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1. 发明申请

WO2020236642A1 METHODS, DEVICES, AND APPARATUS FOR DISPENSING AND ASPIRATING LIQUIDS ON ARRAY PLATES 审中-公开
公开(公告)号：WO2020236642A1
公开(公告)日：2020-11-26
申请号：PCT/US2020/033251
申请日：2020-05-15
申请人： CURIOX BIOSYSTEMS PTE LTD. , KIM, Namyong
发明人： KIM, Namyong , CHENG, Kong, Leong
IPC分类号： B01L3/02 , C12M1/32 , G01N1/28 , G01N1/34 , G01N35/10
摘要： A method includes dispensing a liquid from a dispenser having a first piston channel and a first nozzle channel that is non-parallel to the first piston channel and is connected to the first piston channel at a first intersection. The dispenser includes a first piston configured to slide within the first piston channel; a first nozzle coupled with the first nozzle channel; a first valve located between a dispensing-liquid reservoir and the first intersection; and a second valve located between the first intersection and the first nozzle. Dispensing the liquid from the first dispenser includes pulling the first piston to initiate flow of a liquid in the dispensing-liquid reservoir to the first intersection; and subsequent to pulling the first piston, pushing the first piston to initiate flow of the liquid in the first intersection to the first nozzle so that the liquid is dispensed from the first nozzle.

2. 发明申请

WO2012011877A2 APPARATUS AND METHOD FOR MULTIPLE REACTIONS IN SMALL VOLUMES 审中-公开
标题翻译：小容量多重反应的装置和方法
公开(公告)号：WO2012011877A2
公开(公告)日：2012-01-26
申请号：PCT/SG2011/000263
申请日：2011-07-25
申请人： CURIOX BIOSYSTEMS PTE LTD , KIM, Namyong , CHEONG, Siah Chong , LYE, Melvin, Han Wen , PHONG, Mark, Siew, Peng , LI, Li , SEAH, Teow, Soon
发明人： KIM, Namyong , CHEONG, Siah Chong , LYE, Melvin, Han Wen , PHONG, Mark, Siew, Peng , LI, Li , SEAH, Teow, Soon
IPC分类号： B01L3/00 , C12M1/00
CPC分类号： B01L3/5085 , B01L3/50853 , B01L3/50855 , B01L2200/0689 , B01L2300/0618 , B01L2300/0829 , C12M23/12 , C12M23/34
摘要： In some embodiments, the invention relates to a removable grid insertable into an apparatus comprising a plate comprising a number of elements having a first surface energy arranged in an array with an overlay having a second surface energy and a wall circumferential to the plate, said grid comprising dividers enclosing a number of through-holes, said through-holes spaced in the grid to allow alignment of the through- holes of the grid over the elements in the plate when said grid is inserted into the apparatus, wherein said dividers of the grid inserted into the apparatus form sides of wells bottomed by the plate and at least one element on said plate. In other embodiments, the invention also relates to an apparatus comprising: a plate comprising a number of elements, said elements each having an identical diameter and having a first surface energy, said elements arranged in an array in an overlay having a second surface energy, and a wall circumferential to the plate, wherein said overlay is a height over the elements of between about 5% and 100% of the diameter of the elements. In yet addition embodiments, the invention relates to methods for using the apparatuses described herein to perform multiple reactions in small volumes.
摘要翻译：在一些实施例中，本发明涉及一种可插入到装置中的可拆卸格栅，包括：板，该板包括多个元件，该元件具有排列成阵列的第一表面能，其中覆盖层具有第二表面能和围绕该板的壁，包括分隔件，其包围多个通孔，所述通孔在网格中间隔开，以便当所述格栅插入设备中时允许栅格的通孔对齐在板上的元件上，其中网格的分隔器插入到设备的形式的侧面，底板的底部和所述板上的至少一个元件。在其它实施例中，本发明还涉及一种装置，包括：板，其包括多个元件，所述元件各自具有相同的直径并具有第一表面能，所述元件排列成具有第二表面能的覆盖层，以及围绕所述板的壁的壁，其中所述覆盖层是所述元件之间的高度在所述元件的直径的约5％至100％之间。在另外的实施方案中，本发明涉及使用本文所述装置以小体积进行多重反应的方法。

3. 发明申请

WO2010120249A1 USE OF CHEMICALLY PATTERNED SUBSTRATE FOR LIQUID HANDLING, CHEMICAL AND BIOLOGICAL REACTIONS 审中-公开
标题翻译：用于液体处理，化学和生物反应的化学图案的使用
公开(公告)号：WO2010120249A1
公开(公告)日：2010-10-21
申请号：PCT/SG2010/000153
申请日：2010-04-16
申请人： CURIOX BIOSYSTEMS PTE LTD , KIM, NAMYONG , CHENG, Kong Leong , LI, Li , SEAH, Teow Soon
发明人： KIM, NAMYONG , CHENG, Kong Leong , LI, Li , SEAH, Teow Soon
IPC分类号： G01N1/28 , B01L3/00 , B01L9/00
CPC分类号： G01N1/28 , B01L3/505 , B01L3/5088 , B01L9/52 , B01L9/523 , B01L2200/142 , B01L2300/021 , B01L2300/022 , B01L2300/0829 , B01L2300/123 , B01L2300/161
摘要： Methods and devices for adding liquids to and washing a microfluidic element array are disclosed. The method and devices feature a microfluidic plate holder with a sloped wall for improved draining of liquid, a machine readable/writable identifier, plate leveling systems, liquid filling systems, a hydrophilic-liquid coating, and an automated washing station.
摘要翻译：公开了用于将液体添加到微流体元件阵列和洗涤微流体元件阵列的方法和装置。该方法和装置具有带有倾斜壁的微流体板保持器，用于改进液体排出，机器可读/可写标识符，平板调平系统，液体填充系统，亲水液体涂层和自动清洗站。

4. 发明申请

WO2012011877A3 APPARATUS AND METHOD FOR MULTIPLE REACTIONS IN SMALL VOLUMES 审中-公开
标题翻译：用于小体积中的多次反应的装置和方法
公开(公告)号：WO2012011877A3
公开(公告)日：2012-04-26
申请号：PCT/SG2011000263
申请日：2011-07-25
申请人： CURIOX BIOSYSTEMS PTE LTD , KIM NAMYONG , CHEONG SIAH CHONG , LYE MELVIN HAN WEN , PHONG MARK SIEW PENG , LI LI , SEAH TEOW SOON
发明人： KIM NAMYONG , CHEONG SIAH CHONG , LYE MELVIN HAN WEN , PHONG MARK SIEW PENG , LI LI , SEAH TEOW SOON
IPC分类号： B01L3/00 , C12M1/00
CPC分类号： B01L3/5085 , B01L3/50853 , B01L3/50855 , B01L2200/0689 , B01L2300/0618 , B01L2300/0829 , C12M23/12 , C12M23/34
摘要： In some embodiments, the invention relates to a removable grid insertable into an apparatus comprising a plate comprising a number of elements having a first surface energy arranged in an array with an overlay having a second surface energy and a wall circumferential to the plate, said grid comprising dividers enclosing a number of through-holes, said through-holes spaced in the grid to allow alignment of the through- holes of the grid over the elements in the plate when said grid is inserted into the apparatus, wherein said dividers of the grid inserted into the apparatus form sides of wells bottomed by the plate and at least one element on said plate. In other embodiments, the invention also relates to an apparatus comprising: a plate comprising a number of elements, said elements each having an identical diameter and having a first surface energy, said elements arranged in an array in an overlay having a second surface energy, and a wall circumferential to the plate, wherein said overlay is a height over the elements of between about 5% and 100% of the diameter of the elements. In yet addition embodiments, the invention relates to methods for using the apparatuses described herein to perform multiple reactions in small volumes.
摘要翻译：在一些实施例中，本发明涉及一种可插入到设备中的可移除栅格，所述设备包括板，所述板包括具有第一表面能的多个元件，所述第一表面能布置成具有第二表面能和板周向的壁的覆盖层，所述栅格包括分隔器，所述分隔器包围多个通孔，所述通孔在所述格栅中间隔开以允许当所述格栅插入所述设备时所述格栅的所述通孔在所述板中的所述元件上对齐，其中所述格栅的所述分隔器从所述板的底部和所述板上的至少一个元件形成插入到所述设备中的侧壁。在其它实施例中，本发明还涉及一种设备，其包括：包括多个元件的板，所述元件各自具有相同的直径并且具有第一表面能，所述元件以具有第二表面能的覆盖物排列成阵列，以及围绕所述板的壁，其中所述覆盖层的高度在所述元件之上的高度在所述元件的直径的约5％和100％之间。在另外的实施方案中，本发明涉及使用本文所述的装置以小体积进行多重反应的方法。

5. 发明申请

WO2006036307A9 COATING PROCESS FOR MICROFLUIDIC SAMPLE ARRAYS 审中-公开
标题翻译：微流体样品阵列涂层工艺
公开(公告)号：WO2006036307A9
公开(公告)日：2006-06-01
申请号：PCT/US2005028048
申请日：2005-08-04
申请人： BIOTROVE INC , BRENAN COLIN J H , CHO JAMIE , GARCIA JAVIER , HESS ROBERT , KANIGAN TANYA S , KATZ ARRIN , KIM NAMYONG , LINTON JOHN , SRIVASTAVA SHAILESH
发明人： BRENAN COLIN J H , CHO JAMIE , GARCIA JAVIER , HESS ROBERT , KANIGAN TANYA S , KATZ ARRIN , KIM NAMYONG , LINTON JOHN , SRIVASTAVA SHAILESH
IPC分类号： G01N35/10
CPC分类号： B41J2/1631 , B41J2/1433 , B41J2/162 , B41J2/1629 , B41J2/1632 , B41J2/1642 , B41J2/1646 , G01N35/1011 , G01N2035/00158 , G01N2035/1041
摘要： A differentially coated device for conducting a plurality of nano-volume specified reactions, the device comprising a platen having at least one exterior surface modified to a specified physicochemical property, a plurality of nano-volume channels, each nano-volume channel having at least one interior surface in communication with the at least one exterior surface that is selectively coated with an optionally dissolvable coating agent physisorbed to at least one interior surface, wherein the optionally dissolvable coating agent comprises a coating agent and a first component for the plurality of specified reactions. Methods for preparing and using such devices are also provided, as well as a method of registering a location of a dispenser array in relation to a microfluidic array. A first one of the dispenser array and the microfluidic array is movable in relation to the frame, and the other of the first one of the dispenser array and the microfluidic array is fixed relative to the frame. Quantities related to a vector displacement from the alignment position to a fixed position on the one of the dispenser array and the microfluidic array is determined. The quantities thus determined are used to guide positioning of the dispenser array relative to the microfluidic array.
摘要翻译：一种用于进行多个纳米体积规定的反应的差异涂覆的装置，所述装置包括具有至少一个被修饰至指定理化特性的外表面的压板，多个纳米体积通道，每个纳米体积通道具有至少一个与所述至少一个外表面连通的内表面，其被选择性地涂覆有物理吸附到至少一个内表面上的任选可溶解的涂覆剂，其中所述任选可溶解的涂覆剂包含涂层剂和用于多个特定反应的第一组分。还提供了用于制备和使用这种装置的方法，以及相对于微流体阵列登记分配器阵列的位置的方法。分配器阵列和微流体阵列中的第一个可相对于框架移动，并且分配器阵列和微流体阵列中的第一个中的另一个相对于框架是固定的。确定与分配器阵列和微流体阵列之一上的对准位置到固定位置的矢量位移有关的量。这样确定的量用于引导分配器阵列相对于微流体阵列的定位。

6. 发明申请

WO2015138493A1 LIDS FOR CONTROLLING EVAPORATION 审中-公开
标题翻译：控制蒸发的LIDS
公开(公告)号：WO2015138493A1
公开(公告)日：2015-09-17
申请号：PCT/US2015/019760
申请日：2015-03-10
申请人： CURIOX BIOSYSTEMS PTE LTD. , KIM, Namyong
发明人： KIM, Namyong
IPC分类号： B01L3/00
CPC分类号： B01L3/50853 , B01L2200/142 , B01L2300/046 , B01L2300/048 , B01L2300/069 , B01L2300/0829 , B01L2300/089 , B01L2300/161 , B65B7/28
摘要： A lid for controlling evaporation of liquid aliquots is disclosed. In some embodiments, the lid includes a cover plate configured to cover at least a portion of a sample plate. The cover plate has a bottom surface configured to face the sample plate. The lid also includes one or more evaporators coupled to the bottom surface of the cover plate. Each evaporator of the one or more evaporators includes absorbent material, and the one or more evaporators define one or more exclusion areas on the bottom surface of the cover plate. Each exclusion area is exposed from the one or more evaporators.
摘要翻译：公开了一种用于控制液体等分试样蒸发的盖子。在一些实施例中，盖包括构造成覆盖样品板的至少一部分的盖板。盖板具有配置成面对样品板的底面。盖子还包括耦合到盖板的底表面的一个或多个蒸发器。一个或多个蒸发器的每个蒸发器包括吸收材料，并且一个或多个蒸发器在盖板的底表面上限定一个或多个排除区域。每个排除区域从一个或多个蒸发器暴露出来。

7. 发明申请

WO2006036307A3 METHOD AND SYSTEM FOR REGISTERING DISPENSER ARRAY LOCATION 审中-公开
标题翻译：用于注册分配器阵列位置的方法和系统
公开(公告)号：WO2006036307A3
公开(公告)日：2006-08-17
申请号：PCT/US2005028048
申请日：2005-08-04
申请人： BIOTROVE INC , BRENAN COLIN J H , CHO JAMIE , GARCIA JAVIER , HESS ROBERT , KANIGAN TANYA S , KATZ ARRIN , KIM NAMYONG , LINTON JOHN , SRIVASTAVA SHAILESH
发明人： BRENAN COLIN J H , CHO JAMIE , GARCIA JAVIER , HESS ROBERT , KANIGAN TANYA S , KATZ ARRIN , KIM NAMYONG , LINTON JOHN , SRIVASTAVA SHAILESH
IPC分类号： G01N35/10
CPC分类号： B41J2/1631 , B41J2/1433 , B41J2/162 , B41J2/1629 , B41J2/1632 , B41J2/1642 , B41J2/1646 , G01N35/1011 , G01N2035/00158 , G01N2035/1041
摘要： A differentially coated device for conducting a plurality of nano-volume specified reactions, the device comprising a platen having at least one exterior surface modified to a specified physicochemical property, a plurality of nano-volume channels, each nano-volume channel having at least one interior surface in communication with the at least one exterior surface that is selectively coated with an optionally dissolvable coating agent physisorbed to at least one interior surface, wherein the optionally dissolvable coating agent comprises a coating agent and a first component for the plurality of specified reactions. Methods for preparing and using such devices are also provided, as well as a method of registering a location of a dispenser array in relation to a microfluidic array. A first one of the dispenser array and the microfluidic array is movable in relation to the frame, and the other of the first one of the dispenser array and the microfluidic array is fixed relative to the frame. Quantities related to a vector displacement from the alignment position to a fixed position on the one of the dispenser array and the microfluidic array is determined. The quantities thus determined are used to guide positioning of the dispenser array relative to the microfluidic array.
摘要翻译：一种用于进行多个纳米体积规定的反应的差异涂覆的装置，所述装置包括具有至少一个被修饰至指定理化特性的外表面的压板，多个纳米体积通道，每个纳米体积通道具有至少一个与所述至少一个外表面连通的内表面，其被选择性地涂覆有物理吸附到至少一个内表面上的任选可溶解的涂覆剂，其中所述任选可溶解的涂覆剂包含涂层剂和用于多个特定反应的第一组分。还提供了用于制备和使用这种装置的方法，以及相对于微流体阵列登记分配器阵列的位置的方法。分配器阵列和微流体阵列中的第一个可相对于框架移动，并且分配器阵列和微流体阵列中的第一个中的另一个相对于框架是固定的。确定与分配器阵列和微流体阵列之一上的对准位置到固定位置的矢量位移有关的量。这样确定的量用于引导分配器阵列相对于微流体阵列的定位。

8. 发明申请

WO2006036307A2 COATING PROCESS FOR MICROFLUIDIC SAMPLE ARRAYS 审中-公开
标题翻译：微流体样品阵列的涂覆工艺
公开(公告)号：WO2006036307A2
公开(公告)日：2006-04-06
申请号：PCT/US2005/028048
申请日：2005-08-04
申请人： BIOTROVE, INC. , BRENAN, Colin J. H. , CHO, Jamie , GARCIA, Javier , HESS, Robert , KANIGAN, Tanya S. , KATZ, Arrin , KIM, Namyong , LINTON, John , SRIVASTAVA, Shailesh
发明人： BRENAN, Colin J. H. , CHO, Jamie , GARCIA, Javier , HESS, Robert , KANIGAN, Tanya S. , KATZ, Arrin , KIM, Namyong , LINTON, John , SRIVASTAVA, Shailesh
IPC分类号： G01N35/10
CPC分类号： B41J2/1631 , B41J2/1433 , B41J2/162 , B41J2/1629 , B41J2/1632 , B41J2/1642 , B41J2/1646 , G01N35/1011 , G01N2035/00158 , G01N2035/1041
摘要： A differentially coated device for conducting a plurality of nano-volume specified reactions, the device comprising a platen having at least one exterior surface modified to a specified physicochemical property, a plurality of nano-volume channels, each nano-volume channel having at least one interior surface in communication with the at least one exterior surface that is selectively coated with an optionally dissolvable coating agent physisorbed to at least one interior surface, wherein the optionally dissolvable coating agent comprises a coating agent and a first component for the plurality of specified reactions. Methods for preparing and using such devices are also provided, as well as a method of registering a location of a dispenser array in relation to a microfluidic array. A first one of the dispenser array and the microfluidic array is movable in relation to the frame, and the other of the first one of the dispenser array and the microfluidic array is fixed relative to the frame. Quantities related to a vector displacement from the alignment position to a fixed position on the one of the dispenser array and the microfluidic array is determined. The quantities thus determined are used to guide positioning of the dispenser array relative to the microfluidic array.
摘要翻译：一种用于进行多个纳米体积特定反应的差示涂布装置，所述装置包括具有至少一个被修改为指定物理化学性质的外表面的平台，多个纳米体积通道，每个纳米体积通道，所述纳米体积通道具有与所述至少一个外表面连通的至少一个内表面，所述至少一个内表面选择性地涂覆有物理吸附到至少一个内表面的任选可溶解的涂层剂，其中所述任选可溶解的涂层剂包含涂层剂和第一组分用于多个指定的反应。还提供了用于制备和使用这种装置的方法，以及相对于微流体阵列记录分配器阵列的位置的方法。分配器阵列和微流体阵列中的第一个相对于框架是可移动的，并且分配器阵列和微流体阵列中的第一个中的另一个相对于框架固定。确定与从分配器阵列和微流体阵列中的一个上的对准位置到固定位置的向量位移有关的量。这样确定的量用于指导分配器阵列相对于微流体阵列的定位。

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