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1. 发明申请

WO2008073420A2 SYSTEMS AND METHODS FOR TREATING PATIENT HYPERTONICITY 审中-公开
标题翻译：用于治疗患者高血压的系统和方法
公开(公告)号：WO2008073420A2
公开(公告)日：2008-06-19
申请号：PCT/US2007/025311
申请日：2007-12-11
申请人： NORTHSTAR NEUROSCIENCE, INC. , GLINER, Bradford, Evan , FOWLER, Brad , HULVERSHORN, Justin , SLOAN, Leif, R.
发明人： GLINER, Bradford, Evan , FOWLER, Brad , HULVERSHORN, Justin , SLOAN, Leif, R.
IPC分类号： A61N2/02
CPC分类号： A61N1/36082 , A61N1/0531 , A61N2/006
摘要： Systems and methods for treating patient hypertonicity are disclosed. A method in accordance with one embodiment includes identifying a cortical target neural population associated with hypertonicity in a patient, and reducing or eliminating patient hypertonicity by applying electromagnetic signals to the target neural population. In further particular embodiments, the electromagnetic signals are first electromagnetic signals, and the method can further include reducing or eliminating an additional patient dysfunction by applying second electromagnetic signals.
摘要翻译：公开了用于治疗患者高渗性的系统和方法。根据一个实施例的方法包括识别与患者中的高渗性相关的皮质靶神经群体，以及通过向目标神经群体施加电磁信号来减少或消除患者的高渗性。在另外的特定实施例中，电磁信号是第一电磁信号，并且该方法还可以包括通过施加第二电磁信号来减少或消除另外的患者功能障碍。

2. 发明申请

WO2009073891A1 SYSTEMS AND METHODS FOR PROVIDING TARGETED NEURAL STIMULATION THERAPY TO ADDRESS NEUROLOGICAL DISORDERS, INCLUDING NEUROPYSCHIATRIC AND NEUROPYSCHOLOGICAL DISORDERS 审中-公开
标题翻译：用于提供针对性神经刺激治疗方法的系统和方法来治疗神经病变，包括神经病学和神经病学疾病
公开(公告)号：WO2009073891A1
公开(公告)日：2009-06-11
申请号：PCT/US2008/085973
申请日：2008-12-08
申请人： NORTHSTAR NEUROSCIENCE, INC. , HULVERSHORN, Justin , FOWLER, Brad , GLINER, Bradford, Evan , SLOAN, Leif, R. , KOPELL, Brian , SOLTYSIK, David, Alan
发明人： HULVERSHORN, Justin , FOWLER, Brad , GLINER, Bradford, Evan , SLOAN, Leif, R. , KOPELL, Brian , SOLTYSIK, David, Alan
IPC分类号： A61N1/00
CPC分类号： A61N1/36082
摘要： Systems and methods for providing targeted neural stimulation therapy to address neurological disorders, including neuropsychiatric and neuropsychological disorders are disclosed. A method for treating a patient's neurological disorder in accordance with a particular embodiment includes, in a patient identified as having at least one of a neuropsychological disorder and a neuropsychiatric disorder, implanting at least one stimulation electrode within the patient's skull cavity, and outside a cortical surface of the patient's brain. The electrode is implanted at a location in a range of about 15 mm to about 35 mm anterior to a precentral sulcus reference point that is positioned at the precentral sulcus and at the patient's middle frontal gyrus. The method can further include treating the patient's disorder by applying electrical stimulation to the patient via the at least one stimulation electrode.
摘要翻译：公开了用于提供靶向神经刺激治疗以解决神经障碍（包括神经精神和神经心理障碍）的系统和方法。根据特定实施方案的用于治疗患者神经障碍的方法包括在被鉴定为具有神经心理障碍和神经精神障碍中的至少一种的患者中，将至少一个刺激电极植入患者的颅骨腔内，皮质外患者脑部表面。将电极植入在位于中心龈沟处和患者中额叶回的前中央龈下参考点前方约15mm至约35mm范围内的位置处。该方法还可以包括通过经由至少一个刺激电极向患者施加电刺激来治疗患者的病症。

3. 发明申请

WO2008130837A1 METHODS AND SYSTEMS FOR ESTABLISHING NEURAL STIMULATION PARAMETERS AND PROVIDING NEURAL STIMULATION 审中-公开
标题翻译：建立神经刺激参数并提供神经刺激的方法和系统
公开(公告)号：WO2008130837A1
公开(公告)日：2008-10-30
申请号：PCT/US2008/059645
申请日：2008-04-08
申请人： NORTHSTAR NEUROSCIENCE, INC. , FOWLER, Brad , HULVERSHORN, Justin , GLINER, Bradford, Evan , SLOAN, Leif, R.
发明人： FOWLER, Brad , HULVERSHORN, Justin , GLINER, Bradford, Evan , SLOAN, Leif, R.
IPC分类号： A61N1/36
CPC分类号： A61N1/36082 , A61N1/36025
摘要： Methods for providing electrical stimulation therapy to a cortex of a patient via a plurality of electrodes proximate to the cortex and a pulse generator implanted in the patient. One embodiment of a method in accordance with the invention comprises determining whether the current applied via the plurality of electrodes results in a sufficient current density in the cortex. The current density, for example, may need to be high enough to induce a response in the patient for determining the activation threshold of the specific stimulation site, or the current density may need to be high enough to perform a specific therapy. If the current density is not sufficient, the method continues by selecting a subset of the plurality of electrodes, and applying electrical current to the cortex via the subset of the electrodes. For example, if the current density is not sufficient when the current is applied to the full plurality of electrodes at approximately the maximum output of the pulse generator, then the current level from the pulse generator can be applied to only a subset of the electrodes to effectively increase the current density in the cortex at the active electrodes.
摘要翻译：用于通过靠近皮层的多个电极和植入患者中的脉冲发生器向患者的皮层提供电刺激治疗的方法。根据本发明的方法的一个实施例包括确定经由多个电极施加的电流是否导致皮层中的足够的电流密度。例如，电流密度可能需要足够高以在患者中诱导用于确定特定刺激部位的激活阈值的响应，或者电流密度可能需要足够高以执行特定治疗。如果电流密度不足，则该方法通过选择多个电极的子集，并且经由电极的子集将电流施加到皮层来继续。例如，如果电流密度在脉冲发生器的大致最大输出处施加到整个多个电极上时电流密度不足，则来自脉冲发生器的电流电平可以仅施加到电极的子集有效增加有源电极皮质中的电流密度。

4. 发明申请

WO2012083227A1 TISSUE ACCESS, PRESSURE MONITORING 审中-公开
标题翻译：组织接触，压力监测
公开(公告)号：WO2012083227A1
公开(公告)日：2012-06-21
申请号：PCT/US2011/065602
申请日：2011-12-16
申请人： MIRADOR BIOMEDICAL , HULVERSHORN, Justin , SCHMIDT, Karl , SWARTZ, Douglas
发明人： HULVERSHORN, Justin , SCHMIDT, Karl , SWARTZ, Douglas
IPC分类号： A61B5/0215
CPC分类号： A61B5/02152 , A61B5/489 , A61B5/6844
摘要： Methods and devices for access and monitoring positioning of a probe or positioned catheter in a tissue of a patient. In one aspect, the present invention provides methods and structures for positioning, detecting or monitoring a probe for disposal in a vein or artery of a patient, such as a target vein (e.g., jugular vein, subclavian vein, femoral vein, etc.). A method can include providing a detection device as described herein. The device can be advanced distally such that the tip or a distal portion of a coupled probe (e.g., needle probe attached to a port of the detection device) advances through the tissue of the patient and toward the target site or vein of the patient.
摘要翻译：用于访问和监测探针或定位导管在患者组织中的定位的方法和装置。一方面，本发明提供了用于定位，检测或监测用于患者静脉或动脉（例如，颈静脉，锁骨下静脉，股静脉等）的静脉或动脉的定位，检测或监测的方法和结构，。一种方法可以包括提供如本文所述的检测装置。该装置可以向远侧前进，使得耦合的探针的尖端或远端部分（例如，附接到检测装置的端口的针头探针）前进穿过患者的组织并朝向患者的目标部位或静脉。

5. 发明申请

WO2011022073A1 SYSTEMS, METHODS, AND DEVICES FOR FACILITATING ACCESS TO TARGET ANATOMICAL SITES OR ENVIRONMENTS 审中-公开
标题翻译：用于促进获取目标解剖学场或环境的系统，方法和装置
公开(公告)号：WO2011022073A1
公开(公告)日：2011-02-24
申请号：PCT/US2010/002305
申请日：2010-08-19
申请人： MIRADOR BIOMEDICAL , HULVERSHORN, Justin , SCHMIDT, Karl , SWARTZ, Douglas
发明人： HULVERSHORN, Justin , SCHMIDT, Karl , SWARTZ, Douglas
IPC分类号： A61B5/05
CPC分类号： A61B5/4887 , A61B5/0006 , A61B5/0205 , A61B5/0215 , A61B5/032 , A61B5/036 , A61B5/0408 , A61B5/044 , A61B5/14542 , A61B5/4821 , A61B5/4839 , A61B5/489 , A61B5/4896 , A61B5/742 , A61B8/0833 , A61B8/4472 , A61B17/3401 , A61B2090/064 , A61M5/16854 , A61M5/42 , A61M5/427 , A61M5/46 , A61M5/484 , A61M5/486 , A61M25/06 , A61M25/0693
摘要： Methods and structures for detecting a physiologic parameter of a target anatomical environment. The device including a housing with a distal portion first port couplable to a probe and a proximal portion; and a sensing unit, a processing unit, and an output unit carried by the housing, the output unit configured to output a reporting signal based on the determined physiologic parameter value such as pressure; the sensing unit, processing unit, and output unit being disposed substantially between the first port and the proximal portion of the housing.
摘要翻译：用于检测目标解剖环境的生理参数的方法和结构。该装置包括具有可与探针连接的远端部分第一端口和近端部分的壳体; 以及感测单元，处理单元和由壳体承载的输出单元，所述输出单元被配置为基于所确定的生理参数值（例如压力）输出报告信号; 感测单元，处理单元和输出单元基本上设置在壳体的第一端口和近端部分之间。

6. 发明申请

WO2008073420A3 SYSTEMS AND METHODS FOR TREATING PATIENT HYPERTONICITY 审中-公开
标题翻译：用于治疗患者HYPERONICITY的系统和方法
公开(公告)号：WO2008073420A3
公开(公告)日：2008-10-09
申请号：PCT/US2007025311
申请日：2007-12-11
申请人： NORTHSTAR NEUROSCIENCE INC , GLINER BRADFORD EVAN , FOWLER BRAD , HULVERSHORN JUSTIN , SLOAN LEIF R
发明人： GLINER BRADFORD EVAN , FOWLER BRAD , HULVERSHORN JUSTIN , SLOAN LEIF R
IPC分类号： A61N1/05
CPC分类号： A61N1/36082 , A61N1/0531 , A61N2/006
摘要： Systems and methods for treating patient hypertonicity are disclosed. A method in accordance with one embodiment includes identifying a cortical target neural population associated with hypertonicity in a patient, and reducing or eliminating patient hypertonicity by applying electromagnetic signals to the target neural population. In further particular embodiments, the electromagnetic signals are first electromagnetic signals, and the method can further include reducing or eliminating an additional patient dysfunction by applying second electromagnetic signals.
摘要翻译：公开了用于治疗患者高渗性的系统和方法。根据一个实施例的方法包括：识别与患者中的高渗性相关的皮层目标神经群体;以及通过将电磁信号应用于目标神经群体来减少或消除患者高张性。在进一步的特定实施例中，电磁信号是第一电磁信号，并且该方法还可以包括通过施加第二电磁信号来减少或消除额外的患者功能障碍。

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