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1. 发明申请

WO2012039802A2 DIFFERENTIAL INTERFERENCE CONTRAST SERIAL TIME ENCODED AMPLIFIED MICROSCOPY 审中-公开
标题翻译：差分干涉对比度序列时间编码放大显微镜
公开(公告)号：WO2012039802A2
公开(公告)日：2012-03-29
申请号：PCT/US2011041283
申请日：2011-06-21
申请人： UNIV CALIFORNIA , JALALI BAHRAM , MOTAFAKKER ALI
发明人： JALALI BAHRAM , MOTAFAKKER ALI
IPC分类号： G01B9/02 , G01B11/24
CPC分类号： G01J1/0411 , G02B21/002 , G02B21/14 , H04N5/14
摘要： We describe methods and apparatus for high-speed high-contrast imaging one-, two- and three-dimensional imaging enabled by differential interference contrast time encoded amplified microscopy of transparent media without the need for chemical staining, that are suitable for a broad range of applications from semiconductor process monitoring to blood screening. Our methods and apparatus build on a unique combination of serial time-encoded amplified microscopy (STEAM) and differential interference contrast (DIC) microscopy. These methods and apparatus are ideally suited for identification of rare diseased cells in a large population of healthy cells and have the potential to revolutionize blood analysis and pathology including identification of cancer cells, such as Circulating Tumor Cells (CTC) in early stage disease.
摘要翻译：我们描述了用于高速高对比度成像的一维，二维和三维成像的方法和装置，其通过微分干涉对比度时间编码的透明介质的放大显微镜而不需要化学染色，适用于广泛的从半导体过程监测到血液筛查的应用。我们的方法和设备基于串行时间编码放大显微镜（STEAM）和差分干涉对比（DIC）显微镜的独特组合。这些方法和设备非常适合于鉴定大量健康细胞中罕见的患病细胞，并有可能革新血液分析和病理学，包括癌细胞的鉴定，例如早期疾病中的循环肿瘤细胞（CTC）。

2. 发明申请

WO2010011875A3 APPARATUS AND METHOD FOR DISPERSIVE FOURIER-TRANSFORM IMAGING 审中-公开
标题翻译：用于分散式FOURIER-TRANSFORM成像的装置和方法
公开(公告)号：WO2010011875A3
公开(公告)日：2010-04-08
申请号：PCT/US2009051608
申请日：2009-07-23
申请人： UNIV CALIFORNIA , GODA KEISUKE , JALALI BAHRAM , TSIA KEVIN KIN-MAN
发明人： GODA KEISUKE , JALALI BAHRAM , TSIA KEVIN KIN-MAN
IPC分类号： G06K9/20 , G06K7/10
CPC分类号： G06K7/1439 , G06K7/10712 , G06K7/10831 , G06K7/14
摘要： A barcode reading apparatus and method in which the spectrum of a probe light is first Fourier-transformed into space, directed upon a barcode, and then Fourier-transformed converting the spectrally encoded barcode pattern to a time domain waveform. In one implementation, the Fourier transformation from the spectrum domain into a spatial domain is performed by a dispersive element, while the Fourier transformation from the spectrally encoded barcode pattern to a time domain waveform is performed by group-velocity dispersion (GVD). The temporally encoded barcode pattern is detected by a photodetector, digitized by a digitizer, and analyzed by a digital signal processor. The invention is applicable to a number of fields which involve the reading of one- and two-dimensional barcodes, displacement sensing, surface measurements, measurement of width and gap, flow cytometry, reading of optical media, presence or absence detection, and other related fields.
摘要翻译：一种条形码读取装置和方法，其中探针光的光谱首先被傅里叶变换为空间，指向条形码，然后经频谱转换成频谱编码的条形码图案到时域波形。在一个实现中，通过色散元素执行从频域到空间域的傅里叶变换，而通过组速度色散（GVD）执行从频谱编码的条形码图案到时域波形的傅里叶变换。时间编码的条形码图案由光电检测器检测，由数字化仪数字化，并由数字信号处理器分析。本发明适用于涉及读取一维和二维条形码，位移检测，表面测量，宽度和间隙测量，流式细胞术，光学介质读数，有无检测等相关领域的多个领域领域。

3. 发明申请

WO0180507A3 METHOD AND APPARATUS FOR ARBITRARY WAVEFORM GENERATION USING PHOTONICS 审中-公开
标题翻译：方法和装置使用光电子产生的波形波形
公开(公告)号：WO0180507A3
公开(公告)日：2002-06-13
申请号：PCT/US0112213
申请日：2001-04-13
申请人： UNIV CALIFORNIA , JALALI BAHRAM , KELKAR PARAG V
发明人： JALALI BAHRAM , KELKAR PARAG V
IPC分类号： H04B10/155 , H04L25/03 , H04B10/152
CPC分类号： H04L25/03828 , H04B10/503 , H04L25/03834
摘要： An apparatus and method for synthesizing waveforms with arbitrary amplitude, frequency, and phase modulation. Pulses from a broadband (supercontinuum) optical source are filtered into a plurality of wavelength channels, and the intensity of each wavelength channel is adjusted to an appropriate level depending on the desired shape of the envelope of the output pulse. The envelope of the sampling wavelength channels can be stretched, compressed, or inverted in the time domain later using a dispersive medium. After time domain manipulation, the optical pulse train is observed with a combination of high-speed photodetectors and a radio frequency low-pass filter, a low-speed photodetector.
摘要翻译：用于合成具有任意幅度，频率和相位调制的波形的装置和方法。来自宽带（超连续谱）光源的脉冲被滤波成多个波长信道，并且根据输出脉冲的包络的期望形状将每个波长信道的强度调整到适当的电平。采样波长通道的包络线可以在时域中拉伸，压缩或反转，然后使用分散介质。在时域操纵之后，用高速光电探测器和射频低通滤波器，低速光电探测器组合观察光脉冲串。

4. 发明申请

WO2010011875A2 APPARATUS AND METHOD FOR DISPERSIVE FOURIER-TRANSFORM IMAGING 审中-公开
标题翻译：用于色散傅立叶变换成像的装置和方法
公开(公告)号：WO2010011875A2
公开(公告)日：2010-01-28
申请号：PCT/US2009/051608
申请日：2009-07-23
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , GODA, Keisuke , JALALI, Bahram , TSIA, Kevin, Kin-Man
发明人： GODA, Keisuke , JALALI, Bahram , TSIA, Kevin, Kin-Man
IPC分类号： G06K9/20 , G06K7/10
CPC分类号： G06K7/1439 , G06K7/10712 , G06K7/10831 , G06K7/14
摘要： A barcode reading apparatus and method in which the spectrum of a probe light is first Fourier-transformed into space, directed upon a barcode, and then Fourier-transformed converting the spectrally encoded barcode pattern to a time domain waveform. In one implementation, the Fourier transformation from the spectrum domain into a spatial domain is performed by a dispersive element, while the Fourier transformation from the spectrally encoded barcode pattern to a time domain waveform is performed by group-velocity dispersion (GVD). The temporally encoded barcode pattern is detected by a photodetector, digitized by a digitizer, and analyzed by a digital signal processor. The invention is applicable to a number of fields which involve the reading of one- and two-dimensional barcodes, displacement sensing, surface measurements, measurement of width and gap, flow cytometry, reading of optical media, presence or absence detection, and other related fields.
摘要翻译：一种条形码读取设备和方法，其中探测光的光谱首先被傅里叶变换为指向条形码的空间，然后经傅立叶变换将光谱编码的条形码图案转换为时域波形。在一个实现中，从频谱域到空间域的傅立叶变换由色散元件执行，而从光谱编码的条码图案到时域波形的傅立叶变换通过群速度色散（GVD）执行。时间编码的条码图案由光电检测器检测，由数字化仪数字化，并由数字信号处理器分析。本发明适用于涉及读取一维和二维条形码，位移感测，表面测量，宽度和间隙测量，流式细胞术，光学介质读取，存在或不存在检测以及其他相关的多个领域字段。

5. 发明申请

WO2007112449A3 APPARATUS AND METHOD FOR RAMAN SPECTROSCOPY AND MICROSCOPY WITH TIME DOMAIN SPECTRAL ANALYSIS 审中-公开
标题翻译：拉曼光谱法和具有时域光谱分析的显微镜的装置和方法
公开(公告)号：WO2007112449A3
公开(公告)日：2008-08-07
申请号：PCT/US2007065393
申请日：2007-03-28
申请人： UNIV CALIFORNIA , SOLLI DANIEL , CHOU JASON , JALALI BAHRAM
发明人： SOLLI DANIEL , CHOU JASON , JALALI BAHRAM
IPC分类号： G01J3/44
CPC分类号： G01J3/4412 , G01J3/10 , G01J3/457 , G01N21/636 , G01N21/65 , G01N21/658 , G01N2021/653 , G01N2021/655
摘要： An apparatus and method for measuring Raman-type spectra using optical dispersion to convert an optical spectrum into a waveform which can be detected directly in the time domain without the use of a conventional spectrometer. In the example of stimulated Raman spectroscopy, the apparatus and method exposes a sample to a chirped, pulsed probe beam and a Raman pump beam and the resulting Raman spectra is detected by an optical detector in the time domain, and analyzed. Alternatively, the Raman spectra from the probe and pump beams is chirped with a dispersive element prior to detection and analysis. Each probe pulse provides a snapshot of the Raman spectrum that is sampled in time so that neither repetitive waveforms nor static samples are required. Therefore, high speed acquisitions and high throughput assays can be conducted. To facilitate detection, these spectral signals can also be amplified using distributed Raman amplification directly in the dispersive element.
摘要翻译：一种使用光学色散测量拉曼光谱的装置和方法，用于将光谱转换成可在时域中直接检测的波形，而不需要使用常规光谱仪。在受激拉曼光谱的实例中，该装置和方法将样品暴露于啁啾脉冲探测光束和拉曼泵浦光束，并且通过时域中的光学检测器检测所得拉曼光谱，并进行分析。或者，来自探针和泵浦光束的拉曼光谱在检测和分析之前用分散元件啁啾。每个探针脉冲提供了在时间上采样的拉曼光谱的快照，以便不需要重复波形和静态样本。因此，可以进行高速采集和高通量测定。为了便于检测，这些光谱信号也可以使用分散拉曼放大直接在色散元件中进行扩增。

6. 发明申请

WO2006042239A2 CASCADED CAVITY SILICON RAMAN LASER WITH ELECTRICAL MODULATION, SWITCHING, AND ACTIVE MODE LOCKING CAPABILITY 审中-公开
标题翻译：具有电气调制，开关和主动模式锁定能力的CASCA CAI CAI SILICON拉曼激光器
公开(公告)号：WO2006042239A2
公开(公告)日：2006-04-20
申请号：PCT/US2005/036435
申请日：2005-10-06
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , JALALI, Bahram , BOYRAZ, Ozdal
发明人： JALALI, Bahram , BOYRAZ, Ozdal
IPC分类号： H01S3/30
CPC分类号： H01S3/30 , H01S3/0632 , H01S3/083 , H01S3/094042 , H01S3/1109 , H01S3/1628
摘要： A silicon Raman laser that can be electrically switched or modulated and which demonstrates active mode-locking capabilities. The laser can be used with a more traditional glass fiber cavity, or can be fabricated on a single chip with a cavity, or a cascaded cavity, in which the chip fabrication is compatible with widely used silicon chip fabrication methods. The laser can be tuned by adjusting a source pump laser to product specific output and operates at room temperature. Output is present in the near- and mid-infrared frequency range, and the laser can simultaneously produce output at the Stokes and at the anti-Stokes wavelengths.
摘要翻译：可以进行电气切换或调制的硅拉曼激光器，并显示主动模式锁定功能。激光可以与更传统的玻璃纤维腔一起使用，或者可以在具有空腔或级联腔的单个芯片上制造，其中芯片制造与广泛使用的硅芯片制造方法兼容。可以通过将源泵浦激光器调整为产品特定输出并在室温下运行来调节激光器。输出在近红外频率范围内，激光器可以同时在斯托克斯和反斯托克斯波长处产生输出。

7. 发明申请

WO2011062842A1 APPARATUS AND METHOD FOR MULTIPLE-PULSE IMPULSIVE STIMULATED RAMAN SPECTROSCOPY 审中-公开
标题翻译：多脉冲刺激拉曼光谱的装置与方法
公开(公告)号：WO2011062842A1
公开(公告)日：2011-05-26
申请号：PCT/US2010/056475
申请日：2010-11-12
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , OLYMPUS CORPORATION , JALALI, Bahram , GODA, Keisuke , SATO, Akira , TAIRA, Kenji
发明人： JALALI, Bahram , GODA, Keisuke , SATO, Akira , TAIRA, Kenji
IPC分类号： G01J3/44
CPC分类号： G01N21/65 , G01N2021/655
摘要： Spectroscopic measurements are described based on light-molecule interaction in response to a resonant rate optical pulse train so that a Raman spectrum is reflected containing at least two types of vibrational mode information (e.g., vibrational frequency, and vibrational phase relaxation) on the molecules comprising the object. A pump optical pulse train generation means is configured for generating an optical pulse train having an arbitrary repetition rate which is directed through irradiation means to the sample object. Light from the sample object is collected and vibrational coherence is detected for the sample object. The sample is tested across a plurality of different repetition frequencies. The detected information can be compared with data from other known samples from within a database when analyzing the information collected.
摘要翻译：基于响应于谐振速率光脉冲序列的光分子相互作用来描述光谱测量，使得反射的拉曼光谱包含至少两种类型的振动模式信息（例如振动频率和振动相松弛），包括物体。泵浦光脉冲串产生装置被配置为产生具有任意重复频率的光脉冲序列，其通过照射装置被引导到样本物体。收集来自样品物体的光并检测样品物体的振动相干性。在多个不同的重复频率上测试样本。当分析收集的信息时，检测到的信息可以与数据库内其他已知样本的数据进行比较。

8. 发明申请

WO2009070768A1 METHOD AND APPARATUS FOR GENERATION AND DETECTION OF ROGUE WAVES 审中-公开
标题翻译：用于生成和检测ROGUE波的方法和装置
公开(公告)号：WO2009070768A1
公开(公告)日：2009-06-04
申请号：PCT/US2008/085041
申请日：2008-11-26
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , JALALI, Bahram , SOLLI, Daniel , ROPERS, Claus
发明人： JALALI, Bahram , SOLLI, Daniel , ROPERS, Claus
IPC分类号： H01S3/10
CPC分类号： G02F1/353 , G02F1/365 , G02F2001/3528
摘要： Methods and systems are provided for generation and detection of rogue waves, including hydrodynamic rogue waves and optical rogue waves. A method for generating an optical rogue wave comprises the steps of generating an input pulse into a nonlinear optical medium, and perturbing the input pulse by directing a narrow¬ band seed radiation into the input pulse. The seed radiation has a frequency and timing to generate broadband radiation within the nonlinear optical medium.
摘要翻译：提供了用于产生和检测流氓波的方法和系统，包括流体动力学流氓波和光学流氓波。一种用于产生光流氓波的方法包括以下步骤：将输入脉冲产生到非线性光学介质中，并通过将窄带种子辐射引入输入脉冲来扰乱输入脉冲。种子辐射具有在非线性光学介质内产生宽带辐射的频率和时间。

9. 发明申请

WO2006033853A3 CHROMOMODAL DISPERSION APPARATUS AND METHODS 审中-公开
标题翻译：色谱分散装置和方法
公开(公告)号：WO2006033853A3
公开(公告)日：2007-06-07
申请号：PCT/US2005032126
申请日：2005-09-07
申请人： UNIV CALIFORNIA , JALALI BAHRAM , SIENICKI TODD
发明人： JALALI BAHRAM , SIENICKI TODD
IPC分类号： G02B6/32 , G02B6/26 , G02B6/42
CPC分类号： G02B6/29392 , G02B6/29311 , G02B6/29314 , H04B10/25133
摘要： A system and method to chromomodally generate dispersion in light waves. The system and method may be used to control dispersive effects of an optical element such as a single-mode fiber. A light beam from the optical element is first collimated and then directed on to a spatially diffractive element where it is spatially dispersed into various chromatic frequency components. This frequency-separated light is then imparted onto a dispersion slope equalizer, and then passed into a highly multimode waveguide, where it is further dispersed. The light is then collected and focused back into an outgoing fiber-optic or other optical device.
摘要翻译：在光波中色散地产生色散的系统和方法。该系统和方法可用于控制诸如单模光纤的光学元件的色散效应。来自光学元件的光束首先被准直，然后被引导到空间衍射元件，其中它被空间分散成各种彩色频率分量。然后将该频率分离的光赋予色散斜率均衡器，然后传递到高度多模波导中，在此进一步分散。然后将光收集并聚焦回出射光纤或其它光学装置。

10. 发明申请

WO2012039802A3 DIFFERENTIAL INTERFERENCE CONTRAST SERIAL TIME ENCODED AMPLIFIED MICROSCOPY 审中-公开
公开(公告)号：WO2012039802A3
公开(公告)日：2012-03-29
申请号：PCT/US2011/041283
申请日：2011-06-21
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , JALALI, Bahram , MOTAFAKKER, Ali
发明人： JALALI, Bahram , MOTAFAKKER, Ali
IPC分类号： G01B9/02 , G01B11/24
摘要： We describe methods and apparatus for high-speed high-contrast imaging one-, two- and three-dimensional imaging enabled by differential interference contrast time encoded amplified microscopy of transparent media without the need for chemical staining, that are suitable for a broad range of applications from semiconductor process monitoring to blood screening. Our methods and apparatus build on a unique combination of serial time-encoded amplified microscopy (STEAM) and differential interference contrast (DIC) microscopy. These methods and apparatus are ideally suited for identification of rare diseased cells in a large population of healthy cells and have the potential to revolutionize blood analysis and pathology including identification of cancer cells, such as Circulating Tumor Cells (CTC) in early stage disease.

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