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1. 发明申请

WO2006034036A1 FLUORESCENT DYE COMPOUNDS, CONJUGATES AND USES THEREOF 审中-公开
标题翻译：荧光染料化合物，结合物及其用途
公开(公告)号：WO2006034036A1
公开(公告)日：2006-03-30
申请号：PCT/US2005/033174
申请日：2005-09-16
申请人： APPLERA CORPORATION , GRAHAM, Ronald J. , ZOU, Ruiming , UPADHYA, Krishna G. , BENSON, Scott C.
发明人： GRAHAM, Ronald J. , ZOU, Ruiming , UPADHYA, Krishna G. , BENSON, Scott C.
IPC分类号： C09K11/06 , C12Q1/68 , C09B15/00 , C07D219/04
CPC分类号： C07H21/00 , C07D219/06 , C09B15/00 , C09K11/06 , C09K2211/1011 , C09K2211/1029 , C12Q1/6816 , C12Q1/6869 , G01N33/582 , Y10S436/80 , Y10T436/143333
摘要： The present teachings generally relate to fluorescent dyes, linkable forms of fluorescent dyes, energy transfer dyes, reagents labeled with fluorescent dyes and uses thereof.
摘要翻译：本教导通常涉及荧光染料，荧光染料的可连接形式，能量转移染料，用荧光染料标记的试剂及其用途。

2. 发明申请

WO2006031851A1 MULTI-CHROMOPHORIC QUENCHER CONSTRUCTS FOR USE IN HIGH SENSITIVITY ENERGY TRANSFER PROBES 审中-公开
标题翻译：用于高灵敏度能量转移探测器的多色猝发器结构
公开(公告)号：WO2006031851A1
公开(公告)日：2006-03-23
申请号：PCT/US2005/032659
申请日：2005-09-14
申请人： APPLERA CORPORATION , BENSON, Scott, C. , MENCHEN, Steven, M. , UPADHYA, Krishna, G.
发明人： BENSON, Scott, C. , MENCHEN, Steven, M. , UPADHYA, Krishna, G.
IPC分类号： G01N33/542
CPC分类号： C07C245/08 , C07C50/18 , C07D311/90 , C07H21/00 , C07H21/04 , C09B6/00 , C09B11/08 , C09B33/02 , C09B35/021 , C09B35/50 , G01N33/542
摘要： Dark quencher constructs, termed "multi-chromophoric quenchers" are described herein that comprise at least two dark quenching moieties, which can be the same or different, linked together by at least owe multivalent linking moiety. The structure of the multi-chromophoric quenchers can be varied to selectively enhance quenching within a specific range of reporter emission wavelengths. This can be accomplished by linking together, into a single molecule, two or more identical quenchers, by reacting the quenchers with a multivalent tinker. The structure of the multi-chromophoric quencher can 0lso be varied to quench a broader range of reporter emission' wavelengths than previously possible. This can be accomplished by linking together, into a single molecule, two or more different quenchers, by reacting the quenchers with a multivalent linker. The structure of the multi-chromophoric quencher can also be varied to simultaneously broaden the absorption range and increase the total absorption within the absorption range. This can be done by combining the two concepts described above. In other words, multiple types of quenching moieties can be employed to increase the absorption range and a multiple number of each type of quenching moiety can be used to increase the total absorptivity within the absorption range. The multi-chromophoric quenchers can be tethered to probes for biomolecules, insoluble supports and/or fluorescent dyes for use in a wide variety of biomolecular assays.
摘要翻译：本文描述了称为“多发色猝灭剂”的暗猝灭剂构建体，其包含至少两个可由相同或不同的至少两个猝灭部分，通过至少多余的多价连接部分连接在一起。可以改变多发色猝灭剂的结构以选择性地增强在特定范围的报道发射波长内的猝灭。这可以通过将猝灭剂与多价修补剂反应来连接在一起成为单个分子，两个或多个相同的猝灭剂来实现。多发色猝灭剂的结构也可以改变，以猝灭比之前可能的更广泛的报告基因发射波长。这可以通过将猝灭剂与多价连接体反应来连接在一起成为单个分子，两个或多个不同的猝灭剂。多发色猝灭剂的结构也可以改变，以同时扩大吸收范围并增加吸收范围内的总吸收。这可以通过组合上述两个概念来完成。换句话说，可以使用多种类型的淬灭部分来增加吸收范围，并且可以使用多个每种类型的淬灭部分来增加吸收范围内的总吸收率。多发色猝灭剂可以束缚于用于生物分子，不溶性支持物和/或荧光染料的探针，用于各种各样的生物分子测定。

3. 发明申请

WO2004101709A1 PHENYL XANTHENE DYES 审中-公开
标题翻译：苯尼辛
公开(公告)号：WO2004101709A1
公开(公告)日：2004-11-25
申请号：PCT/US2004/013801
申请日：2004-05-04
申请人： APPLERA CORPORATION , LAM, Joe, Y., L. , MENCHEN, Steven, M. , RUIMING, Zou , BENSON, Scott, C.
发明人： LAM, Joe, Y., L. , MENCHEN, Steven, M. , RUIMING, Zou , BENSON, Scott, C.
IPC分类号： C09K11/06
CPC分类号： C09B11/24 , C07D311/82 , C07D491/14 , C09B11/06 , C09B11/12 , C09B11/22 , C09B11/26 , C09B13/00 , C09B57/00 , C09B62/0025
摘要： Fluorescent phenyl xanthene dyes are described that comprise any fluorescein, rhodamine or rhodol comprising a particular C9 phenyl ring. One or both of the ortho groups on the lower C9 phenyl ring is ortho substituted with a group selected from alkyl, heteroalkyl, alkoxy, halo, haloalkyl, amino, mercapto, alkylthio, cyano, isocyano, cyanato, mercaptocyanato, nitroso, nitro, azido, sulfeno, sulfinyl, and sulfino. In one embodiment, halo and/or hydroxy groups are used. Optimal dyes contain a lower C9 phenyl ring in which both ortho groups are the same and the lower ring exhibits some form a symmetry relative to an imaginary axis running from the phenyl rings point of attachment to the remainder of the xanthene dye through a point para to the point of attachment. The phenyl xanthene dyes may be activated. Furthermore, the phenyl xanthene dyes may be conjugated to one or more substances including other dyes. The phenyl xanthene dyes are useful for a number of purposes, including labels for use in automated DNA sequencing as well the formation of fluorescent "bar codes" for polymeric particles used in the multiplexed analysis of analytes.
摘要翻译：描述了包含任何包含特定C 9苯环的任何荧光素，罗丹明或rhodol的荧光苯基呫吨染料。低级C 9苯环上的一个或两个原子基团被选自烷基，杂烷基，烷氧基，卤素，卤代烷基，氨基，巯基，烷硫基，氰基，异氰基，氰基，巯基氰基，亚硝基，硝基，叠氮基，磺酰亚胺基，亚磺酰基和亚磺酰基。在一个实施方案中，使用卤素和/或羟基。最佳染料含有较低的C 9苯环，其中两个邻基团相同，并且下环表现出相对于从苯环连接点到呫吨染料的其余部分的假想轴的对称性。附件点。苯基呫吨染料可以被活化。此外，苯基呫吨染料可以与一种或多种包括其它染料的物质共轭。苯基呫吨染料可用于许多目的，包括用于自动DNA测序的标记，以及用于分析物复用分析中使用的聚合物颗粒的荧光“条形码”。

4. 发明申请

WO2007115265A3 REAGENTS USEFUL FOR SYNTHESIZING RHODAMINE-LABELED OLIGONUCLEOTIDES 审中-公开
标题翻译：用于合成罗丹明标记的寡核苷酸的试剂
公开(公告)号：WO2007115265A3
公开(公告)日：2008-01-17
申请号：PCT/US2007065798
申请日：2007-04-02
申请人： APPLERA CORP , BENSON SCOTT C , ZOU RUIMING N , UPADHYA KRISHNA G , KENNEY PAUL M , CASSEL JONATHAN M
发明人： BENSON SCOTT C , ZOU RUIMING N , UPADHYA KRISHNA G , KENNEY PAUL M , CASSEL JONATHAN M
IPC分类号： C07D405/00
CPC分类号： C07F9/6561 , C07D311/96 , C07F9/2408 , C07F9/242 , C07F9/650958 , C07F9/65312 , C07F9/65515 , C07H19/04 , C07H21/04 , C09B11/24
摘要： The present disclosure provides reagents that can be used to label synthetic oligonucleotides with rhodamin
摘要翻译：本公开提供可用于用罗丹明标记合成的寡核苷酸的试剂

5. 发明申请

WO2007115265A2 REAGENTS USEFUL FOR SYNTHESIZING RHODAMINE-LABELED OLIGONUCLEOTIDES 审中-公开
标题翻译：用于合成罗丹明标记的寡核苷酸的试剂
公开(公告)号：WO2007115265A2
公开(公告)日：2007-10-11
申请号：PCT/US2007/065798
申请日：2007-04-02
申请人： APPLERA CORPORATION , BENSON, Scott, C. , ZOU, Ruiming, N. , UPADHYA, Krishna, G. , KENNEY, Paul, M. , CASSEL, Jonathan, M.
发明人： BENSON, Scott, C. , ZOU, Ruiming, N. , UPADHYA, Krishna, G. , KENNEY, Paul, M. , CASSEL, Jonathan, M.
IPC分类号： C07H21/04
CPC分类号： C07F9/6561 , C07D311/96 , C07F9/2408 , C07F9/242 , C07F9/650958 , C07F9/65312 , C07F9/65515 , C07H19/04 , C07H21/04 , C09B11/24
摘要： The present disclosure provides reagents that can be used to label synthetic oligonucleotides with rhodamine dyes or dye networks that contain rhodamine dyes.
摘要翻译：本公开提供可用于使用含有罗丹明染料的罗丹明染料或染料网络来标记合成寡核苷酸的试剂。

6. 发明申请

WO2004101708A1 FLUORESCENT POLYMERIC MATERIALS CONTAINING LIPID SOLUBLE RHODAMINE DYES 审中-公开
标题翻译：含有可溶性罗丹明染色体的荧光聚合材料
公开(公告)号：WO2004101708A1
公开(公告)日：2004-11-25
申请号：PCT/US2004/013798
申请日：2004-05-04
申请人： APPLERA CORPORATION , LAM, Joe, Y.L. , MENCHEN, Steven, M. , RUIMING, Zou , BENSON, Scott, C.
发明人： LAM, Joe, Y.L. , MENCHEN, Steven, M. , RUIMING, Zou , BENSON, Scott, C.
IPC分类号： C09K11/06
CPC分类号： C09K11/025 , C07D311/80 , C09B11/24 , C09B67/0092 , C09B67/0097 , C09B69/103 , C09K11/06 , C09K2211/1088 , C09K2211/1416 , C09K2211/145
摘要： Fluorescent polymeric materials are disclosed comprising a polymer and one or more lipid soluble rhodamine dyes. The materials are especially useful in the preparation of multicolored microparticles, especially multicolored polystyrene microparticle, for use in the multiplexed analysis of a plurality of analytes in a single sample. When excited by a light source, the materials give off a unique emission based on the nature, concentration and ratio of the dyes therein. Methods of preparing and using said materials are also disclosed.
摘要翻译：公开了包含聚合物和一种或多种脂溶性罗丹明染料的荧光聚合物材料。这些材料在制备多彩色微粒，特别是多色聚苯乙烯微粒中是特别有用的，用于在单个样品中多个分析物的多重分析。当被光源激发时，材料基于其中染料的性质，浓度和比例发出独特的发射。还公开了制备和使用所述材料的方法。

7. 发明申请

WO2012092403A1 DDAO COMPOUNDS AS FLUORESCENT REFERENCE STANDARDS 审中-公开
标题翻译： DDAO化合物作为荧光参考标准
公开(公告)号：WO2012092403A1
公开(公告)日：2012-07-05
申请号：PCT/US2011/067680
申请日：2011-12-28
申请人： LIFE TECHNOLOGIES CORPORATION , BENSON, Scott C. , MONIGHETTI, Cinna , KOEPF, Sandy M.
发明人： BENSON, Scott C. , MONIGHETTI, Cinna , KOEPF, Sandy M.
IPC分类号： C12Q1/68 , C09B15/00
CPC分类号： C12Q1/6818 , C09B15/00 , C12Q1/6844 , C12Q1/6851 , C12Q2527/125 , C12Q2545/101 , C12Q2561/113 , C12Q2563/107
摘要： According to the present teachings, methods and compositions are provided that utilize at least one reference dye of formula (I): In some embodiments, a method comprises measuring a detection signal of a reporter dye and at least one reference dye of formula (I). In some embodiments, a composition comprises a reference dye of formula (1), a buffer, a selection of nucleotides and a protein.
摘要翻译：根据本教导，提供利用至少一种式（I）的参考染料的方法和组合物：在一些实施方案中，一种方法包括测量报道染料和至少一种式（I）的参考染料的检测信号，。在一些实施方案中，组合物包含式（1）的参考染料，缓冲液，核苷酸和蛋白质的选择。

8. 发明申请

WO2007115265A9 REAGENTS USEFUL FOR SYNTHESIZING RHODAMINE-LABELED OLIGONUCLEOTIDES 审中-公开
标题翻译：用于合成罗丹明标记的寡核苷酸的试剂
公开(公告)号：WO2007115265A9
公开(公告)日：2007-11-29
申请号：PCT/US2007065798
申请日：2007-04-02
申请人： APPLERA CORP , BENSON SCOTT C , ZOU RUIMING N , UPADHYA KRISHNA G , KENNEY PAUL M , CASSEL JONATHAN M
发明人： BENSON SCOTT C , ZOU RUIMING N , UPADHYA KRISHNA G , KENNEY PAUL M , CASSEL JONATHAN M
IPC分类号： C07H21/04
CPC分类号： C07F9/6561 , C07D311/96 , C07F9/2408 , C07F9/242 , C07F9/650958 , C07F9/65312 , C07F9/65515 , C07H19/04 , C07H21/04 , C09B11/24
摘要： The present disclosure provides reagents that can be used to label synthetic oligonucleotides with rhodamin
摘要翻译：本公开提供可用于用罗丹明标记合成的寡核苷酸的试剂

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