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1. 发明申请

WO0230561A3 APPARATUS FOR ASSAY, SYNTHESIS AND STORAGE, AND METHODS OF MANUFACTURE, USE, AND MANIPULATION THEREOF 审中-公开
标题翻译：用于测定，合成和储存的装置及其制造，使用和操作方法
公开(公告)号：WO0230561A3
公开(公告)日：2003-05-22
申请号：PCT/US0131770
申请日：2001-10-10
申请人： BIOTROVE INC , HESS ROBERT A , KANIGAN TANYA S , BRENAN COLIN J H , OZBAL CAN , LINTON JOHN DUDLEY
发明人： HESS ROBERT A , KANIGAN TANYA S , BRENAN COLIN J H , OZBAL CAN , LINTON JOHN DUDLEY
IPC分类号： G01N21/78 , B01D61/00 , B01D71/20 , B01J19/00 , B01L3/00 , B01L3/02 , B01L99/00 , B81B1/00 , C12M1/00 , C12N5/02 , C12N15/09 , C12Q1/02 , C12Q1/68 , C40B60/14 , G01N30/46 , G01N30/60 , G01N30/82 , G01N30/84 , G01N35/02 , G01N37/00
CPC分类号： G01N30/466 , B01J19/0046 , B01J2219/00317 , B01J2219/00319 , B01J2219/00351 , B01J2219/0036 , B01J2219/00369 , B01J2219/00387 , B01J2219/00389 , B01J2219/00423 , B01J2219/0043 , B01J2219/00479 , B01J2219/00495 , B01J2219/005 , B01J2219/00511 , B01J2219/00585 , B01J2219/00587 , B01J2219/00596 , B01J2219/00648 , B01J2219/00653 , B01J2219/00659 , B01J2219/00673 , B01L3/0244 , B01L3/0262 , B01L3/0268 , B01L3/5025 , B01L3/50255 , B01L3/5085 , B01L99/00 , B01L2200/0657 , B01L2300/0845 , C40B60/14 , G01N30/6095 , G01N30/82 , G01N2030/8417 , Y10T29/301 , Y10T29/49938
摘要： The invention features methods of making devices, or "platens" having a high-density array of through-holes, as well as methods of cleaning and refurbishing the surfaces of the platens. The invention further features methods of making high-density arrays of chemical, biochemical, and biological compounds, having many advantages over conventional, lower-density arrays. The invention includes methods by which many physical, chemical or biological transformations can be implemented in serial or in parallel within each addressable through-hole of the devices. Additionally, the invention includes methods of analizying the contents of the array, including assaying of physical properties of the samples. In various embodiments, the reagents can be contained within the through-holes by capillary action, attached to the walls of the through-hole. The porous material can be, for example, a gel, a bead, sintered glass, or particulate matter, or can be the inner wall of a ghrough-hole that has been chemically etched. In particular embodiments, the arrays can include invidual molecules, complexes of molecules, viruses, cells, groups of cells, pieces of tissue, or small particles or beads. The members of the arrays can aslo, for example, function as transducers that report the presence of an analyte (e.g., by providing an easily detected signal), or they can function as selective binding agents for the retention of analytes of interest. Using these methods, arrays corresponding to a large plurality of human genes (e.g., using nucleic acid probes) can also be prepared.
摘要翻译：本发明的特征在于制造具有高密度阵列通孔的装置或“压板”的方法，以及清洁和翻新压板表面的方法。本发明还涉及制备化学，生物化学和生物化合物的高密度阵列的方法，其具有优于常规的较低密度阵列的许多优点。本发明包括许多物理，化学或生物转化可以在装置的每个可寻址通孔内串联或并行地实现的方法。此外，本发明包括分析阵列的内容物的方法，包括测定样品的物理性质。在各种实施方案中，试剂可通过毛细管作用包含在通孔内，附着在通孔的壁上。多孔材料可以是例如凝胶，珠粒，烧结玻璃或颗粒物质，或者可以是经化学蚀刻的孔洞的内壁。在具体实施方案中，阵列可以包括隐窝分子，分子复合物，病毒，细胞，细胞群，组织块或小颗粒或珠粒。例如，阵列的成员可以作为报告分析物的存在（例如通过提供容易检测到的信号）的换能器起作用，或者它们可以用作保留感兴趣分析物的选择性结合剂。使用这些方法，也可以制备对应于大量人类基因（例如使用核酸探针）的阵列。

2. 发明申请

WO2005089945A1 NANOLITER ARRAY LOADING 审中-公开
标题翻译： NANOLITER阵列加载
公开(公告)号：WO2005089945A1
公开(公告)日：2005-09-29
申请号：PCT/US2005/008248
申请日：2005-03-11
申请人： BIOTROVE, INC. , KANIGAN, Tanya, S. , SMITH, Steve , LINTON, John , HESS, Robert , YODER, Karl , BRENNAN, Colin
发明人： KANIGAN, Tanya, S. , SMITH, Steve , LINTON, John , HESS, Robert , YODER, Karl , BRENNAN, Colin
IPC分类号： B01L3/00
CPC分类号： B01L3/5085 , B01L3/0241 , B01L3/0244 , B01L3/5025 , B01L3/50857 , B01L3/563 , B01L2200/021 , B01L2200/027 , B01L2200/0605 , B01L2200/0636 , B01L2200/0642 , B01L2200/16 , B01L2300/0816 , B01L2300/0829 , B01L2300/0864 , B01L2300/12 , B01L2300/161 , B33Y70/00 , B33Y80/00 , Y10T137/0318 , Y10T137/1624 , Y10T137/206 , Y10T436/2525
摘要： An interface is provided for storing microfluidic samples in a nanoliter sample chip (10). A fluid access structure provides a fluid access region to a selected subset (20) of sample wells (12) from an array of sample wells (12). A fluid introduction mechanism introduces a sample fluid to the fluid access region so that the sample wells (12) in the selected subset (20) are populated with the sample fluid without the unselected sample wells being populated with the sample fluid.
摘要翻译：提供了用于将微流体样品存储在纳升级样品芯片（10）中的界面。流体通道结构从样品阱阵列（12）向样品阱（12）的选定子集（20）提供流体通路区域。流体引入机构将样品流体引入流体存取区域，使得所选择的子集（20）中的样品阱（12）填充有样品流体，而未选择的样品孔填充有样品流体。

3. 发明申请

WO2007022026A2 APPARATUS FOR ASSAY, SYNTHESIS AND STORAGE, AND METHODS OF MANUFACTURE, USE, AND MANIPULATION THEREOF 审中-公开
标题翻译：用于测定，合成和储存的装置及其制造，使用和操作方法
公开(公告)号：WO2007022026A2
公开(公告)日：2007-02-22
申请号：PCT/US2006031534
申请日：2006-08-10
申请人： BIOTROVE INC , HESS ROBERT , LINTON JOHN , KANIGAN TANYA S , BRENAN COLIN , OZBAL CAN , HOROWITZ DANIEL , ILYIN SERGEY E
发明人： HESS ROBERT , LINTON JOHN , KANIGAN TANYA S , BRENAN COLIN , OZBAL CAN , HOROWITZ DANIEL , ILYIN SERGEY E
IPC分类号： C12M3/00
CPC分类号： B01L3/50255 , B01L3/0268 , B01L3/0293 , B01L3/50857 , B01L2200/0689 , B01L2300/0819 , B01L2300/10 , B01L2400/0442 , G01N35/1074 , H01J49/0418
摘要： The invention features methods of making devices, or "platens", having a high-density array of through-holes, as well as methods of cleaning and refurbishing the surfaces of the platens. The invention further features methods of making high- density arrays of chemical, biochemical, and biological compounds, having many advantages over conventional, lower-density arrays. The invention includes methods by which many physical, chemical or biological transformations can be implemented in serial or in parallel within each addressable through-hole of the devices. Additionally, the invention includes methods of analyzing the contents of the array, including assaying of physical properties of the samples.
摘要翻译：本发明的特征在于制造具有高密度阵列通孔的装置或“压板”的方法，以及清洁和翻新压板表面的方法。本发明还涉及制备化学，生物化学和生物化合物的高密度阵列的方法，其具有优于常规的较低密度阵列的许多优点。本发明包括许多物理，化学或生物转化可以在装置的每个可寻址通孔内串联或并行地实现的方法。此外，本发明包括分析阵列的内容物的方法，包括测定样品的物理性质。

4. 发明申请

WO2009111696A1 DEVICES AND METHODS FOR THERMALLY-MEDIATED CHEMICAL REACTIONS 审中-公开
标题翻译：用于热介质化学反应的装置和方法
公开(公告)号：WO2009111696A1
公开(公告)日：2009-09-11
申请号：PCT/US2009/036324
申请日：2009-03-06
申请人： BIOTROVE, INC. , BRENAN, Colin, J. H. , MORRISON, Tom , KANIGAN, Tanya, S.
发明人： BRENAN, Colin, J. H. , MORRISON, Tom , KANIGAN, Tanya, S.
IPC分类号： C12P19/34
CPC分类号： C12Q1/686 , B01L3/5027 , B01L3/502715 , B01L3/50851 , B01L3/50857 , B01L7/52 , B01L2200/027 , B01L2200/10 , B01L2300/0819 , B01L2300/0848 , B01L2300/0877 , B01L2300/12 , B01L2300/1822 , B01L2300/1827 , B01L2300/1833 , B01L2300/1844 , B01L2300/185 , B01L2300/1894
摘要： One aspect of the invention provides container for thermal cycling a plurality of samples in a microfluidic array. The container includes a plurality of walls defining an interior volume and a conductive member for heating the interior volume. Another aspect of the invention provides container for thermal cycling a plurality of samples in a microfluidic array. The container includes a plurality of walls defining an interior volume and a plurality of conductive members for heating an interior volume. Another aspect of the invention provides a container for thermal cycling a plurality of samples in a microfluidic array. The container includes a plurality of walls defining an interior volume and a first conductive member located in the interior volume and adapted to contact a first end of the microfluidic array.
摘要翻译：本发明的一个方面提供用于热循环多个微流体阵列中的样品的容器。容器包括限定内部容积的多个壁和用于加热内部空间的导电构件。本发明的另一方面提供了用于在微流体阵列中热循环多个样品的容器。容器包括限定内部容积的多个壁和用于加热内部容积的多个导电构件。本发明的另一方面提供了一种用于在微流体阵列中热循环多个样品的容器。容器包括限定内部容积的多个壁和位于内部容积中并适于接触微流体阵列的第一端的第一导电构件。

5. 发明申请

WO2006036307A3 METHOD AND SYSTEM FOR REGISTERING DISPENSER ARRAY LOCATION 审中-公开
标题翻译：用于注册分配器阵列位置的方法和系统
公开(公告)号：WO2006036307A3
公开(公告)日：2006-08-17
申请号：PCT/US2005028048
申请日：2005-08-04
申请人： BIOTROVE INC , BRENAN COLIN J H , CHO JAMIE , GARCIA JAVIER , HESS ROBERT , KANIGAN TANYA S , KATZ ARRIN , KIM NAMYONG , LINTON JOHN , SRIVASTAVA SHAILESH
发明人： BRENAN COLIN J H , CHO JAMIE , GARCIA JAVIER , HESS ROBERT , KANIGAN TANYA S , KATZ ARRIN , KIM NAMYONG , LINTON JOHN , SRIVASTAVA SHAILESH
IPC分类号： G01N35/10
CPC分类号： B41J2/1631 , B41J2/1433 , B41J2/162 , B41J2/1629 , B41J2/1632 , B41J2/1642 , B41J2/1646 , G01N35/1011 , G01N2035/00158 , G01N2035/1041
摘要： A differentially coated device for conducting a plurality of nano-volume specified reactions, the device comprising a platen having at least one exterior surface modified to a specified physicochemical property, a plurality of nano-volume channels, each nano-volume channel having at least one interior surface in communication with the at least one exterior surface that is selectively coated with an optionally dissolvable coating agent physisorbed to at least one interior surface, wherein the optionally dissolvable coating agent comprises a coating agent and a first component for the plurality of specified reactions. Methods for preparing and using such devices are also provided, as well as a method of registering a location of a dispenser array in relation to a microfluidic array. A first one of the dispenser array and the microfluidic array is movable in relation to the frame, and the other of the first one of the dispenser array and the microfluidic array is fixed relative to the frame. Quantities related to a vector displacement from the alignment position to a fixed position on the one of the dispenser array and the microfluidic array is determined. The quantities thus determined are used to guide positioning of the dispenser array relative to the microfluidic array.
摘要翻译：一种用于进行多个纳米体积规定的反应的差异涂覆的装置，所述装置包括具有至少一个被修饰至指定理化特性的外表面的压板，多个纳米体积通道，每个纳米体积通道具有至少一个与所述至少一个外表面连通的内表面，其被选择性地涂覆有物理吸附到至少一个内表面上的任选可溶解的涂覆剂，其中所述任选可溶解的涂覆剂包含涂层剂和用于多个特定反应的第一组分。还提供了用于制备和使用这种装置的方法，以及相对于微流体阵列登记分配器阵列的位置的方法。分配器阵列和微流体阵列中的第一个可相对于框架移动，并且分配器阵列和微流体阵列中的第一个中的另一个相对于框架是固定的。确定与分配器阵列和微流体阵列之一上的对准位置到固定位置的矢量位移有关的量。这样确定的量用于引导分配器阵列相对于微流体阵列的定位。

6. 发明申请

WO2006036307A2 COATING PROCESS FOR MICROFLUIDIC SAMPLE ARRAYS 审中-公开
标题翻译：微流体样品阵列的涂覆工艺
公开(公告)号：WO2006036307A2
公开(公告)日：2006-04-06
申请号：PCT/US2005/028048
申请日：2005-08-04
申请人： BIOTROVE, INC. , BRENAN, Colin J. H. , CHO, Jamie , GARCIA, Javier , HESS, Robert , KANIGAN, Tanya S. , KATZ, Arrin , KIM, Namyong , LINTON, John , SRIVASTAVA, Shailesh
发明人： BRENAN, Colin J. H. , CHO, Jamie , GARCIA, Javier , HESS, Robert , KANIGAN, Tanya S. , KATZ, Arrin , KIM, Namyong , LINTON, John , SRIVASTAVA, Shailesh
IPC分类号： G01N35/10
CPC分类号： B41J2/1631 , B41J2/1433 , B41J2/162 , B41J2/1629 , B41J2/1632 , B41J2/1642 , B41J2/1646 , G01N35/1011 , G01N2035/00158 , G01N2035/1041
摘要： A differentially coated device for conducting a plurality of nano-volume specified reactions, the device comprising a platen having at least one exterior surface modified to a specified physicochemical property, a plurality of nano-volume channels, each nano-volume channel having at least one interior surface in communication with the at least one exterior surface that is selectively coated with an optionally dissolvable coating agent physisorbed to at least one interior surface, wherein the optionally dissolvable coating agent comprises a coating agent and a first component for the plurality of specified reactions. Methods for preparing and using such devices are also provided, as well as a method of registering a location of a dispenser array in relation to a microfluidic array. A first one of the dispenser array and the microfluidic array is movable in relation to the frame, and the other of the first one of the dispenser array and the microfluidic array is fixed relative to the frame. Quantities related to a vector displacement from the alignment position to a fixed position on the one of the dispenser array and the microfluidic array is determined. The quantities thus determined are used to guide positioning of the dispenser array relative to the microfluidic array.
摘要翻译：一种用于进行多个纳米体积特定反应的差示涂布装置，所述装置包括具有至少一个被修改为指定物理化学性质的外表面的平台，多个纳米体积通道，每个纳米体积通道，所述纳米体积通道具有与所述至少一个外表面连通的至少一个内表面，所述至少一个内表面选择性地涂覆有物理吸附到至少一个内表面的任选可溶解的涂层剂，其中所述任选可溶解的涂层剂包含涂层剂和第一组分用于多个指定的反应。还提供了用于制备和使用这种装置的方法，以及相对于微流体阵列记录分配器阵列的位置的方法。分配器阵列和微流体阵列中的第一个相对于框架是可移动的，并且分配器阵列和微流体阵列中的第一个中的另一个相对于框架固定。确定与从分配器阵列和微流体阵列中的一个上的对准位置到固定位置的向量位移有关的量。这样确定的量用于指导分配器阵列相对于微流体阵列的定位。

7. 发明申请

WO2007022026A3 APPARATUS FOR ASSAY, SYNTHESIS AND STORAGE, AND METHODS OF MANUFACTURE, USE, AND MANIPULATION THEREOF 审中-公开
公开(公告)号：WO2007022026A3
公开(公告)日：2007-02-22
申请号：PCT/US2006/031534
申请日：2006-08-11
申请人： BIOTROVE, INC. , HESS, Robert , LINTON, John , KANIGAN, Tanya, S. , BRENAN, Colin , OZBAL, Can , HOROWITZ, Daniel , ILYIN, Sergey, E.
发明人： HESS, Robert , LINTON, John , KANIGAN, Tanya, S. , BRENAN, Colin , OZBAL, Can , HOROWITZ, Daniel , ILYIN, Sergey, E.
IPC分类号： C12M1/34 , C12Q1/00
摘要： The invention features methods of making devices, or "platens", having a high-density array of through-holes, as well as methods of cleaning and refurbishing the surfaces of the platens. Further, methods of making high density arrays of chemical, biochemical, and biological compounds, having many advantages over conventional, lower-density arrays are provided. The invention includes methods by which many physical, chemical or biological transformations can be implemented in seπal or in parallel within each addressable through-hole of the devices. Additionally, methods of analyzing the contents of the array, including assaying of physical properties of the samples are included.

8. 发明申请

WO2006036307A9 COATING PROCESS FOR MICROFLUIDIC SAMPLE ARRAYS 审中-公开
标题翻译：微流体样品阵列涂层工艺
公开(公告)号：WO2006036307A9
公开(公告)日：2006-06-01
申请号：PCT/US2005028048
申请日：2005-08-04
申请人： BIOTROVE INC , BRENAN COLIN J H , CHO JAMIE , GARCIA JAVIER , HESS ROBERT , KANIGAN TANYA S , KATZ ARRIN , KIM NAMYONG , LINTON JOHN , SRIVASTAVA SHAILESH
发明人： BRENAN COLIN J H , CHO JAMIE , GARCIA JAVIER , HESS ROBERT , KANIGAN TANYA S , KATZ ARRIN , KIM NAMYONG , LINTON JOHN , SRIVASTAVA SHAILESH
IPC分类号： G01N35/10
CPC分类号： B41J2/1631 , B41J2/1433 , B41J2/162 , B41J2/1629 , B41J2/1632 , B41J2/1642 , B41J2/1646 , G01N35/1011 , G01N2035/00158 , G01N2035/1041
摘要： A differentially coated device for conducting a plurality of nano-volume specified reactions, the device comprising a platen having at least one exterior surface modified to a specified physicochemical property, a plurality of nano-volume channels, each nano-volume channel having at least one interior surface in communication with the at least one exterior surface that is selectively coated with an optionally dissolvable coating agent physisorbed to at least one interior surface, wherein the optionally dissolvable coating agent comprises a coating agent and a first component for the plurality of specified reactions. Methods for preparing and using such devices are also provided, as well as a method of registering a location of a dispenser array in relation to a microfluidic array. A first one of the dispenser array and the microfluidic array is movable in relation to the frame, and the other of the first one of the dispenser array and the microfluidic array is fixed relative to the frame. Quantities related to a vector displacement from the alignment position to a fixed position on the one of the dispenser array and the microfluidic array is determined. The quantities thus determined are used to guide positioning of the dispenser array relative to the microfluidic array.
摘要翻译：一种用于进行多个纳米体积规定的反应的差异涂覆的装置，所述装置包括具有至少一个被修饰至指定理化特性的外表面的压板，多个纳米体积通道，每个纳米体积通道具有至少一个与所述至少一个外表面连通的内表面，其被选择性地涂覆有物理吸附到至少一个内表面上的任选可溶解的涂覆剂，其中所述任选可溶解的涂覆剂包含涂层剂和用于多个特定反应的第一组分。还提供了用于制备和使用这种装置的方法，以及相对于微流体阵列登记分配器阵列的位置的方法。分配器阵列和微流体阵列中的第一个可相对于框架移动，并且分配器阵列和微流体阵列中的第一个中的另一个相对于框架是固定的。确定与分配器阵列和微流体阵列之一上的对准位置到固定位置的矢量位移有关的量。这样确定的量用于引导分配器阵列相对于微流体阵列的定位。

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