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1. 发明申请

WO2007123444A1 A PIEZOELECTRIC SENSOR, A METHOD FOR MANUFACTURING A PIEZOELECTRIC SENSOR AND A MEDICAL IMPLANTABLE LEAD COMPRISING SUCH A PIEZOELECTRIC SENSOR 审中-公开
标题翻译：压电传感器，制造压电传感器的方法和包含这种压电传感器的医用可植入引线
公开(公告)号：WO2007123444A1
公开(公告)日：2007-11-01
申请号：PCT/SE2006/000479
申请日：2006-04-25
申请人： ST. JUDE MEDICAL AB , ERIKSSON, Tom , NILSSON, Kenth , HEDBERG, Sven-Erik
发明人： ERIKSSON, Tom , NILSSON, Kenth , HEDBERG, Sven-Erik
IPC分类号： A61B5/0215 , A61N1/05 , H01L41/087
CPC分类号： A61N1/056 , A61B5/0215 , A61N1/0565 , A61N1/36542 , A61N1/36564 , G01L9/0026 , G01L9/08 , H01L41/087 , H01L41/1132
摘要： The invention relates to a piezoelectric sensor comprising a layer of a piezoelectric material (3) , having aligned, polarized dipoles, which is applied to a tubular supporting substrate (2) , and having at least one electrode (2) connected to its outer surface as well as at least one electrode (5) connected to its inner surface. The piezoelectric material (3) is applied on the inner circumference of the tubular supporting substrate (2) . The invention also relates to a method for manufacturing a piezoelectric sensor and a medical implantable lead comprising such a piezoelectric sensor.
摘要翻译：本发明涉及一种压电传感器，其包括压电材料层（3），其具有对准的偏振偶极子，其被施加到管状支撑衬底（2）上，并且具有连接到其外表面的至少一个电极（2）以及连接到其内表面的至少一个电极（5）。压电材料（3）被施加在管状支撑衬底（2）的内圆周上。本发明还涉及一种用于制造压电传感器的方法和包括这种压电传感器的医用可植入引线。

2. 发明申请

WO2007111542A1 MEDICAL SYSTEM FOR MONITORING AND LOCALISATION OF ELECTRODE LEADS IN THE HEART 审中-公开
标题翻译：用于监测和定位心脏中电极引线的医疗系统
公开(公告)号：WO2007111542A1
公开(公告)日：2007-10-04
申请号：PCT/SE2006/000384
申请日：2006-03-27
申请人： ST. JUDE MEDICAL AB , HEDBERG, Sven-Erik , NILSSON, Kenth
发明人： HEDBERG, Sven-Erik , NILSSON, Kenth
IPC分类号： A61B5/06 , A61N1/37
CPC分类号： A61N1/37 , A61B2034/2053 , A61N1/368 , A61N1/3682 , A61N1/3684 , A61N1/3704
摘要： Medical system to be used in connection with an implantable heart stimulator provided with sensing and stimulating heart electrodes. The system comprises a predetermined number of electrode pairs (4), e.g. three patch electrodes, to be arranged at or within a human being or animal such that an electric field through the heart is generated between the electrodes of respective electrode pair. The electric field(s) is/are adapted to be generated by an excitation means (6), including electric field excitation voltage generators, connected to the electrodes, by applying alternating voltages at a preset frequency to the electrodes of the electrode pair(s). The system includes a signal receiving means (8) adapted to receive a signal representing the voltage potential difference between the voltage potential at one of the heart electrodes used as detecting electrode and a reference electrode, wherein the voltage potential is related to the generated electric field. The signal receiving means then to generates a potential difference signal that is applied to a signal controlling and processing means (10) adapted to process the detected potential difference signal in order to determine parameters representing heart activity.
摘要翻译：医疗系统与可植入式心脏刺激器结合使用，可提供感应和刺激心脏电极。该系统包括预定数量的电极对（4），例如，三个贴片电极被布置在人或动物中或内部，使得在各个电极对的电极之间产生通过心脏的电场。电场通过施加连接到电极的电场激励电压发生器的激励装置（6）产生，通过以预定频率向电极对的电极施加交流电压（s））。该系统包括适于接收表示用作检测电极的一个心电极上的电压电位与参考电极之间的电压电位差的信号的信号接收装置（8），其中电压电位与产生的电场相关。然后，信号接收装置产生施加到适于处理检测到的电位差信号的信号控制和处理装置（10）的电位差信号，以便确定表示心脏活动的参数。

3. 发明申请

WO2007064259A1 IMPLANTABLE CARDIAC STIMULATOR, SYSTEM, DEVICE AND METHOD FOR MONITORING CARDIAC SYNCHRONY 审中-公开
标题翻译：可注射的心脏刺激器，系统，设备和监测心脏同步的方法
公开(公告)号：WO2007064259A1
公开(公告)日：2007-06-07
申请号：PCT/SE2005/001806
申请日：2005-11-30
申请人： ST. JUDE MEDICAL AB , JÄRVERUD, Karin , NILSSON, Kenth , HEDBERG, Sven-Erik
发明人： JÄRVERUD, Karin , NILSSON, Kenth , HEDBERG, Sven-Erik
IPC分类号： A61N1/362 , A61B5/00 , A61N1/365
CPC分类号： A61N1/3627 , A61B5/1107 , A61B5/6869 , A61B2562/0219 , A61N1/36514 , A61N1/36578
摘要： A heart stimulator and a device for monitoring cardiac synchrony in a human heart. At least a first and a second sensor are adapted to be positioned at a first cardiac wall location and a second cardiac wall location subjected to movements related to longitudinal valve plane movements along the longitudinal axis of the heart, respectively. The sensors are arranged for measuring cardiac wall movements at the respective cardiac wall locations. Processing circuitry is arranged for receiving output signals from the sensors, the output signals being indicative of longitudinal valve plane movements at the respective cardiac wall location. The processing circuitry is further arranged for processing the signals and output a synchronization signal indicative of the synchrony in the valve plane movements at the cardiac wall locations .
摘要翻译：心脏刺激器和用于监测人心脏心脏同步的装置。至少第一和第二传感器适于被定位在第一心脏壁位置处，并且第二心脏壁位置分别经受与心脏的纵向轴线的纵向瓣膜平面运动相关的运动。传感器被布置用于测量各个心脏壁位置处的心脏壁移动。处理电路被布置成用于接收来自传感器的输出信号，输出信号表示在相应的心脏壁位置处的纵向阀平面运动。处理电路还被布置用于处理信号并输出指示在心脏壁位置处的阀平面运动中的同步的同步信号。

4. 发明申请

WO2008039116A1 MEDICAL IMPLANTABLE PIEZOELECTRIC SENSOR AND METHOD FOR MANUFACTURING THE SAME 审中-公开
标题翻译：医用可植入式压电传感器及其制造方法
公开(公告)号：WO2008039116A1
公开(公告)日：2008-04-03
申请号：PCT/SE2006/001101
申请日：2006-09-28
申请人： ST. JUDE MEDICAL AB , HEDBERG, Sven-Erik , NILSSON, Kenth
发明人： HEDBERG, Sven-Erik , NILSSON, Kenth
IPC分类号： A61B5/0215 , G01L9/08 , H01L41/083
CPC分类号： A61B5/0215 , A61B5/02014 , H01L41/1132
摘要： The invention relates to a medical implantable piezoelectric sensor comprising a piezoelectric layer and an electrode layer on each side of the piezoelectric layer. The piezoelectric sensor is formed of two or more piezoelectric layers (Ia-Ic) being arranged one over another and having separating layers, comprising electrode layers (2a-2b, 3a-3c) , between the piezoelectric layers. The invention also relates to a method for manufacturing such a piezoelectric sensor.
摘要翻译：本发明涉及一种医用植入式压电传感器，其包括压电层和压电层每侧的电极层。所述压电传感器由两层以上压电层（1a-1c）形成，所述两层或多层压电层（Ia-1c）彼此重叠配置并具有包含在所述压电层之间的电极层（2a-2b，3a-3c）的分离层。本发明还涉及一种用于制造这种压电传感器的方法。

5. 发明申请

WO2007100283A1 MEDICAL DEVICE AND METHOD FOR MONITORING HEMATOCRIT AND SVO2 审中-公开
标题翻译：用于监测血液透析和SVO2的医疗装置和方法
公开(公告)号：WO2007100283A1
公开(公告)日：2007-09-07
申请号：PCT/SE2007/000165
申请日：2007-02-22
申请人： ST. JUDE MEDICAL AB , ÖHLANDER, Malin , NOREN, Kjell , ECKERDAL, Johan , HIETANEN, Mika , NILSSON, Kenth , LÖNN, Urban
发明人： ÖHLANDER, Malin , NOREN, Kjell , ECKERDAL, Johan , HIETANEN, Mika , NILSSON, Kenth , LÖNN, Urban
IPC分类号： A61B5/02 , A61B5/1455
CPC分类号： A61B5/02055 , A61B5/0086 , A61B5/053 , A61B5/0538 , A61B5/14535 , A61N1/36521 , G06F19/00 , G06Q50/22
摘要： The present invention generally relates to cardiac pacing systems and, in particular, to a method and an implantable medical device (2; 20) for monitoring physiological parameters such as hematocrit and SvO2 levels of a patient to determine a patient status. The implantable medical device (2; 20) comprises a blood constituent determining device (30) adapted to determine a present hematocrit level and a SvO2 level and a patient status determining device (31) adapted to determine a patient status based on an evaluation of a present hematocrit level and a present SvO2 level, wherein a change of a condition of the patient can be derived.
摘要翻译：本发明一般涉及心脏起搏系统，尤其涉及一种用于监测患者的生理参数例如血细胞比容和SvO2水平以确定患者状态的方法和可植入医疗装置（2; 20）。可植入医疗装置（2; 20）包括适于确定当前血细胞比容水平和SvO2水平的血液成分确定装置（30）和适于基于对所述血液成分确定装置的评估来确定患者状态的患者状态确定装置（31）目前的血细胞比容水平和目前的SvO2水平，其中可以导出患者状况的改变。

6. 发明申请

WO2008105698A1 DEVICE AND METHOD OF A MEDICAL IMPLANT FOR MONITORING PROGRESSION OF HEART FAILURE IN A HUMAN HEART 审中-公开
标题翻译：用于监测人心脏心脏衰竭进展的医用植入物的装置和方法
公开(公告)号：WO2008105698A1
公开(公告)日：2008-09-04
申请号：PCT/SE2007/000855
申请日：2007-09-27
申请人： ST. JUDE MEDICAL AB , BJÖRLING, Anders , ÖHLANDER, Malin , ERIKSSON, Tom , ECKERDAL, Johan , LÖNN, Urban , NILSSON, Kenth , TUVSTEDT, Cecilia , SVAHN, Johan , JOHANSSON, Anna-Karin , NOREN, Kjell , BROOME, Michael
发明人： BJÖRLING, Anders , ÖHLANDER, Malin , ERIKSSON, Tom , ECKERDAL, Johan , LÖNN, Urban , NILSSON, Kenth , TUVSTEDT, Cecilia , SVAHN, Johan , JOHANSSON, Anna-Karin , NOREN, Kjell , BROOME, Michael
IPC分类号： A61N1/372 , A61B5/0205 , A61B5/145
CPC分类号： A61B5/14542 , A61B5/0031 , A61B5/076 , A61B5/1459 , A61B2562/0219 , A61N1/3627 , A61N1/36542 , A61N1/36557 , A61N1/36585
摘要： A device and method of a medical implant for monitoring progression of heart failure in a human heart. An activity sensor provides information related to the activity level of a patient and an oxygen sensor provides information related to the level of oxygen content in venous blood. A determined level of venous oxygen content at a determined activity level is obtained, and that level of venous oxygen content is compared to stored values at a corresponding activity level. The result of the comparison is used as a basis for determining a degree of heart failure.
摘要翻译：用于监测人类心脏心脏衰竭进展的医用植入物的装置和方法。活动传感器提供与患者的活动水平相关的信息，氧传感器提供与静脉血中氧含量水平相关的信息。在确定的活性水平获得确定水平的静脉氧含量，并将静脉氧含量的水平与在相应活动水平的储存值进行比较。将比较结果用作确定心力衰竭程度的基础。

7. 发明申请

WO2006130056A1 IMPLANTABLE LEAD 审中-公开
标题翻译：可塑性铅
公开(公告)号：WO2006130056A1
公开(公告)日：2006-12-07
申请号：PCT/SE2005/000829
申请日：2005-05-31
申请人： ST. JUDE MEDICAL AB , NILSSON, Kenth , JOHANSSON, Anna-Karin , ERIKSSON, Tom
发明人： NILSSON, Kenth , JOHANSSON, Anna-Karin , ERIKSSON, Tom
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N1/36564
摘要： Implantable lead for sensing mechanical activity of a human heart. The lead comprises an insulating polymeric tube extending from a proximal end to a distal end of the lead, an electric conductor provided in the lumen of the polymeric tube, and a sensor connected to the conductor at a distal end thereof. The polymeric tube is provided with a conductive surface layer along the interface between the polymeric tube and the electric conductor. Thereby, accumulation of electrical charges between the electric conductor and the polymeric tube is prevented.
摘要翻译：用于感测人体心脏的机械活动的植入性铅。引线包括从引线的近端延伸到远端的绝缘聚合物管，设置在聚合物管的内腔中的电导体，以及在其远端连接到导体的传感器。聚合物管沿着聚合物管和电导体之间的界面设置有导电表面层。由此，能够防止电导体与聚合物管之间的电荷积聚。

8. 发明申请

WO2008133552A1 IMPLANTABLE MEDICAL DEVICE AND METHOD FOR MONITORING VALVE MOVEMENTS OF A HEART 审中-公开
标题翻译：用于监测心脏瓣膜运动的可植入医疗装置和方法
公开(公告)号：WO2008133552A1
公开(公告)日：2008-11-06
申请号：PCT/SE2007/000411
申请日：2007-04-27
申请人： ST. JUDE MEDICAL AB , BJÖRLING, Anders , TUVSTEDT, Cecilia , NILSSON, Kenth , NOREN, Kjeil
发明人： BJÖRLING, Anders , TUVSTEDT, Cecilia , NILSSON, Kenth , NOREN, Kjeil
IPC分类号： A61N1/365 , A61N1/368
CPC分类号： A61N1/36521 , A61N1/36578 , A61N1/3682
摘要： The present invention relates to an implantable medical device (10) for monitoring the movements of the valve planes of the heart to determine at least one hemodynamic measure reflecting a mechanical functioning of a heart of a patient. The device includes an impedance measuring circuit (146) adapted to, measure impedance signals between at least electrode pairs including at least one electrode (26, 36; 45; 55; 65, 67; 75, 77; 85, 87; 95, 97; 105, 111, 112) placed substantially at the level of the valve plane (6) , wherein impedances reflecting valve plane movements are obtained. Further, a hemodynamic parameter determining circuit (152) is adapted to determine at least one hemodynamic parameter based on the impedances reflecting the mechanical functioning of a heart.
摘要翻译：本发明涉及一种用于监测心脏的瓣膜平面运动以确定反映患者心脏的机械功能的至少一个血液动力学测量的可植入医疗装置（10）。该装置包括阻抗测量电路（146），该阻抗测量电路（146）适于在至少包括至少一个电极（26,36; 45; 55; 65,67; 75,77; 85,87; 95,97 ; 105,111,112），其基本位于所述阀平面（6）的高度处，其中获得反映阀平面运动的阻抗。此外，血液动力学参数确定电路（152）适于基于反映心脏的机械功能的阻抗来确定至少一个血液动力学参数。

9. 发明申请

WO2006135293A1 FLOW SENSOR AND METHOD FOR MEASURING THE FLOW OF A BODY FLUID 审中-公开
标题翻译：流体传感器和测量体液流量的方法
公开(公告)号：WO2006135293A1
公开(公告)日：2006-12-21
申请号：PCT/SE2005/000945
申请日：2005-06-16
申请人： ST. JUDE MEDICAL AB , NILSSON, Kenth
发明人： NILSSON, Kenth
IPC分类号： A61B5/026 , G01F1/688
CPC分类号： G01F1/6886 , A61B5/028
摘要： An implantable flow sensor intended to be implanted into the circulatory system of a human being for sensing the flow of a body fluid comprises a heating element for heating a pyroelectric sensing element of a pyroelectric detector which is adapted to generate a temperature signal representing changes in temperature of its sensing element after interruption of the heating. A flow determining means is provided for determining from the temperature signal data about the body fluid flow rate from cooling of said sensing element after interruption of the heating. The heating element and the sensing element are one and the same, combined heating and sensing element (100). The combined heating and sensing element is piezoelectric, and a voltage source is provided for applying a vibration exciting voltage on the combined heating and sensing element for heating the element. A corresponding method for measuring the flow of the body fluid is described too.
摘要翻译：旨在被植入到用于感测体液流动的人的循环系统中的可植入流量传感器包括用于加热热电检测器的热电感测元件的加热元件，其适于产生表示温度变化的温度信号的加热中断后的感应元件。提供流量确定装置，用于根据温度信号来确定来自加热中断之后所述感测元件的冷却的体液流速。加热元件和感测元件是同一的，组合的加热和感测元件（100）。组合的加热和感测元件是压电的，并且提供电压源以在组合的加热和感测元件上施加振动激励电压以加热元件。还描述了用于测量体液流量的相应方法。

10. 发明申请

WO2007149019A1 IMPLANTABLE HEART STIMULATING DEVICE WITH STIMULATION RATE OPTIMIZATION 审中-公开
标题翻译：具有刺激率优化的可植入心脏刺激装置
公开(公告)号：WO2007149019A1
公开(公告)日：2007-12-27
申请号：PCT/SE2006/000757
申请日：2006-06-21
申请人： ST. JUDE MEDICAL AB , NORÉN, Kjell , NILSSON, Kenth
发明人： NORÉN, Kjell , NILSSON, Kenth
IPC分类号： A61N1/365
CPC分类号： A61N1/36585 , A61N1/36521 , A61N1/36564 , A61N1/36578
摘要： Implantable heart stimulating device adapted to generate stimulation pulses at a stimulation rate to be applied to a patients heart, comprising an activity sensor (2), generating an activity signal (4) in response of detected activity of the patient, and a physiological parameter sensor (6), preferably a pressure sensor, generating a physiological sensor signal (8) in response of a detected physiological parameter. The activity and physiological sensor signals are applied to a control means (10, 12, 14) adapted to determine a stimulation rate based upon an stimulation rate algorithm in dependence of those signals, such that if the physiological signal indicates an emotional stress for the patient, the stimulation rate is increased to an adjustable emotional stress rate level and if no increase of the activity signal is indicated, during a predetermined time period from the stimulation rate increase, the stimulation rate is decreased.
摘要翻译：植入式心脏刺激装置，其适于以刺激速率产生刺激速率以施加到患者心脏，包括活动传感器（2），响应于检测到的患者的活动而产生活动信号（4）和生理参数传感器（6），优选地是压力传感器，响应检测到的生理参数产生生理传感器信号（8）。活动和生理传感器信号被施加到适于根据这些信号基于刺激速率算法确定刺激速率的控制装置（10,12,14），使得如果生理信号指示患者的情绪压力刺激率增加到可调情绪应激速率水平，并且如果没有指示活动信号的增加，则在从刺激速率增加的预定时间段期间，刺激速率降低。

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