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1. 发明申请

WO2006034036A1 FLUORESCENT DYE COMPOUNDS, CONJUGATES AND USES THEREOF 审中-公开
标题翻译：荧光染料化合物，结合物及其用途
公开(公告)号：WO2006034036A1
公开(公告)日：2006-03-30
申请号：PCT/US2005/033174
申请日：2005-09-16
申请人： APPLERA CORPORATION , GRAHAM, Ronald J. , ZOU, Ruiming , UPADHYA, Krishna G. , BENSON, Scott C.
发明人： GRAHAM, Ronald J. , ZOU, Ruiming , UPADHYA, Krishna G. , BENSON, Scott C.
IPC分类号： C09K11/06 , C12Q1/68 , C09B15/00 , C07D219/04
CPC分类号： C07H21/00 , C07D219/06 , C09B15/00 , C09K11/06 , C09K2211/1011 , C09K2211/1029 , C12Q1/6816 , C12Q1/6869 , G01N33/582 , Y10S436/80 , Y10T436/143333
摘要： The present teachings generally relate to fluorescent dyes, linkable forms of fluorescent dyes, energy transfer dyes, reagents labeled with fluorescent dyes and uses thereof.
摘要翻译：本教导通常涉及荧光染料，荧光染料的可连接形式，能量转移染料，用荧光染料标记的试剂及其用途。

2. 发明申请

WO2006031851A1 MULTI-CHROMOPHORIC QUENCHER CONSTRUCTS FOR USE IN HIGH SENSITIVITY ENERGY TRANSFER PROBES 审中-公开
标题翻译：用于高灵敏度能量转移探测器的多色猝发器结构
公开(公告)号：WO2006031851A1
公开(公告)日：2006-03-23
申请号：PCT/US2005/032659
申请日：2005-09-14
申请人： APPLERA CORPORATION , BENSON, Scott, C. , MENCHEN, Steven, M. , UPADHYA, Krishna, G.
发明人： BENSON, Scott, C. , MENCHEN, Steven, M. , UPADHYA, Krishna, G.
IPC分类号： G01N33/542
CPC分类号： C07C245/08 , C07C50/18 , C07D311/90 , C07H21/00 , C07H21/04 , C09B6/00 , C09B11/08 , C09B33/02 , C09B35/021 , C09B35/50 , G01N33/542
摘要： Dark quencher constructs, termed "multi-chromophoric quenchers" are described herein that comprise at least two dark quenching moieties, which can be the same or different, linked together by at least owe multivalent linking moiety. The structure of the multi-chromophoric quenchers can be varied to selectively enhance quenching within a specific range of reporter emission wavelengths. This can be accomplished by linking together, into a single molecule, two or more identical quenchers, by reacting the quenchers with a multivalent tinker. The structure of the multi-chromophoric quencher can 0lso be varied to quench a broader range of reporter emission' wavelengths than previously possible. This can be accomplished by linking together, into a single molecule, two or more different quenchers, by reacting the quenchers with a multivalent linker. The structure of the multi-chromophoric quencher can also be varied to simultaneously broaden the absorption range and increase the total absorption within the absorption range. This can be done by combining the two concepts described above. In other words, multiple types of quenching moieties can be employed to increase the absorption range and a multiple number of each type of quenching moiety can be used to increase the total absorptivity within the absorption range. The multi-chromophoric quenchers can be tethered to probes for biomolecules, insoluble supports and/or fluorescent dyes for use in a wide variety of biomolecular assays.
摘要翻译：本文描述了称为“多发色猝灭剂”的暗猝灭剂构建体，其包含至少两个可由相同或不同的至少两个猝灭部分，通过至少多余的多价连接部分连接在一起。可以改变多发色猝灭剂的结构以选择性地增强在特定范围的报道发射波长内的猝灭。这可以通过将猝灭剂与多价修补剂反应来连接在一起成为单个分子，两个或多个相同的猝灭剂来实现。多发色猝灭剂的结构也可以改变，以猝灭比之前可能的更广泛的报告基因发射波长。这可以通过将猝灭剂与多价连接体反应来连接在一起成为单个分子，两个或多个不同的猝灭剂。多发色猝灭剂的结构也可以改变，以同时扩大吸收范围并增加吸收范围内的总吸收。这可以通过组合上述两个概念来完成。换句话说，可以使用多种类型的淬灭部分来增加吸收范围，并且可以使用多个每种类型的淬灭部分来增加吸收范围内的总吸收率。多发色猝灭剂可以束缚于用于生物分子，不溶性支持物和/或荧光染料的探针，用于各种各样的生物分子测定。

3. 发明申请

WO2007100506A3 MASS TAGS FOR QUANTITATIVE ANALYSES 审中-公开
标题翻译：量词分析的质量标签
公开(公告)号：WO2007100506A3
公开(公告)日：2008-04-24
申请号：PCT/US2007003990
申请日：2007-02-15
申请人： APPLERA CORP , YAN XIONGWEI , YUAN PAU-MIAU , YUEN SYLVIA W , HSI KUO-LIANG , LAM JOE Y , UPADHYA KRISHNA G , DEY SUBHAKAR , PAPPIN DARRYL J C , PILLAI SASI , HUANG HELENA , PURKAYASTHA SUBHASISH
发明人： YAN XIONGWEI , YUAN PAU-MIAU , YUEN SYLVIA W , HSI KUO-LIANG , LAM JOE Y , UPADHYA KRISHNA G , DEY SUBHAKAR , PAPPIN DARRYL J C , PILLAI SASI , HUANG HELENA , PURKAYASTHA SUBHASISH
IPC分类号： G01N33/68 , C07D239/54 , C07D295/18 , C07K1/13
CPC分类号： C07D295/185 , C07B2200/05 , C07D239/54 , C07D239/553 , C07K5/0806 , C07K5/1013 , C07K7/06 , C07K7/08 , G01N33/6848 , G01N2458/15 , Y10T436/143333 , Y10T436/24
摘要： This invention pertains to methods, mixtures, kits and/or compositions for the determination of analytes by mass analysis using unique labeling reagents or sets of unique labeling reagents. The labeling reagents can be isomeric or isobaric and can be used to produce mixtures suitable for multiplex analysis of the labeled analytes.
摘要翻译：本发明涉及通过使用独特标记试剂或独特标记试剂组的质量分析来测定分析物的方法，混合物，试剂盒和/或组合物。标记试剂可以是异构体或同量异构体，并且可用于产生适于多重分析标记分析物的混合物。

4. 发明申请

WO2007115265A9 REAGENTS USEFUL FOR SYNTHESIZING RHODAMINE-LABELED OLIGONUCLEOTIDES 审中-公开
标题翻译：用于合成罗丹明标记的寡核苷酸的试剂
公开(公告)号：WO2007115265A9
公开(公告)日：2007-11-29
申请号：PCT/US2007065798
申请日：2007-04-02
申请人： APPLERA CORP , BENSON SCOTT C , ZOU RUIMING N , UPADHYA KRISHNA G , KENNEY PAUL M , CASSEL JONATHAN M
发明人： BENSON SCOTT C , ZOU RUIMING N , UPADHYA KRISHNA G , KENNEY PAUL M , CASSEL JONATHAN M
IPC分类号： C07H21/04
CPC分类号： C07F9/6561 , C07D311/96 , C07F9/2408 , C07F9/242 , C07F9/650958 , C07F9/65312 , C07F9/65515 , C07H19/04 , C07H21/04 , C09B11/24
摘要： The present disclosure provides reagents that can be used to label synthetic oligonucleotides with rhodamin
摘要翻译：本公开提供可用于用罗丹明标记合成的寡核苷酸的试剂

5. 发明申请

WO2007100506A2 MASS TAGS FOR QUANTITATIVE ANALYSES 审中-公开
标题翻译：量词分析的质量标签
公开(公告)号：WO2007100506A2
公开(公告)日：2007-09-07
申请号：PCT/US2007/003990
申请日：2007-02-15
申请人： APPLERA CORPORATION , YAN, Xiongwei , YUAN, Pau-Miau , YUEN, Sylvia, W. , HSI, Kuo-liang , LAM, Joe, Y. , UPADHYA, Krishna, G. , DEY, Subhakar , PAPPIN, Darryl, J.C. , PILLAI, Sasi , HUANG, Helena , PURKAYASTHA, Subhasish
发明人： YAN, Xiongwei , YUAN, Pau-Miau , YUEN, Sylvia, W. , HSI, Kuo-liang , LAM, Joe, Y. , UPADHYA, Krishna, G. , DEY, Subhakar , PAPPIN, Darryl, J.C. , PILLAI, Sasi , HUANG, Helena , PURKAYASTHA, Subhasish
CPC分类号： C07D295/185 , C07B2200/05 , C07D239/54 , C07D239/553 , C07K5/0806 , C07K5/1013 , C07K7/06 , C07K7/08 , G01N33/6848 , G01N2458/15 , Y10T436/143333 , Y10T436/24
摘要： This invention pertains to methods, mixtures, kits and/or compositions for the determination of analytes by mass analysis using unique labeling reagents or sets of unique labeling reagents. The labeling reagents can be isomeric or isobaric and can be used to produce mixtures suitable for multiplex analysis of the labeled analytes.
摘要翻译：本发明涉及通过使用独特标记试剂或独特标记试剂组的质量分析来测定分析物的方法，混合物，试剂盒和/或组合物。标记试剂可以是异构体或同量异构体，并且可用于产生适于多重分析标记分析物的混合物。

6. 发明申请

WO2007115265A3 REAGENTS USEFUL FOR SYNTHESIZING RHODAMINE-LABELED OLIGONUCLEOTIDES 审中-公开
标题翻译：用于合成罗丹明标记的寡核苷酸的试剂
公开(公告)号：WO2007115265A3
公开(公告)日：2008-01-17
申请号：PCT/US2007065798
申请日：2007-04-02
申请人： APPLERA CORP , BENSON SCOTT C , ZOU RUIMING N , UPADHYA KRISHNA G , KENNEY PAUL M , CASSEL JONATHAN M
发明人： BENSON SCOTT C , ZOU RUIMING N , UPADHYA KRISHNA G , KENNEY PAUL M , CASSEL JONATHAN M
IPC分类号： C07D405/00
CPC分类号： C07F9/6561 , C07D311/96 , C07F9/2408 , C07F9/242 , C07F9/650958 , C07F9/65312 , C07F9/65515 , C07H19/04 , C07H21/04 , C09B11/24
摘要： The present disclosure provides reagents that can be used to label synthetic oligonucleotides with rhodamin
摘要翻译：本公开提供可用于用罗丹明标记合成的寡核苷酸的试剂

7. 发明申请

WO2007115265A2 REAGENTS USEFUL FOR SYNTHESIZING RHODAMINE-LABELED OLIGONUCLEOTIDES 审中-公开
标题翻译：用于合成罗丹明标记的寡核苷酸的试剂
公开(公告)号：WO2007115265A2
公开(公告)日：2007-10-11
申请号：PCT/US2007/065798
申请日：2007-04-02
申请人： APPLERA CORPORATION , BENSON, Scott, C. , ZOU, Ruiming, N. , UPADHYA, Krishna, G. , KENNEY, Paul, M. , CASSEL, Jonathan, M.
发明人： BENSON, Scott, C. , ZOU, Ruiming, N. , UPADHYA, Krishna, G. , KENNEY, Paul, M. , CASSEL, Jonathan, M.
IPC分类号： C07H21/04
CPC分类号： C07F9/6561 , C07D311/96 , C07F9/2408 , C07F9/242 , C07F9/650958 , C07F9/65312 , C07F9/65515 , C07H19/04 , C07H21/04 , C09B11/24
摘要： The present disclosure provides reagents that can be used to label synthetic oligonucleotides with rhodamine dyes or dye networks that contain rhodamine dyes.
摘要翻译：本公开提供可用于使用含有罗丹明染料的罗丹明染料或染料网络来标记合成寡核苷酸的试剂。

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