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1. 发明申请

WO0036398A2 METHOD AND DEVICES FOR DETECTING OPTICAL PROPERTIES, ESPECIALLY LUMINESCENCE REACTIONS AND REFRACTION BEHAVIOUR OF MOLECULES WHICH ARE DIRECTLY OR INDIRECTLY BOUND ON A SUPPORT 审中-公开
标题翻译：用于测定光学特性，尤其是，发光反应和中断特性的方法和设备，通过载体直接或间接结合分子
公开(公告)号：WO0036398A2
公开(公告)日：2000-06-22
申请号：PCT/DE9903981
申请日：1999-12-14
申请人： DEUTSCHES KREBSFORSCH , EUROP LAB MOLEKULARBIOLOG , POUSTKA ANNEMARIE , BREITLING FRANK , GROSS KARL HEINZ , DUEBEL STEFAN , SAFFRICH RAINER
发明人： POUSTKA ANNEMARIE , BREITLING FRANK , GROSS KARL-HEINZ , DUEBEL STEFAN , SAFFRICH RAINER
IPC分类号： B01J19/00 , C07K1/04 , C40B40/10 , C40B60/14 , C40B70/00 , G01N21/64 , G01N21/00
CPC分类号： G01N21/6428 , B01J19/0046 , B01J2219/00378 , B01J2219/00441 , B01J2219/00542 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00644 , B01J2219/00659 , B01J2219/00711 , B01J2219/00725 , B82Y30/00 , C07K1/047 , C40B40/10 , C40B60/14 , C40B70/00 , G01N21/6454
摘要： According to the method for detecting optical properties, especially luminescence reactions and refraction behaviour of molecules which are directly or indirectly bound on a support, electromagnetic waves, especially laser light, are radiated onto the support. The light that is emitted or refracted by the molecules is then detected by a detector. The detector and the support are moved in relation to each other during and after the radiation of the electromagnetic waves. The support used is especially a transparent support with integrated position markings which can be detected by a detector, especially an optoelectronic scanning system. At least one of the integrated position markings is selected while the support and the detector are being moved in relation to each other or thereafter so that the light that is detected by the detector can be associated with a location on the support. A device for carrying out the method is provided with a detector, especially an optoelectronic scanning system, for detecting the position markings that are integrated in the support.
摘要翻译：在用于检测的光学特性的方法，特别是发光反应和在载体上的直接或间接结合的分子的电磁波的折射行为，尤其是激光，被照射到载体上。检测器检测由分子发射或折射的光。在电磁波检测器和载体的照射期间和之后相对于彼此移动。作为支撑体，一个透明支撑体和具有集成，由检测器检测的，特别是optoeletronischen扫描位置标记在特定使用。这里，集成位置标记中的一个的至少期间或载体和检测器的相对运动之后被读取时，使得检测到的光的分配由所述检测器，以在载体上的位置是可能的。在用于Durchfühnung提供了一种装置的方法中，检测器，特别是用于检测集成在支持位置标记的光电扫描系统。

2. 发明申请

WO1987004653A1 ROBOT ARM WITH TOOL MOUNTING FLANGE 审中-公开
标题翻译：机具臂与工具安装法兰
公开(公告)号：WO1987004653A1
公开(公告)日：1987-08-13
申请号：PCT/DE1987000007
申请日：1987-01-10
申请人： ROBERT BOSCH GMBH , DREXEL, Peter , ERNE, Hans , GOSDOWSKI, Gerhard , GROSS, Karl, Heinz , KIRSTEN, Ulrich , LEISNER, Ernst
发明人： ROBERT BOSCH GMBH
IPC分类号： B25J15/04
CPC分类号： B25J19/0029 , B25J15/04
摘要： A robot arm (10) is provided with a mounting flange (17) for tools or basic components of systems of interchangeable tools. The mounting flange (17) is formed by a wall (17) of a housing (14) forming the main component of a structural housing component (12) that works as an energy supply flange. The sides (18, 19, 26, 27) of the housing (14) are provided with openings (36, 38, 28, 29) closed by covering plates (40, 40a, 42, 44, 44a, 46) provided with inner and outer connections (58, 72, 72a, 80, 80a) for energy lines (54) and control lines (56) for the mounted tools. This modular construction of the housing structural component (12) makes it possible to adapt the flange to different tools by simply exchanging standardized, plug-in, auxiliary and controlling elements.
摘要翻译：机器人臂（10）设置有用于可互换工具系统的工具或基本部件的安装凸缘（17）。安装凸缘（17）由形成作为能量供应凸缘的结构性壳体部件（12）的主要部件的壳体（14）的壁（17）形成。壳体（14）的侧面（18,19,26,27）设置有由设置有内部的盖板（40,40,40,44,44a，46）封闭的开口（36,38,28,29）以及用于能量管线（54）和用于所安装的工具的控制线（56）的外部连接件（58,72,72a，80,80a）。壳体结构部件（12）的这种模块化构造使得可以通过简单地交换标准化，插入，辅助和控制元件来将凸缘适配到不同的工具。

3. 发明申请

WO2001056691A3 VERFAHREN UND VORRICHTUNG ZUR SYNTHESE UND ANALYSE VON TRÄGERGEBUNDENEN ARRAYS VON OLIGOMEREN, INSBESONDERE VON PRIMERPAAREN FÜR DIE PCR, SOWIE TRÄGER MIT OLIGOMEREN 审中-公开
公开(公告)号：WO2001056691A3
公开(公告)日：2001-08-09
申请号：PCT/DE2001/000435
申请日：2001-02-02
申请人： DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES ÖFFENTLICHEN RECHTS , BREITLING, Frank , POUSTKA, Annemarie , GROSS, Karl-Heinz , BREITLING, Frieder
发明人： BREITLING, Frank , POUSTKA, Annemarie , GROSS, Karl-Heinz , BREITLING, Frieder
IPC分类号： C12Q1/68
摘要： Zur Synthese eines träger-gebundenen Arrays von Oligomeren mit freien Enden A, wobei am 5'-OH-Ende der Oligomere eine temporäre Schutzgruppe und an reaktiven Seitengruppen permanente Schutzgruppen vorgesehen sind wird vorgeschlagen, dass nach der kombinatorischen Synthese der Oligomere auf den Träger die temporäre Schutzgruppe vom Ende B abgespalten wird, anschiessend noch vor dem Abspalten der permanenten Schutzgruppen die freien Enden B quervernetzt werden, dann die kovalente Bindung der synthetisierten Oligomere über das Ende A auf den Träger abgespalten werden kann, so dass freie Enden A entstehen und auch nach der Abspaltung der Enden A vom Träger ein Teil der synthetisierten Oligomere kovalent an den Träger bindet.

4. 发明申请

WO0156691A2 METHOD AND DEVICE FOR THE SYNTHESIS AND THE ANALYSIS OF SUPPORT-BOUND ARRAYS OF OLIGOMERS, ESPECIALLY OF PRIMER PAIRS FOR PCR, AS WELL AS OLIGOMER-CARRYING SUPPORTS 审中-公开
标题翻译：方法和设备综合和分析CARRIER低聚物载体结合阵列，用于PCR尤其是引物对和与低聚物
公开(公告)号：WO0156691A2
公开(公告)日：2001-08-09
申请号：PCT/DE0100435
申请日：2001-02-02
申请人： DEUTSCHES KREBSFORSCH , BREITLING FRANK , POUSTKA ANNEMARIE , GROSS KARL HEINZ , BREITLING FRIEDER
发明人： BREITLING FRANK , POUSTKA ANNEMARIE , GROSS KARL-HEINZ , BREITLING FRIEDER
IPC分类号： B01J19/00 , C07B61/00 , C07H21/00 , C12Q1/68 , C40B40/06
CPC分类号： C07H21/00 , B01J19/0046 , B01J2219/00529 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00626 , B01J2219/00659 , B01J2219/00702 , B01J2219/00722 , B01J2219/00729 , C07B2200/11 , C12Q1/6837 , C40B40/06 , Y02P20/55 , C12Q2565/537
摘要： The aim of the invention is to synthesize a support-bound array of oligomers with free ends A, said oligomers having a temporary protecting group on the 5'-OH end of the oligomers and permanent protecting groups on the reactive side-groups. To this end, the temporary protecting group is removed from the end B after the combinatorial synthesis of the oligomers onto the support. The free ends B are cross-linked before the permanent protecting groups are removed and the covalent bonds of the synthesized oligomers on the support can be removed via the end A so that free ends A are formed and so that a part of the synthesized oligomers covalently binds to the support even when the free ends A have been removed from the support.
摘要翻译：对于具有游离低聚物的支持物结合的阵列的合成端A，其特征在于，反应性侧基的临时保护基团和永久性的，在低聚物的5'-OH端提供的保护基团中，提出的是，根据在载体上的低聚物的组合合成，临时保护基团被从B端移除时，自由端B是永久保护基团的裂解之前交联anschiessend，从端A到载体上的合成寡聚体的共价键可以被切割，以使自由端上形成有与后从载体的端部的切割结合合成低聚物的部分共价到载体上。

5. 发明申请

WO0036398A9 METHOD AND DEVICES FOR DETECTING OPTICAL PROPERTIES, ESPECIALLY LUMINESCENCE REACTIONS AND REFRACTION BEHAVIOUR OF MOLECULES WHICH ARE DIRECTLY OR INDIRECTLY BOUND ON A SUPPORT 审中-公开
标题翻译：用于测定光学特性，尤其是，发光反应和中断特性的方法和设备，通过载体直接或间接结合分子
公开(公告)号：WO0036398A9
公开(公告)日：2001-04-05
申请号：PCT/DE9903981
申请日：1999-12-14
申请人： DEUTSCHES KREBSFORSCH , EUROP LAB MOLEKULARBIOLOG , POUSTKA ANNEMARIE , BREITLING FRANK , GROSS KARL HEINZ , DUEBEL STEFAN , SAFFRICH RAINER
发明人： POUSTKA ANNEMARIE , BREITLING FRANK , GROSS KARL-HEINZ , DUEBEL STEFAN , SAFFRICH RAINER
IPC分类号： B01J19/00 , C07K1/04 , C40B40/10 , C40B60/14 , C40B70/00 , G01N21/64 , G01N15/14
CPC分类号： G01N21/6428 , B01J19/0046 , B01J2219/00378 , B01J2219/00441 , B01J2219/00542 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00644 , B01J2219/00659 , B01J2219/00711 , B01J2219/00725 , B82Y30/00 , C07K1/047 , C40B40/10 , C40B60/14 , C40B70/00 , G01N21/6454
摘要： According to the method for detecting optical properties, especially luminescence reactions and refraction behaviour of molecules (14) which are directly or indirectly bound on a support (12), electromagnetic waves, especially laser light (26), are radiated onto the support. The light that is emitted or refracted by the molecules is then detected by a detector (28). The detector and the support are moved in relation to each other during and after the radiation of the electromagnetic waves. The support used is especially a transparent support with integrated position markings (20) which can be detected by a detector, especially an optoelectronic scanning system. At least one of the integrated position markings is selected while the support and the detector are being moved in relation to each other or thereafter so that the light that is detected by the detector can be associated with a location on the support. A device for carrying out the method is provided with a detector, especially an optoelectronic scanning system, for detecting the position markings that are integrated in the support.
摘要翻译：在用于检测光学特性，特别是发光反应和在载体上的（12）直接或间接地结合的分子折射行为的方法（14）的电磁波，特别是激光（26）照射到支持。光由所述分子发射或折射的光被检测器（28）检测。期间和电磁波检测器和载体的照射后相对于彼此移动。作为支撑体，具有集成和可检测的透明支持通过一个检测器，特别是optoeletronischen扫描位置标记（20）是特别使用。这里，集成位置标记中的一个的至少期间或载体和检测器的相对运动之后被读取时，使得检测到的光的分配由所述检测器，以在载体上的位置是可能的。在用于Durchfühnung提供了一种装置的方法中，检测器，特别是用于检测集成在支持位置标记的光电扫描系统。

6. 发明申请

WO0035940A3 METHOD AND DEVICES FOR APPLYING SUBSTANCES TO A SUPPORT, ESPECIALLY MONOMERS FOR THE COMBINATORIAL SYNTHESIS OF MOLECULE LIBRARIES 审中-公开
标题翻译：方法以及应用物质在载波设备，特别是用单体而言分子库的组合合成
公开(公告)号：WO0035940A3
公开(公告)日：2000-10-12
申请号：PCT/DE9903982
申请日：1999-12-14
申请人： DEUTSCHES KREBSFORSCH , EUROP LAB MOLEKULARBIOLOG , POUSTKA ANNEMARIE , BREITLING FRANK , GROSS KARL HEINZ , DUEBEL STEFAN , SAFFRICH RAINER
发明人： POUSTKA ANNEMARIE , BREITLING FRANK , GROSS KARL-HEINZ , DUEBEL STEFAN , SAFFRICH RAINER
IPC分类号： C12N15/09 , B01J19/00 , C07B61/00 , C07K1/04 , C07K1/06 , C12M1/00 , C40B40/10 , C40B60/14 , C40B70/00 , G01N21/64 , C07H21/00
CPC分类号： G01N21/6452 , B01J19/0046 , B01J2219/00378 , B01J2219/00441 , B01J2219/00542 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00626 , B01J2219/00641 , B01J2219/00659 , B01J2219/00711 , B01J2219/00725 , B82Y30/00 , C07K1/047 , C40B40/10 , C40B60/14 , C40B70/00 , G01N21/6428
摘要： According to the inventive method for applying substances to a support, especially monomers for the combinatorial synthesis of molecule libraries, the substances are first embedded in a matrix consisting of at least one solvent, said solvent being in a solid state of aggregation at a temperature below 90 DEG C, preferably below 50 DEG C. The substances that are embedded in the matrix form transport units which are subsequently applied to the support in a solid state of aggregation, at a temperature below 90 DEG C, preferably below 50 DEG C. Alternatively, the transport units can be dissolved with a second solvent part and applied to the support in a liquid state of aggregation, where they adopt a solid or gel-like stage of aggregation after said solvent part has completely or partially evaporated. The substances on the matrix are then mobilised by modifying their physical environment and brought into the vicinity of the support surface through a physical process. Here, the substances link up with the molecules. This method can be repeated to apply multiple layers to the support in precise positions. The method can be carried out using a device which essentially has the structure of a laser printer or a laser copier or an ink-jet printer.
摘要翻译：在用于在载体上施加的物质，特别是用于分子文库的组合合成的单体的方法，所述物质在第一嵌入在低于90℃的温度下由至少一种溶剂的基质，优选低于50℃ C是存在于固体状态。这些包埋在基质形成物质的运输单元，其随后在固态沉积在低于90℃的温度，优选低于50℃在载体上。可替换地，传送单元可以由第二溶剂部分得到解决，在液体状态下的载流子，在那里他们假设完全或部分蒸发后的固体或凝胶状物理状态的所述第二溶剂部分上被施加。随后，沉积在载体上物质制成通过改变物理环境移动，并且在支撑表面附近通过物理方法转化。有新人物质的分子。通过重复这个过程的物质几层在本地精确地施加到载体上。实质上具有一个激光打印机或激光复印机，或喷墨打印机的结构的装置用于执行该方法。

7. 发明申请

WO0036398A8 METHOD AND DEVICES FOR DETECTING OPTICAL PROPERTIES, ESPECIALLY LUMINESCENCE REACTIONS AND REFRACTION BEHAVIOUR OF MOLECULES WHICH ARE DIRECTLY OR INDIRECTLY BOUND ON A SUPPORT 审中-公开
标题翻译：用于测定光学特性，尤其是，发光反应和中断特性的方法和设备，通过载体直接或间接结合分子
公开(公告)号：WO0036398A8
公开(公告)日：2000-08-17
申请号：PCT/DE9903981
申请日：1999-12-14
申请人： DEUTSCHES KREBSFORSCH , EUROP LAB MOLEKULARBIOLOG , POUSTKA ANNEMARIE , BREITLING FRANK , GROSS KARL HEINZ , DUEBEL STEFAN , SAFFRICH RAINER
发明人： POUSTKA ANNEMARIE , BREITLING FRANK , GROSS KARL-HEINZ , DUEBEL STEFAN , SAFFRICH RAINER
IPC分类号： B01J19/00 , C07K1/04 , C40B40/10 , C40B60/14 , C40B70/00 , G01N21/64 , G01N21/00
CPC分类号： G01N21/6428 , B01J19/0046 , B01J2219/00378 , B01J2219/00441 , B01J2219/00542 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00644 , B01J2219/00659 , B01J2219/00711 , B01J2219/00725 , B82Y30/00 , C07K1/047 , C40B40/10 , C40B60/14 , C40B70/00 , G01N21/6454
摘要： According to the method for detecting optical properties, especially luminescence reactions and refraction behaviour of molecules which are directly or indirectly bound on a support, electromagnetic waves, especially laser light, are radiated onto the support. The light that is emitted or refracted by the molecules is then detected by a detector. The detector and the support are moved in relation to each other during and after the radiation of the electromagnetic waves. The support used is especially a transparent support with integrated position markings which can be detected by a detector, especially an optoelectronic scanning system. At least one of the integrated position markings is selected while the support and the detector are being moved in relation to each other or thereafter so that the light that is detected by the detector can be associated with a location on the support. A device for carrying out the method is provided with a detector, especially an optoelectronic scanning system, for detecting the position markings that are integrated in the support.
摘要翻译：在用于检测的光学特性的方法，特别是发光反应和在载体上的直接或间接结合的分子的电磁波的折射行为，尤其是激光，被照射到载体上。光由所述分子发射或折射的光被检测器检测。期间和电磁波检测器和载体的照射后相对于彼此移动。作为支撑体，一个透明支撑体和具有集成，由检测器检测的，特别是optoeletronischen扫描位置标记在特定使用。这里，集成位置标记中的一个的至少期间或载体和检测器的相对运动之后被读取时，使得检测到的光的分配由所述检测器，以在载体上的位置是可能的。在用于Durchfühnung提供了一种装置的方法中，检测器，特别是用于检测集成在支持位置标记的光电扫描系统。

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