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1. 发明申请

WO2011163188A1 ENDOVASCULAR PLATFORMS FOR UNIFORM THERAPEUTIC DELIVERY TO LOCAL TARGETS 审中-公开
标题翻译：用于统一治疗局部目标的内分泌平台
公开(公告)号：WO2011163188A1
公开(公告)日：2011-12-29
申请号：PCT/US2011/041190
申请日：2011-06-21
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , KOLACHALAMA, Vijaya , LEVINE, Evan, G. , EDELMAN, Elazer, R.
发明人： KOLACHALAMA, Vijaya , LEVINE, Evan, G. , EDELMAN, Elazer, R.
IPC分类号： A61F2/90
CPC分类号： G09B23/28 , A61F2/91 , A61F2/915 , A61F2002/91525 , G09B23/30 , Y10T29/49826
摘要： An endovascular platform is provided that includes a periodic tiling-based stent structure having a parallelogram tile associated with a fundamental domain and an intrinsic cell-shape. A lattice vector includes a section of the parallelogram tile where the lattice vector is circumferentially folded to create helical repetition of cells.
摘要翻译：提供了一种血管内平台，其包括具有与基本区域和内在细胞形状相关联的平行四边形瓦片的基于周期性的基于平铺的支架结构。格子矢量包括平行四边形瓦片的一部分，其中晶格矢量被圆周折叠以产生细胞的螺旋重复。

2. 发明申请

WO2009089518A2 ENDOVASCULAR PLATFORMS FOR THE DIFFERENTIAL TARGETING OF MOLECULES TO VESSEL WALL AND VESSEL LUMEN 审中-公开
标题翻译：用于差异分配到血管壁和血管壁的分子的内部平台
公开(公告)号：WO2009089518A2
公开(公告)日：2009-07-16
申请号：PCT/US2009/030712
申请日：2009-01-12
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , KOLANDAIVELU, Kumaran , TZAFRIRI, Abraham , KOLACHALAMA, Vijaya, B. , EDELMAN, Elazer, R.
发明人： KOLANDAIVELU, Kumaran , TZAFRIRI, Abraham , KOLACHALAMA, Vijaya, B. , EDELMAN, Elazer, R.
IPC分类号： A61M31/00 , A61M37/00 , A61F2/06
CPC分类号： A61F2/82 , A61F2002/068 , A61F2250/0067
摘要： A drug delivering medical system intended for placement into a blood vessel is provided. The drug delivering medical system includes a stent device having a plurality of interconnected distinct strut elements comprising distinct strut element surfaces. At least some of the distinct strut surfaces are neither in contact with the lumen wall nor in contact with wall-contacting flow recirculation zones. The stent device releases at least one biologically active compound intended for distal delivery and provides sufficient surface area for delivering the required drug dose to a distal tissue.
摘要翻译：提供了用于放置在血管中的药物递送医疗系统。药物递送医疗系统包括支架装置，其具有包括不同的支柱元件表面的多个互连的不同的支柱元件。至少一些不同的支柱表面既不与管腔壁接触，也不与壁接触的流动再循环区域接触。支架装置释放用于远端输送的至少一种生物活性化合物，并提供足够的表面积以将所需药物剂量递送至远端组织。

3. 发明申请

WO2011150419A1 MECHANICAL TESTING SYSTEM AND METHOD 审中-公开
标题翻译：机械试验系统及方法
公开(公告)号：WO2011150419A1
公开(公告)日：2011-12-01
申请号：PCT/US2011/038581
申请日：2011-05-31
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , EDELMAN, Elazer, R. , FURMAN, Kay, Dee , DESANY, Gerard, J.
发明人： EDELMAN, Elazer, R. , FURMAN, Kay, Dee , DESANY, Gerard, J.
IPC分类号： G01N3/04 , G01N3/32
CPC分类号： G01N3/08 , G01N3/04 , G01N3/32 , G01N2203/0005 , G01N2203/0023 , G01N2203/0026 , G01N2203/0028 , G01N2203/0073 , G01N2203/0089 , G01N2203/0242 , G01N2203/0246 , G01N2203/0266 , G01N2203/0274 , G01N2203/0435
摘要： A fixture facilitates using a linear force of a uni-axial test machine to subject a test sample to bending forces. The test machine includes a frame and a crosshead. To generate the linear force, the crosshead translates with reference to the frame in a plane of motion. The fixture includes an upper connecting link, a lower connecting link, and two transverse arms. The upper connecting link is configured to attach to the crosshead for receiving the linear force, and the lower connecting link is configured to attach to the frame. The two transverse arms are pivotably carried between the upper and lower links. Each transverse arm has an inner end configured to attach to the test sample, the test sample being suspended between the arms. The transverse arms pivot in opposite directions in response to the linear force applied to the upper connecting link, exposing the sample to bending forces.
摘要翻译：固定装置有助于使用单轴测试机的线性力来使测试样品承受弯曲力。试验机包括框架和十字头。为了产生线性力，十字头在运动平面中相对于框架进行平移。固定装置包括上连接连杆，下连接连杆和两横向臂。上连接链接被配置为附接到十字头以接收线性力，并且下连接链路被配置为附接到框架。两个横向臂可枢转地承载在上部和下部连杆之间。每个横臂具有构造成附接到测试样品的内端，测试样品悬挂在臂之间。横向臂响应于施加到上连接连杆的线性力而以相反的方向枢转，将样品暴露于弯曲力。

4. 发明申请

WO2009061334A1 TISSUE-ENGINEERED ENDOTHELIAL AND EPITHELIAL IMPLANTS DIFFERENTIALLY AND SYNERGISTICALLY REGULATE TISSUE REPAIR 审中-公开
标题翻译：组织工程内皮和上皮植入物不同程度地和协调地调节组织修复
公开(公告)号：WO2009061334A1
公开(公告)日：2009-05-14
申请号：PCT/US2008/005922
申请日：2008-05-06
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , EDELMAN, Elazer, R. , ZANI, Brett
发明人： EDELMAN, Elazer, R. , ZANI, Brett
IPC分类号： A61K35/42 , A61L27/38 , C12N5/06
CPC分类号： A61K35/36 , A61K35/12 , A61K35/42 , A61L27/3808 , C12N5/0688 , C12N2500/38 , C12N2501/11 , C12N2501/115 , C12N2501/25 , C12N2501/385 , C12N2501/39 , C12N2501/395 , C12N2501/81 , C12N2502/28 , C12N2533/00 , C12N2533/54
摘要： Endothelial implants restore vascular homeostasis after injury without reconstituting vascular architecture. Endothelial cells line the vascular epithelium and underlying vasa vasorum precluding distinction between cellular controls. Unlike blood vessels, the airway epithelium is highly differentiated and distinct from endothelial cells that line the bronchial vasa allowing investigation of the differential control tissue engineered cells may provide in airways and blood vessels. Through airway injury and cell culture models, tissue engineered implants of the bronchial epithelium and endothelium were found to promote synergistic repair of the airway through biochemical regulation of the airway microenvironment. While epithelial cells modulate local tissue composition and reaction, endothelial cells preserve the epithelium; together their relative impact was enhanced suggesting both cell types act synergistically for airway repair.
摘要翻译：内皮植入物在损伤后恢复血管稳态，而不会重建血管结构。内皮细胞对血管上皮细胞和下面的vasa血管排除细胞对照之间的区别。与血管不同，气道上皮与血管内皮细胞高度分化，区别于支气管血管，允许调查差异对照组织工程细胞可能在气道和血管中提供。通过气道损伤和细胞培养模型，发现支气管上皮和内皮的组织工程植入物通过气道微环境的生物化学调节促进气道的协同修复。虽然上皮细胞调节局部组织组成和反应，内皮细胞保留上皮细胞; 一起，他们的相对影响被增强，表明两种细胞类型协同作用用于气道修复。

5. 发明申请

WO2010091206A1 COMPOSITIONS AND USES TO GOVERN CANCER CELL GROWTH 审中-公开
标题翻译：组合物和用于治癌细胞生长的用途
公开(公告)号：WO2010091206A1
公开(公告)日：2010-08-12
申请号：PCT/US2010/023237
申请日：2010-02-04
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , FRANSES, Joseph, W. , EDELMAN, Elazer, R. , CARDOSO, Angelo, Manuel De Almeida , NUGENT, Helen, Marie
发明人： FRANSES, Joseph, W. , EDELMAN, Elazer, R. , CARDOSO, Angelo, Manuel De Almeida , NUGENT, Helen, Marie
IPC分类号： A61K47/42 , A61K9/00 , A61K35/00
CPC分类号： A61L27/3808 , A61K9/0024 , A61K35/12 , A61K39/0011 , A61K47/42 , A61K2039/5152 , A61L27/3804 , A61L27/40 , A61L27/50 , A61L2400/18
摘要： The invention relates to composition and a method of using the composition for modulating proliferation, invasiveness, the expression of a biomarker of an abnormal cell, of reducing the risk of a patient cell becoming abnormal, or of modulating proliferation of a carcinoma-associated fibroblast or of a tumor- associated macrophage. The invention also relates to a method of culturing the composition to produce molecules that modulate abnormal cell proliferation, invasiveness, or metastasis. The composition comprises a biocompatible matrix and cells engrafted thereon.
摘要翻译：本发明涉及组合物和使用该组合物调节增殖，侵袭性，异常细胞生物标志物表达，降低患者细胞变得异常风险或调节癌相关成纤维细胞增殖的方法的肿瘤相关巨噬细胞。本发明还涉及培养组合物以产生调节异常细胞增殖，侵袭或转移的分子的方法。组合物包含生物相容性基质和植入其上的细胞。

6. 发明申请

WO2008013803A2 ENDOVASCULAR DEVICES WITH AXIAL PERTURBATIONS 审中-公开
标题翻译：具有轴向扰动的腔内装置
公开(公告)号：WO2008013803A2
公开(公告)日：2008-01-31
申请号：PCT/US2007/016629
申请日：2007-07-24
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , TZAFRIRI, Abraham , KOLANDAIVELU, Kumaran , EDELMAN, Elazer, R.
发明人： TZAFRIRI, Abraham , KOLANDAIVELU, Kumaran , EDELMAN, Elazer, R.
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/06 , A61F2/90 , A61F2002/068 , A61F2210/0014 , A61F2250/0067
摘要： Endovascular devices are provided. The endovascular devices include a conformable scaffold with one or more outpocketings. The outpocketing in the endovascular device creates a corresponding outpocketing of a vessel wall, thereby altering local fluid dynamics.
摘要翻译：提供了血管内装置。血管内装置包括具有一个或多个输出管的适形支架。血管内装置的外泄使血管壁出现相应的溢出，从而改变局部流体动力学。

7. 发明申请

WO2012142470A1 BIOCOMPATIBLE ADHESIVE MATERIALS AND METHODS 审中-公开
标题翻译：生物胶粘材料和方法
公开(公告)号：WO2012142470A1
公开(公告)日：2012-10-18
申请号：PCT/US2012/033604
申请日：2012-04-13
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , ARTZI, Natalie , EDELMAN, Elazer, R. , JORGE, Nuria, Oliva , SOLANES, Maria, Carcole
发明人： ARTZI, Natalie , EDELMAN, Elazer, R. , JORGE, Nuria, Oliva , SOLANES, Maria, Carcole
IPC分类号： A61L24/00 , A61L24/04 , A61L24/08
CPC分类号： A61L24/043 , A61L24/0005 , A61L24/0015 , A61L24/08 , A61M5/19 , A61M5/31596 , C08L5/02
摘要： Biocompatible adhesive materials, such as for use with biological tissues and/or medical implants, are provided, as well as methods and kits for making and using the biocompatible adhesive materials. The biocompatible adhesive materials include a dendrimer component and a polymer component, and may be tailored for specific tissue types and conditions.
摘要翻译：提供生物相容的粘合剂材料，例如用于生物组织和/或医疗植入物，以及用于制备和使用生物相容性粘合剂材料的方法和试剂盒。生物相容性粘合剂材料包括树枝状聚合物组分和聚合物组分，并且可以针对特定组织类型和条件而定制。

8. 发明申请

WO2010042944A2 METHOD FOR IMAGING BIOMATERIAL EROSION IN VIVO 审中-公开
标题翻译：用于在生物体内形成生物膜侵蚀的方法
公开(公告)号：WO2010042944A2
公开(公告)日：2010-04-15
申请号：PCT/US2009/060517
申请日：2009-10-13
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , ARTIZ, Natalie , EDELMAN, Elazer, R.
发明人： ARTIZ, Natalie , EDELMAN, Elazer, R.
IPC分类号： A61B5/00
CPC分类号： A61B5/0059 , G06F19/00 , G06F19/321 , G06T7/0012
摘要： A method for imaging the erosion of a biomaterial is disclosed. More specifically, the present invention provides a method for imaging a labeled biomaterial so that the erosion of the biomaterial is measured in vivo over a period of time. A biomaterial such as, for example, a hydrogel including polyethylene glycol (PEG) is labeled with a fluorescent or bioluminescent marker. The labeled biomaterial is then employed in the construction of an implanted medical device such as, for example, an endovascular stent. Furthermore, the labeled biomaterial may be utilized to form a drug delivery system that releases a controlled amount of a drug into a local region within a patient. The erosion of the biomaterial is monitored through a noninvasive imaging method.
摘要翻译：公开了一种用于对生物材料侵蚀进行成像的方法。更具体地，本发明提供了一种用于对标记的生物材料进行成像的方法，使得在一段时间内在体内测量生物材料的侵蚀。诸如例如包括聚乙二醇（PEG）的水凝胶的生物材料用荧光或生物发光标记物标记。然后将标记的生物材料用于构建植入的医疗装置，例如血管内支架。此外，标记的生物材料可以用于形成将受控量的药物释放到患者内的局部区域中的药物递送系统。通过非侵入性成像方法监测生物材料的侵蚀。

9. 发明申请

WO2009086269A3 ENDOVASCULAR DEVICES/CATHETER PLATFORMS AND METHODS FOR ACHIEVING CONGRUENCY IN SEQUENTIALLY DEPLOYED DEVICES 审中-公开
公开(公告)号：WO2009086269A3
公开(公告)日：2009-07-09
申请号：PCT/US2008/087950
申请日：2008-12-22
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , KOLANDAIVELU, Kumaran , SWAMINATHAN, Rajesh, V. , GIBSON, William, J. , EDELMAN, Elazer, R.
发明人： KOLANDAIVELU, Kumaran , SWAMINATHAN, Rajesh, V. , GIBSON, William, J. , EDELMAN, Elazer, R.
IPC分类号： A61M25/10 , A61M25/14 , A61M25/04
摘要： A stent alignment system includes an implantable stent and catheter that allows the ability to precisely control translational and rotational position in a vessel of the implantable stent and catheter.

10. 发明申请

WO2009105624A2 SIMULTANEOUS DELIVERY OF RECEPTORS AND/OR CO-RECEPTORS FOR GROWTH FACTOR STABILITY AND ACTIVITY 审中-公开
标题翻译：受体和/或共同受体同时递送生长因子稳定性和活性
公开(公告)号：WO2009105624A2
公开(公告)日：2009-08-27
申请号：PCT/US2009/034654
申请日：2009-02-20
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , EDELMAN, Elazer, R. , BAKER, Aaron, B.
发明人： EDELMAN, Elazer, R. , BAKER, Aaron, B.
IPC分类号： A61K47/48 , A61K38/18 , A61P9/00
CPC分类号： A61K38/1825 , A61K38/177 , A61K38/179 , A61K38/1793 , A61K38/1841 , A61K38/39 , A61K38/47 , A61K47/6911 , A61K2300/00
摘要： The compositions and methods of the present invention relate to the co- delivery of a molecule and a polypeptide to cells to improve the therapeutic efficacy of the molecules. In one embodiment of the invention, the invention may improve delivery of growth factors by co-delivering these growth factors with their receptors and co-receptors, such as syndecans. Co-delivery of growth factors with syndecans, for example, may protect growth factors from proteolysis, enhance their activity, and target the growth factors to the cell surface to facilitate growth factor signaling. This novel approach to growth factor therapy could be extended to other systems and growth factors enabling the enhancement of multiple signaling pathways to achieve a desired therapeutic outcome.
摘要翻译：本发明的组合物和方法涉及将分子和多肽共同递送至细胞以改善分子的治疗功效。在本发明的一个实施方案中，本发明可以通过将这些生长因子与它们的受体和共受体（例如syndecans）共同递送来改善生长因子的递送。例如，与综合征共同递送生长因子可以保护生长因子免于蛋白水解，增强其活性，并将生长因子靶向细胞表面以促进生长因子信号传导。这种生长因子治疗的新方法可以扩展到其他系统和生长因子，从而能够增强多个信号传导途径以实现期望的治疗结果。

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