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    • 2. 发明申请
    • THROMBOPOIETIN MIMETICS
    • THROMBOPOIETINMIMTCS
    • WO2008070583A3
    • 2008-08-14
    • PCT/US2007086186
    • 2007-11-30
    • STATEGICS INCSPENCER JEFFREY RPUNNONEN JUHA
    • SPENCER JEFFREY RPUNNONEN JUHA
    • A61K31/655
    • C07D231/46C07D401/12
    • The invention relates to compounds and their use in the treatment of thrombocytopenia resulting from diseases or conditions such as immune thrombocytopenic purpura, cancer chemotherapy, surgery, bone marrow or stem cell transplantation, radiation injury or treatment, chronic viral infection, and pancytopenia. The invention further relates to pharmaceutical compositions containing the compounds and compositions of the invention as well as methods for treating such diseases or conditions in a mammal, including a human, by administering to such mammal an effective amount of a selected thrombopoietin receptor agonist.
    • 本发明涉及化合物及其在治疗由免疫性血小板减少性紫癜,癌症化疗,手术,骨髓或干细胞移植,放射性损伤或治疗,慢性病毒感染和全血细胞减少等疾病或病症引起的血小板减少症中的用途。 本发明进一步涉及含有本发明化合物和组合物的药物组合物,以及通过向该哺乳动物施用有效量的选择的血小板生成素受体激动剂来治疗哺乳动物(包括人)中的这些疾病或病症的方法。