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    • 1. 发明申请
    • APPARATUS AND METHOD FOR RAMAN SPECTROSCOPY AND MICROSCOPY WITH TIME DOMAIN SPECTRAL ANALYSIS
    • 拉曼光谱法和具有时域光谱分析的显微镜的装置和方法
    • WO2007112449A2
    • 2007-10-04
    • PCT/US2007/065393
    • 2007-03-28
    • THE REGENTS OF THE UNIVERSITY OF CALIFORNIASOLLI, DanielCHOU, JasonJALALI, Bahram
    • SOLLI, DanielCHOU, JasonJALALI, Bahram
    • G01J5/56
    • G01J3/4412G01J3/10G01J3/457G01N21/636G01N21/65G01N21/658G01N2021/653G01N2021/655
    • An apparatus and method for measuring Raman-type spectra using optical dispersion to convert an optical spectrum into a waveform which can be detected directly in the time domain without the use of a conventional spectrometer. In the example of stimulated Raman spectroscopy, the apparatus and method exposes a sample to a chirped, pulsed probe beam and a Raman pump beam and the resulting Raman spectra is detected by an optical detector in the time domain, and analyzed. Alternatively, the Raman spectra from the probe and pump beams is chirped with a dispersive element prior to detection and analysis. Each probe pulse provides a snapshot of the Raman spectrum that is sampled in time so that neither repetitive waveforms nor static samples are required. Therefore, high speed acquisitions and high throughput assays can be conducted. To facilitate detection, these spectral signals can also be amplified using distributed Raman amplification directly in the dispersive element.
    • 一种使用光学色散测量拉曼光谱的装置和方法,用于将光谱转换成可在时域中直接检测的波形,而不需要使用常规光谱仪。 在受激拉曼光谱的实例中,该装置和方法将样品暴露于啁啾脉冲探针光束和拉曼泵浦光束,并且通过时域中的光学检测器检测所得拉曼光谱,并进行分析。 或者,来自探针和泵浦光束的拉曼光谱在检测和分析之前用分散元件啁啾。 每个探针脉冲提供了在时间上采样的拉曼光谱的快照,以便不需要重复波形和静态样本。 因此,可以进行高速采集和高通量测定。 为了便于检测,这些光谱信号也可以使用分散拉曼放大直接在色散元件中进行扩增。
    • 3. 发明申请
    • APPARATUS AND METHOD FOR RAMAN SPECTROSCOPY AND MICROSCOPY WITH TIME DOMAIN SPECTRAL ANALYSIS
    • 拉曼光谱法和具有时域光谱分析的显微镜的装置和方法
    • WO2007112449A3
    • 2008-08-07
    • PCT/US2007065393
    • 2007-03-28
    • UNIV CALIFORNIASOLLI DANIELCHOU JASONJALALI BAHRAM
    • SOLLI DANIELCHOU JASONJALALI BAHRAM
    • G01J3/44
    • G01J3/4412G01J3/10G01J3/457G01N21/636G01N21/65G01N21/658G01N2021/653G01N2021/655
    • An apparatus and method for measuring Raman-type spectra using optical dispersion to convert an optical spectrum into a waveform which can be detected directly in the time domain without the use of a conventional spectrometer. In the example of stimulated Raman spectroscopy, the apparatus and method exposes a sample to a chirped, pulsed probe beam and a Raman pump beam and the resulting Raman spectra is detected by an optical detector in the time domain, and analyzed. Alternatively, the Raman spectra from the probe and pump beams is chirped with a dispersive element prior to detection and analysis. Each probe pulse provides a snapshot of the Raman spectrum that is sampled in time so that neither repetitive waveforms nor static samples are required. Therefore, high speed acquisitions and high throughput assays can be conducted. To facilitate detection, these spectral signals can also be amplified using distributed Raman amplification directly in the dispersive element.
    • 一种使用光学色散测量拉曼光谱的装置和方法,用于将光谱转换成可在时域中直接检测的波形,而不需要使用常规光谱仪。 在受激拉曼光谱的实例中,该装置和方法将样品暴露于啁啾脉冲探测光束和拉曼泵浦光束,并且通过时域中的光学检测器检测所得拉曼光谱,并进行分析。 或者,来自探针和泵浦光束的拉曼光谱在检测和分析之前用分散元件啁啾。 每个探针脉冲提供了在时间上采样的拉曼光谱的快照,以便不需要重复波形和静态样本。 因此,可以进行高速采集和高通量测定。 为了便于检测,这些光谱信号也可以使用分散拉曼放大直接在色散元件中进行扩增。