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1. 发明申请

WO2008039076A1 SYSTEM AND METHOD FOR THE PRODUCTION OF COMPOSITE TUBULAR MEMBERS AND A TUBULAR MEMBER MADE THEREOF 审中-公开
标题翻译：用于生产复合管状构件的系统和方法及其制造的管状构件
公开(公告)号：WO2008039076A1
公开(公告)日：2008-04-03
申请号：PCT/NO2007/000336
申请日：2007-09-24
申请人： NTNU TECHNOLOGY TRANSFER AS , GUSTAFSSON, Claes-Göran , VEDVIK, Nils-Petter
发明人： GUSTAFSSON, Claes-Göran , VEDVIK, Nils-Petter
IPC分类号： B29C53/82 , B29C53/62 , B29C70/32 , B29D23/00 , B29C70/38 , B65H81/08 , F16L9/16 , B29K105/08 , B29L23/00
CPC分类号： B29C70/32 , B29C53/60 , B29C53/821 , B29C70/56 , F16L9/165
摘要： The present invention discloses a system and method for the production of composite tubular members and a tubular member made thereof. Filament winding is used for the production of long tubular elements, and an internal tension support member is arranged for the support of the mandrel or liner about which the fiber tows of the filament winding process is wound. A system arranged for the production of tubulars according to said method is further provided.
摘要翻译：本发明公开了一种用于生产复合管状构件的系统和方法及其制成的管状构件。长丝卷绕用于生产长管状元件，并且布置内部张力支撑构件以用于卷绕纤维缠绕过程的纤维束的心轴或衬垫的支撑。还提供了一种用于根据所述方法生产管状体的系统。

2. 发明申请

WO2007022260A2 SYSTEMS AND METHODS FOR DESIGNING AND ORDERING POLYNUCLEOTIDES 审中-公开
标题翻译：用于设计和订购多核苷酸的系统和方法
公开(公告)号：WO2007022260A2
公开(公告)日：2007-02-22
申请号：PCT/US2006/031976
申请日：2006-08-15
申请人： DNA 2.0 INC. , GUSTAFSSON, Claes , GOVINDARAJAN, Sridhar , NESS, Jon, E. , VILLALOBOS, Alan, Marco , MINSHULL, Jeremy
发明人： GUSTAFSSON, Claes , GOVINDARAJAN, Sridhar , NESS, Jon, E. , VILLALOBOS, Alan, Marco , MINSHULL, Jeremy
IPC分类号： G06F19/00
CPC分类号： G06F19/26 , G06F19/18 , G06F19/20
摘要： Computer systems, computer program products and methods for designing oligonucleotides are provided. A set of sequence elements is defined. Each sequence element represents an amino acid sequence segment or a nucleic acid sequence segment. The set of sequence elements collectively represent a design nucleic acid sequence. The set of sequence elements are displayed as a plurality of icons in a linear or a near linear arrangement such that each respective icon in the plurality of icons uniquely represents a corresponding sequence element in the set of sequence elements. In this representation, neighboring icons in the plurality of icons represent neighboring sequence elements in the set of sequence elements. Each respective icon in the plurality of icons depicts a directional property for the corresponding sequence element in the set of sequence elements. An oligonucleotide selection module is used to identify oligonucleotides in the design nucleic acid sequence.
摘要翻译：提供了用于设计寡核苷酸的计算机系统，计算机程序产品和方法。定义了一组序列元素。每个序列元件代表氨基酸序列区段或核酸序列区段。该组序列元件共同表示设计核酸序列。该组序列元素以线性或近似线性排列显示为多个图标，使得多个图标中的每个相应图标唯一地表示该组序列元素中的对应序列元素。在该表示中，多个图标中的相邻图标表示该组序列元素中的相邻序列元素。多个图标中的每个相应图标描绘了该组序列元素中的对应序列元素的方向属性。寡核苷酸选择模块用于鉴定设计核酸序列中的寡核苷酸。

3. 发明申请

WO2005012877A3 SYSTEMS AND METHODS FOR ANTIBODY ENGINEERING 审中-公开
标题翻译：用于抗体工程的系统和方法
公开(公告)号：WO2005012877A3
公开(公告)日：2006-04-06
申请号：PCT/US2004024751
申请日：2004-07-30
申请人： DNA TWOPOINTO INC , GUSTAFSSON CLAES , GOVINDARAJAN SRIDHAR , MINSHULL JEREMY STEPHEN
发明人： GUSTAFSSON CLAES , GOVINDARAJAN SRIDHAR , MINSHULL JEREMY STEPHEN
IPC分类号： C07K16/10 , C07K16/46 , G01N20060101 , G06F20060101 , G06F19/16 , G06F19/18 , G06F19/24 , G01N33/00 , G01N33/48
CPC分类号： G06F19/18 , C07K16/1027 , C07K16/461 , C07K2317/76 , G06F19/16 , G06F19/24
摘要： Methods, computer systems, and computer program products for antibody engineering. A variant set for an antibody of interest is constructed by identifying, using a plurality of roles, a plurality of positions in the antibody of interest and, for each respective position in the plurality of positions, substitutions for the respective position. The plurality of positions and the substitutions for each respective position in the plurality of positions collectively define an antibody sequence space. A variant set comprising a plurality of variants of the antibody of interest is selected. A property of all or a portion of the variants in the variant set is measured. A sequence-activity relationship is modeled between (i) one or more substitutions at one or more positions of the antibody of interest represented by the variant set and (ii) the property measured for all or the portion of the variants in the variant set. The variant set is redefined to comprise variants that include substitutions in the plurality of positions that are selected based on a function of the sequence-activity relationship.
摘要翻译：方法，计算机系统和抗体工程的计算机程序产品。通过使用多个角色来鉴定感兴趣的抗体中的多个位置，并且对于多个位置中的每个相应位置，通过识别相应位置的替换来构建用于感兴趣抗体的变体。多个位置中的各个位置的多个位置和替换共同限定抗体序列空间。选择包含感兴趣抗体的多个变体的变体集合。测量变体集中全部或部分变体的属性。在（i）由变体组表示的感兴趣抗体的一个或多个位置处的一个或多个取代和（ii）针对变体组中的全部或部分变体测量的性质之间建立序列活性关系。变体集被重新定义为包括基于序列活动关系的函数而选择的多个位置中的替换的变体。

4. 发明申请

WO2003075129A2 METHODS, SYSTEMS, AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIO-MOLECULES 审中-公开
标题翻译：用于鉴定功能性生物分子的方法，系统和软件
公开(公告)号：WO2003075129A2
公开(公告)日：2003-09-12
申请号：PCT/US2003/006551
申请日：2003-03-03
申请人： MAXYGEN, INC. , GUSTAFSSON, Claes , GOVINDARAJAN, Sridar , EMIG, Robin , FOX, Richard, John , ROY, Ajoy , MINSHULL, Jeremy , DAVIS, S., Christopher , COX, Anthony , PATTEN, Phil , CASTLE, Linda, A. , SIEHL, Daniel, L. , GORTON, Rebecca, Lynne , CHEN, Teddy
发明人： GUSTAFSSON, Claes , GOVINDARAJAN, Sridar , EMIG, Robin , FOX, Richard, John , ROY, Ajoy , MINSHULL, Jeremy , DAVIS, S., Christopher , COX, Anthony , PATTEN, Phil , CASTLE, Linda, A. , SIEHL, Daniel, L. , GORTON, Rebecca, Lynne , CHEN, Teddy
IPC分类号： G06F
CPC分类号： C40B50/02 , C40B30/02 , G06F19/18 , G06F19/24
摘要： The present invention generally relates to methods of rapidly and efficiently searching biologically-related data space. More specifically, the invention includes methods of identifying bio-molecules with desired properties, or which are most suitable for acquiring such properties, from complex bio-molecule libraries or sets of such libraries. The invention also provides methods of modeling sequence-activity relationships. As many of the methods are computer-implemented, the invention additionally provides digital systems and software for performing these methods.
摘要翻译：本发明一般涉及快速有效地搜索生物相关数据空间的方法。更具体地，本发明包括从复杂的生物分子文库或这些文库集合鉴定具有所需性质或最适合于获得这些性质的生物分子的方法。本发明还提供了对序列活性关系建模的方法。由于许多方法是计算机实现的，本发明另外提供用于执行这些方法的数字系统和软件。

5. 发明申请

WO2003068955A2 STREPTOMYCES AVERMITILIS GENE DIRECTING THE RATIO OF B2:B1 AVERMECTINS 审中-公开
标题翻译：表达B2基因比例的方差分析基因
公开(公告)号：WO2003068955A2
公开(公告)日：2003-08-21
申请号：PCT/IB2003/000348
申请日：2003-01-31
申请人： PFIZER PRODUCTS INC. , STUTZMAN-ENGWALL, Kim, Jonelle , GUSTAFSSON, Claes, Eric, Daniel , KREBBER, Anke , RAILLARD, Sun, Ai , MINSHULL, Jeremy, Stephen , KIM, Seran , CHEN, Yan
发明人： STUTZMAN-ENGWALL, Kim, Jonelle , GUSTAFSSON, Claes, Eric, Daniel , KREBBER, Anke , RAILLARD, Sun, Ai , MINSHULL, Jeremy, Stephen , KIM, Seran , CHEN, Yan
IPC分类号： C12N15/00
CPC分类号： C12N9/88 , C12P17/181 , C12P19/623
摘要： The present invention relates to polynucleotide comprising nucleotide sequences encoding an aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of S. avermitis. The present invention further relates to vectors, host cells, and mutant strains of S. avermitis in which the aveC gene has been inactivated, or mutated so as to change the ratio or amount of class 2:1 avermectins produced.
摘要翻译：本发明涉及包含编码aveC基因产物的核苷酸序列的多核苷酸，该多核苷酸分子可用于改变在阿维菌素的发酵培养物中产生的2:1级阿凡曼菌素的比例或量。本发明还涉及其中aveC基因已经失活或突变以改变所产生的2:1类阿维菌素的比例或量的阿维链霉菌的载体，宿主细胞和突变株。

6. 发明申请

WO2008127213A2 METHODS, SYSTEMS, AND SOFTWARE FOR REGULATED OLIGONUCLEOTIDE-MEDIATED RECOMBINATION 审中-公开
标题翻译：用于调控寡核苷酸介导的重组的方法，系统和软件
公开(公告)号：WO2008127213A2
公开(公告)日：2008-10-23
申请号：PCT/US2002/014866
申请日：2002-05-09
申请人： MAXYGEN, INC. , MINSHULL, Jeremy , GUSTAFSSON, Claes , GOVINDARAJAN, Sridar , ROY, Ajoy
发明人： MINSHULL, Jeremy , GUSTAFSSON, Claes , GOVINDARAJAN, Sridar , ROY, Ajoy
IPC分类号： C12Q1/68
CPC分类号： G06F19/22 , B01J2219/007 , B01J2219/00722 , C12N15/1089 , C12Q1/6806 , C12Q2531/113
摘要： The present invention provides novel in silico recombination techniques in which all or part of a nucleic acid recombination procedure is performed or modeled in a digital system. In particular, this invention relates to methods of designing oligonucleotides for regulated recombination that approximates linkage characteristics obtained from fragmentation-based recombination techniques, such as family-based recombination. The methods of this invention include adjusting overlap regions in pairs of overlapping oligonucleotide character strings to bias recombination towards a desired genetic linkage. This invention also provides systems, computer program products, and kits for practicing the methods of the invention.
摘要翻译：本发明提供新颖的计算机重组技术，其中全部或部分核酸重组程序在数字系统中进行或模拟。具体而言，本发明涉及设计用于调控重组的寡核苷酸的方法，其接近从基于片段化的重组技术获得的连锁特征，例如基于家族的重组。本发明的方法包括调整重叠的寡核苷酸字符串对中的重叠区域以偏向重要的遗传连锁。本发明还提供用于实施本发明方法的系统，计算机程序产品和试剂盒。

7. 发明申请

WO2005012877A2 SYSTEMS AND METHODS FOR ANTIBODY ENGINEERING 审中-公开
标题翻译：用于抗体工程的系统和方法
公开(公告)号：WO2005012877A2
公开(公告)日：2005-02-10
申请号：PCT/US2004/024751
申请日：2004-07-30
申请人： DNA TWOPOINTO INC. , GUSTAFSSON, Claes , GOVINDARAJAN, Sridhar , MINSHULL, Jeremy, Stephen
发明人： GUSTAFSSON, Claes , GOVINDARAJAN, Sridhar , MINSHULL, Jeremy, Stephen
IPC分类号： G01N
CPC分类号： G06F19/18 , C07K16/1027 , C07K16/461 , C07K2317/76 , G06F19/16 , G06F19/24
摘要： Methods, computer systems, and computer program products for antibody engineering. A variant set for an antibody of interest is constructed by identifying, using a plurality of roles, a plurality of positions in the antibody of interest and, for each respective position in the plurality of positions, substitutions for the respective position. The plurality of positions and the substitutions for each respective position in the plurality of positions collectively define an antibody sequence space. A variant set comprising a plurality of variants of the antibody of interest is selected. A property of all or a portion of the variants in the variant set is measured. A sequence-activity relationship is modeled between (i) one or more substitutions at one or more positions of the antibody of interest represented by the variant set and (ii) the property measured for all or the portion of the variants in the variant set. The variant set is redefined to comprise variants that include substitutions in the plurality of positions that are selected based on a function of the sequence-activity relationship.
摘要翻译：方法，计算机系统和抗体工程的计算机程序产品。通过使用多个角色来识别感兴趣抗体中的多个位置，并且对于多个位置中的每个相应位置，通过识别相应位置的替换来构建用于感兴趣抗体的变体。多个位置中的各个位置的多个位置和替换共同限定抗体序列空间。选择包含感兴趣的抗体的多个变体的变体组。测量变体集中全部或部分变体的属性。在（i）由变体组表示的感兴趣抗体的一个或多个位置处的一个或多个取代和（ii）针对变体组中全部或部分变体测量的性质的序列活性关系进行建模。变体集被重新定义为包括在基于序列活动关系的函数选择的多个位置中的替换的变体。

8. 发明申请

WO2003075129A3 METHODS, SYSTEMS, AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIO-MOLECULES 审中-公开
公开(公告)号：WO2003075129A3
公开(公告)日：2003-09-12
申请号：PCT/US2003/006551
申请日：2003-03-03
申请人： MAXYGEN, INC. , GUSTAFSSON, Claes , GOVINDARAJAN, Sridar , EMIG, Robin , FOX, Richard, John , ROY, Ajoy , MINSHULL, Jeremy , DAVIS, S., Christopher , COX, Anthony , PATTEN, Phil , CASTLE, Linda, A. , SIEHL, Daniel, L. , GORTON, Rebecca, Lynne , CHEN, Teddy
发明人： GUSTAFSSON, Claes , GOVINDARAJAN, Sridar , EMIG, Robin , FOX, Richard, John , ROY, Ajoy , MINSHULL, Jeremy , DAVIS, S., Christopher , COX, Anthony , PATTEN, Phil , CASTLE, Linda, A. , SIEHL, Daniel, L. , GORTON, Rebecca, Lynne , CHEN, Teddy
IPC分类号： G01N33/48
摘要： The present invention generally relates to methods of rapidly and efficiently searching biologically-related data space. More specifically, the invention includes methods of identifying bio-molecules with desired properties, or which are most suitable for acquiring such properties, from complex bio-molecule libraries or sets of such libraries. The invention also provides methods of modeling sequence-activity relationships. As many of the methods are computer-implemented, the invention additionally provides digital systems and software for performing these methods.

9. 发明申请

WO0200717A9 NOVEL CO-STIMULATORY MOLECULES 审中-公开
标题翻译：新型的协同刺激分子
公开(公告)号：WO0200717A9
公开(公告)日：2003-02-06
申请号：PCT/US0119973
申请日：2001-06-22
申请人： MAXYGEN INC , PUNNONEN JUHA , LAZETIC ALEXANDRA L L , LEONG STEVEN R , CHANG CHIA-CHUN JEAN , APT DORIS , GUSTAFSSON CLAES
发明人： PUNNONEN JUHA , LAZETIC ALEXANDRA L L , LEONG STEVEN R , CHANG CHIA-CHUN JEAN , APT DORIS , GUSTAFSSON CLAES
IPC分类号： C12N15/09 , A61K38/00 , C07K14/47 , C07K14/705 , C12N15/12
CPC分类号： C07K14/70503 , A61K38/00
摘要： The invention provides polynucleotides and polypeptides encoded therefrom having advantageous properties, including an ability of the polypeptides to preferentially bind a CD28 or CTLA-4 receptor at a level greater or less than the ability of human B7-1 to bind CD28 or CTLA-4, or to induce or inhibit altered level of T cell proliferation response greater compared to that generated by human B7-1. The polypeptides and polynucleotides of the invention are useful in therapeutic and prophylactic treatment methods, gene therapy applications, and vaccines.
摘要翻译：本发明提供了多核苷酸和由其编码的多肽，其具有有利的性质，包括多肽以比人B7-1结合CD28或CTLA-4的能力更高或更低的水平优先结合CD28或CTLA-4受体的能力，或诱导或抑制比人B7-1产生的T细胞增殖反应水平更高的T细胞增殖反应。本发明的多肽和多核苷酸可用于治疗和预防性治疗方法，基因治疗应用和疫苗。

10. 发明申请

WO2009148616A2 SYSTEMS AND METHODS FOR DETERMINING PROPERTIES THAT AFFECT AN EXPRESSION PROPERTY VALUE OF POLYNUCLEOTIDES IN AN EXPRESSION SYSTEM 审中-公开
标题翻译：用于确定在表达系统中影响多核苷酸的表达性质的性质的系统和方法
公开(公告)号：WO2009148616A2
公开(公告)日：2009-12-10
申请号：PCT/US2009/003412
申请日：2009-06-05
申请人： DNA 2.0 INC. , WELCH, Mark , GUSTAFSSON, Claes
发明人： WELCH, Mark , GUSTAFSSON, Claes
IPC分类号： C40B30/02 , C40B60/12
CPC分类号： C12N15/67 , G06F19/20 , G06F19/22
摘要： A method of designing a polynucleotide sequence encoding a polypeptide sequence of a predetermined polypeptide is provided. A frequency lookup table corresponding to an expression system is obtained. The table comprises a plurality of sequence elements and a plurality of frequency ranges, each frequency range for a corresponding sequence element. Each frequency range is a range of frequencies with which a corresponding sequence element can occur in a polynucleotide. The polynucleotide sequence is defined using the frequency lookup table by determining, for each respective sequence element in the frequency lookup table, whether the respective sequence element encodes a portion of the polypeptide sequence. When the respective sequence element encodes a portion of the polypeptide sequence, the sequence element is incorporated into the polynucleotide at a frequency of occurrence that is within the frequency range specified for the respective sequence element in the lookup table.
摘要翻译：提供了设计编码预定多肽的多肽序列的多核苷酸序列的方法。获得与表达式系统对应的频率查找表。该表包括多个序列元素和多个频率范围，每个频率范围用于相应的序列元素。每个频率范围是在多核苷酸中可以发生相应序列元件的频率范围。使用频率查找表来定义多核苷酸序列，对于频率查找表中的每个相应序列元件，确定各个序列元件是否编码多肽序列的一部分。当各个序列元件编码多肽序列的一部分时，序列元件以在查找表中对于相应序列元件指定的频率范围内的发生频率被并入多核苷酸。

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