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1. 发明申请

WO2006018682A3 OXAZOLIDINONE DERIVATIVES AS ANTIMICROBIALS 审中-公开
标题翻译：氧杂环丁酮衍生物作为抗微生物剂
公开(公告)号：WO2006018682A3
公开(公告)日：2006-07-06
申请号：PCT/IB2005002226
申请日：2005-07-27
申请人： RANBAXY LAB LTD , DAS BISWAJIT , AHMED SHAHADAT , YADAV AJAY SINGH , GHOSH SOMA , RATTAN ASHOK
发明人： DAS BISWAJIT , AHMED SHAHADAT , YADAV AJAY SINGH , GHOSH SOMA , RATTAN ASHOK
IPC分类号： C07D413/10 , A61K31/506 , A61P31/04 , C07D413/14
CPC分类号： C07D413/10 , C07D413/14
摘要： The present invention relates to certain substituted phenyl oxazolidinones and to process for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiple-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms such as Bacterioides spp. and Clostridia spp. species, and acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.
摘要翻译：本发明涉及某些取代的苯基恶唑烷酮，并涉及其合成方法。本发明还涉及含有作为抗微生物剂的本发明化合物的药物组合物。这些化合物是有用的抗微生物剂，对许多人类和兽医病原体有效，包括革兰氏阳性好氧细菌如多重耐药葡萄球菌，链球菌和肠球菌以及厌氧生物如细菌属。和梭菌属（Clostridia spp。）物种和酸性快速生物如结核分枝杆菌，鸟分枝杆菌和分枝杆菌属。

2. 发明申请

WO2006038100A1 OXAZOLIDINONE DERIVATIVES AS ANTIMICROBIALS 审中-公开
标题翻译：氧杂环丁酮衍生物作为抗微生物剂
公开(公告)号：WO2006038100A1
公开(公告)日：2006-04-13
申请号：PCT/IB2005/002971
申请日：2005-10-06
申请人： RANBAXY LABORATORIES LIMITED , DAS, Biswajit , AHMED, Shahadat , YADAV, Ajay, Singh , GHOSH, Soma , GUJRATI, Arti , SHARMA, Pankaj , RATTAN, Ashok
发明人： DAS, Biswajit , AHMED, Shahadat , YADAV, Ajay, Singh , GHOSH, Soma , GUJRATI, Arti , SHARMA, Pankaj , RATTAN, Ashok
IPC分类号： C07D413/14 , C07D263/22 , C07D417/14 , A61K31/422 , A61P31/04
CPC分类号： C07D263/22 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/14
摘要： The present invention relates to certain substituted phenyl oxazolidinones and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria, for example, multiple-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms, for example, Bacterioides spp. and Clostridia spp. species, and acid fast organisms, for example, Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp .
摘要翻译：本发明涉及某些取代的苯基恶唑烷酮及其合成方法。本发明还涉及含有作为抗微生物剂的本发明化合物的药物组合物。这些化合物是有用的抗微生物剂，对许多人和兽医病原体有效，包括革兰氏阳性好氧细菌，例如多重耐药葡萄球菌，链球菌和肠球菌，以及厌氧生物，例如细菌属。和梭菌属（Clostridia spp。）物种和酸性快速生物，例如结核分枝杆菌，鸟分枝杆菌和分枝杆菌属。

3. 发明申请

WO2006018682A2 OXAZOLIDINONE DERIVATIVES AS ANTIMICROBIALS 审中-公开
标题翻译：恶唑烷酮衍生物作为抗微生物剂
公开(公告)号：WO2006018682A2
公开(公告)日：2006-02-23
申请号：PCT/IB2005/002226
申请日：2005-07-27
申请人： RANBAXY LABORATORIES LIMITED , DAS, Biswajit , AHMED, Shahadat , YADAV, Ajay, Singh , GHOSH, Soma , RATTAN, Ashok
发明人： DAS, Biswajit , AHMED, Shahadat , YADAV, Ajay, Singh , GHOSH, Soma , RATTAN, Ashok
IPC分类号： C07D413/10 , C07D413/14 , A61K31/506 , A61P31/04
CPC分类号： C07D413/10 , C07D413/14
摘要： The present invention relates to certain substituted phenyl oxazolidinones and to process for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiple-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms such as Bacterioides spp . and Clostridia spp . species, and acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.
摘要翻译：本发明涉及某些取代的苯基恶唑烷酮并且涉及其合成方法。本发明还涉及含有本发明化合物作为抗菌剂的药物组合物。这些化合物是有用的抗微生物剂，能够有效地对抗许多人类和兽医病原体，包括革兰氏阳性好氧细菌，如多重抗性葡萄球菌，链球菌和肠球菌以及厌氧生物如杆菌属（Bacterioides spp。）。和梭菌属（Clostridia spp）。物种和酸快速生物如结核分枝杆菌，鸟分枝杆菌和分枝杆菌属物种。

4. 发明申请

WO2010142934A1 INDOLE DERIVATIVES AS LIGANDS OF CRTH2 RECEPTORS 审中-公开
标题翻译：作为CRTH2受体配体的衍生物
公开(公告)号：WO2010142934A1
公开(公告)日：2010-12-16
申请号：PCT/GB2009/050671
申请日：2009-06-12
申请人： PULMAGEN THERAPEUTICS (ASTHMA) LIMITED , HYND, George , MONTANA, John Gary , FINCH, Harry , ARIENZO, Rosa , AHMED, Shahadat
发明人： HYND, George , MONTANA, John Gary , FINCH, Harry , ARIENZO, Rosa , AHMED, Shahadat
IPC分类号： C07D209/10 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , A61P37/00 , A61K31/4439 , C07D409/06 , C07D409/14 , C07D413/06 , C07D417/06 , C07D417/14 , A61K31/4178 , A61K31/422 , A61K31/404
CPC分类号： C07D417/14 , C07D209/10 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D409/06 , C07D413/06 , C07D417/06
摘要： The following compounds are CRTH2 antagonists, useful in treatment of respiratory disease: {3-[3-chloro-4-(pyridine-2-sulfonyl)isothiazol-5-ylmethyl]-5-fluoro-2- methylindol-1-yl}acetic acid, [3-(5-benzenesulfonyl-3-methyl-3H-imidazol-4-ylmethyl)-5-fluoro-2- methylindol-1-yl]acetic acid, [3-(5-benzenesulfonyloxazol-4-ylmethyl)-5-fluoro-2-methylindol-1-yl]acetic acid, [3-(3-benzenesulfonyl-4-met ylthiophen-2-ylmethyl)-5-fluoro-2-methylindol-1- yl]acetic acid, {5-fluoro-2-methyl-3-[2-(pyridin-2-ylsulfamoyl)benzyl]indol-1-yl}acetic acid, {5-fluoro-2-methyl-3-[4-methyl-3-(pyridine-2-sulfonyl)thiophen-2- ylmethyl]indol-1-yl}acetic acid, {5-fluoro-2-methyl-3-[3-methyl-5-(pyridine-2-sulfonyl)-3H-imidazol-4- ylmethyl]indol-1-yl}acetic acid, {5-fluoro-3-[2-(3-fluorophenylsulfamoyl)pyridin-3-ylmethyl]-2-methylindol-1- yl}acetic acid, [3-(4-benzenesulfonyloxazol-5-ylmethyl)-5-fluoro-2-methylindol-1- yl]acetic acid, {3-[2-(3-cyanophenylsulfamoyl)benzyl]-5-fluoro-2-methylindol-1-yl}acetic acid, [3-(4-benzenesulfonylthiazol-5-ylmethyl)-5-chloro-2-methyl-indol-1-yl]acetic acid, [3-(4-benzenesulfonyl-2-methylthiazol-5-ylmethyl)-5-fluoro-2-methylindol-1- yl]acetic acid, and [3-(4-benzenesulfonyl-3-methylisothiazol-5-ylmethyl)-5-fluoro-2- methylindol-1-yl]acetic acid.
摘要翻译：以下化合物是可用于治疗呼吸系统疾病的CRTH2拮抗剂：{3- [3-氯-4-（吡啶-2-磺酰基）异噻唑-5-基甲基] -5-氟-2-甲基吲哚-1-基} 乙酸，[3-（5-苯磺酰基-3-甲基-3H-咪唑-4-基甲基）-5-氟-2-甲基吲哚-1-基]乙酸[3-（5-苯磺酰基恶唑-4-基甲基）-5-氟-2-甲基吲哚-1-基]乙酸，[3-（3-苯磺酰基-4-甲基噻吩-2-基甲基）-5-氟-2-甲基吲哚-1-基]乙酸， {5-氟-2-甲基-3- [2-（吡啶-2-基氨磺酰基）苄基]吲哚-1-基}乙酸{5-氟-2-甲基-3- [4-甲基-3- （吡啶-2-磺酰基）噻吩-2-基甲基]吲哚-1-基}乙酸{5-氟-2-甲基-3- [3-甲基-5-（吡啶-2-磺酰基）咪唑-4-基甲基]吲哚-1-基}乙酸，{5-氟-3- [2-（3-氟苯基氨磺酰基）吡啶-3-基甲基] -2-甲基吲哚-1-基}乙酸[3 - （4-苯磺酰氧基-5-基甲基）-5-氟-2-甲基吲哚-1-基]乙酸{3- [2-（3-氰基苯基氨磺酰基）苄基] -5-氟-2-甲基吲哚-1-基] 乙酸，[3- （4-苯磺酰基噻唑-5-基甲基）-5-氯-2-甲基 - 吲哚-1-基]乙酸[3-（4-苯磺酰基-2-甲基噻唑-5-基甲基）-5-氟-2- 甲基吲哚-1-基]乙酸和[3-（4-苯磺酰基-3-甲基异噻唑-5-基甲基）-5-氟-2-甲基吲哚-1-基]乙酸。

5. 发明申请

WO2006117762A8 ANTIMICROBIAL AGENTS 审中-公开
标题翻译：抗菌药物
公开(公告)号：WO2006117762A8
公开(公告)日：2009-03-05
申请号：PCT/IB2006051397
申请日：2006-05-03
申请人： RANBAXY LAB LTD , DAS BISWAJIT , ARORA JASBIR SINGH , AHMED SHAHADAT , BANDYOPADHYAY ANISH , KATOCH RITA , KURHADE SANTOSH HARIBHAU , RATHY SUJATA , GHOSH SOMA , KHOJE ABHIJIT DATTA , GUJRATI ARTI , UPADHYAY DILIP J
发明人： DAS BISWAJIT , ARORA JASBIR SINGH , AHMED SHAHADAT , BANDYOPADHYAY ANISH , KATOCH RITA , KURHADE SANTOSH HARIBHAU , RATHY SUJATA , GHOSH SOMA , KHOJE ABHIJIT DATTA , GUJRATI ARTI , UPADHYAY DILIP J
IPC分类号： C07D333/34 , A61K31/381
CPC分类号： C07D209/48 , C07D213/81 , C07D213/82 , C07D231/20 , C07D239/42 , C07D249/12 , C07D277/36 , C07D295/096 , C07D307/68 , C07D333/34 , C07D333/38 , C07D333/62 , C07D409/04 , C07D409/12 , C07D413/04 , C07D513/04
摘要： Provided herein are substituted aromatic compounds, which are tRNA synthetase inhibitors, and hence can be used as antimicrobial agents. Compounds described herein can be used for the treatment or prevention of a condition caused by or contributed to by gram positive, gram negative, anaerobic bacteria or fungal organisms, more particularly against bacterium, for example, Staphylococci, Enterococci, Streptococci, Haemophilus, Moraxalla, Escherichia, Chlamydia,Rickettsiae, Mycoplasm, Legionella, Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus or Enterobactericeae, and fungal organisms, for example, Aspergillus, Blastomyces, Candida, Coccidiodes,Cryptococcus, Epidermophyton, Hendersonula, Histoplasma, Microsporum, Paecilomyces, Paracoccidiodes, Pneumocystis, Trichophyton, or Trichosporium. Processes for the preparation of these compounds, pharmaceutical compositions thereof, and methods of treating microbial infections are also provided.
摘要翻译：本文提供的是取代的芳族化合物，其是tRNA合成酶抑制剂，因此可以用作抗微生物剂。本文所述的化合物可用于治疗或预防由革兰氏阳性，革兰氏阴性，厌氧菌或真菌生物引起或促成的病症，特别是针对细菌，例如葡萄球菌，肠球菌，链球菌，嗜血杆菌，莫萨拉，大肠杆菌，衣原体，立克次氏体，支原体，军团菌，分枝杆菌，幽门螺杆菌，梭菌属，拟杆菌属，棒状杆菌属，芽孢杆菌属或肠杆菌属，以及真菌生物体，例如曲霉属，布氏酵母属，假丝酵母属，椰子球菌属，隐球菌属，表皮癣菌，亨氏球菌，组织胞浆菌，，副球菌属，肺孢子虫属，毛癣菌属或Trichosporium。还提供了制备这些化合物的方法，其药物组合物和治疗微生物感染的方法。

6. 发明申请

WO2007077508A3 DERIVATIVES OF BETA-AMINO ACID AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS 审中-公开
标题翻译：作为DIPEPTIDYL PEPTIDASE-IV抑制剂的β-氨基酸的衍生物
公开(公告)号：WO2007077508A3
公开(公告)日：2007-10-25
申请号：PCT/IB2006055006
申请日：2006-12-21
申请人： RANBAXY LAB LTD , SATTIGERI JITENDRA A , AHMED SHAHADAT , ANDAPPAN MURUGAIAH M S , SETHI SACHIN , SHARMA LALIMA , PAL CHANCHAL KUMAR , KANDALKAR SACHIN RAMESH , MAHAJAN DIPAK C , KISHORE KAUSHAL , BHATIA SUMATI , GADHAVE ANIL G , BANSAL VINAY S , DAVIS JOSEPH ALEXANAND
发明人： SATTIGERI JITENDRA A , AHMED SHAHADAT , ANDAPPAN MURUGAIAH M S , SETHI SACHIN , SHARMA LALIMA , PAL CHANCHAL KUMAR , KANDALKAR SACHIN RAMESH , MAHAJAN DIPAK C , KISHORE KAUSHAL , BHATIA SUMATI , GADHAVE ANIL G , BANSAL VINAY S , DAVIS JOSEPH ALEXANAND
IPC分类号： C07D487/08 , A61K31/4468 , A61P3/10 , C07C237/20 , C07D209/44 , C07D209/52 , C07D211/58 , C07D401/12 , C07D405/12 , C07D409/12
CPC分类号： C07D409/12 , C07C237/20 , C07C2603/74 , C07D209/44 , C07D209/52 , C07D211/58 , C07D401/12 , C07D405/12 , C07D487/08
摘要： The present invention relates to ß-amino acid derivatives as dipeptidyl peptidase- IV inhibitors and the processes for the synthesis of the same. This invention also relates to pharmacological compositions containing the compounds of the present invention, and methods of treating diabetes, especially type 2 diabetes, as well as prediabetes, diabetic dyslipidemia, metabolic acidosis, ketosis, satiety disorders, and obesity. These inhibitors can also be used to treat conditions manifested by a variety of metabolic, neurological, anti-inflammatory, and autoimmune disorders like inflammatory disease, multiple sclerosis, rheumatoid arthritis; viral, cancer and gastrointestinal disorders. The compounds of this invention can also be used for treatment of infertility arising due to polycystic ovary syndrome.
摘要翻译：本发明涉及作为二肽基肽酶-IV抑制剂的β-氨基酸衍生物及其合成方法。本发明还涉及含有本发明化合物的药物组合物，以及治疗糖尿病，特别是2型糖尿病以及糖尿病前期，糖尿病性血脂异常，代谢性酸中毒，酮症，饱腹感和肥胖症的方法。这些抑制剂也可用于治疗由各种代谢，神经，抗炎和自身免疫性疾病如炎症性疾病，多发性硬化症，类风湿性关节炎，病毒，癌症和胃肠道疾病。本发明的化合物也可用于治疗由于多囊卵巢综合征引起的不育症。

7. 发明申请

WO2011092671A1 PROLINE DERIVATIVES FOR USE IN THE TREATMENT OF DIABETES 审中-公开
标题翻译：用于治疗糖尿病的精氨酸衍生物
公开(公告)号：WO2011092671A1
公开(公告)日：2011-08-04
申请号：PCT/IB2011/050424
申请日：2011-01-31
申请人： RANBAXY LABORATORIES LIMITED , SATTIGERI, Jitendra, A. , AHMED, Shahadat , SETHI, Sachin , GADHAVE, Anil, Gorakshnath , KAUR, Kirandeep , SHARMA, Lalima , JADHAV, Balasaheb, Gangadhar , DATTA, Dhrubajyoti , CHILLA, Satyanarayan, Murthy , BHATNAGER, Pradip, Kumar , RAY, Abhijit , BANSAL, Vinay , DAVIS, Joseph, Alexanand , RAYASAM, Geeta, Vani , TULASI, Vamshi, Krishna
发明人： SATTIGERI, Jitendra, A. , AHMED, Shahadat , SETHI, Sachin , GADHAVE, Anil, Gorakshnath , KAUR, Kirandeep , SHARMA, Lalima , JADHAV, Balasaheb, Gangadhar , DATTA, Dhrubajyoti , CHILLA, Satyanarayan, Murthy , BHATNAGER, Pradip, Kumar , RAY, Abhijit , BANSAL, Vinay , DAVIS, Joseph, Alexanand , RAYASAM, Geeta, Vani , TULASI, Vamshi, Krishna
IPC分类号： C07D207/16 , C07K5/06 , A61K31/401 , A61P3/10
CPC分类号： C07D207/16 , A61K38/00 , C07K5/06026 , C07K5/06043 , C07K5/06052 , C07K5/0606 , C07K5/06078 , C07K5/06104 , C07K5/06113 , C07K5/06165
摘要： The present invention provides novel heterocyclic compounds and methods of preparing such compounds. The compounds of the invention are useful for palliative, curative or prophylactic treatment of diseases or conditions of diabetes and/or hypertension. This invention also relates to pharmaceutical compositions containing the compounds of the present invention, and methods for palliative, curative or prophylactic treatment of diseases or conditions of diabetes and/or hypertension. The present invention also provides pharmaceutical compositions consisting of the heterocyclic compounds along with one or more dyslipidemic agents, antiobesity agents, anti-hyperglycemic agents, antihypertensive agents and anti-inflammatory agents.
摘要翻译：本发明提供新颖的杂环化合物及其制备方法。本发明的化合物可用于缓解，治疗或预防性治疗糖尿病和/或高血压疾病或病症。本发明还涉及含有本发明化合物的药物组合物，以及用于缓解，治疗或预防性治疗糖尿病和/或高血压疾病或病症的方法。本发明还提供了由杂环化合物与一种或多种血脂异常剂，抗肥胖剂，抗高血糖剂，抗高血压药和抗炎剂组成的药物组合物。

8. 发明申请

WO2007029086A2 DERIVATIVES OF 3-AZABICYCLO[3.1.0]HEXANE AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS 审中-公开
标题翻译： 3-亚氨基半胱氨酸[3.1.0] HEXANE作为DIPEPTIDYL PEPTIDASE-IV抑制剂的衍生物
公开(公告)号：WO2007029086A2
公开(公告)日：2007-03-15
申请号：PCT/IB2006/002419
申请日：2006-09-01
申请人： RANBAXY LABORATORIES LIMITED , SATTIGERI, Jitendra, A. , ANDAPPAN, Murugaiah, M S , KISHORE, Kaushal , SETHI, Sachin , KANDALKAR, Sachin, Ramesh , PAL, Chanchal, Kumar , MAHAJAN, Dipak, C. , AHMED, Shahadat , PARKALE, Santhosh, Sadashiv , SRINIVASAN, T , SHARMA, Lalima , BANSAL, Vinay, S. , CHUGH, Anita , DAVIS, Joseph, Alexanand
发明人： SATTIGERI, Jitendra, A. , ANDAPPAN, Murugaiah, M S , KISHORE, Kaushal , SETHI, Sachin , KANDALKAR, Sachin, Ramesh , PAL, Chanchal, Kumar , MAHAJAN, Dipak, C. , AHMED, Shahadat , PARKALE, Santhosh, Sadashiv , SRINIVASAN, T , SHARMA, Lalima , BANSAL, Vinay, S. , CHUGH, Anita , DAVIS, Joseph, Alexanand
CPC分类号： C07D403/12 , C07D209/52 , C07D401/14 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention relates to novel 3-azabicyclo[3.1.0]hexane derivatives as dipeptidyl peptidase-IV inhibitors and the processes for the synthesis of the said compounds. This invention also relates to pharmacological compositions containing the compounds of the present invention, and methods of treating diabetes, especially type 2 diabetes, as well as prediabetes, diabetic dyslipidemia, metabolic acidosis, ketosis, satiety disorders, and obesity. These inhibitors can also be used to treat conditions manifested by a variety of metabolic, neurological, anti-inflammatory, and autoimmune disorders like inflammatory disease, multiple sclerosis, rheumatoid arthritis; viral, cancer and gastrointestinal disorders. The compounds of this invention can also be used for treatment of infertility arising due to polycystic ovary syndrome.
摘要翻译：本发明涉及作为二肽基肽酶-IV抑制剂的新型3-氮杂双环[3.1.0]己烷衍生物及其合成方法。本发明还涉及含有本发明化合物的药物组合物，以及治疗糖尿病，特别是2型糖尿病以及糖尿病前期，糖尿病性血脂异常，代谢性酸中毒，酮症，饱腹感和肥胖症的方法。这些抑制剂也可用于治疗由各种代谢，神经，抗炎和自身免疫性疾病如炎症性疾病，多发性硬化症，类风湿性关节炎，病毒，癌症和胃肠道疾病。本发明的化合物也可用于治疗由于多囊卵巢综合征引起的不育症。

9. 发明申请

WO2007029076A1 ISOINDOLE DERIVATIVES AS ANTIMICROBIAL AGENTS 审中-公开
标题翻译：作为抗微生物剂的ISOINDOLE衍生物
公开(公告)号：WO2007029076A1
公开(公告)日：2007-03-15
申请号：PCT/IB2006/002368
申请日：2006-08-30
申请人： RANBAXY LABORATORIES LIMITED , AHMED, Shahadat , DAS, Biswajit , UPADHYAY, Dilip, J.
发明人： AHMED, Shahadat , DAS, Biswajit , UPADHYAY, Dilip, J.
IPC分类号： C07D209/46 , C07D209/48 , C07D403/12 , C07D401/12 , C07D417/12 , A61K31/4035 , A61K31/4192 , A61K31/4427 , A61K31/433 , A61P31/00
CPC分类号： C07D209/46 , C07D209/44 , C07D209/48 , C07D401/14 , C07D403/12 , C07D417/12
摘要： Provided herein are substituted aromatic compound of Formula (I), which are tRNA synthetase inhibitors, and hence can be used as antimicrobial agents. Compounds disclosed herein can be used for the treatment or prevention of a condition caused by or contributed to by gram positive, gram negative, anaerobic bacteria or fungal organisms, more particularly against bacterium, for example, Staphylococci, Enterococci, Streptococci, Haemophilus, Moraxalla, Escherichia, Chlamydia, Rickettsiae, Mycoplasm, Legionella, Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus or Enterobactericeae, and fungal organisms, for example, Aspergillus, Blastomyces, Candida, Coccidiodes, Cryptococcus, Epidermophyton, Hendersonula, Histoplasma, Microsporum, Paecilomyces, Paracoccidiodes, Pneumocystis, Trichophyton, or Trichosporium. Processes for the preparation of these compounds, pharmaceutical compositions thereof, and method of treating microbial infections are also provided.
摘要翻译：本文提供了取代的式（I）芳族化合物，其为tRNA合成酶抑制剂，因此可用作抗微生物剂。本文公开的化合物可用于治疗或预防由革兰氏阳性，革兰氏阴性，厌氧细菌或真菌生物引起的或由其贡献的病症，特别是针对细菌，例如葡萄球菌，肠球菌，链球菌，嗜血杆菌，莫萨拉，大肠杆菌，衣原体，立克次氏体，支原体，军团菌，分枝杆菌，幽门螺杆菌，梭菌属，拟杆菌属，棒状杆菌属，芽孢杆菌属或肠杆菌属，以及真菌生物体，例如曲霉属，布氏酵母属，假丝酵母属，椰子球菌属，隐球菌属，表皮癣菌，亨氏球菌，组织胞浆菌，，副球孢子虫，肺孢子虫，发癣菌或三孢子虫。还提供了用于制备这些化合物的方法，其药物组合物和治疗微生物感染的方法。

10. 发明申请

WO2015200341A1 SUBSTITUTED IMIDAZO[1,2-A]PYRIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF PAIN 审中-公开
标题翻译：用于治疗疼痛的替代咪达唑[1,2-A]吡啶化合物
公开(公告)号：WO2015200341A1
公开(公告)日：2015-12-30
申请号：PCT/US2015/037214
申请日：2015-06-23
申请人： DR. REDDY'S LABORATORIES LTD. , SASMAL, Pradip, Kumar , AHMED, Shahadat , TEHIM, Ashok , PARADKAR, Vidyadhar
发明人： SASMAL, Pradip, Kumar , AHMED, Shahadat , TEHIM, Ashok , PARADKAR, Vidyadhar
IPC分类号： C07D471/04 , A61K31/437 , A61P35/04
CPC分类号： A61K31/437 , A61K31/4025 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/5377 , A61K31/55 , A61K31/635 , C07D471/04 , C07K5/06 , Y02A50/414
摘要： The present application relates to a series of substituted imidazo[l,2-a]pyridine compounds of formula (I), pharmaceutically acceptable salts, pharmaceutically acceptable solvates or stereoisomers thereof, their use as tropomyosin receptor kinase (Trk) family protein kinase inhibitors, method of making and pharmaceutical compositions comprising such compounds.
摘要翻译：本申请涉及一系列取代的式（I）咪唑并[1,2-a]吡啶化合物，其药学上可接受的盐，药学上可接受的溶剂合物或立体异构体，其用作原肌球蛋白受体激酶（Trk）家族蛋白激酶抑制剂，制备方法和包含这些化合物的药物组合物。

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