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1. 发明申请

WO2007075899A8 DUAL AGONIST COMPOUNDS AND USES THEREOF 审中-公开
标题翻译：双激素化合物及其用途
公开(公告)号：WO2007075899A8
公开(公告)日：2007-11-01
申请号：PCT/US2006048807
申请日：2006-12-20
申请人： MAXYGEN INC , PARMLEY STEPHEN F , PAIDHUNGAT MADAN M , LATHROP STEPHANIE J , PATRICK SARAH , KREBBER CLAUS M , KURTZMAN AARON , NEIGHBORS MARGARET , ANDERSEN KIM V , BASS STEVEN H , VISWANATHAN SRIDHAR
发明人： PARMLEY STEPHEN F , PAIDHUNGAT MADAN M , LATHROP STEPHANIE J , PATRICK SARAH , KREBBER CLAUS M , KURTZMAN AARON , NEIGHBORS MARGARET , ANDERSEN KIM V , BASS STEVEN H , VISWANATHAN SRIDHAR
IPC分类号： A61K38/20 , C07K14/54
CPC分类号： C07K14/7155 , A61K38/00 , C07K14/524 , C07K14/5403 , C07K14/7158
摘要： The invention provides dual agonist compounds that exhibit agonist activity with . respect to both human thrombopoeitin c-Mpl receptor and human IL-3 receptor.. The invention provides dual agonist compounds that include dual agonist polypeptides, and also provides related nucleic acids, conjugates, vectors, cells, and methods of producing and using the dual agonist compounds.
摘要翻译：本发明提供了具有激动剂活性的双重激动剂化合物。本发明提供了包括双重激动剂多肽的双重激动剂化合物，并且还提供了相关的核酸，共轭物，载体，细胞以及生产和使用双重激素多肽的相关核酸激动剂化合物。

2. 发明申请

WO2007075899A2 DUAL AGONIST COMPOUNDS AND USES THEREOF 审中-公开
标题翻译：双重激动剂化合物及其用途
公开(公告)号：WO2007075899A2
公开(公告)日：2007-07-05
申请号：PCT/US2006048807
申请日：2006-12-20
申请人： MAXYGEN INC , PARMLEY STEPHEN F , PAIDHUNGAT MADAN M , LATHROP STEPHANIE J , PATRICK SARAH , KREBBER CLAUS M , KURTZMAN AARON , NEIGHBORS MARGARET , ANDERSEN KIM V , BASS STEVEN H , VISWANATHAN SRIDHAR
发明人： PARMLEY STEPHEN F , PAIDHUNGAT MADAN M , LATHROP STEPHANIE J , PATRICK SARAH , KREBBER CLAUS M , KURTZMAN AARON , NEIGHBORS MARGARET , ANDERSEN KIM V , BASS STEVEN H , VISWANATHAN SRIDHAR
IPC分类号： A61K38/20 , C07K14/54
CPC分类号： C07K14/7155 , A61K38/00 , C07K14/524 , C07K14/5403 , C07K14/7158
摘要： The invention provides dual agonist compounds that exhibit agonist activity with . respect to both human thrombopoeitin c-Mpl receptor and human IL-3 receptor.. The invention provides dual agonist compounds that include dual agonist polypeptides, and also provides related nucleic acids, conjugates, vectors, cells, and methods of producing and using the dual agonist compounds.
摘要翻译：本发明提供了显示出激动剂活性的双重激动剂化合物。本发明提供了包含双重激动剂多肽的双重激动剂化合物，并且还提供了相关的核酸，缀合物，载体，细胞以及生产和使用双重激动剂多肽的双重激动剂化合物激动剂化合物。

3. 发明申请

WO2006002267A1 METHODS, SYSTEMS, AND SOFTWARE FOR IDENTIFYING FUNTIONAL BIOMOLECULES 审中-公开
标题翻译：用于识别功能生物分子的方法，系统和软件
公开(公告)号：WO2006002267A1
公开(公告)日：2006-01-05
申请号：PCT/US2005/022119
申请日：2005-06-21
申请人： MAXYGEN, INC. , FOX, Richard, John
发明人： FOX, Richard, John
IPC分类号： G06F19/00
CPC分类号： G06F19/18 , C12N15/1058 , C40B30/02 , C40B50/02 , G01N33/6818 , G06F17/50 , G06F19/22 , G06F19/24 , G06N99/005
摘要： The present invention generally relates to methods of rapidly and efficiently searching biologically-related data space. More specifically, the invention includes methods of identifying bio-molecules with desired properties, or which are most suitable for acquiring such properties, from complex bio-molecule libraries or sets of such libraries. The invention also provides methods of modeling sequence-activity relationships. As many of the methods are computer-implemented, the invention additionally provides digital systems and software for performing these methods.
摘要翻译：本发明一般涉及快速有效地搜索生物相关数据空间的方法。更具体地，本发明包括从复杂的生物分子文库或这些文库集合鉴定具有所需性质或最适合于获得这些性质的生物分子的方法。本发明还提供了对序列活性关系建模的方法。由于许多方法是计算机实现的，本发明另外提供用于执行这些方法的数字系统和软件。

4. 发明申请

WO2003075129A2 METHODS, SYSTEMS, AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIO-MOLECULES 审中-公开
标题翻译：用于鉴定功能性生物分子的方法，系统和软件
公开(公告)号：WO2003075129A2
公开(公告)日：2003-09-12
申请号：PCT/US2003/006551
申请日：2003-03-03
申请人： MAXYGEN, INC. , GUSTAFSSON, Claes , GOVINDARAJAN, Sridar , EMIG, Robin , FOX, Richard, John , ROY, Ajoy , MINSHULL, Jeremy , DAVIS, S., Christopher , COX, Anthony , PATTEN, Phil , CASTLE, Linda, A. , SIEHL, Daniel, L. , GORTON, Rebecca, Lynne , CHEN, Teddy
发明人： GUSTAFSSON, Claes , GOVINDARAJAN, Sridar , EMIG, Robin , FOX, Richard, John , ROY, Ajoy , MINSHULL, Jeremy , DAVIS, S., Christopher , COX, Anthony , PATTEN, Phil , CASTLE, Linda, A. , SIEHL, Daniel, L. , GORTON, Rebecca, Lynne , CHEN, Teddy
IPC分类号： G06F
CPC分类号： C40B50/02 , C40B30/02 , G06F19/18 , G06F19/24
摘要： The present invention generally relates to methods of rapidly and efficiently searching biologically-related data space. More specifically, the invention includes methods of identifying bio-molecules with desired properties, or which are most suitable for acquiring such properties, from complex bio-molecule libraries or sets of such libraries. The invention also provides methods of modeling sequence-activity relationships. As many of the methods are computer-implemented, the invention additionally provides digital systems and software for performing these methods.
摘要翻译：本发明一般涉及快速有效地搜索生物相关数据空间的方法。更具体地，本发明包括从复杂的生物分子文库或这些文库集合鉴定具有所需性质或最适合于获得这些性质的生物分子的方法。本发明还提供了对序列活性关系建模的方法。由于许多方法是计算机实现的，本发明另外提供用于执行这些方法的数字系统和软件。

5. 发明申请

WO2002068931A2 SCREENING FOR ENZYME STEREOSELECTIVITY UTILIZING MASS SPECTROMETRY 审中-公开
标题翻译：筛选使用质谱的酶选择性
公开(公告)号：WO2002068931A2
公开(公告)日：2002-09-06
申请号：PCT/US2002/005646
申请日：2002-02-22
申请人： MAXYGEN, INC. , DAVIS, S., Christopher , CHEN, Yong, Hong , GIVER, Lorraine, J. , VOGEL, Kurt
发明人： DAVIS, S., Christopher , CHEN, Yong, Hong , GIVER, Lorraine, J. , VOGEL, Kurt
IPC分类号： G01N
CPC分类号： C12Q1/34 , H01J49/00
摘要： Methods of screening for enzyme stereoselectivity that include detecting isotopically labeled products by mass spectrometry are provided. The methods are particularly suitable for screening enzyme libraries for stereoselectivity.
摘要翻译：提供了通过质谱法检测同位素标记产物的酶立体选择性筛选方法。该方法特别适用于筛选立体选择性酶库。

6. 发明申请

WO0173000A3 METHODS FOR MODULATING CELLULAR AND ORGANISMAL PHENOTYPES 审中-公开
标题翻译：调节细胞和有机基因的方法
公开(公告)号：WO0173000A3
公开(公告)日：2002-06-27
申请号：PCT/US0109203
申请日：2001-03-23
申请人： MAXYGEN INC , STEMMER WILLEM P C , MINSHULL JEREMY , KEENAN ROBERT J
发明人： STEMMER WILLEM P C , MINSHULL JEREMY , KEENAN ROBERT J
IPC分类号： C12N15/10 , C12N15/113 , C12N15/66 , C12N15/11 , C12N15/63 , C12Q1/68
CPC分类号： C12N15/1079 , C07K2319/00 , C12N15/1027 , C12N15/1034 , C12N15/113 , C12N15/66 , C12N2310/111
摘要： Methods for identifying and controlling the genetic and metabolic pathways underlying complex phenotypes are provided. Conjoint polynucleotide segments that contribute to or disrupt elements of a multigenic phenotype are produced and expressed in cells of interest. Conjoint polynucleotide segments are recombined and/or mutated to give rise to libraries of recombinant concatamers which are expressed in cells of interest. Libraries of conjoint polynucleotide segments and recombinant concatamers are expressed episomally or integrated into the DNA of organelles or chromosomes. Cells are screened or selected to identify members of the population of cells exhibiting a desired phenotype. Libraries and vectors comprising conjoint polynucleotide segments and recombinant concatamers, as well as cells expressing such libraries and vectors or their components are provided. Kits containing conjoint polynucleotide segments, recombinant concatamers, vectors including such polynucleotides, and cells including such polynucleotides and vectors are provided.
摘要翻译：提供了鉴定和控制复杂表型下遗传和代谢途径的方法。有助于或破坏多基因表型的元件的连接多核苷酸片段在感兴趣的细胞中产生并表达。连接的多核苷酸片段被重组和/或突变以产生在感兴趣的细胞中表达的重组连接体的文库。联合多核苷酸片段和重组连接体的文库以附加方式表达或整合到细胞器或染色体的DNA中。筛选或选择细胞以鉴定呈现所需表型的细胞群体的成员。提供了包含组合多核苷酸片段和重组连接体的文库和载体，以及表达这些文库和载体或其组分的细胞。提供了含有联合多核苷酸片段，重组连接体，包含此类多核苷酸的载体和包含此类多核苷酸和载体的细胞的试剂盒。

7. 发明申请

WO0132712A3 ANTIBODY DIVERSITY GENERATION 审中-公开
标题翻译：抗体多样性生成
公开(公告)号：WO0132712A3
公开(公告)日：2002-03-21
申请号：PCT/US0030247
申请日：2000-11-01
申请人： MAXYGEN INC , KARRER ERIK , BASS STEVEN H , WHALEN ROBERT , PATTEN PHILLIP A
发明人： KARRER ERIK , BASS STEVEN H , WHALEN ROBERT , PATTEN PHILLIP A
IPC分类号： C07K16/00 , C07K16/12 , C12N1/21 , C12N15/13 , C12N15/49 , A61K39/21 , A61K39/42 , C07K14/16 , C07K16/10 , C07K16/46 , C12N15/62 , G06F17/30
CPC分类号： C07K16/1271 , C07K16/00 , C07K16/1275 , C07K2317/24
摘要： Methods for improving antibodies by a variety of DNA diversification and selection procedures are provided. Improvements include increases in affinity, alterations in specificity and effector function, as well as reduced antigenicity, e.g. humanization. Libraries of recombinant antibody sequences are provided, as are cells expressing members of such libraries. Novel phage display vectors are provided. Methods for the coevolution of an antibody and its cognate antigen are provided. Coevolution is used to evolve HIV envelope proteins with increased antigencity and broadly neutralizing antibodies that interact therewith. Methods of improving antibodies for use in the detection of biological warfare agents are provided.
摘要翻译：提供了通过多种DNA多样化和选择程序改进抗体的方法。改善包括亲和力的增加，特异性和效应子功能的改变，以及降低的抗原性，例如。人性化。提供重组抗体序列的文库，以及表达这些文库成员的细胞。提供了新的噬菌体展示载体。提供了抗体及其同源抗原共转化方法。共转化用于发展具有增加的抗原性的HIV包膜蛋白和与之相互作用的广泛中和抗体。提供了改进用于检测生物战剂的抗体的方法。

8. 发明申请

WO0170947A3 METHOD FOR GENERATING RECOMBINANT DNA MOLECULES IN COMPLEX MIXTURES 审中-公开
标题翻译：在复合混合物中产生重组DNA分子的方法
公开(公告)号：WO0170947A3
公开(公告)日：2002-02-28
申请号：PCT/US0108250
申请日：2001-03-14
申请人： MAXYGEN INC , CARR BRIAN , YAMAMOTO TAKASHI , PATTEN PHILLIP A
发明人： CARR BRIAN , YAMAMOTO TAKASHI , PATTEN PHILLIP A
IPC分类号： C12N15/10
CPC分类号： C12N15/1093 , C12N15/1027 , C12N15/1058
摘要： Methods for generating libraries of recombinant DNA molecules by simultaneously recombining populations of DNA fragments in complex mixtures without cloning are provided. DNA derived from environmental samples, crude lysates, or partially enriched fractions of bacterial, or eukaryotic cells, or to cDNAs corresponding to RNA populations so derived, are fragmented and recombined. Optionally, the recombination is recursive. Methods for recovering and identifying recombinant DNA molecules encoding proteins with desirable characteristics are provided. Libraries of recombinant DNA molecules generated by the methods of the invention, as well as, cells incorporating such recombinant DNA molecules are provided.
摘要翻译：提供了通过在复杂混合物中同时重组DNA片段的群体而不克隆来产生重组DNA分子库的方法。衍生自环境样品，粗裂解物或部分富集的细菌或真核细胞部分的DNA或对应于如此衍生的RNA群体的cDNA被分段和重组。任选地，重组是递归的。提供了用于回收和鉴定编码具有期望特征的蛋白质的重组DNA分子的方法。提供了通过本发明的方法产生的重组DNA分子的图书馆，以及包含这种重组DNA分子的细胞。

9. 发明申请

WO2002010750A3 BIOSENSORS, REAGENTS AND DIAGNOSTIC APPLICATIONS OF DIRECTED EVOLUTION 审中-公开
公开(公告)号：WO2002010750A3
公开(公告)日：2002-02-07
申请号：PCT/US2001/024182
申请日：2001-07-31
申请人： MAXYGEN, INC. , MINSHULL, Jeremy , DAVIS, S., Christopher , WELCH, Mark , RAILLARD, Sun, Ai , VOGEL, Kurt , KREBBER, Claus
发明人： MINSHULL, Jeremy , DAVIS, S., Christopher , WELCH, Mark , RAILLARD, Sun, Ai , VOGEL, Kurt , KREBBER, Claus
IPC分类号： G01N33/50
摘要： Methods for sensing test stimuli using arrays of biopolymers are provided. Libraries of biopolymers, such nucleic acid variants, and expression products encoded by nucleic acid variants are provided. Reusable library arrays, and methods for their use are provided.

10. 发明申请

WO9941368A3 OPTIMIZATION OF IMMUNOMODULATORY PROPERTIES OF GENETIC VACCINES 审中-公开
标题翻译：遗传疫苗免疫组化特性的优化
公开(公告)号：WO9941368A3
公开(公告)日：1999-12-16
申请号：PCT/US9903020
申请日：1999-02-10
申请人： MAXYGEN INC
发明人： PUNNONEN JUHA , STEMMER WILLEM P C , WHALEN ROBERT GERALD , HOWARD RUSSELL
IPC分类号： C12N15/09 , A61K35/76 , A61K39/00 , A61K45/00 , A61K48/00 , A61P11/06 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/04 , A61P37/06 , A61P37/08 , C07K14/02 , C07K14/16 , C07K14/24 , C07K14/54 , C07K14/705 , C12N5/10 , C12N15/10 , C12Q1/68 , C12Q1/70 , C40B40/02 , G01N33/15 , G01N33/50 , G01N33/566
CPC分类号： C40B40/02 , A61K39/00 , A61K2039/53 , C07K14/005 , C07K14/24 , C07K2319/02 , C07K2319/40 , C07K2319/74 , C12N15/1027 , C12N15/1034 , C12N15/1037 , C12N2730/10122 , C12N2740/16222
摘要： This invention provides methods for obtaining molecules that can modulate an immune response, and immunomodulatory molecules obtained using the methods. The molecules find use, for example, in the tailoring of an immune response induced by a genetic vaccine for a desired purpose.
摘要翻译：本发明提供了获得可调节免疫应答的分子的方法，以及使用该方法获得的免疫调节分子。分子可用于例如为了期望目的而定制由遗传疫苗诱导的免疫应答。

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