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1. 发明申请

WO2009148616A2 SYSTEMS AND METHODS FOR DETERMINING PROPERTIES THAT AFFECT AN EXPRESSION PROPERTY VALUE OF POLYNUCLEOTIDES IN AN EXPRESSION SYSTEM 审中-公开
标题翻译：用于确定在表达系统中影响多核苷酸的表达性质的性质的系统和方法
公开(公告)号：WO2009148616A2
公开(公告)日：2009-12-10
申请号：PCT/US2009/003412
申请日：2009-06-05
申请人： DNA 2.0 INC. , WELCH, Mark , GUSTAFSSON, Claes
发明人： WELCH, Mark , GUSTAFSSON, Claes
IPC分类号： C40B30/02 , C40B60/12
CPC分类号： C12N15/67 , G06F19/20 , G06F19/22
摘要： A method of designing a polynucleotide sequence encoding a polypeptide sequence of a predetermined polypeptide is provided. A frequency lookup table corresponding to an expression system is obtained. The table comprises a plurality of sequence elements and a plurality of frequency ranges, each frequency range for a corresponding sequence element. Each frequency range is a range of frequencies with which a corresponding sequence element can occur in a polynucleotide. The polynucleotide sequence is defined using the frequency lookup table by determining, for each respective sequence element in the frequency lookup table, whether the respective sequence element encodes a portion of the polypeptide sequence. When the respective sequence element encodes a portion of the polypeptide sequence, the sequence element is incorporated into the polynucleotide at a frequency of occurrence that is within the frequency range specified for the respective sequence element in the lookup table.
摘要翻译：提供了设计编码预定多肽的多肽序列的多核苷酸序列的方法。获得与表达式系统对应的频率查找表。该表包括多个序列元素和多个频率范围，每个频率范围用于相应的序列元素。每个频率范围是在多核苷酸中可以发生相应序列元件的频率范围。使用频率查找表来定义多核苷酸序列，对于频率查找表中的每个相应序列元件，确定各个序列元件是否编码多肽序列的一部分。当各个序列元件编码多肽序列的一部分时，序列元件以在查找表中对于相应序列元件指定的频率范围内的发生频率被并入多核苷酸。

2. 发明申请

WO2018009729A3 MODIFICATION OF DNA POLYMERASES FOR IN VITRO APPLICATIONS 审中-公开
公开(公告)号：WO2018009729A3
公开(公告)日：2018-01-11
申请号：PCT/US2017/040994
申请日：2017-07-06
申请人： DNA2.0, INC. DBA ATUM , LUCIGEN CORPORATION , WELCH, Mark , GOVINDARAJAN, Sridhar , MEAD, David , MEI, Baigen
发明人： WELCH, Mark , GOVINDARAJAN, Sridhar , MEAD, David , MEI, Baigen
IPC分类号： C12N9/12 , C12N9/14 , C12N9/00
摘要： The present invention provides DNA polymerase sequences for in vitro applications including PCR for creation of next generation sequencing libraries, and for reverse-transcriptase PCR.

3. 发明申请

WO2018009726A2 MODIFICATION OF DNA POLYMERASES FOR IN VITRO APPLICATIONS 审中-公开
公开(公告)号：WO2018009726A2
公开(公告)日：2018-01-11
申请号：PCT/US2017/040991
申请日：2017-07-06
申请人： DNA2.0, INC. DBA ATUM , WELCH, Mark , GOVINDARAJAN, Sridhar
发明人： WELCH, Mark , GOVINDARAJAN, Sridhar
IPC分类号： C12Q1/68 , C12N9/22
CPC分类号： C12N9/1252 , C12Q1/6844 , C12Q2521/101
摘要： The present invention provides DNA polymerase sequences for in vitro applications including PCR for creation of next generation sequencing libraries, and for reverse-transcriptase PCR.

4. 发明申请

WO2018009726A3 MODIFICATION OF DNA POLYMERASES FOR IN VITRO APPLICATIONS 审中-公开
公开(公告)号：WO2018009726A3
公开(公告)日：2018-01-11
申请号：PCT/US2017/040991
申请日：2017-07-06
申请人： DNA2.0, INC. DBA ATUM , WELCH, Mark , GOVINDARAJAN, Sridhar
发明人： WELCH, Mark , GOVINDARAJAN, Sridhar
IPC分类号： C12N15/09 , C12N9/96 , C12Q1/68 , C07H21/04 , G06F19/22 , C40B60/12 , C40B30/02 , C40B50/02
摘要： The present invention provides DNA polymerase sequences for in vitro applications including PCR for creation of next generation sequencing libraries, and for reverse-transcriptase PCR.

5. 发明申请

WO2018009729A2 MODIFICATION OF DNA POLYMERASES FOR IN VITRO APPLICATIONS 审中-公开
标题翻译： DNA聚合酶修饰用于体外应用
公开(公告)号：WO2018009729A2
公开(公告)日：2018-01-11
申请号：PCT/US2017/040994
申请日：2017-07-06
申请人： DNA2.0, INC. DBA ATUM , LUCIGEN CORPORATION , WELCH, Mark , GOVINDARAJAN, Sridhar , MEAD, David , MEI, Baigen
发明人： WELCH, Mark , GOVINDARAJAN, Sridhar , MEAD, David , MEI, Baigen
IPC分类号： C12Q1/68 , C12N9/22
摘要： The present invention provides DNA polymerase sequences for in vitro applications including PCR for creation of next generation sequencing libraries, and for reverse-transcriptase PCR.
摘要翻译：本发明提供用于体外应用的DNA聚合酶序列，包括用于产生下一代测序文库的PCR和用于逆转录酶PCR的PCR。

6. 发明申请

WO2022020680A1 ANTI-ABETA ANTIBODIES 审中-公开
公开(公告)号：WO2022020680A1
公开(公告)日：2022-01-27
申请号：PCT/US2021/042900
申请日：2021-07-23
申请人： OTHAIR PROTHENA LIMITED , SKOV, Michael , NIJJAR, Tarlochan, S. , GOVINDARAJAN, Sridhar , PURCELL, Tom , WELCH, Mark , BARD, Frédérique , BARBOUR, Robin , ZAGO, Wagner
发明人： SKOV, Michael , NIJJAR, Tarlochan, S. , GOVINDARAJAN, Sridhar , PURCELL, Tom , WELCH, Mark , BARD, Frédérique , BARBOUR, Robin , ZAGO, Wagner
IPC分类号： C07K16/00 , C07K16/18 , C07K16/44
摘要： Antibodies that bind human beta-amyloid peptide, methods of detecting, measuring and treating amyloidogenic disorders with said antibodies, pharmaceutical compositions comprising the antibodies and methods of manufacture are provided.

7. 发明申请

WO2002010750A3 BIOSENSORS, REAGENTS AND DIAGNOSTIC APPLICATIONS OF DIRECTED EVOLUTION 审中-公开
公开(公告)号：WO2002010750A3
公开(公告)日：2002-02-07
申请号：PCT/US2001/024182
申请日：2001-07-31
申请人： MAXYGEN, INC. , MINSHULL, Jeremy , DAVIS, S., Christopher , WELCH, Mark , RAILLARD, Sun, Ai , VOGEL, Kurt , KREBBER, Claus
发明人： MINSHULL, Jeremy , DAVIS, S., Christopher , WELCH, Mark , RAILLARD, Sun, Ai , VOGEL, Kurt , KREBBER, Claus
IPC分类号： G01N33/50
摘要： Methods for sensing test stimuli using arrays of biopolymers are provided. Libraries of biopolymers, such nucleic acid variants, and expression products encoded by nucleic acid variants are provided. Reusable library arrays, and methods for their use are provided.

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