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1. 发明申请

WO2005062823A3 DIGITAL ELECTRODE FOR CARDIAC RHYTHM MANAGEMENT 审中-公开
标题翻译：数字电极用于心脏循环管理
公开(公告)号：WO2005062823A3
公开(公告)日：2006-05-26
申请号：PCT/US2004042694
申请日：2004-12-17
申请人： SAVACOR INC , MANN BRIAN , WHITING JAMES S , EIGLER NEAL L
发明人： MANN BRIAN , WHITING JAMES S , EIGLER NEAL L
IPC分类号： A61N1/18 , A61N1/05 , G09B23/28
CPC分类号： G09B23/288 , A61N1/025 , A61N1/056 , A61N1/057 , A61N1/08 , A61N1/37211 , A61N1/37229 , A61N1/37252
摘要： A cardiac rhythm management apparatus includes a proximal housing, a distal housing and a lead. The proximal housing includes a first energy storage device. The distal module is implantable within a patient's heart, and includes a second energy storage device, at least one electrode, and a control module. The control module controls the delivery of at least one electrical stimulus from the second energy storage device to a location in communication with the patient's heart. The lead connects the proximal housing to the distal module and is configured to communicate one or more digital signals between the proximal housing and the distal module.
摘要翻译：心律管理装置包括近端壳体，远侧壳体和引线。近侧壳体包括第一能量存储装置。远端模块可植入患者的心脏内，并且包括第二能量存储装置，至少一个电极和控制模块。控制模块控制至少一个电刺激从第二能量存储装置到与患者心脏通信的位置的传送。引线将近端壳体连接到远端模块并且被配置为在近端壳体和远端模块之间传递一个或多个数字信号。

2. 发明申请

WO2003098177A2 APPARATUS AND METHOD FOR MINIMALLY INVASIVE CALIBRATION OF IMPLANTED PRESSURE TRANSDUCERS 审中-公开
标题翻译：嵌入式压力传感器的微型入侵校准装置和方法
公开(公告)号：WO2003098177A2
公开(公告)日：2003-11-27
申请号：PCT/US2003/015174
申请日：2003-05-14
申请人： SAVACOR, INC. , EIGLER, Neal, L. , WHITING, James, S. , MANN, Brian, M.
发明人： EIGLER, Neal, L. , WHITING, James, S. , MANN, Brian, M.
IPC分类号： G01L
CPC分类号： A61B5/03 , A61B5/0215 , A61B5/076 , A61B5/087 , A61B5/418 , A61B5/4528 , A61B5/4884 , A61B2560/0223 , A61B2560/0252 , A61B2560/0257
摘要： This invention relates generally to apparatus and methods for the calibration of implanted pressure transducers (25). It is an object of several embodiments of the present invention to provide apparatus and methods for the calibration of one or more implanted pressure transducers (25) implanted in the body of medical patients. Various embodiments of the present invention are particularly advantageous because they offer a calibration system that is less invasive than the systems currently available.
摘要翻译：本发明一般涉及用于校准植入的压力传感器（25）的装置和方法。本发明的几个实施例的目的是提供用于校准植入医疗患者体内的一个或多个植入的压力换能器（25）的装置和方法。本发明的各种实施例是特别有利的，因为它们提供比目前可用的系统侵入性较小的校准系统。

3. 发明申请

WO2005062823A2 DIGITAL ELECTRODE FOR CARDIAC RHYTHM MANAGEMENT 审中-公开
标题翻译：数字电极用于心脏循环管理
公开(公告)号：WO2005062823A2
公开(公告)日：2005-07-14
申请号：PCT/US2004/042694
申请日：2004-12-17
申请人： SAVACOR, INC. , MANN, Brian , WHITING, James, S. , EIGLER, Neal, L.
发明人： MANN, Brian , WHITING, James, S. , EIGLER, Neal, L.
IPC分类号： A61N1/05 , G09B23/28
CPC分类号： G09B23/288 , A61N1/025 , A61N1/056 , A61N1/057 , A61N1/08 , A61N1/37211 , A61N1/37229 , A61N1/37252 , G06F19/00
摘要： A cardiac rhythm management apparatus includes a proximal housing, a distal housing and a lead. The proximal housing includes a first energy storage device. The distal module is implantable within a patient's heart, and includes a second energy storage device, at least one electrode, and a control module. The control module controls the delivery of at least one electrical stimulus from the second energy storage device to a location in communication with the patient's heart. The lead connects the proximal housing to the distal module and is configured to communicate one or more digital signals between the proximal housing and the distal module.
摘要翻译：心律管理装置包括近端壳体，远侧壳体和引线。近侧壳体包括第一能量存储装置。远端模块可植入患者的心脏内，并且包括第二能量存储装置，至少一个电极和控制模块。控制模块控制至少一个电刺激从第二能量存储装置到与患者心脏通信的位置的传送。引线将近端壳体连接到远端模块并且被配置为在近端壳体和远端模块之间传递一个或多个数字信号。

4. 发明申请

WO1993004735A1 METHOD AND APPARATUS FOR RESTENOSIS TREATMENT 审中-公开
标题翻译：用于保留治疗的方法和装置
公开(公告)号：WO1993004735A1
公开(公告)日：1993-03-18
申请号：PCT/US1992007447
申请日：1992-09-04
申请人： CEDARS-SINAI MEDICAL CENTER , HESS, Robert, L. , SHEFER, Arie , EIGLER, Neal, L. , WHITING, James, S.
发明人： CEDARS-SINAI MEDICAL CENTER
IPC分类号： A61N05/00
CPC分类号： A61N5/1002 , A61B2017/22068 , A61M2025/1047 , A61N2005/1004 , A61N2005/1023
摘要： Method and apparatus (10) for treatment and post-treatment of the stenosed region (14) of an artery (12) after reduction of the region by angioplasty or other means by applying a radioactive dose (30) to said reduced region of the artery by positioning a radioactive dose to the reduced region is disclosed. Low dose, local ionizing irradiation (38) is delivered to the site of an intravascular intervention to prevent and/or minimize excessive cell proliferation. The irradiating source may be located external to the site or may involve a source located within the vessel. The low dose, local ionizing irradiation may also be delivered during the interventional session or thereafter, preferably within 72 hours of the intervention, in a single dose or a fractionated dose, and alone or in combination with at least one radiosensitizing agent.
摘要翻译：用于通过血管成形术或其他手段减少该区域的动脉（12）的狭窄区域（14）进行治疗和后处理的方法和装置（10），其通过对所述动脉的所述减少区域施加放射性剂量（30）公开了将放射性剂量定位到还原区域。将低剂量局部电离辐射（38）输送到血管内干预部位，以预防和/或最小化过度的细胞增殖。照射源可以位于该场所的外部，或者可以涉及位于容器内的源。低剂量局部电离照射也可以在介入治疗期间或其后，优选在干预的72小时内以单一剂量或分次剂量，单独或与至少一种放射增敏剂组合递送。

5. 发明申请

WO2006036319A3 BIFURCATION STENT WITH CRUSHABLE END AND METHOD FOR DELIVERY OF A STENT TO A BIFURCATION 审中-公开
标题翻译：具有可裁剪端的分支支架和用于将支柱输送到分支的方法
公开(公告)号：WO2006036319A3
公开(公告)日：2007-12-13
申请号：PCT/US2005028477
申请日：2005-08-10
申请人： CONOR MEDSYSTEMS INC , EIGLER NEAL L , LITVACK FRANK , SHANLEY JOHN F , DIAZ STEPHEN HUNTER
发明人： EIGLER NEAL L , LITVACK FRANK , SHANLEY JOHN F , DIAZ STEPHEN HUNTER
IPC分类号： A61F2/06
CPC分类号： A61F2/856 , A61F2/852 , A61F2/91 , A61F2/915 , A61F2/954 , A61F2/958 , A61F2002/91541 , A61F2002/91558 , A61F2250/0018 , A61F2250/0039 , A61F2250/0068
摘要： A bifurcation stent (400) includes a first end (410) which is deformable or crushable at a lower force than a second end. The crushable firs end (410) and more rigid second end (412) of the bifurcation stent allow one end of the stent to remain expanded in a side branch (300) of a vessel bifurcation while the other end is easily crushed against the side wall of the main vessel into which it extends. A method of supporting a bifurcated body lumen involves delivering the bifurcation stent in an unexpanded configuration to a bifurcation in a body lumen, positioning the bifurcation stent with the distal portion substantially within a side branch vessel of the bifurcation and the proximal crushable portion substantially within the main vessel, expanding the bifurcation stent, and expanding a main vessel stent alongside the bifurcation stent, thereby crushing at least a portion of the bifurcation stent against the main vessel wall.
摘要翻译：分叉支架（400）包括第一端（410），该第一端以比第二端更低的力可变形或可压溃。分叉支架的可压溃的末端（410）和更刚性的第二端（412）允许支架的一端在血管分叉的侧支（300）中保持膨胀，而另一端容易被压在侧壁的主要船只。支撑分叉体腔的方法包括将未扩张构型的分叉支架输送到体腔中的分叉，将分叉支架与远侧部分基本上位于分叉的侧分支容器内，并将近端可压溃部分基本上位于主血管，扩张分叉支架，以及在分叉支架旁边扩张主血管支架，从而将至少一部分分叉支架压在主血管壁上。

6. 发明申请

WO2005000206A2 SYSTEM AND METHOD FOR DETECTING, DIAGNOSING, AND TREATING CARDIOVASCULAR DISEASE 审中-公开
标题翻译：用于检测，诊断和治疗心血管疾病的系统和方法
公开(公告)号：WO2005000206A2
公开(公告)日：2005-01-06
申请号：PCT/US2004/016186
申请日：2004-05-12
申请人： SAVACOR, INC. , EIGLER, Neal, L. , WHITING, James, S., Ph. D. , MANN, Brian
发明人： EIGLER, Neal, L. , WHITING, James, S., Ph. D. , MANN, Brian
IPC分类号： A61K
CPC分类号： A61N1/36564 , A61B5/021 , A61B5/02108 , A61B5/0215 , A61B5/4839 , A61B5/6882 , A61B2560/0209 , A61N1/3627 , A61N1/37247 , G06F19/00 , G06F19/3418 , G06F19/3456 , G06F19/3481 , G16H40/63
摘要： An apparatus for treating cardiovascular disease in a medical patient includes one or more sensors 155, an implantable housing 7, at least one implantable lead 402, a signal processor 157, and a signaling device 113. The sensor 155 is operable to generate a sensor signal indicative of fluid pressure within the left atrium 36 of the heart 33. The implantable housing 7 includes a cardiac rhythm management apparatus 159, such as a pacemaker or a defibrillator. The cardiac rhythm management apparatus 159 includes an electrode 204, which is operable to deliver an electrical stimulus to a location in the heart 33. The electrical stimulus is delivered based at least in part on the sensor signal. The lead 402 is coupled to the implantable housing 7, and to the electrode 204. The signal processor 157 is operable to generate a processor output indicative of a treatment, and is based at least in part on the sensor signal. The signaling device 113 is operable to generate at least two distinct treatment signais distinguishable from one another by the patient. Each signal is indicative of a différent therapeutic treatment, and is based at least in part on the processor output.
摘要翻译：用于治疗医疗患者心血管疾病的装置包括一个或多个传感器155，可植入壳体7，至少一个可植入引线402，信号处理器157和信号装置113.传感器155可操作以产生传感器信号指示心脏33的左心房36内的流体压力。可植入壳体7包括诸如起搏器或除颤器的心律管理装置159。心律管理装置159包括电极204，电极204可操作以将电刺激递送到心脏33中的位置。电刺激至少部分地基于传感器信号传送。引线402耦合到可植入壳体7和电极204.信号处理器157可操作以产生指示治疗的处理器输出，并且至少部分地基于传感器信号。信号装置113可操作以产生由患者彼此区分的至少两个不同的治疗信号。每个信号表示不同的治疗处理，并且至少部分地基于处理器输出。

7. 发明申请

WO2004028348A3 CARDIOVASCULAR ANCHORING DEVICE AND METHOD OF DEPLOYING SAME 审中-公开
标题翻译：心血管锚固装置及其相应的方法
公开(公告)号：WO2004028348A3
公开(公告)日：2004-06-17
申请号：PCT/US0330525
申请日：2003-09-26
申请人： SAVACOR INC , WARDLE JOHN L , EIGLER NEAL L
发明人： WARDLE JOHN L , EIGLER NEAL L
IPC分类号： A61B20060101 , A61B5/00 , A61B5/0215 , A61B5/04 , A61B5/042 , A61B17/00 , A61B17/064 , A61K9/22 , A61N1/05 , A61N1/37
CPC分类号： A61B5/0215 , A61B5/042 , A61B5/145 , A61B5/6882 , A61B17/064 , A61B2017/00243 , A61N1/057
摘要： An anchoring device and a delivery method thereof can effectively provide a means for securing an implant to a wall of an internal organ within a patient in a variety of clinical applications. In one embodiment, an anchoring device used to retain a cardiac pressure measurement device is provided. The device is implanted in the body by deforming it to a small cross section profile, sliding it through a low profile delivery device and ejecting from the delivery device at a targeted site. The anchoring mechanism, when ejected from the delivery device, reverts back to pre-formed configuration and engages opposite sides of an organ wall, thereby anchoring the implant in the organ wall.
摘要翻译：锚定装置及其递送方法可以有效地提供用于在多种临床应用中将植入物固定到患者内部器官的壁的装置。在一个实施例中，提供了用于保持心脏压力测量装置的锚定装置。通过将其变形成小的横截面轮廓将装置植入体内，将其通过低轮廓输送装置滑动并从目标部位的输送装置排出。当从输送装置弹出时，锚定机构回复到预先形成的构型并且接合器官壁的相对侧，从而将植入物固定在器官壁中。

8. 发明申请

WO2003098177A3 MINIMALLY INVASIVE CALIBRATION OF IMPLANTED PRESSURE TRANSDUCERS 审中-公开
公开(公告)号：WO2003098177A3
公开(公告)日：2003-11-27
申请号：PCT/US2003/015174
申请日：2003-05-14
申请人： SAVACOR, INC. , EIGLER, Neal, L. , WHITING, James, S. , MANN, Brian, M.
发明人： EIGLER, Neal, L. , WHITING, James, S. , MANN, Brian, M.
IPC分类号： A61B5/00
摘要： This invention relates generally to apparatus and methods for the calibration of implanted pressure transducers (25). It is an object of several embodiments of the present invention to provide apparatus and methods for the calibration of one or more implanted pressure transducers (25) implanted in the body of medical patients. Various embodiments of the present invention are particularly advantageous because they offer a calibration system that is less invasive than the systems currently available.

9. 发明申请

WO2006039531A2 TRANSMEMBRANE ACCESS SYSTEMS AND METHODS 审中-公开
标题翻译： TRANSMEMBRANE访问系统和方法
公开(公告)号：WO2006039531A2
公开(公告)日：2006-04-13
申请号：PCT/US2005/035256
申请日：2005-09-28
申请人： SAVACOR, INC. , WHITING, James, S. , EIGLER, Neal, L. , WARDLE, John, L. , HAFELFINGER, Werner , MANN, Brian
IPC分类号： A61M31/00
CPC分类号： A61M25/007 , A61B2017/06076 , A61M25/0041 , A61M25/005 , A61M25/0051 , A61M25/0052 , A61M25/0054 , A61M25/0067 , A61M25/0068 , A61M25/0082 , A61M25/0084 , A61M25/09 , A61M2025/0004 , A61M2025/0089
摘要： Systems and methods for penetrating a tissue membrane to gain access to a target site are disclosed. In some examples, systems and methods for accessing the left atrium from the right atrium of a patient's heart are carried out by puncturing the intra-atrial septal wall. One embodiment provides a system for transseptal cardiac access that includes a stabilizer sheath having a side port, a shaped guiding catheter configured to exit the side port and a tissue penetration member disposed within and extendable from the distal end of the guide catheter. The tissue penetration member may be configured to penetrate tissue upon rotation and may be coupled to a distal portion of a torquable shaft. In some embodiments, the stabilizer sheath and shaped guiding catheter may be moved relative to the patient's body structure and relative to each other so that a desired approach angle may be obtained for the tissue penetration member with respect to the target tissue.
摘要翻译：公开了渗透组织膜以获得进入目标部位的系统和方法。在一些实例中，通过穿刺房间隔壁来进行从患者心脏的右心房进入左心房的系统和方法。一个实施例提供了一种经心脏通道的系统，其包括具有侧端口的稳定器护套，构造成离开侧端口的成形引导导管和设置在引导导管的远端内并且可从引导导管的远端延伸的组织穿透构件。组织穿透构件可以构造成在旋转时穿透组织并且可以联接到可扭转轴的远侧部分。在一些实施例中，稳定器护套和成形引导导管可以相对于患者的身体结构相对于彼此移动，使得组织穿透构件相对于目标组织可以获得期望的接近角。

10. 发明申请

WO2005000206A3 SYSTEM AND METHOD FOR DETECTING, DIAGNOSING, AND TREATING CARDIOVASCULAR DISEASE 审中-公开
标题翻译：用于检测，诊断和治疗心血管疾病的系统和方法
公开(公告)号：WO2005000206A3
公开(公告)日：2005-04-07
申请号：PCT/US2004016186
申请日：2004-05-12
申请人： SAVACOR INC , EIGLER NEAL L , WHITING JAMES S PH D , MANN BRIAN
发明人： EIGLER NEAL L , WHITING JAMES S PH D , MANN BRIAN
IPC分类号： A61B5/0215 , A61N1/362 , A61N1/365
CPC分类号： A61N1/36564 , A61B5/021 , A61B5/02108 , A61B5/0215 , A61B5/4839 , A61B5/6882 , A61B2560/0209 , A61N1/3627 , A61N1/37247 , G06F19/3418 , G06F19/3456 , G06F19/3481 , G16H40/63
摘要： An apparatus for treating cardiovascular disease in a medical patient includes one or more sensors (155), an implantable housing (7), at least one implantable lead (10), a signal processor (157), and a signaling device (166). The sensor (155) is operable to generate a sensor signal indicative of fluid pressure within the left atrium (36) of the heart (33). The implantable housing (7) includes a cardiac rhythm management apparatus (159), such as a pacemaker or a defibrillator. The cardiac rhythm management apparatus (159) includes an electrode (15), which is operable to deliver an electrical stimulus to a location in the heart (33). The electrical stimulus is delivered based at least in part on the sensor signal. The lead (10) is coupled to the implantable housing (7), and to the electrode (14). The signal processor (157) is operable to generate a processor output indicative of a treatment, and is based at least in part on the sensor signal. The signaling device (166) is operable to generate at least two distinct treatment signais distinguishable from one another by the patient. Each signal is indicative of a différent therapeutic treatment, and is based at least in part on the processor output.
摘要翻译：用于治疗医疗患者心血管疾病的装置包括一个或多个传感器（155），可植入壳体（7），至少一个可植入引线（10），信号处理器（157）和信号装置（166）。传感器（155）可操作以产生指示心脏（33）的左心房（36）内的流体压力的传感器信号。可植入壳体（7）包括心律管理装置（159），例如起搏器或去纤颤器。心律管理装置（159）包括电极（15），其可操作以将电刺激递送到心脏（33）中的位置。至少部分地基于传感器信号传送电刺激。引线（10）耦合到可植入壳体（7）和电极（14）。信号处理器（157）可操作以产生指示处理的处理器输出，并且至少部分地基于传感器信号。信号装置（166）可操作以产生由患者彼此区分的至少两个不同的治疗信号。每个信号表示不同的治疗处理，并且至少部分地基于处理器输出。

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