/60
摘要： A single reactor process for formation of block copolymers comprising aromatic ester mesogenic units containing flexible alkane spacers and polyester flexible coil units in the main chain thereof which comprises reacting an (alpha), (omega)-bis(hydroxybenzoyloxy) alkane monomer with an aromatic acid chloride in the presence of a functionalized flexible coil oligomer under temperature conditions in which an acid chloride-terminated bis(hydroxyalkyl terephthalate) oligomer was first formed at a first, lower temperature and the block copolymer was then formed at a second, higher temperature by reacting this oligomer with the functionalized flexible coil oligomer.
摘要翻译：用于形成嵌段共聚物的单反应器方法，其包括在其主链中含有柔性烷烃间隔物和聚酯柔性线圈单元的芳族酯介晶单元，其包括使（α），（ω） - 双（羟基苯甲酰氧基）烷烃单体与芳族酸反应氯化物在官能化的柔性线圈低聚物的存在下，在其中首先在第一个较低温度下首先形成酰氯封端的双（羟烷基对苯二甲酸酯）低聚物的温度条件下，然后通过使第二较高温度下的该低聚物具有功能化的柔性线圈低聚物。

7. 发明申请

WO2011031882A2 METHODS OF MANUFACTURING DRUG-LOADED SUBSTRATES 审中-公开
标题翻译：制造药物载体基质的方法
公开(公告)号：WO2011031882A2
公开(公告)日：2011-03-17
申请号：PCT/US2010048300
申请日：2010-09-09
申请人： SABIN CORP , LIU JIAN-LIN , DEMARS BRUCE J
发明人： LIU JIAN-LIN , DEMARS BRUCE J
IPC分类号： A61L29/14
CPC分类号： A61M25/0009 , A61L29/04 , A61L29/085 , A61L29/14 , A61L2400/10
摘要： Described are methods for modifying a substrate by exposing the substrate to a densified fluid. The substrate may be a polymer or a metal alloy, and the densified fluid may be carbon dioxide. Uses of such substrate modification include impregnation of the substrate with one or more drugs, impregnation of microcellular particles, and formation of microcellular compositions.
摘要翻译：描述了通过将基底暴露于致密化流体来修饰基底的方法。基底可以是聚合物或金属合金，并且致密化的流体可以是二氧化碳。这种基质改性的用途包括用一种或多种药物浸渍底物，浸渍微细胞颗粒和形成微孔组合物。

8. 发明申请

WO1994010243A1 SOLID STATE POLYMERIZATION OF A POLYESTER BLEND 审中-公开
标题翻译：聚酯混合物的固态聚合
公开(公告)号：WO1994010243A1
公开(公告)日：1994-05-11
申请号：PCT/US1993010583
申请日：1993-11-02
申请人： AKZO NOBEL N.V. , KIM, Ki-Soo , DASHEVSKY, Sophia , PALMAKA, Stanley, W. , LIU, Jian-Lin
发明人： AKZO NOBEL N.V.
IPC分类号： C08L67/02
CPC分类号： C08G63/80 , C08L67/02 , C08L67/00
摘要： A blend of polyester resin and a compatible thermotropic liquid crystalline non-monomeric additive can have its physical properties improved, for example, for use in the melt spinning of fibers, by heating of the blend to solid state polymerize the blend of polyester resin and additive. Thermotropic liquid crystal segmented block copolymers containing mesogenic blocks and flexible coil blocks can be used as the additive. Liquid crystalline oligomers comprising a mesogen containing aromatic ester units and flexible alkylene spacers can also be used.
摘要翻译：聚酯树脂和相容的热致液晶非单体添加剂的混合物可以改善其物理性能，例如用于纤维的熔融纺丝，通过将共混物加热至固态聚合聚酯树脂和添加剂的共混物。可以使用含有介晶块和柔性线圈块的热致液晶分段嵌段共聚物作为添加剂。也可以使用包含含有芳族酯单元和柔性亚烷基间隔物的介晶的液晶低聚物。

9. 发明申请

WO2011031827A3 MANUFACTURE OF EXTRACELLULAR MATRIX PRODUCTS USING SUPERCRITICAL OR NEAR SUPERCRITICAL FLUIDS 审中-公开
标题翻译：用超临界或近超临界流体制备细胞外基质产品
公开(公告)号：WO2011031827A3
公开(公告)日：2011-06-03
申请号：PCT/US2010048223
申请日：2010-09-09
申请人： COOK BIOTECH INC , SABIN CORP , LIU JIAN-LIN , DEMARS BRUCE J , SHAH BHAVIN
发明人： LIU JIAN-LIN , DEMARS BRUCE J , SHAH BHAVIN
IPC分类号： A61L27/36
CPC分类号： A61L27/50 , A61L27/3633 , A61L27/3683 , A61L2430/40
摘要： Described are methods for preparing extracellular matrix materials using treatment with a fluid under conditions at which the fluid is at least substantially supercritical. Preferred prepared extracellular matrix materials beneficially retain endogenous bioactive molecules and/or beneficial native mechanical properties even after treatment with the fluid. Also described are materials that can be prepared by such methods, and uses of such materials.
摘要翻译：描述了在流体至少基本上超临界的条件下使用流体处理制备细胞外基质材料的方法。优选制备的细胞外基质材料甚至在用流体处理之后有利地保留内源性生物活性分子和/或有益的天然机械性质。还描述了可以通过这些方法制备的材料以及这些材料的用途。

10. 发明申请

WO2011031827A2 MANUFACTURE OF EXTRACELLULAR MATRIX PRODUCTS USING SUPERCRITICAL OR NEAR SUPERCRITICAL FLUIDS 审中-公开
标题翻译：使用超临界流体或超临界流体制造细菌基质产品
公开(公告)号：WO2011031827A2
公开(公告)日：2011-03-17
申请号：PCT/US2010/048223
申请日：2010-09-09
申请人： COOK BIOTECH INCORPORATED , SABIN CORPORATION , LIU, Jian-lin , DEMARS, Bruce, J. , SHAH, Bhavin
发明人： LIU, Jian-lin , DEMARS, Bruce, J. , SHAH, Bhavin
IPC分类号： A61L27/36
CPC分类号： A61L27/50 , A61L27/3633 , A61L27/3683 , A61L2430/40
摘要： Described are methods for preparing extracellular matrix materials using treatment with a fluid under conditions at which the fluid is at least substantially supercritical. Preferred prepared extracellular matrix materials beneficially retain endogenous bioactive molecules and/or beneficial native mechanical properties even after treatment with the fluid. Also described are materials that can be prepared by such methods, and uses of such materials.
摘要翻译：描述了在流体至少基本上是超临界的条件下用流体处理制备细胞外基质材料的方法。优选的制备的细胞外基质材料即使在用流体处理后也有利地保留内生生物活性分子和/或有益的天然机械性能。还描述了可以通过这些方法制备的材料和这些材料的用途。

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