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1. 发明申请

WO2007146616A3 DEVICES AND METHODS FOR DETECTION OF MARKERS OF AXIAL PAIN WITH OR WITHOUT RADICULOPATHY 审中-公开
标题翻译：用于检测具有或不具有RADICULOPATHY的轴向疼痛标记物的装置和方法
公开(公告)号：WO2007146616A3
公开(公告)日：2008-04-10
申请号：PCT/US2007070174
申请日：2007-06-01
申请人： WARSAW ORTHOPEDIC INC , MCKAY WILLIAM F , GROSS JEFFREY M , TRIEU HAI H , ROY JOSEE , DRAPEAU SUSAN J , SCHENDEL MICHAEL J , WALSH ANDREW J L
发明人： MCKAY WILLIAM F , GROSS JEFFREY M , TRIEU HAI H , ROY JOSEE , DRAPEAU SUSAN J , SCHENDEL MICHAEL J , WALSH ANDREW J L
IPC分类号： A61B5/00 , A61B5/03 , A61B5/06 , A61B17/00 , A61B17/56 , C12Q1/00 , G01N33/94
CPC分类号： A61B5/14546 , A61B5/0031 , A61B5/0071 , A61B5/0084 , A61B5/01 , A61B5/032 , A61B5/14539 , A61B5/4514 , A61B5/4561 , A61B5/4824 , A61B5/4896 , A61B5/6848 , G01N33/54366 , G01N33/6896 , G01N2800/2842
摘要： The invention provides devices and related methods and composition useful for diagnosis and monitoring the pain generator(s) of axial pain with or without radiculopathy and methods for screening test compounds potentially useful for treating axial pain with or without radiculopathy. Alternatively, degenerated discs can be monitored and treated before occurrence of a pathological pain condition. Pain markers and markers of degenerating disc include markers of neuronal, vascular, immune and matrix elements.
摘要翻译：本发明提供了用于诊断和监测具有或不具有神经根病变的轴向疼痛的疼痛发生器的装置和相关方法和组合，以及用于筛选潜在地可用于治疗或不发生神经根病变的轴向疼痛的测试化合物的方法。或者，可以在发生病理性疼痛状况之前监测和治疗退化的椎间盘。退行性椎间盘的疼痛标志物和标志物包括神经元，血管，免疫和基质元件的标记物。

2. 发明申请

WO2003000146A1 DEVICE AND METHOD FOR LOCATING AN ANATOMICAL CAVITY IN A BODY 审中-公开
标题翻译：用于定位身体中的解剖腔的装置和方法
公开(公告)号：WO2003000146A1
公开(公告)日：2003-01-03
申请号：PCT/NL2002/000405
申请日：2002-06-20
申请人： VAN NIEKERK, Jan , TEUNISSEN, Leonardus, Johannes, Maria , VAN WIJK, Maarten Gerardus, Fransiscus , DROST, Marinus, Adriaan , VAN DORSTEN, Franklin, Robert, Christiaan , LANGENBERG, Christianus, Jacobus, Maria , MAAS, Adrianus, Jacobus, Johannes , LECHNER, Timotheus, Joan, Marie
发明人： LECHNER, Timotheus, Joan, Marie
IPC分类号： A61B17/34
CPC分类号： A61B5/4896 , A61B5/032 , A61B5/4839 , A61B5/7415 , A61B17/3401
摘要： The invention describes a device (1) for locating an anatomical cavity (15) inside a body (10). The device comprises a fluid-filled reservoir (30) which is closed off in a sealed manner by a displaceable plunger (32) and is connected to a hollow puncture needle (20). To measure the pressure prevailing in the fluid, the device comprises a pressure gauge (40). A signal converter (50) is used to convert a continuous pressure-measurement signal provided by the pressure gauge (40) into a form which is suitable for further processing. A synthesizer (60) is designed to process the converted pressure-measurement signal into a continuous sound signal which is representative of the pressure. If, during a displacement of the puncture needle (20), a needle point (21) reaches the anatomical cavity (15), the result is a readily perceptible change in the sound signal. The device comprises recording means for recording the pressure-measurement signal over the course of time.
摘要翻译：本发明描述了一种用于在身体（10）内定位解剖腔（15）的装置（1）。该装置包括流体填充的储存器（30），其通过可移位的柱塞（32）以密封方式封闭并连接到中空穿刺针（20）。为了测量流体中的压力，装置包括压力计（40）。信号转换器（50）用于将由压力计（40）提供的连续压力测量信号转换为适于进一步处理的形式。合成器（60）被设计成将转换的压力测量信号处理成代表压力的连续声音信号。如果在穿刺针（20）的位移期间，针尖（21）到达解剖腔（15），结果是声音信号中容易察觉的变化。该装置包括用于在一段时间内记录压力测量信号的记录装置。

3. 发明申请

WO2011158227A2 ANATOMICAL-POSITIONING APPARATUS AND METHOD WITH AN EXPANDABLE DEVICE 审中-公开
标题翻译：具有可扩展设备的解剖学定位装置和方法
公开(公告)号：WO2011158227A2
公开(公告)日：2011-12-22
申请号：PCT/IL2011/000465
申请日：2011-06-13
申请人： OMEQ - INNOVATIVE MEDICAL DEVICES LTD , TSAMIR, Oded , MARGALIT, Lior
发明人： TSAMIR, Oded , MARGALIT, Lior
IPC分类号： A61B1/005
CPC分类号： A61B5/1075 , A61B5/0053 , A61B5/4896 , A61B5/6848 , A61B5/6853 , A61B5/6885 , A61B10/0233 , A61B17/3401 , A61B2017/00557 , A61M5/00 , A61M19/00 , A61M25/01
摘要： An anatomical-positioning apparatus for acquiring mechanical data from a tissue to facilitate determining type of the tissue and transition between different tissues and cavities. The anatomical-positioning apparatus includes a cannula, having a tip, an expandable device having a contracted form size and an expanded form size, wherein the expanded form size is substantially larger than the contracted form size. The anatomical-positioning apparatus further includes an introducer, having a longitudinal axis and a distal end, facilitating the introduction of the expandable device into the tissue, the expandable device being in a contracted state, an expanding-mechanism for expanding and contracting the expandable device, and a sensor for measuring physical parameters associated with the expandable device. An aspect of the present invention is to provide a method for acquiring mechanical data from a tissue by an expandable device, while the expandable device exerts pressure onto portions of the tissue.
摘要翻译：一种用于从组织获取机械数据以便于确定组织类型和不同组织和腔之间的转变的解剖定位装置。解剖定位装置包括具有尖端的插管，具有收缩形状尺寸和膨胀形式尺寸的可扩张装置，其中扩张形式尺寸基本上大于收缩形式尺寸。解剖定位装置还包括导引器，其具有纵向轴线和远端，便于将可扩张装置引入组织中，该可扩张装置处于收缩状态，扩张机构用于扩张和收缩可扩张装置以及用于测量与所述可扩张装置相关联的物理参数的传感器。本发明的一个方面是提供一种用于通过可扩张装置从组织获取机械数据的方法，同时可扩张装置对组织的部分施加压力。

4. 发明申请

WO1992015256A1 METHOD AND APPARATUS FOR LOCATING ANATOMICAL CAVITIES 审中-公开
标题翻译：用于定位解剖学的方法和装置
公开(公告)号：WO1992015256A1
公开(公告)日：1992-09-17
申请号：PCT/ES1991000011
申请日：1991-02-28
申请人： INDUSTRIAS PALEX, S.A. , UCHA CALVO, Eloy
发明人： INDUSTRIAS PALEX, S.A.
IPC分类号： A61B17/34
CPC分类号： A61B5/4896 , A61B5/032 , A61B17/3401 , A61B2090/064
摘要： The present invention relates to a method and apparatus for locating anatomical cavities such as the epidural space. The puncture will be made on the basis of the loss of resistance technique with a seringe (12). The tapping is facilitated by taking some measurements in the operation region (15) and by the emission of acoustic and visual warning signals, as well as by the provision of data displayed on a screen (16), all of which quantify and corroborate the tactile feelings of the operator, influencing the operator's work and allowing the operator to make proximal trials which are not harmful or damaging, and to be extremely sure that the cavity has been reached. The method is applicable independently of the pressure characteristics of the space to be detected, and uses a conventional needle, which also makes an apprenticeship possible in optimal safety conditions.

5. 发明申请

WO2011158227A3 ANATOMICAL-POSITIONING APPARATUS AND METHOD WITH AN EXPANDABLE DEVICE 审中-公开
标题翻译：具有可扩展设备的解剖学定位装置和方法
公开(公告)号：WO2011158227A3
公开(公告)日：2016-05-19
申请号：PCT/IL2011000465
申请日：2011-06-13
申请人： OMEQ INNOVATIVE MEDICAL DEVICES LTD , TSAMIR ODED , MARGALIT LIOR
发明人： TSAMIR ODED , MARGALIT LIOR
IPC分类号： A61B5/103 , A61B5/107
CPC分类号： A61B5/1075 , A61B5/0053 , A61B5/4896 , A61B5/6848 , A61B5/6853 , A61B5/6885 , A61B10/0233 , A61B17/3401 , A61B2017/00557 , A61M5/00 , A61M19/00 , A61M25/01
摘要： An anatomical-positioning apparatus for acquiring mechanical data from a tissue to facilitate determining type of the tissue and transition between different tissues and cavities. The anatomical-positioning apparatus includes a cannula, having a tip, an expandable device having a contracted form size and an expanded form size, wherein the expanded form size is substantially larger than the contracted form size. The anatomical-positioning apparatus further includes an introducer, having a longitudinal axis and a distal end, facilitating the introduction of the expandable device into the tissue, the expandable device being in a contracted state, an expanding-mechanism for expanding and contracting the expandable device, and a sensor for measuring physical parameters associated with the expandable device. An aspect of the present invention is to provide a method for acquiring mechanical data from a tissue by an expandable device, while the expandable device exerts pressure onto portions of the tissue.
摘要翻译：一种用于从组织获取机械数据以便于确定组织类型和不同组织和腔之间的转变的解剖定位装置。解剖定位装置包括具有尖端的套管，具有收缩形状尺寸和膨胀形式尺寸的可扩张装置，其中膨胀形式尺寸基本上大于收缩形式尺寸。解剖定位装置还包括导引器，其具有纵向轴线和远端，便于将可扩张装置引入组织，该可扩张装置处于收缩状态，扩张机构用于扩张和收缩可扩张装置以及用于测量与可扩展装置相关联的物理参数的传感器。本发明的一个方面是提供一种用于通过可扩张装置从组织获取机械数据的方法，同时可扩张装置对组织的部分施加压力。

6. 发明申请

WO2011094957A1 一次性使用硬膜外穿刺负压指示器审中-公开
公开(公告)号：WO2011094957A1
公开(公告)日：2011-08-11
申请号：PCT/CN2010/070748
申请日：2010-02-25
申请人：天津美迪斯医疗用品有限公司 , 邹德伟
发明人：邹德伟
IPC分类号： A61B5/03 , A61B17/34 , A61M19/00
CPC分类号： A61B5/032 , A61B5/4896 , A61B17/3401 , A61B90/06 , A61B2017/0023 , A61B2090/064 , A61M19/00 , A61M2205/3344

7. 发明申请

WO2011022073A1 SYSTEMS, METHODS, AND DEVICES FOR FACILITATING ACCESS TO TARGET ANATOMICAL SITES OR ENVIRONMENTS 审中-公开
标题翻译：用于促进获取目标解剖学场或环境的系统，方法和装置
公开(公告)号：WO2011022073A1
公开(公告)日：2011-02-24
申请号：PCT/US2010/002305
申请日：2010-08-19
申请人： MIRADOR BIOMEDICAL , HULVERSHORN, Justin , SCHMIDT, Karl , SWARTZ, Douglas
发明人： HULVERSHORN, Justin , SCHMIDT, Karl , SWARTZ, Douglas
IPC分类号： A61B5/05
CPC分类号： A61B5/4887 , A61B5/0006 , A61B5/0205 , A61B5/0215 , A61B5/032 , A61B5/036 , A61B5/0408 , A61B5/044 , A61B5/14542 , A61B5/4821 , A61B5/4839 , A61B5/489 , A61B5/4896 , A61B5/742 , A61B8/0833 , A61B8/4472 , A61B17/3401 , A61B2090/064 , A61M5/16854 , A61M5/42 , A61M5/427 , A61M5/46 , A61M5/484 , A61M5/486 , A61M25/06 , A61M25/0693
摘要： Methods and structures for detecting a physiologic parameter of a target anatomical environment. The device including a housing with a distal portion first port couplable to a probe and a proximal portion; and a sensing unit, a processing unit, and an output unit carried by the housing, the output unit configured to output a reporting signal based on the determined physiologic parameter value such as pressure; the sensing unit, processing unit, and output unit being disposed substantially between the first port and the proximal portion of the housing.
摘要翻译：用于检测目标解剖环境的生理参数的方法和结构。该装置包括具有可与探针连接的远端部分第一端口和近端部分的壳体; 以及感测单元，处理单元和由壳体承载的输出单元，所述输出单元被配置为基于所确定的生理参数值（例如压力）输出报告信号; 感测单元，处理单元和输出单元基本上设置在壳体的第一端口和近端部分之间。

8. 发明申请

WO1988003420A1 METHOD AND APPARATUS FOR DETECTING TISSUE PENETRATION 审中-公开
标题翻译：检测组织渗透的方法和装置
公开(公告)号：WO1988003420A1
公开(公告)日：1988-05-19
申请号：PCT/US1986002450
申请日：1986-11-14
申请人： JACKSON, Anthony
IPC分类号： A61M23/00
CPC分类号： A61B17/3401 , A61B5/4896 , A61M5/486 , A61M5/488
摘要： Apparatus and method for detecting probe penetration of human target tissue having predetermined internal pressure includes: an elongated hollow probe (12), a valve (14) having first and second orifices (16, 18) with the first orifice (16) communicating with the hollow probe (12), a conduit (22), communicating with the second orifice (18) of the valve, a piston (44) movable resident within the conduit in response to conduit pressure, for limiting pressure within the conduit to the predetermined internal pressure and providing visible indication upon pressure within the conduit reaching the predetermined internal pressure and has a hand squeezable bulb (42) communicating with the conduit intermediate the movable piston (44) and the valve (14), for increasing pressure within the conduit and the probe until the movable piston limits pressure within the conduit to the predetermined pressure.
摘要翻译：用于检测具有预定内部压力的人类靶组织的探针穿透的装置和方法包括：细长的中空探针（12），具有第一和第二孔（16,18）的阀（14），其中第一孔（16）与中空探针（12），与阀的第二孔（18）连通的导管（22），响应于导管压力可移动地驻留在导管内的活塞（44），用于将管道内的压力限制到预定的内部压力并且在管道内的压力上提供可见的指示，达到预定的内部压力，并且具有与可移动的活塞（44）和阀（14）之间的导管连通的可手动挤压的灯泡（42），以增加管道内的压力探针，直到可移动活塞将管道内的压力限制到预定压力。

9. 发明申请

WO2015198223A1 IDENTIFYING A TARGET ANATOMIC LOCATION IN A SUBJECT'S BODY, AND DELIVERING A MEDICINAL SUBSTANCE THERETO 审中-公开
标题翻译：确定主体的目标解剖位置，并提供药物物质
公开(公告)号：WO2015198223A1
公开(公告)日：2015-12-30
申请号：PCT/IB2015/054704
申请日：2015-06-23
申请人： OMEQ MEDICAL LTD
发明人： TSAMIR, Oded , MARGALIT, Lior
IPC分类号： A61B17/34 , A61M25/01
CPC分类号： A61B5/4896 , A61B5/0053 , A61B5/6847 , A61B5/6848 , A61B5/6885 , A61B17/3401 , A61B17/3496 , A61B90/06 , A61B2090/061 , A61B2090/064 , A61M5/31 , A61M25/065 , A61M2025/0007
摘要： Identifying target anatomic locations in a subject's body, and delivering medicinal substances thereto, following transtissual progression (penetrating, cutting through body tissue) and reaching body tissue with medical device distal tip. Involves acquiring mechanical properties of body tissue. Exemplary medicinal substance is, or includes, a drug (anesthetic agent), and exemplary target anatomic location is epidural space in subject's body. Exemplary system includes: cannular member enclosing cannula lumen; pusher-probe having distal end in cannula lumen and positionable from retracted to protruding positions, wherein pusher-probe distal end protrudes out of cannula distal end; and extending mechanism including cam member, a follower shiftable from first to second stations on cam member, and plunger selectively traveling in cannula lumen while forcing relative motion between cam member and follower, wherein pusher-probe distal end repositions between retracted and protruding positions. Optionally, includes data-information analyzing device having triggering mechanism via a winged hub member and associated components.
摘要翻译：识别受试者身体中的目标解剖位置，并在经过平均进展（穿透，穿过身体组织）并用医疗装置远端到达身体组织之后递送药物。涉及获取身体组织的机械性质。示例性药用物质是或包括药物（麻醉剂），并且示例性目标解剖位置是受试者体内的硬膜外腔。示例性系统包括：包封套管内腔的管状构件; 推动器探针具有在套管内腔中的远端并且可从缩回位置到突出位置，其中推动器 - 探针远端从套管远端突出; 以及延伸机构，其包括凸轮构件，可从凸轮构件上的第一站移动到第二站的从动件，以及选择性地在套管腔中行进的柱塞，同时迫使凸轮构件和从动件之间的相对运动，其中推动器 - 探针远端在缩回位置和突出位置之间重新定位。可选地，包括具有经由翼状轮毂构件和相关组件的触发机构的数据信息分析装置。

10. 发明申请

WO2013144928A1 MEDICAL NEEDLE 审中-公开
标题翻译：医用针
公开(公告)号：WO2013144928A1
公开(公告)日：2013-10-03
申请号：PCT/IB2013/052573
申请日：2013-03-30
申请人： KONINKLIJKE PHILIPS N.V. , PHILIPS DEUTSCHLAND GMBH
发明人： ROGGEVEEN, Stephan Adriaan , LUCASSEN, Gerhardus Wilhelmus , VAN DER VOORT, Marjolein , WINKEL, Axel , VOSS, Stephan , KLEWER, Jasper , HENDRIKS, Bernardus Hendrikus Wilhelmus , BIERHOFF, Waltherus Cornelis Jozef , MÜLLER, Manfred
IPC分类号： A61B5/06 , A61B5/00 , A61B17/34
CPC分类号： A61B19/5244 , A61B1/07 , A61B5/0053 , A61B5/0075 , A61B5/0084 , A61B5/065 , A61B5/4839 , A61B5/4896 , A61B5/7264 , A61B17/3401 , A61B34/20 , A61B90/11 , A61B90/13 , A61B2017/00061 , A61B2034/2055 , A61M5/3287 , A61M2205/3303 , A61M2205/3306 , A61M2205/3375 , A61M2205/52
摘要： The present invention relates to a medical needle which comprises a needle (1) having at least one channel (21), at least one optical waveguide (22) and a syringe connector (20). The syringe connector (20) is in communication with the at least one channel (21) and permits further communication with an additional syringe (25), thereby permitting the correspondence of fluid between the syringe (25) and the tip of the needle (1). The optical waveguides (22) are arranged within the needle (1) in order to make optical measurements at the tip of the needle (1). The cross section of the distal end of the elongate tube (1) has a dividing line for each channel (21) which separates that channel (21) from the one or more optical waveguides (22).
摘要翻译：本发明涉及一种医用针，其包括具有至少一个通道（21）的针（1），至少一个光波导（22）和注射器连接器（20）。注射器连接器（20）与至少一个通道（21）连通，并允许与额外的注射器（25）进一步连通，从而允许注射器（25）和针头（1）的尖端之间的流体对应）。光波导（22）布置在针（1）内，以便在针（1）的尖端进行光学测量。细长管（1）的远端的横截面具有用于将该通道（21）与一个或多个光波导（22）分离的每个通道（21）的分隔线。

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