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1. 发明申请

WO2008073420A2 SYSTEMS AND METHODS FOR TREATING PATIENT HYPERTONICITY 审中-公开
标题翻译：用于治疗患者高血压的系统和方法
公开(公告)号：WO2008073420A2
公开(公告)日：2008-06-19
申请号：PCT/US2007/025311
申请日：2007-12-11
申请人： NORTHSTAR NEUROSCIENCE, INC. , GLINER, Bradford, Evan , FOWLER, Brad , HULVERSHORN, Justin , SLOAN, Leif, R.
发明人： GLINER, Bradford, Evan , FOWLER, Brad , HULVERSHORN, Justin , SLOAN, Leif, R.
IPC分类号： A61N2/02
CPC分类号： A61N1/36082 , A61N1/0531 , A61N2/006
摘要： Systems and methods for treating patient hypertonicity are disclosed. A method in accordance with one embodiment includes identifying a cortical target neural population associated with hypertonicity in a patient, and reducing or eliminating patient hypertonicity by applying electromagnetic signals to the target neural population. In further particular embodiments, the electromagnetic signals are first electromagnetic signals, and the method can further include reducing or eliminating an additional patient dysfunction by applying second electromagnetic signals.
摘要翻译：公开了用于治疗患者高渗性的系统和方法。根据一个实施例的方法包括识别与患者中的高渗性相关的皮质靶神经群体，以及通过向目标神经群体施加电磁信号来减少或消除患者的高渗性。在另外的特定实施例中，电磁信号是第一电磁信号，并且该方法还可以包括通过施加第二电磁信号来减少或消除另外的患者功能障碍。

2. 发明申请

WO2009073891A1 SYSTEMS AND METHODS FOR PROVIDING TARGETED NEURAL STIMULATION THERAPY TO ADDRESS NEUROLOGICAL DISORDERS, INCLUDING NEUROPYSCHIATRIC AND NEUROPYSCHOLOGICAL DISORDERS 审中-公开
标题翻译：用于提供针对性神经刺激治疗方法的系统和方法来治疗神经病变，包括神经病学和神经病学疾病
公开(公告)号：WO2009073891A1
公开(公告)日：2009-06-11
申请号：PCT/US2008/085973
申请日：2008-12-08
申请人： NORTHSTAR NEUROSCIENCE, INC. , HULVERSHORN, Justin , FOWLER, Brad , GLINER, Bradford, Evan , SLOAN, Leif, R. , KOPELL, Brian , SOLTYSIK, David, Alan
发明人： HULVERSHORN, Justin , FOWLER, Brad , GLINER, Bradford, Evan , SLOAN, Leif, R. , KOPELL, Brian , SOLTYSIK, David, Alan
IPC分类号： A61N1/00
CPC分类号： A61N1/36082
摘要： Systems and methods for providing targeted neural stimulation therapy to address neurological disorders, including neuropsychiatric and neuropsychological disorders are disclosed. A method for treating a patient's neurological disorder in accordance with a particular embodiment includes, in a patient identified as having at least one of a neuropsychological disorder and a neuropsychiatric disorder, implanting at least one stimulation electrode within the patient's skull cavity, and outside a cortical surface of the patient's brain. The electrode is implanted at a location in a range of about 15 mm to about 35 mm anterior to a precentral sulcus reference point that is positioned at the precentral sulcus and at the patient's middle frontal gyrus. The method can further include treating the patient's disorder by applying electrical stimulation to the patient via the at least one stimulation electrode.
摘要翻译：公开了用于提供靶向神经刺激治疗以解决神经障碍（包括神经精神和神经心理障碍）的系统和方法。根据特定实施方案的用于治疗患者神经障碍的方法包括在被鉴定为具有神经心理障碍和神经精神障碍中的至少一种的患者中，将至少一个刺激电极植入患者的颅骨腔内，皮质外患者脑部表面。将电极植入在位于中心龈沟处和患者中额叶回的前中央龈下参考点前方约15mm至约35mm范围内的位置处。该方法还可以包括通过经由至少一个刺激电极向患者施加电刺激来治疗患者的病症。

3. 发明申请

WO2008130837A1 METHODS AND SYSTEMS FOR ESTABLISHING NEURAL STIMULATION PARAMETERS AND PROVIDING NEURAL STIMULATION 审中-公开
标题翻译：建立神经刺激参数并提供神经刺激的方法和系统
公开(公告)号：WO2008130837A1
公开(公告)日：2008-10-30
申请号：PCT/US2008/059645
申请日：2008-04-08
申请人： NORTHSTAR NEUROSCIENCE, INC. , FOWLER, Brad , HULVERSHORN, Justin , GLINER, Bradford, Evan , SLOAN, Leif, R.
发明人： FOWLER, Brad , HULVERSHORN, Justin , GLINER, Bradford, Evan , SLOAN, Leif, R.
IPC分类号： A61N1/36
CPC分类号： A61N1/36082 , A61N1/36025
摘要： Methods for providing electrical stimulation therapy to a cortex of a patient via a plurality of electrodes proximate to the cortex and a pulse generator implanted in the patient. One embodiment of a method in accordance with the invention comprises determining whether the current applied via the plurality of electrodes results in a sufficient current density in the cortex. The current density, for example, may need to be high enough to induce a response in the patient for determining the activation threshold of the specific stimulation site, or the current density may need to be high enough to perform a specific therapy. If the current density is not sufficient, the method continues by selecting a subset of the plurality of electrodes, and applying electrical current to the cortex via the subset of the electrodes. For example, if the current density is not sufficient when the current is applied to the full plurality of electrodes at approximately the maximum output of the pulse generator, then the current level from the pulse generator can be applied to only a subset of the electrodes to effectively increase the current density in the cortex at the active electrodes.
摘要翻译：用于通过靠近皮层的多个电极和植入患者中的脉冲发生器向患者的皮层提供电刺激治疗的方法。根据本发明的方法的一个实施例包括确定经由多个电极施加的电流是否导致皮层中的足够的电流密度。例如，电流密度可能需要足够高以在患者中诱导用于确定特定刺激部位的激活阈值的响应，或者电流密度可能需要足够高以执行特定治疗。如果电流密度不足，则该方法通过选择多个电极的子集，并且经由电极的子集将电流施加到皮层来继续。例如，如果电流密度在脉冲发生器的大致最大输出处施加到整个多个电极上时电流密度不足，则来自脉冲发生器的电流电平可以仅施加到电极的子集有效增加有源电极皮质中的电流密度。

4. 发明申请

WO2007090054A2 SYSTEMS AND METHODS FOR VARYING ELECTROMAGNETIC AND ADJUNCTIVE NEURAL THERAPIES 审中-公开
标题翻译：改变电磁和相关神经治疗的系统和方法
公开(公告)号：WO2007090054A2
公开(公告)日：2007-08-09
申请号：PCT/US2007/061125
申请日：2007-01-26
申请人： NORTHSTAR NEUROSCIENCE, INC. , GLINER, Bradford, Evan , BALZER, Jeffrey , FOWLER, Brad , SLOAN, Leif, R.
发明人： GLINER, Bradford, Evan , BALZER, Jeffrey , FOWLER, Brad , SLOAN, Leif, R.
IPC分类号： A61N1/18
CPC分类号： A61N1/36082 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/36017 , A61N1/36025 , A61N1/37247 , G06F19/00
摘要： Systems and methods for varying electromagnetic and adjunctive neural therapies are disclosed. A method in accordance with one embodiment includes applying electromagnetic signals to a target neural population of a patient over a first period of time in accordance with a first mode (e.g., including signal delivery to the central nervous system or peripheral nervous system, via implanted or non-implanted devices). The method can further include applying electromagnetic stimulation to the patient over a second period of time in accordance with a second mode different than the first mode. Varying the mode between the first period of time and second period of time can increase the efficacy and/or longevity of the stimulation. Systems in accordance with other embodiments can support multiple signal delivery devices.
摘要翻译：公开了用于改变电磁和辅助神经疗法的系统和方法。根据一个实施例的方法包括根据第一模式（例如，包括通过植入的或中间神经系统的中枢神经系统或周围神经系统的信号传递）向第一时间段的患者的目标神经群体施加电磁信号非植入设备）。该方法还可以包括根据与第一模式不同的第二模式，在第二时间段内向患者施加电磁刺激。改变第一时间段和第二时间段之间的模式可以增加刺激的功效和/或寿命。根据其他实施例的系统可以支持多个信号传递装置。

5. 发明申请

WO2008017055A2 METHODS FOR TREATING NEUROLOGICAL DISORDERS, INCLUDING NEUROPSYCHIATRIC AND NEUROPSYCHOLOGICAL DISORDERS, AND ASSOCIATED SYSTEMS 审中-公开
标题翻译：治疗神经系统疾病的方法，包括神经传感器和神经心理疾病及其相关系统
公开(公告)号：WO2008017055A2
公开(公告)日：2008-02-07
申请号：PCT/US2007/075129
申请日：2007-08-02
申请人： NORTHSTAR NEUROSCIENCE, INC. , FOWLER, Brad , GLINER, Bradford, Evan , SHEFIELD, W., Douglas , SLOAN, Leif, R.
发明人： FOWLER, Brad , GLINER, Bradford, Evan , SHEFIELD, W., Douglas , SLOAN, Leif, R.
IPC分类号： A61N1/32
CPC分类号： A61N1/36082
摘要： Methods for treating neurological disorders, including neuropsychiatric and neuropsychological disorders, and associated systems are disclosed. One such method includes identifying one or more neural populations, including a cortical target neural population, associated with a neurological condition. The method can further include comparing a patient-specific measure of a characteristic parameter for a selected one of the neural populations with a target measure for the same parameter. If the patient-specific measure differs from the target measure by at least a target amount, the method can include selecting an electrical signal polarity, frequency, or both polarity and frequency based at least in part on the difference between the patient-specific measure and the target measure. The method can further include applying electrical signals to the target neural population at the selected signal polarity, frequency, or both polarity and frequency to reduce the difference between the patient- specific measure and the target measure.
摘要翻译：公开了用于治疗神经障碍（包括神经精神病学和神经心理障碍）和相关系统的方法。一种这样的方法包括识别一个或多个神经群体，包括与神经病症相关的皮层目标神经群体。该方法可以进一步包括将针对所选择的一个神经群体的特征参数的患者特异性测量值与针对相同参数的目标测量值进行比较。如果患者特异性测量与目标测量相差至少目标量，则该方法可以包括至少部分地基于患者特异性测量与患者特异性测量之间的差异来选择电信号极性，频率或极性和频率两者目标措施。该方法可以进一步包括以选定的信号极性，频率或极性和频率两者向目标神经群体施加电信号以减小患者特异性测量值和目标测量值之间的差异。

6. 发明申请

WO2007121133A2 ELECTROMAGNETIC SIGNAL DELIVERY FOR TISSUE AFFECTED BY NEURONAL DYSFUNCTION, DEGRADATION, DAMAGE, AND/OR NECROSIS, AND ASSOCIATED SYSTEMS AND METHODS 审中-公开
标题翻译：由神经元功能丧失，降解，损伤和/或坏死以及相关系统和方法影响的组织的电磁信号传递
公开(公告)号：WO2007121133A2
公开(公告)日：2007-10-25
申请号：PCT/US2007/066220
申请日：2007-04-09
申请人： NORTHSTAR NEUROSCIENCE, INC. , FOWLER, Brad , GLINER, Bradford, Evan , HIMES, David
发明人： FOWLER, Brad , GLINER, Bradford, Evan , HIMES, David
IPC分类号： A61N1/20
CPC分类号： A61N2/006 , A61N1/36017 , A61N1/36025 , A61N1/36082
摘要： Electromagnetic signal delivery for tissue affected by neuronal dysfunction, degradation, damage, and/or necrosis, and associated systems and methods are disclosed. A method in accordance with one embodiment of the invention includes identifying an affected region, with the affected region including neuronal tissue that, at least during a pre-dysfunctional period, was in neural communication with neuronal tissue in a dysfunctional region. The affected tissue can be functionally adversely affected by neuronal dysfunction in the dysfunctional region. The method can further include applying electromagnetic signals to the neuronal tissue in the affected region. For example, the electromagnetic signals can be applied to a hypo-active neural region that is not physically damaged, and has been identified as likely to recover at least in part as a result of electromagnetic signals. Signals can be applied at sub-threshold levels to cortical and/or subcortical regions.
摘要翻译：公开了由神经元功能障碍，降解，损伤和/或坏死以及相关系统和方法影响的组织的电磁信号传递。根据本发明的一个实施例的方法包括识别受影响的区域，其中受影响的区域包括神经元组织，至少在功能失调之前期间，与功能障碍区域中的神经元组织进行神经交流。受影响的组织可能在功能障碍区域的神经元功能障碍中受功能不良的影响。该方法还可以包括将电磁信号应用于受影响区域中的神经元组织。例如，电磁信号可以应用于没有物理损坏的低活性神经区域，并且已被鉴定为可能至少部分地由于电磁信号而恢复。信号可以在亚阈值水平应用于皮层和/或皮质下区域。

7. 发明申请

WO2006053114A2 ELECTRODE CONFIGURATIONS FOR REDUCING INVASIVENESS AND /OR ENHANCING NEURAL STIMULATION EFFICACY, AND ASSOCIATED METHODS 审中-公开
标题翻译：用于降低不可接受性和/或增强神经刺激效力的电极配置及相关方法
公开(公告)号：WO2006053114A2
公开(公告)日：2006-05-18
申请号：PCT/US2005/040714
申请日：2005-11-10
申请人： NORTHSTAR NEUROSCIENCE, INC. , FOWLER, Brad , GLINER, Bradford, Evan
发明人： FOWLER, Brad , GLINER, Bradford, Evan
IPC分类号： A61N1/32
CPC分类号： A61N1/0529 , A61N1/0531 , A61N1/36017 , A61N1/36082
摘要： Electrode configurations for reducing invasiveness and/or enhancing neural stimulation efficacy, and associated methods, are disclosed. A method in accordance with one embodiment of the invention for treating a brain disorder includes identifying a target neural structure within a patient's skull and implanting an electrode device within the patient's skull so that an axis that is generally normal to the skull proximate to the electrode device and that passes through at least one electrical contact of the electrode device is offset from the target neural structure. The method further includes stimulating the target neural structure by applying an electrical signal to the at least one electrical contact. In particular embodiments, the electrode device can be positioned between, along, across, or adjacent to a fissure, recess, groove, and/or vascular structure of the patient's brain.
摘要翻译：公开了用于降低侵袭性和/或增强神经刺激功效的电极配置，以及相关的方法。根据本发明的一个实施例的用于治疗脑障碍的方法包括识别患者颅骨内的目标神经结构并将电极装置植入患者颅骨内，使得与颅骨接近的电极装置并且穿过电极装置的至少一个电触点的电极偏离目标神经结构。该方法还包括通过将电信号施加到至少一个电触点来刺激目标神经结构。在特定实施例中，电极装置可以定位在患者大脑的裂隙，凹槽，凹槽和/或血管结构之间，沿着，穿过或邻近于其。

8. 发明申请

WO2005011805A2 APPARATUS AND METHODS FOR APPLYING NEURAL STIMULATION TO A PATIENT 审中-公开
标题翻译：将患者应用于神经刺激的装置和方法
公开(公告)号：WO2005011805A2
公开(公告)日：2005-02-10
申请号：PCT/US2004/025010
申请日：2004-08-02
申请人： NORTHSTAR NEUROSCIENCE, INC. , FOWLER, Brad , GLINER, Bradford, Evan
发明人： FOWLER, Brad , GLINER, Bradford, Evan
IPC分类号： A61N
CPC分类号： A61N1/36082 , A61N1/0531 , A61N1/0539
摘要： Systems and methods for neural stimulation may include a stimulus unit; a first electrode assembly having a first set of contacts; and a second set of contacts. The stimulus unit can be an implantable pulse generator including a first terminal that can be biased at a first signal polarity and a second terminal that can be biased at a second signal polarity. The first electrode assembly includes a support member configured to be placed at the stimulation site, the first set of contacts carried by the support member, and a first lead configured to be attached to the first terminal of the implantable pulse generator for biasing the surface contacts at the first polarity. The second set of contacts is detached from the surface electrode assembly. The second set of contacts can be one or more conductive elements fixed to or forming portions of the implantable pulse generator, or a separate electrode array.
摘要翻译：用于神经刺激的系统和方法可以包括刺激单位; 具有第一组触点的第一电极组件; 和第二组联系人。刺激单元可以是可植入脉冲发生器，其包括可以以第一信号极性偏置的第一端子和可以以第二信号极性偏置的第二端子。第一电极组件包括被配置为放置在刺激部位的支撑构件，由支撑构件承载的第一组触点，以及构造成附接到可植入脉冲发生器的第一端子的第一引线，用于偏置表面触点在第一极性。第二组触点与表面电极组件脱离。第二组触点可以是固定到可植入脉冲发生器的一部分或形成部分的一个或多个导电元件或单独的电极阵列。

9. 发明申请

WO2009011947A1 METHODS FOR ESTABLISHING PARAMETERS FOR NEURAL STIMULATION, INCLUDING VIA PERFORMANCE OF WORKING MEMORY TASKS, AND ASSOCIATED KITS 审中-公开
标题翻译：用于建立神经刺激参数的方法，包括通过工作记忆任务的性能和相关工具
公开(公告)号：WO2009011947A1
公开(公告)日：2009-01-22
申请号：PCT/US2008/060739
申请日：2008-04-18
申请人： NORTHSTAR NEUROSCIENCE, INC. , FOWLER, Brad , SLOAN, Leif, R. , BORGERDING, Joleen
发明人： FOWLER, Brad , SLOAN, Leif, R. , BORGERDING, Joleen
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/36082 , A61N1/0531 , A61N1/0534 , A61N1/36096
摘要： Methods for establishing parameters for neural stimulation, including via performance of working memory tasks, and associated kits, are disclosed. A method in accordance with one embodiment includes engaging a patient in a function controlled at least in part by a target neural population, and applying electromagnetic signals to the target neural population. A target parameter in accordance with which the electromagnetic signals are applied is adjusted, based at least in part on a characteristic of the patient's performance of the function. Electromagnetic signals are applied to the patient with the adjusted target parameter, and the patient's response to the electromagnetic signals, including the characteristic of the patient's performance, is evaluated. Based at least in part on the evaluation of the patient's response, an embodiment of the method includes determining whether to apply further electromagnetic signals to the patient, establishing a value of the target parameter for applying further electromagnetic signals to the patient, and/or adjusting another target parameter in accordance with which the electromagnetic signals are applied to the patient.
摘要翻译：公开了用于建立神经刺激参数的方法，包括通过执行工作记忆任务以及相关工具包。根据一个实施例的方法包括使患者至少部分地由目标神经群体控制的功能并且向目标神经群体施加电磁信号。至少部分地基于患者对功能的执行的特性来调整施加电磁信号的目标参数。利用调整后的目标参数对病人施加电磁信号，评价病人对电磁信号的反应，包括病人的表现特点。至少部分地基于对患者的反应的评估，该方法的实施例包括确定是否向患者施加进一步的电磁信号，建立用于向患者施加进一步的电磁信号的目标参数的值，和/或调整电磁信号被施加到患者的另一目标参数。

10. 发明申请

WO2003035163A2 METHODS AND APPARATUS FOR EFFECTUATING A LASTING CHANGE IN A NEURAL-FUNCTION OF A PATIENT 审中-公开
标题翻译：影响患者神经功能变化的方法和装置
公开(公告)号：WO2003035163A2
公开(公告)日：2003-05-01
申请号：PCT/US2002/031127
申请日：2002-09-27
申请人： VERTIS NEUROSCIENCE, INC. , GLINER, Bradford, Evan , FOWLER, Brad , FIRLIK, Andrew, D. , BALZER, Jeffrey , LEVY, Alan, J.
发明人： GLINER, Bradford, Evan , FOWLER, Brad , FIRLIK, Andrew, D. , BALZER, Jeffrey , LEVY, Alan, J.
IPC分类号： A61N1/00
CPC分类号： A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/36017 , A61N1/3605 , A61N1/36082 , A61N1/36103 , A61N1/3756
摘要： The following disclosure describes several methods and apparatus for intracranial electrical stimulation to treat or otherwise effectuate a change in neural-functions of a patient. Certain embodiments of methods in accordance with the invention electrically stimulate the brain at a stimulation site where neuroplasticity is occurring or is expected to occur. The stimulation site may be different than the region in the brain where neural activity is typically present to perform the particular neural function according to the functional organization of the brain. In one embodiment in which neuroplasticity related to the neural-function occurs in the brain, the method can include identifying the location where such neuroplasticity is present or expected to occur. In an alternative embodiment in which neuroplasticity is not occurring in the brain, an alternative aspect is to induce neuroplasticity at a stimulation site where it is expected to occur. Several embodiments of these methods that are expected to produce a lasting effect on the intended neural activity at the stimulation site use electrical pulses that increase the resting membrane potential of neurons at the stimulation site to a subthreshold level.
摘要翻译：以下公开内容描述了用于治疗或以其他方式实现患者神经功能变化的颅内电刺激的几种方法和装置。根据本发明的方法的某些实施方案在神经可塑性发生或预期发生的刺激部位电刺激脑。刺激部位可能不同于大脑中通常存在神经活动的区域，以根据脑的功能组织来执行特定的神经功能。在与神经功能相关的神经可塑性发生在脑中的一个实施方案中，该方法可以包括鉴定存在或预期发生这种神经可塑性的位置。在脑中不发生神经可塑性的替代实施方案中，替代方面是在预期发生的刺激位点处诱导神经可塑性。预期对刺激部位的预期神经活动产生持久影响的这些方法的若干实施方案使用增加刺激部位的神经元的静息膜电位至亚阈值水平的电脉冲。

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