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1. 发明申请

WO2011150419A1 MECHANICAL TESTING SYSTEM AND METHOD 审中-公开
标题翻译：机械试验系统及方法
公开(公告)号：WO2011150419A1
公开(公告)日：2011-12-01
申请号：PCT/US2011/038581
申请日：2011-05-31
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , EDELMAN, Elazer, R. , FURMAN, Kay, Dee , DESANY, Gerard, J.
发明人： EDELMAN, Elazer, R. , FURMAN, Kay, Dee , DESANY, Gerard, J.
IPC分类号： G01N3/04 , G01N3/32
CPC分类号： G01N3/08 , G01N3/04 , G01N3/32 , G01N2203/0005 , G01N2203/0023 , G01N2203/0026 , G01N2203/0028 , G01N2203/0073 , G01N2203/0089 , G01N2203/0242 , G01N2203/0246 , G01N2203/0266 , G01N2203/0274 , G01N2203/0435
摘要： A fixture facilitates using a linear force of a uni-axial test machine to subject a test sample to bending forces. The test machine includes a frame and a crosshead. To generate the linear force, the crosshead translates with reference to the frame in a plane of motion. The fixture includes an upper connecting link, a lower connecting link, and two transverse arms. The upper connecting link is configured to attach to the crosshead for receiving the linear force, and the lower connecting link is configured to attach to the frame. The two transverse arms are pivotably carried between the upper and lower links. Each transverse arm has an inner end configured to attach to the test sample, the test sample being suspended between the arms. The transverse arms pivot in opposite directions in response to the linear force applied to the upper connecting link, exposing the sample to bending forces.
摘要翻译：固定装置有助于使用单轴测试机的线性力来使测试样品承受弯曲力。试验机包括框架和十字头。为了产生线性力，十字头在运动平面中相对于框架进行平移。固定装置包括上连接连杆，下连接连杆和两横向臂。上连接链接被配置为附接到十字头以接收线性力，并且下连接链路被配置为附接到框架。两个横向臂可枢转地承载在上部和下部连杆之间。每个横臂具有构造成附接到测试样品的内端，测试样品悬挂在臂之间。横向臂响应于施加到上连接连杆的线性力而以相反的方向枢转，将样品暴露于弯曲力。

2. 发明申请

WO2009061334A1 TISSUE-ENGINEERED ENDOTHELIAL AND EPITHELIAL IMPLANTS DIFFERENTIALLY AND SYNERGISTICALLY REGULATE TISSUE REPAIR 审中-公开
标题翻译：组织工程内皮和上皮植入物不同程度地和协调地调节组织修复
公开(公告)号：WO2009061334A1
公开(公告)日：2009-05-14
申请号：PCT/US2008/005922
申请日：2008-05-06
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , EDELMAN, Elazer, R. , ZANI, Brett
发明人： EDELMAN, Elazer, R. , ZANI, Brett
IPC分类号： A61K35/42 , A61L27/38 , C12N5/06
CPC分类号： A61K35/36 , A61K35/12 , A61K35/42 , A61L27/3808 , C12N5/0688 , C12N2500/38 , C12N2501/11 , C12N2501/115 , C12N2501/25 , C12N2501/385 , C12N2501/39 , C12N2501/395 , C12N2501/81 , C12N2502/28 , C12N2533/00 , C12N2533/54
摘要： Endothelial implants restore vascular homeostasis after injury without reconstituting vascular architecture. Endothelial cells line the vascular epithelium and underlying vasa vasorum precluding distinction between cellular controls. Unlike blood vessels, the airway epithelium is highly differentiated and distinct from endothelial cells that line the bronchial vasa allowing investigation of the differential control tissue engineered cells may provide in airways and blood vessels. Through airway injury and cell culture models, tissue engineered implants of the bronchial epithelium and endothelium were found to promote synergistic repair of the airway through biochemical regulation of the airway microenvironment. While epithelial cells modulate local tissue composition and reaction, endothelial cells preserve the epithelium; together their relative impact was enhanced suggesting both cell types act synergistically for airway repair.
摘要翻译：内皮植入物在损伤后恢复血管稳态，而不会重建血管结构。内皮细胞对血管上皮细胞和下面的vasa血管排除细胞对照之间的区别。与血管不同，气道上皮与血管内皮细胞高度分化，区别于支气管血管，允许调查差异对照组织工程细胞可能在气道和血管中提供。通过气道损伤和细胞培养模型，发现支气管上皮和内皮的组织工程植入物通过气道微环境的生物化学调节促进气道的协同修复。虽然上皮细胞调节局部组织组成和反应，内皮细胞保留上皮细胞; 一起，他们的相对影响被增强，表明两种细胞类型协同作用用于气道修复。

3. 发明申请

WO2003015664A1 EXPANDABLE MEDICAL DEVICE FOR DELIVERY OF BENEFICIAL AGENT 审中-公开
标题翻译：用于交付受益人的可扩展医疗设备
公开(公告)号：WO2003015664A1
公开(公告)日：2003-02-27
申请号：PCT/US2002/017609
申请日：2002-06-05
申请人： CONOR MEDSYSTEMS, INC. , SHANLEY, John, F. , EIGLER, Neal, L. , PARK, Kinam , EDELMAN, Elazer, R.
发明人： SHANLEY, John, F. , EIGLER, Neal, L. , PARK, Kinam , EDELMAN, Elazer, R.
IPC分类号： A61F2/06
CPC分类号： A61L31/10 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2002/91558 , A61F2210/0004 , A61F2210/0076 , A61F2250/003 , A61F2250/0031 , A61F2250/0068 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/42 , A61L2300/602 , A61L2300/622
摘要： An expandable medical device has a plurality of elongated struts joined together to form a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter. At least one of the plurality of struts includes at least one opening extending at least partially through a thickness of said strut. A beneficial agent is loaded into the opening within the strut in layers to achieve desired temporal release kinetics of the agent. Alternatively, the beneficial agent is loaded in a shape which is configured to achieve the desired agent delivery profile. A wide variety of delivery profiles can be achieved including zero order, pulsatile, increasing, decrease, sinusoidal, and other delivery profiles.
摘要翻译：可扩张医疗装置具有连接在一起的多个细长支柱，以形成可从具有第一直径的圆柱体扩展到具有第二直径的圆筒的基本上圆柱形的装置。所述多个支柱中的至少一个支柱包括至少部分穿过所述支柱的厚度延伸的至少一个开口。将有益剂加载到支柱内的开口中以实现试剂的期望的释放动力学。或者，有益试剂被加载成被配置成实现所需试剂输送曲线的形状。可以实现各种各样的输送曲线，包括零级，脉冲，增加，减少，正弦和其他输送曲线。

4. 发明申请

WO2011163188A1 ENDOVASCULAR PLATFORMS FOR UNIFORM THERAPEUTIC DELIVERY TO LOCAL TARGETS 审中-公开
标题翻译：用于统一治疗局部目标的内分泌平台
公开(公告)号：WO2011163188A1
公开(公告)日：2011-12-29
申请号：PCT/US2011/041190
申请日：2011-06-21
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , KOLACHALAMA, Vijaya , LEVINE, Evan, G. , EDELMAN, Elazer, R.
发明人： KOLACHALAMA, Vijaya , LEVINE, Evan, G. , EDELMAN, Elazer, R.
IPC分类号： A61F2/90
CPC分类号： G09B23/28 , A61F2/91 , A61F2/915 , A61F2002/91525 , G09B23/30 , Y10T29/49826
摘要： An endovascular platform is provided that includes a periodic tiling-based stent structure having a parallelogram tile associated with a fundamental domain and an intrinsic cell-shape. A lattice vector includes a section of the parallelogram tile where the lattice vector is circumferentially folded to create helical repetition of cells.
摘要翻译：提供了一种血管内平台，其包括具有与基本区域和内在细胞形状相关联的平行四边形瓦片的基于周期性的基于平铺的支架结构。格子矢量包括平行四边形瓦片的一部分，其中晶格矢量被圆周折叠以产生细胞的螺旋重复。

5. 发明申请

WO2010091206A1 COMPOSITIONS AND USES TO GOVERN CANCER CELL GROWTH 审中-公开
标题翻译：组合物和用于治癌细胞生长的用途
公开(公告)号：WO2010091206A1
公开(公告)日：2010-08-12
申请号：PCT/US2010/023237
申请日：2010-02-04
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , FRANSES, Joseph, W. , EDELMAN, Elazer, R. , CARDOSO, Angelo, Manuel De Almeida , NUGENT, Helen, Marie
发明人： FRANSES, Joseph, W. , EDELMAN, Elazer, R. , CARDOSO, Angelo, Manuel De Almeida , NUGENT, Helen, Marie
IPC分类号： A61K47/42 , A61K9/00 , A61K35/00
CPC分类号： A61L27/3808 , A61K9/0024 , A61K35/12 , A61K39/0011 , A61K47/42 , A61K2039/5152 , A61L27/3804 , A61L27/40 , A61L27/50 , A61L2400/18
摘要： The invention relates to composition and a method of using the composition for modulating proliferation, invasiveness, the expression of a biomarker of an abnormal cell, of reducing the risk of a patient cell becoming abnormal, or of modulating proliferation of a carcinoma-associated fibroblast or of a tumor- associated macrophage. The invention also relates to a method of culturing the composition to produce molecules that modulate abnormal cell proliferation, invasiveness, or metastasis. The composition comprises a biocompatible matrix and cells engrafted thereon.
摘要翻译：本发明涉及组合物和使用该组合物调节增殖，侵袭性，异常细胞生物标志物表达，降低患者细胞变得异常风险或调节癌相关成纤维细胞增殖的方法的肿瘤相关巨噬细胞。本发明还涉及培养组合物以产生调节异常细胞增殖，侵袭或转移的分子的方法。组合物包含生物相容性基质和植入其上的细胞。

6. 发明申请

WO2009086269A2 ENDOVASCULAR DEVICES/CATHETER PLATFORMS AND METHODS FOR ACHIEVING CONGRUENCY IN SEQUENTIALLY DEPLOYED DEVICES 审中-公开
标题翻译：用于实现顺序部署的装置的内部装置/导管平台和方法
公开(公告)号：WO2009086269A2
公开(公告)日：2009-07-09
申请号：PCT/US2008087950
申请日：2008-12-22
申请人： MASSACHUSETTS INST TECHNOLOGY , KOLANDAIVELU KUMARAN , SWAMINATHAN RAJESH V , GIBSON WILLIAM J , EDELMAN ELAZER R
发明人： KOLANDAIVELU KUMARAN , SWAMINATHAN RAJESH V , GIBSON WILLIAM J , EDELMAN ELAZER R
IPC分类号： A61F2/82 , A61F2/86 , A61M25/04 , A61M25/14
CPC分类号： A61F2/86 , A61F2/852 , A61F2/958 , A61F2002/826 , A61F2210/009 , A61F2250/0063 , A61M25/1011 , A61M2025/1013
摘要： A stent alignment system includes an implantable stent and catheter that allows the ability to precisely control translational and rotational position in a vessel of the implantable stent and catheter.
摘要翻译：支架对准系统包括可植入支架和导管，其允许精确地控制可植入支架和导管的容器中的平移和旋转位置的能力。

7. 发明申请

WO2008057580A3 MATERIALS AND METHODS FOR TREATING AND MANAGING ANGIOGENESIS-MEDIATED DISEASES 审中-公开
标题翻译：用于治疗和管理血管生成介质性疾病的材料和方法
公开(公告)号：WO2008057580A3
公开(公告)日：2008-07-31
申请号：PCT/US2007023535
申请日：2007-11-07
申请人： PERVASIS THERAPEUTICS INC , NUGENT HELEN MARIE , EDELMAN ELAZER R , TJIN THAM SJIN ROBERT M , NG YIN SHAN
发明人： NUGENT HELEN MARIE , EDELMAN ELAZER R , TJIN THAM SJIN ROBERT M , NG YIN SHAN
IPC分类号： A61K35/12 , A61F2/06 , A61L27/38 , A61L29/16 , A61P19/02 , A61P37/00 , A61P43/00
CPC分类号： A61K35/36 , A61K35/44 , A61L31/005
摘要： Disclosed herein are materials and methods suitable for treating sites of pathological angiogenesis and abnormal neovascularization. Sites of pathological angiogenesis or abnormal neovascularization can be treated by contacting a surface at or adjacent or in the vicinity of an area of pathological angiogenesis or abnormal neovascularization with an implantable material. The implantable material comprises a biocompatible matrix and cells and is in an amount effective to treat the affected site. The composition can be a flexible planar material or a flowable composition. Diseases susceptible to treatment with the present invention include, for example, macular degeneration, rheumatoid arthritis, psoriasis, psoriatic arthritis, systemic inflammatory diseases, and treatment of tumors by surgical resection, radiation therapy or chemotherapy.
摘要翻译：本文公开了适用于治疗病理性血管生成和异常新血管形成的部位的材料和方法。病理性血管生成或异常新血管形成的部位可以通过将病理性血管发生或异常新生血管形成区域附近的表面与可植入材料接触来处理。可植入材料包括生物相容性基质和细胞，并且具有有效治疗受影响部位的量。组合物可以是柔性平面材料或可流动组合物。用本发明治疗的疾病包括例如黄斑变性，类风湿性关节炎，牛皮癣，银屑病关节炎，全身性炎症性疾病，以及通过手术切除，放射治疗或化疗治疗肿瘤。

8. 发明申请

WO2008013803A2 ENDOVASCULAR DEVICES WITH AXIAL PERTURBATIONS 审中-公开
标题翻译：具有轴向扰动的腔内装置
公开(公告)号：WO2008013803A2
公开(公告)日：2008-01-31
申请号：PCT/US2007/016629
申请日：2007-07-24
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , TZAFRIRI, Abraham , KOLANDAIVELU, Kumaran , EDELMAN, Elazer, R.
发明人： TZAFRIRI, Abraham , KOLANDAIVELU, Kumaran , EDELMAN, Elazer, R.
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/06 , A61F2/90 , A61F2002/068 , A61F2210/0014 , A61F2250/0067
摘要： Endovascular devices are provided. The endovascular devices include a conformable scaffold with one or more outpocketings. The outpocketing in the endovascular device creates a corresponding outpocketing of a vessel wall, thereby altering local fluid dynamics.
摘要翻译：提供了血管内装置。血管内装置包括具有一个或多个输出管的适形支架。血管内装置的外泄使血管壁出现相应的溢出，从而改变局部流体动力学。

9. 发明申请

WO2007012947A2 METHOD OF TREATING ISCHEMIA-REPERFUSION INJURY 审中-公开
标题翻译：治疗异位再灌注损伤的方法
公开(公告)号：WO2007012947A2
公开(公告)日：2007-02-01
申请号：PCT/IB2006/002028
申请日：2006-07-25
申请人： BIOREST LTD. , RICHTER, Yoram , EDELMAN, Elazer, R. , GOLOMB, Gershon , DANENBERG, Haim, D.
发明人： RICHTER, Yoram , EDELMAN, Elazer, R. , GOLOMB, Gershon , DANENBERG, Haim, D.
IPC分类号： A61K31/47
CPC分类号： A61K31/337 , A61K9/127 , A61K31/282 , A61K31/365 , A61K31/436 , A61K31/47 , A61K31/4745 , A61K31/513 , A61K31/56 , A61K31/60 , A61K31/616 , A61K31/663 , A61K31/7072 , A61K33/00 , A61K33/04 , A61K33/24
摘要： The present invention relates to methods and compositions designed for the prevention, reduction, treatment or management of ischemia-reperfusion injury. The methods of the invention comprise the administration of an effective amount of a therapeutic formulation containing one or more active compounds in a formulation which specifically decreases or inhibits the activity of and/or eliminates or diminishes the amount of phagocytic cells including, but not limited to, macrophages and/or monocytes. In preferred embodiments, the active compound is a bisphosphonate. The invention also provides pharmaceutical compositions of therapeutic formulations for administration to subjects currently suffering from, having recently suffered, or at risk of suffering from an ischemia-reperfusion injury.
摘要翻译：本发明涉及设计用于预防，减少，治疗或治疗缺血再灌注损伤的方法和组合物。本发明的方法包括在制剂中施用有效量的含有一种或多种活性化合物的治疗制剂，所述制剂特异性降低或抑制吞噬细胞的活性和/或消除或减少吞噬细胞的量，包括但不限于，巨噬细胞和/或单核细胞。在优选的实施方案中，活性化合物是双膦酸盐。本发明还提供了用于给予目前患有，最近遭受或有遭受缺血再灌注损伤风险的受试者的治疗制剂的药物组合物。

10. 发明申请

WO2005002545A1 METHOD OF TREATING ACUTE CORONARY SYNDROMES 审中-公开
标题翻译：治疗急性冠状动脉综合征的方法
公开(公告)号：WO2005002545A1
公开(公告)日：2005-01-13
申请号：PCT/US2004/020487
申请日：2004-06-24
申请人： BIOREST LTD. , RICHTER, Yoram , EDELMAN, Elazer, R. , GOLOMB, Gershon , DANENBERG, Haim, D.
发明人： EDELMAN, Elazer, R. , GOLOMB, Gershon , DANENBERG, Haim, D.
IPC分类号： A61K9/127
CPC分类号： A61K31/663
摘要： The present invention relates to methods and compositions designed for the treatment or management of acute coronary syndromes, particularly, unstable angina and acute myocardial infarction. The methods of the invention comprise the administration of an effective amount of a formulation containing one or more therapeutic agents which specifically decreases or inhibits the activity of phagocytic cells and/or eliminates or diminishes the amount of phagocytic cells including, but not limited to, macrophages and monocytes. The formulations are specifically targeted to phagocytic cells. The invention also provides pharmaceutical compositions of formulations containing one or more therapeutic agents of the invention for administration to subjects currently suffering from or having recently suffered an acture coronary syndrome such as unstable angina and acute myocardial infarction.
摘要翻译：本发明涉及设计用于治疗或治疗急性冠状动脉综合征，特别是不稳定性心绞痛和急性心肌梗塞的方法和组合物。本发明的方法包括施用有效量的含有一种或多种治疗剂的制剂，其特异性降低或抑制吞噬细胞的活性和/或消除或减少吞噬细胞的量，包括但不限于巨噬细胞和单核细胞。制剂专门针对吞噬细胞。本发明还提供了含有本发明的一种或多种治疗剂的制剂的药物组合物，用于给予目前患有或最近患有冠状动脉综合征如不稳定型心绞痛和急性心肌梗死的受试者。

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