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    • 2. 发明申请
    • APPARATUS AND METHOD FOR RAMAN SPECTROSCOPY AND MICROSCOPY WITH TIME DOMAIN SPECTRAL ANALYSIS
    • 拉曼光谱法和具有时域光谱分析的显微镜的装置和方法
    • WO2007112449A3
    • 2008-08-07
    • PCT/US2007065393
    • 2007-03-28
    • UNIV CALIFORNIASOLLI DANIELCHOU JASONJALALI BAHRAM
    • SOLLI DANIELCHOU JASONJALALI BAHRAM
    • G01J3/44
    • G01J3/4412G01J3/10G01J3/457G01N21/636G01N21/65G01N21/658G01N2021/653G01N2021/655
    • An apparatus and method for measuring Raman-type spectra using optical dispersion to convert an optical spectrum into a waveform which can be detected directly in the time domain without the use of a conventional spectrometer. In the example of stimulated Raman spectroscopy, the apparatus and method exposes a sample to a chirped, pulsed probe beam and a Raman pump beam and the resulting Raman spectra is detected by an optical detector in the time domain, and analyzed. Alternatively, the Raman spectra from the probe and pump beams is chirped with a dispersive element prior to detection and analysis. Each probe pulse provides a snapshot of the Raman spectrum that is sampled in time so that neither repetitive waveforms nor static samples are required. Therefore, high speed acquisitions and high throughput assays can be conducted. To facilitate detection, these spectral signals can also be amplified using distributed Raman amplification directly in the dispersive element.
    • 一种使用光学色散测量拉曼光谱的装置和方法,用于将光谱转换成可在时域中直接检测的波形,而不需要使用常规光谱仪。 在受激拉曼光谱的实例中,该装置和方法将样品暴露于啁啾脉冲探测光束和拉曼泵浦光束,并且通过时域中的光学检测器检测所得拉曼光谱,并进行分析。 或者,来自探针和泵浦光束的拉曼光谱在检测和分析之前用分散元件啁啾。 每个探针脉冲提供了在时间上采样的拉曼光谱的快照,以便不需要重复波形和静态样本。 因此,可以进行高速采集和高通量测定。 为了便于检测,这些光谱信号也可以使用分散拉曼放大直接在色散元件中进行扩增。
    • 4. 发明申请
    • DIFFERENTIAL INTERFERENCE CONTRAST SERIAL TIME ENCODED AMPLIFIED MICROSCOPY
    • 差分干涉对比度序列时间编码放大显微镜
    • WO2012039802A2
    • 2012-03-29
    • PCT/US2011041283
    • 2011-06-21
    • UNIV CALIFORNIAJALALI BAHRAMMOTAFAKKER ALI
    • JALALI BAHRAMMOTAFAKKER ALI
    • G01B9/02G01B11/24
    • G01J1/0411G02B21/002G02B21/14H04N5/14
    • We describe methods and apparatus for high-speed high-contrast imaging one-, two- and three-dimensional imaging enabled by differential interference contrast time encoded amplified microscopy of transparent media without the need for chemical staining, that are suitable for a broad range of applications from semiconductor process monitoring to blood screening. Our methods and apparatus build on a unique combination of serial time-encoded amplified microscopy (STEAM) and differential interference contrast (DIC) microscopy. These methods and apparatus are ideally suited for identification of rare diseased cells in a large population of healthy cells and have the potential to revolutionize blood analysis and pathology including identification of cancer cells, such as Circulating Tumor Cells (CTC) in early stage disease.
    • 我们描述了用于高速高对比度成像的一维,二维和三维成像的方法和装置,其通过微分干涉对比度时间编码的透明介质的放大显微镜而不需要化学染色,适用于广泛的 从半导体过程监测到血液筛查的应用。 我们的方法和设备基于串行时间编码放大显微镜(STEAM)和差分干涉对比(DIC)显微镜的独特组合。 这些方法和设备非常适合于鉴定大量健康细胞中罕见的患病细胞,并有可能革新血液分析和病理学,包括癌细胞的鉴定,例如早期疾病中的循环肿瘤细胞(CTC)。
    • 5. 发明申请
    • APPARATUS AND METHOD FOR DISPERSIVE FOURIER-TRANSFORM IMAGING
    • 用于分散式FOURIER-TRANSFORM成像的装置和方法
    • WO2010011875A3
    • 2010-04-08
    • PCT/US2009051608
    • 2009-07-23
    • UNIV CALIFORNIAGODA KEISUKEJALALI BAHRAMTSIA KEVIN KIN-MAN
    • GODA KEISUKEJALALI BAHRAMTSIA KEVIN KIN-MAN
    • G06K9/20G06K7/10
    • G06K7/1439G06K7/10712G06K7/10831G06K7/14
    • A barcode reading apparatus and method in which the spectrum of a probe light is first Fourier-transformed into space, directed upon a barcode, and then Fourier-transformed converting the spectrally encoded barcode pattern to a time domain waveform. In one implementation, the Fourier transformation from the spectrum domain into a spatial domain is performed by a dispersive element, while the Fourier transformation from the spectrally encoded barcode pattern to a time domain waveform is performed by group-velocity dispersion (GVD). The temporally encoded barcode pattern is detected by a photodetector, digitized by a digitizer, and analyzed by a digital signal processor. The invention is applicable to a number of fields which involve the reading of one- and two-dimensional barcodes, displacement sensing, surface measurements, measurement of width and gap, flow cytometry, reading of optical media, presence or absence detection, and other related fields.
    • 一种条形码读取装置和方法,其中探针光的光谱首先被傅里叶变换为空间,指向条形码,然后经频谱转换成频谱编码的条形码图案到时域波形。 在一个实现中,通过色散元素执行从频域到空间域的傅里叶变换,而通过组速度色散(GVD)执行从频谱编码的条形码图案到时域波形的傅里叶变换。 时间编码的条形码图案由光电检测器检测,由数字化仪数字化,并由数字信号处理器分析。 本发明适用于涉及读取一维和二维条形码,位移检测,表面测量,宽度和间隙测量,流式细胞术,光学介质读数,有无检测等相关领域的多个领域 领域。
    • 6. 发明申请
    • TIME STRETCH ENHANCED RECORDING SCOPE
    • 时间延长增强的记录范围
    • WO2010059993A3
    • 2010-09-10
    • PCT/US2009065411
    • 2009-11-20
    • UNIV CALIFORNIAGUPTA SHALABHJALALI BAHRAMMOTAFAKKER-FARD ALI
    • GUPTA SHALABHJALALI BAHRAMMOTAFAKKER-FARD ALI
    • H03M1/12
    • G01R13/0218G02F1/225G02F7/00H03M1/1042H03M1/12
    • A time-stretched enhanced recording scope (TiSER) is described using time stretch analog-to-digital conversion in a real-time burst mode. A chirped optical signal is modulated in response to receiving segments of an input signal. The optical signal with its modulated input signal, is stretched through an optical medium and digitized to represent the waveform segment. TiSER provides ultra-fast real-time sampling within short segment bursts of the original input signal while providing an ability to detect non-repetitive events. Methods and apparatus are also described for providing real-time information about inter-symbol information (ISI), rapidly determining bit-error rates (BER), performing time-domain reflectometry (TDR), generating eye diagrams for serial data, facilitating digital correction of data, clock recovery, optical carrier phase recovery, and otherwise increasing the speed and/or accuracy of a diverse range of high-speed signal measurement and processing activities.
    • 使用实时突发模式中的时间拉伸模数转换来描述时间延长的增强记录范围(TiSER)。 响应于输入信号的接收段调制啁啾光信号。 具有调制输入信号的光信号通过光学介质被拉伸并数字化以表示波形段。 TiSER在原始输入信号的短片段突发中提供超快速实时采样,同时提供检测非重复事件的能力。 还描述了用于提供关于符号间信息(ISI),快速确定误码率(BER),执行时域反射计(TDR),生成串行数据眼图,促进数字校正的实时信息的方法和装置 的数据,时钟恢复,光载波相位恢复,否则增加了各种范围的高速信号测量和处理活动的速度和/或精度。