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1. 发明申请

WO2018033725A1 AN IMPLANT FOR REPAIR OF BONE DEFECTS 审中-公开
标题翻译：种植体修复骨缺损
公开(公告)号：WO2018033725A1
公开(公告)日：2018-02-22
申请号：PCT/GB2017/052408
申请日：2017-08-16
申请人： FITZBIONICS LIMITED
发明人： FITZPATRICK, Noel , MESWANIA, Jayantilal , BLUNN, Gordon
IPC分类号： A61B17/80 , A61B17/68 , A61F2/28 , A61L27/38 , A61B17/00
CPC分类号： A61F2/2846 , A61B17/68 , A61B17/8061 , A61B2017/00004 , A61F2/28 , A61F2002/2835 , A61F2002/30011 , A61F2002/30433 , A61F2002/30462 , A61F2002/30578 , A61F2002/30677 , A61F2002/307 , A61F2002/30774 , A61F2002/30962 , A61L27/06 , A61L27/56 , A61L31/005 , A61L31/041 , A61L31/044 , A61L31/06 , A61L31/16 , A61L2300/404 , A61L2300/406 , A61L2300/64 , A61L2430/02 , C08L67/04 , C08L89/06 , C08L5/08
摘要： An implant (10) for repairing a segmental defect in a subject's bone at a segmental defect site, the implant comprising a scaffold (20) for implantation at the segmental defect site and the implant optionally comprising: a plate for internal fixation, the plate being attachable to or integral with the scaffold, and the plate having means for securing it to bone outside of the segmental defect site; a hollow cavity within the scaffold; a plurality of longitudinal channels within the scaffold; and or a membrane received around the scaffold.
摘要翻译：（10），用于在节段性缺损部位修复受治疗者骨中的节段性缺损，所述植入物包括用于植入所述节段性缺损部位的支架（20），并且所述植入物可选地包括：用于内部固定的板，所述板可附接到所述支架或与所述支架整合，并且所述板具有用于将所述板固定到所述节段性缺损部位外部的骨骼的装置; 脚手架内的空腔; 支架内的多个纵向通道; 和/或接受支架周围的膜。

2. 发明申请

WO2017161080A1 ORGAN ENCLOSURES FOR INHIBITING TUMOR INVASION AND DETECTING ORGAN PATHOLOGY 审中-公开
标题翻译：用于抑制肿瘤侵袭和检测器官病理的器官外壳
公开(公告)号：WO2017161080A1
公开(公告)日：2017-09-21
申请号：PCT/US2017/022644
申请日：2017-03-16
申请人： RUGART, Eric, S.
发明人： RUGART, Eric, S.
IPC分类号： A61F2/00 , A61F2/02 , A61K35/12
CPC分类号： A61B17/42 , A61B5/02 , A61B5/026 , A61B5/055 , A61B5/4325 , A61B10/02 , A61B17/00234 , A61B17/12 , A61B17/12031 , A61B17/12099 , A61B17/12131 , A61B90/39 , A61B2017/00088 , A61B2017/00287 , A61B2017/00477 , A61B2017/00876 , A61B2017/00893 , A61B2090/0816 , A61B2090/3966 , A61F2/0063 , A61F2/04 , A61K35/35 , A61K35/44 , A61L31/005 , A61L31/14
摘要： An enclosure provides a prophylactic barrier that may be permeable to gases, hormones, proteins, and peritoneal fluid, but restrains tumor cells within the enclosure so as to inhibit ovarian cancer invasion of adjacent tissue, and increase the speed of diagnosis of ovarian dysplasia, including cancer. The enclosure includes one or more of fiducial markers, heat sensors, and blood flow reflectors, which may be imaged non-invasively in order to detect conditions or pathology affecting the ovary. The enclosure may also include an access port that permits sampling of the enclosure's contents to further aid in detecting or treating conditions or pathology affecting the ovary.
摘要翻译：外壳提供了可以透过气体，激素，蛋白质和腹膜液的预防性屏障，但抑制封闭体内的肿瘤细胞以抑制卵巢癌侵袭邻近组织，并增加包括癌症在内的卵巢发育不良的诊断速度。外壳包括基准标记，热传感器和血流反射器中的一个或多个，其可以被非侵入性地成像以便检测影响卵巢的状况或病理。外壳还可以包括进入口，其允许取样外壳的内容物以进一步帮助检测或治疗影响卵巢的病症或病状。

3. 发明申请

WO2017132405A1 PLIABLE SILK MEDICAL DEVICE 审中-公开
标题翻译：彩色丝绸医疗器械
公开(公告)号：WO2017132405A1
公开(公告)日：2017-08-03
申请号：PCT/US2017/015175
申请日：2017-01-26
申请人： SOFREGEN MEDICAL IRELAND LIMITED
发明人： MORTARINO, Enrico , AKERS, Jessica, L. , PATEL, Kantilal, N.
IPC分类号： A61F2/00 , A61F2/12 , A61L27/22
CPC分类号： A61L31/047 , A61F2/0059 , A61F2/0063 , A61F2/12 , A61F2002/0068 , A61L31/005 , D04B21/12 , D10B2211/04 , D10B2509/08
摘要： An implantable, pliable silk device (e.g., in a form of a knitted mesh) for use in human soft tissue support and/or repair that provides stretch or pliable properties, e.g., multi-directional elongation properties. Such a device permits physicians or users to alter or manipulate the device dimension and/or shape at the time of device implantation, thereby permitting the device to conform to the contour of a target area or tissue more easily and providing more precise positioning of the device over the target area or tissue. In some embodiments, the implantable pliable silk device comprises a knit pattern feature that substantially prevents unraveling and preserves the stability of the mesh when cut. For example, the pliable silk device is a knitted mesh comprising at least two yarns laid in a knit direction and engaging each other to define a plurality of nodes.
摘要翻译：可用于人体软组织支撑和/或修复的可植入的柔韧丝绸装置（例如，以针织网的形式），其提供拉伸或柔韧特性，例如多向拉伸特性。这样的装置允许医师或使用者在装置植入时改变或操纵装置尺寸和/或形状，由此允许装置更容易地符合目标区域或组织的轮廓，并提供装置的更精确定位在目标区域或组织上。在一些实施例中，可植入柔韧丝绸装置包括编织图案特征，该编织图案特征基本上防止了散开并且在切割时保持网片的稳定性。例如，柔韧丝绸装置是包括至少两根沿编织方向铺设并相互接合以限定多个节点的纱线的针织网。

4. 发明申请

WO2017015421A1 COMPLIANCE CONTROL STITCHING IN SUBSTRATE MATERIALS 审中-公开
标题翻译：衬底材料中的合格控制缝合
公开(公告)号：WO2017015421A1
公开(公告)日：2017-01-26
申请号：PCT/US2016/043240
申请日：2016-07-21
申请人： TELA BIO, INC.
发明人： GREENHALGH, Skott , ROMANO, John-Paul
IPC分类号： A61F2/00
CPC分类号： A61F2/0063 , A61F2/00 , A61F2002/0068 , A61F2210/0004 , A61F2210/0057 , A61F2210/0076 , A61F2250/0018 , A61F2250/0028 , A61F2250/0029 , A61F2250/003 , A61L31/005 , A61L31/048 , A61L31/146 , A61L2430/34 , D05B93/00 , D05C17/00
摘要： Compliance control stitch patterns sewn or embroidered into biotextile or medical textile substrates impart reinforcing strength, and stretch resistance and control into such substrates. Compliance control stitch patterns may be customizable to particular patients, substrate implantation sites, particular degenerative or diseased conditions, or desired time frames. Substrates having compliance control stitch patterns sewn or embroidered into them may be used in tissue repair or tissue reconstruction applications.
摘要翻译：缝合或绣成生物纺织品或医用纺织品基材的合规性控制针迹图案赋予增强强度，并且对这些基材进行拉伸和控制。适应性控制针迹图案可以针对特定患者，底物植入部位，特定退行性疾病或病变状况或期望的时间框架进行定制。具有缝合或绣在其中的顺应性控制缝合图案的基底可用于组织修复或组织重建应用。

5. 发明申请

WO2016094283A1 TISSUE REPAIR IMPLANTS AND METHODS FOR MAKING AND USING SAME 审中-公开
标题翻译：组织修复植入物及其制造和使用方法
公开(公告)号：WO2016094283A1
公开(公告)日：2016-06-16
申请号：PCT/US2015/064227
申请日：2015-12-07
申请人： VISCUS BIOLOGICS, LLC
发明人： GINGRAS, Peter , PRIEST, Robert M.
IPC分类号： A61F2/02 , A61L31/00
CPC分类号： A61F2/0063 , A61F2002/0068 , A61F2210/0076 , A61F2250/003 , A61F2250/0051 , A61L31/005 , A61L31/10 , C08L89/06
摘要： One aspect of the present disclosure relates to a tissue repair implant comprising a first layer of extracellular matrix and a second support layer of biocompatible material securely attached to the first layer at one or more fixation points. At least one of the fixation points comprises a first projection that is associated with the first layer and securely attached, via a fixation mechanism, to the second support layer.
摘要翻译：本公开的一个方面涉及一种组织修复植入物，其包含细胞外基质的第一层和在一个或多个固定点处牢固地附着到第一层的生物相容性材料的第二支撑层。至少一个固定点包括与第一层相关联的第一突起，并经由固定机构牢固地附接到第二支撑层。

6. 发明申请

WO2014187783A1 VERWENDUNG EINES ISOLIERTEN KOLLAGENHALTIGEN FLÄCHENGEBILDES ZUR HERSTELLUNG EINER FLÄCHIGEN ADHÄSIONSBARRIERE 审中-公开
标题翻译：使用隔离KOLLAGEN CONTAINING片生产表面粘连屏障
公开(公告)号：WO2014187783A1
公开(公告)日：2014-11-27
申请号：PCT/EP2014/060258
申请日：2014-05-19
申请人： BAUMGARTNER, Ludwig
发明人： BAUMGARTNER, Ludwig
IPC分类号： A61L31/04 , A61L31/08 , A61L31/10 , A61F2/00 , A61C8/02
CPC分类号： A61L31/044 , A61F2/0063 , A61F13/00012 , A61F2002/009 , A61L31/005 , A61L31/088 , A61L31/10
摘要： Die vorliegende Erfindung betrifft die Verwendung eines isolierten kollagenhaltigen Flächengebildes zur Herstellung einer flächigen Adhäsionsbarriere.
摘要翻译：本发明涉及使用一个分离的胶原片状材料的用于制造片状粘连屏障。

7. 发明申请

WO2014015274A9 METHODS FOR TISSUE PASSIVATION 审中-公开
标题翻译：组织松动的方法
公开(公告)号：WO2014015274A9
公开(公告)日：2014-04-17
申请号：PCT/US2013051333
申请日：2013-07-19
申请人： GEN HOSPITAL CORP
发明人： AUSTEN WILLIAM G , MC CORMACK MICHAEL , REDMOND ROBERT W , KOCHEVAR IRENE E
IPC分类号： A61L27/50 , A61F2/07 , A61L27/14 , A61N5/06
CPC分类号： A61F2/06 , A61K41/0057 , A61L27/3604 , A61L27/3633 , A61L27/50 , A61L27/505 , A61L27/54 , A61L31/005 , A61L31/14 , A61L31/16 , A61L2300/418 , A61L2300/424 , A61L2300/442 , A61L2400/18 , A61L2430/04 , A61L2430/22 , A61L2430/34 , A61N5/0601 , A61N5/0603 , A61N5/062 , A61N5/0624
摘要： Methods of tissue passivation are described herein for use in preserving normal tissue architecture, reducing post-surgical inflammation, and reducing or preventing the development of pathogenic collagen bundles and adhesions following surgical procedures (e.g., grafting, implanting).
摘要翻译：本文描述了用于保护正常组织结构，减少手术后炎症以及减少或预防外科手术（例如移植，植入）后致病性胶原束和粘连的发展的组织钝化方法。

8. 发明申请

WO2014028328A1 DEHYDRATION DEVICE AND METHODS FOR DRYING BIOLOGICAL MATERIALS 审中-公开
标题翻译：脱水装置和干燥生物材料的方法
公开(公告)号：WO2014028328A1
公开(公告)日：2014-02-20
申请号：PCT/US2013/054325
申请日：2013-08-09
申请人： MIMEDX GROUP INC.
发明人： PRINGLE, Douglas , LEPEAK, Michael
IPC分类号： G01N1/28 , G01N33/48
CPC分类号： A61K35/50 , A01N1/0284 , A61F2/02 , A61K9/0019 , A61K9/14 , A61K45/06 , A61K47/02 , A61L26/0057 , A61L27/36 , A61L29/005 , A61L31/005 , F26B21/004 , A61K2300/00
摘要： This invention relates generally to a dehydration device and methods for drying biological materials to produce dried biological materials having enhanced structural properties. More specifically, the invention relates to a dehydration device and related methods for drying biological tissue to produce enhanced tissue grafts.
摘要翻译：本发明一般涉及脱水装置和用于干燥生物材料以产生具有增强的结构特性的干燥生物材料的方法。更具体地，本发明涉及脱水装置和用于干燥生物组织以产生增强的组织移植物的相关方法。

9. 发明申请

WO2014028325A1 PLACENTAL TISSUE GRAFTS MODIFIED WITH A CROSS-LINKING AGENT AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：用交联剂修饰的特殊组织接头及其制造方法和使用方法
公开(公告)号：WO2014028325A1
公开(公告)日：2014-02-20
申请号：PCT/US2013/054319
申请日：2013-08-09
申请人： MIMEDX GROUP INC.
发明人： DANIEL, John , SPENCER, Randall , MORSE, Brenda , KOOB, Thomas, J. , SITH, Somaly
IPC分类号： A61L27/38 , A61L27/54 , A61F2/20 , C12N5/07
CPC分类号： A61L27/50 , A61L27/3604 , A61L27/3675 , A61L27/3687 , A61L31/005 , A61L2400/02 , A61L2430/10 , A61L2430/14 , A61L2430/16 , A61L2430/40
摘要： Described herein are tissue grafts derived from the placenta that possess good adhesion to biological tissues and are useful in would healing applications. In one aspect, the tissue graft includes (1) two or more layers of amnion, wherein at least one layer of amnion is cross-linked, (2) two or more layers of chorion, wherein at least one layer of chorion is cross-linked, or (3) one or more layers of amnion and chorion, wherein at least one layer of amnion and/or chorion is cross-linked. In another aspect, the grafts are composed of amnion and chorion cross-linked with one another. In a further aspect, the grafts have one or more layers sandwiched between the amnion and chorion membranes. The amnion and/or the chorion are treated with a cross-linking agent prior to the formation of the graft. The presence of the cross-linking agent present on the graft also enhances adhesion to the biological tissue of interest. Also described herein are methods for making and using the tissue grafts.
摘要翻译：本文描述了衍生自胎盘的组织移植物，其对生物组织具有良好的粘附性并且可用于治愈应用。在一个方面，组织移植物包括（1）两层或更多层羊膜，其中至少一层羊膜交联，（2）两层或多层绒毛膜，其中至少一层绒毛层是交叉层，连接或（3）一层或多层羊膜和绒毛膜，其中至少一层羊膜和/或绒毛膜交联。另一方面，移植物由彼此交联的羊膜和绒毛膜组成。在另一方面，移植物具有夹在羊膜和绒毛膜之间的一层或多层。在形成移植物之前，用交联剂处理羊膜和/或绒毛膜。存在于移植物上的交联剂的存在也增强了对感兴趣的生物组织的粘附。本文还描述了用于制造和使用组织移植物的方法。

10. 发明申请

WO2014015274A1 METHODS FOR TISSUE PASSIVATION 审中-公开
标题翻译：方法组织钝化
公开(公告)号：WO2014015274A1
公开(公告)日：2014-01-23
申请号：PCT/US2013/051333
申请日：2013-07-19
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： AUSTEN, William, G. , MC CORMACK, Michael , REDMOND, Robert, W. , KOCHEVAR, Irene, E.
IPC分类号： A61L27/50 , A61L27/14 , A61N5/06 , A61F2/07
CPC分类号： A61F2/06 , A61K41/0057 , A61L27/3604 , A61L27/3633 , A61L27/50 , A61L27/505 , A61L27/54 , A61L31/005 , A61L31/14 , A61L31/16 , A61L2300/418 , A61L2300/424 , A61L2300/442 , A61L2400/18 , A61L2430/04 , A61L2430/22 , A61L2430/34 , A61N5/0601 , A61N5/0603 , A61N5/062 , A61N5/0624
摘要： Methods of tissue passivation are described herein for use in preserving normal tissue architecture, reducing post-surgical inflammation, and reducing or preventing the development of pathogenic collagen bundles and adhesions following surgical procedures (e.g., grafting, implanting).
摘要翻译：组织钝化的方法在本文中描述用于保存正常组织结构，减少手术后炎症，以及减少或防止外科手术后的病原性胶原蛋白束和粘连的发展（例如移植，植入）。

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