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1. 发明申请

WO2007054789A1 PHARMACEUTICAL COMBINATION COMPRISING ATORVASTATIN DERIVATIVES 审中-公开
标题翻译：包含ATORVASTATIN衍生物的药物组合
公开(公告)号：WO2007054789A1
公开(公告)日：2007-05-18
申请号：PCT/IB2006/003152
申请日：2006-11-08
申请人： RANBAXY LABORATORIES LIMITED , SATTIGERI, Jitendra A. , BANSAL, Vinay S.
发明人： SATTIGERI, Jitendra A. , BANSAL, Vinay S.
IPC分类号： A61K31/4025 , A61K31/40
CPC分类号： C07D207/34 , A61K31/397 , A61K31/40 , A61K31/4025 , A61K31/44 , A61K31/4439 , A61K31/445 , A61K31/47 , A61K31/554 , A61K31/70 , A61K45/06 , C07D405/06 , A61K2300/00
摘要： This invention relates to a combination product or medicament comprising at least one novel substituted pyrrole derivative and one or more dyslipidemic agents, antiobesity agents, antihyperglycaemic agents, anti-inflammatory agents or mixture thereof. Also provided herein are the pharmaceutical compositions comprising at least one novel substituted pyrrole derivative and one or more dyslipidemic agents, antiobesity agents, antihyperglycaemic agents, anti-inflammatory agents or mixture thereof and optionally together with at least one pharmaceutically acceptable carrier, and methods for the treatment or prophylaxis of cardiovascular diseases, Alzheimer's disease, obesity, diabetes or inflammatory diseases comprising administering to a mammal in need thereof therapeutically effective amounts of combination pharmaceutical composition comprising at least one novel substituted pyrrole derivative and one or more dyslipidemic agents, antiobesity agents, antihyperglycaemic agents, anti-inflammatory agents or mixtures thereof.
摘要翻译：本发明涉及包含至少一种新的取代的吡咯衍生物和一种或多种血脂异常剂，抗肥胖剂，抗高血糖药，抗炎剂或其混合物的组合产品或药物。本文还提供了包含至少一种新的取代的吡咯衍生物和一种或多种血脂变剂，抗肥胖剂，抗高血糖药，抗炎剂或其混合物以及任选地与至少一种药学上可接受的载体的药物组合物，以及用于治疗或预防心血管疾病，阿尔茨海默氏病，肥胖症，糖尿病或炎性疾病，包括向有需要的哺乳动物施用治疗有效量的组合药物组合物，其包含至少一种新的取代的吡咯衍生物和一种或多种血脂异常剂，抗肥胖剂，抗高血糖药药剂，抗炎剂或其混合物。

2. 发明申请

WO2007029086A3 DERIVATIVES OF 3-AZABICYCLO[3.1.0]HEXANE AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS 审中-公开
标题翻译： 3-亚氨基半胱氨酸[3.1.0] HEXANE作为DIPEPTIDYL PEPTIDASE-IV抑制剂的衍生物
公开(公告)号：WO2007029086A3
公开(公告)日：2007-05-18
申请号：PCT/IB2006002419
申请日：2006-09-01
申请人： RANBAXY LAB LTD , SATTIGERI JITENDRA A , ANDAPPAN MURUGAIAH M S , KISHORE KAUSHAL , SETHI SACHIN , KANDALKAR SACHIN RAMESH , PAL CHANCHAL KUMAR , MAHAJAN DIPAK C , AHMED SHAHADAT , PARKALE SANTHOSH SADASHIV , SRINIVASAN T , SHARMA LALIMA , BANSAL VINAY S , CHUGH ANITA , DAVIS JOSEPH ALEXANAND
发明人： SATTIGERI JITENDRA A , ANDAPPAN MURUGAIAH M S , KISHORE KAUSHAL , SETHI SACHIN , KANDALKAR SACHIN RAMESH , PAL CHANCHAL KUMAR , MAHAJAN DIPAK C , AHMED SHAHADAT , PARKALE SANTHOSH SADASHIV , SRINIVASAN T , SHARMA LALIMA , BANSAL VINAY S , CHUGH ANITA , DAVIS JOSEPH ALEXANAND
IPC分类号： C07D209/52 , A61K31/439 , A61P3/00 , A61P5/00 , C07D403/12
CPC分类号： C07D403/12 , C07D209/52 , C07D401/14 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention relates to 3-azabicyclo[3.1.0] hexane derivatives of formula (I) as \ dipeptidyl peptidase-IV inhibitors and the processes for the synthesis of the said compounds. This invention also relates to pharmacological compositions containing the compounds of the present invention, and methods of treating diabetes, especially type 2 diabetes, as well as prediabetes, diabetic dyslipidemia, metabolic acidosis, ketosis, satiety disorders, and obesity. These inhibitors can also be used to treat conditions manifested by a variety of metabolic, neurological, anti-inflammatory, and autoimmune disorders like inflammatory disease, multiple sclerosis, rheumatoid arthritis; viral, cancer and gastrointestinal disorders. The compounds of this invention can also be used for treatment . of infertility arising due to polycystic ovary syndrome.
摘要翻译：本发明涉及作为\二肽基肽酶-IV抑制剂的式（I）的3-氮杂双环[3.1.0]己烷衍生物和合成所述化合物的方法。本发明还涉及含有本发明化合物的药物组合物，以及治疗糖尿病，特别是2型糖尿病以及糖尿病前期，糖尿病性血脂异常，代谢性酸中毒，酮症，饱腹感和肥胖症的方法。这些抑制剂也可用于治疗由各种代谢，神经，抗炎和自身免疫性疾病如炎症性疾病，多发性硬化症，类风湿性关节炎，病毒，癌症和胃肠道疾病。本发明的化合物也可用于治疗。由多囊卵巢综合症引起的不育症。

3. 发明申请

WO2007029086A2 DERIVATIVES OF 3-AZABICYCLO[3.1.0]HEXANE AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS 审中-公开
标题翻译： 3-亚氨基半胱氨酸[3.1.0] HEXANE作为DIPEPTIDYL PEPTIDASE-IV抑制剂的衍生物
公开(公告)号：WO2007029086A2
公开(公告)日：2007-03-15
申请号：PCT/IB2006/002419
申请日：2006-09-01
申请人： RANBAXY LABORATORIES LIMITED , SATTIGERI, Jitendra, A. , ANDAPPAN, Murugaiah, M S , KISHORE, Kaushal , SETHI, Sachin , KANDALKAR, Sachin, Ramesh , PAL, Chanchal, Kumar , MAHAJAN, Dipak, C. , AHMED, Shahadat , PARKALE, Santhosh, Sadashiv , SRINIVASAN, T , SHARMA, Lalima , BANSAL, Vinay, S. , CHUGH, Anita , DAVIS, Joseph, Alexanand
发明人： SATTIGERI, Jitendra, A. , ANDAPPAN, Murugaiah, M S , KISHORE, Kaushal , SETHI, Sachin , KANDALKAR, Sachin, Ramesh , PAL, Chanchal, Kumar , MAHAJAN, Dipak, C. , AHMED, Shahadat , PARKALE, Santhosh, Sadashiv , SRINIVASAN, T , SHARMA, Lalima , BANSAL, Vinay, S. , CHUGH, Anita , DAVIS, Joseph, Alexanand
CPC分类号： C07D403/12 , C07D209/52 , C07D401/14 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention relates to novel 3-azabicyclo[3.1.0]hexane derivatives as dipeptidyl peptidase-IV inhibitors and the processes for the synthesis of the said compounds. This invention also relates to pharmacological compositions containing the compounds of the present invention, and methods of treating diabetes, especially type 2 diabetes, as well as prediabetes, diabetic dyslipidemia, metabolic acidosis, ketosis, satiety disorders, and obesity. These inhibitors can also be used to treat conditions manifested by a variety of metabolic, neurological, anti-inflammatory, and autoimmune disorders like inflammatory disease, multiple sclerosis, rheumatoid arthritis; viral, cancer and gastrointestinal disorders. The compounds of this invention can also be used for treatment of infertility arising due to polycystic ovary syndrome.
摘要翻译：本发明涉及作为二肽基肽酶-IV抑制剂的新型3-氮杂双环[3.1.0]己烷衍生物及其合成方法。本发明还涉及含有本发明化合物的药物组合物，以及治疗糖尿病，特别是2型糖尿病以及糖尿病前期，糖尿病性血脂异常，代谢性酸中毒，酮症，饱腹感和肥胖症的方法。这些抑制剂也可用于治疗由各种代谢，神经，抗炎和自身免疫性疾病如炎症性疾病，多发性硬化症，类风湿性关节炎，病毒，癌症和胃肠道疾病。本发明的化合物也可用于治疗由于多囊卵巢综合征引起的不育症。

4. 发明申请

WO2008125928A2 STANDARDIZED BIOACTIVE EXTRACTS OF ANNONA SQUAMOSA 审中-公开
标题翻译： ANNONA SQUAMOSA的标准化生物提取物
公开(公告)号：WO2008125928A2
公开(公告)日：2008-10-23
申请号：PCT/IB2007/055302
申请日：2007-12-21
申请人： RANBAXY LABORATORIES LIMITED , KATIYAR, Chandra, Kant , KANAUJIA, Anil , SINGH, Yogendra , PANNAKAL, Steve, Thomas , DUGGAR, Rajeev , AGGARWAL, Manjree , SRINIVAS, Kona , BANSAL, Vinay, S. , SHARMA, Suchitra , MITTRA, Shivani , YADAV, Satyapal, Singh , RAY, Abhijit , LAKSHMI, B., S. , SUJATHA, Sundaresan , SHUKLA, Gyanesh
发明人： KATIYAR, Chandra, Kant , KANAUJIA, Anil , SINGH, Yogendra , PANNAKAL, Steve, Thomas , DUGGAR, Rajeev , AGGARWAL, Manjree , SRINIVAS, Kona , BANSAL, Vinay, S. , SHARMA, Suchitra , MITTRA, Shivani , YADAV, Satyapal, Singh , RAY, Abhijit , LAKSHMI, B., S. , SUJATHA, Sundaresan , SHUKLA, Gyanesh
IPC分类号： A61K36/185 , A61P3/10
CPC分类号： A61K36/185 , C07B2200/09 , C07C59/42 , A61K2300/00
摘要： The invention relates to standardized extracts of aerial parts of plant Annona squamosa, a method of identifying, characterizing and isolating bioactive marker compounds of Formulae I and II from aerial parts of plant Annona squamosa and use thereof. The invention also relates to a method for the preparation of standardized extracts of Annona squamosa aerial parts.
摘要翻译：本发明涉及植物Annona squamosa的地上部分的标准化提取物，鉴定，表征和分离来自植物Annona squamosa的地上部分的式I和II的生物活性标记化合物的方法及其用途。本发明还涉及一种用于制备Annona squamosa空间部分的标准化提取物的方法。

5. 发明申请

WO2007077508A2 DERIVATIVES OF BETA-AMINO ACID AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS 审中-公开
标题翻译：作为二肽基肽酶-IV抑制剂的β-氨基酸衍生物
公开(公告)号：WO2007077508A2
公开(公告)日：2007-07-12
申请号：PCT/IB2006/055006
申请日：2006-12-21
申请人： RANBAXY LABORATORIES LIMITED , SATTIGERI, Jitendra, A. , AHMED, Shahadat , ANDAPPAN, Murugaiah, M S , SETHI, Sachin , SHARMA, Lalima , PAL, Chanchal, Kumar , KANDALKAR, Sachin, Ramesh , MAHAJAN, Dipak, C. , KISHORE, Kaushal , BHATIA, Sumati , GADHAVE, Anil, G. , BANSAL, Vinay, S. , DAVIS, Joseph, Alexanand
发明人： SATTIGERI, Jitendra, A. , AHMED, Shahadat , ANDAPPAN, Murugaiah, M S , SETHI, Sachin , SHARMA, Lalima , PAL, Chanchal, Kumar , KANDALKAR, Sachin, Ramesh , MAHAJAN, Dipak, C. , KISHORE, Kaushal , BHATIA, Sumati , GADHAVE, Anil, G. , BANSAL, Vinay, S. , DAVIS, Joseph, Alexanand
IPC分类号： C07D487/08 , C07D209/44 , C07D209/52 , C07D211/58 , C07D401/12 , C07D405/12 , C07D409/12 , C07C237/20 , A61K31/4468 , A61P3/10
CPC分类号： C07D409/12 , C07C237/20 , C07C2603/74 , C07D209/44 , C07D209/52 , C07D211/58 , C07D401/12 , C07D405/12 , C07D487/08
摘要： The present invention relates to β-amino acid derivatives as dipeptidyl peptidase- IV inhibitors and the processes for the synthesis of the same. This invention also relates to pharmacological compositions containing the compounds of the present invention, and methods of treating diabetes, especially type 2 diabetes, as well as prediabetes, diabetic dyslipidemia, metabolic acidosis, ketosis, satiety disorders, and obesity. These inhibitors can also be used to treat conditions manifested by a variety of metabolic, neurological, anti-inflammatory, and autoimmune disorders like inflammatory disease, multiple sclerosis, rheumatoid arthritis; viral, cancer and gastrointestinal disorders. The compounds of this invention can also be used for treatment of infertility arising due to polycystic ovary syndrome.
摘要翻译：本发明涉及作为二肽基肽酶-IV抑制剂的β-氨基酸衍生物及其合成方法。本发明还涉及含有本发明化合物的药物组合物，以及治疗糖尿病，特别是2型糖尿病以及前驱糖尿病，糖尿病性血脂异常，代谢性酸中毒，酮症，饱足症和肥胖症的方法。这些抑制剂也可用于治疗由各种代谢，神经，抗炎和自身免疫疾病如炎性疾病，多发性硬化症，类风湿性关节炎所表现的病症; 病毒，癌症和胃肠道疾病。本发明的化合物也可以用于治疗由多囊卵巢综合症引起的不育症。

6. 发明申请

WO2003099994A2 METHOD OF DETECTING CHOLESTEROL TRANSPORTING PROTEINS 审中-公开
标题翻译：检测胆固醇转运蛋白的方法
公开(公告)号：WO2003099994A2
公开(公告)日：2003-12-04
申请号：PCT/US2003/015624
申请日：2003-05-16
申请人： MERCK & CO., INC. , DETMERS, Patricia, A. , BANSAL, Vinay, S.
发明人： DETMERS, Patricia, A. , BANSAL, Vinay, S.
IPC分类号： C12N
CPC分类号： G01N33/5044 , G01N33/5008 , G01N33/502 , G01N33/5067
摘要： A method of identifying a protein that is involved in cholesterol uptake, trafficking or transport is disclosed which comprises contacting a mammalian cell, or a mammalian cellular or acellular component with photocholesterol, and characterizing any protein that is identified as containing, complexed or bound to the photocholesterol.
摘要翻译：公开了鉴定涉及胆固醇摄取，运输或运输的蛋白质的方法，其包括将哺乳动物细胞或哺乳动物细胞或细胞成分与光胆固醇接触，并表征任何被鉴定为包含，复合或结合到 photocholesterol。

7. 发明申请

WO2007077508A3 DERIVATIVES OF BETA-AMINO ACID AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS 审中-公开
标题翻译：作为DIPEPTIDYL PEPTIDASE-IV抑制剂的β-氨基酸的衍生物
公开(公告)号：WO2007077508A3
公开(公告)日：2007-10-25
申请号：PCT/IB2006055006
申请日：2006-12-21
申请人： RANBAXY LAB LTD , SATTIGERI JITENDRA A , AHMED SHAHADAT , ANDAPPAN MURUGAIAH M S , SETHI SACHIN , SHARMA LALIMA , PAL CHANCHAL KUMAR , KANDALKAR SACHIN RAMESH , MAHAJAN DIPAK C , KISHORE KAUSHAL , BHATIA SUMATI , GADHAVE ANIL G , BANSAL VINAY S , DAVIS JOSEPH ALEXANAND
发明人： SATTIGERI JITENDRA A , AHMED SHAHADAT , ANDAPPAN MURUGAIAH M S , SETHI SACHIN , SHARMA LALIMA , PAL CHANCHAL KUMAR , KANDALKAR SACHIN RAMESH , MAHAJAN DIPAK C , KISHORE KAUSHAL , BHATIA SUMATI , GADHAVE ANIL G , BANSAL VINAY S , DAVIS JOSEPH ALEXANAND
IPC分类号： C07D487/08 , A61K31/4468 , A61P3/10 , C07C237/20 , C07D209/44 , C07D209/52 , C07D211/58 , C07D401/12 , C07D405/12 , C07D409/12
CPC分类号： C07D409/12 , C07C237/20 , C07C2603/74 , C07D209/44 , C07D209/52 , C07D211/58 , C07D401/12 , C07D405/12 , C07D487/08
摘要： The present invention relates to ß-amino acid derivatives as dipeptidyl peptidase- IV inhibitors and the processes for the synthesis of the same. This invention also relates to pharmacological compositions containing the compounds of the present invention, and methods of treating diabetes, especially type 2 diabetes, as well as prediabetes, diabetic dyslipidemia, metabolic acidosis, ketosis, satiety disorders, and obesity. These inhibitors can also be used to treat conditions manifested by a variety of metabolic, neurological, anti-inflammatory, and autoimmune disorders like inflammatory disease, multiple sclerosis, rheumatoid arthritis; viral, cancer and gastrointestinal disorders. The compounds of this invention can also be used for treatment of infertility arising due to polycystic ovary syndrome.
摘要翻译：本发明涉及作为二肽基肽酶-IV抑制剂的β-氨基酸衍生物及其合成方法。本发明还涉及含有本发明化合物的药物组合物，以及治疗糖尿病，特别是2型糖尿病以及糖尿病前期，糖尿病性血脂异常，代谢性酸中毒，酮症，饱腹感和肥胖症的方法。这些抑制剂也可用于治疗由各种代谢，神经，抗炎和自身免疫性疾病如炎症性疾病，多发性硬化症，类风湿性关节炎，病毒，癌症和胃肠道疾病。本发明的化合物也可用于治疗由于多囊卵巢综合征引起的不育症。

8. 发明申请

WO2003099994A3 METHOD OF DETECTING CHOLESTEROL TRANSPORTING PROTEINS 审中-公开
公开(公告)号：WO2003099994A3
公开(公告)日：2003-12-04
申请号：PCT/US2003/015624
申请日：2003-05-16
申请人： MERCK & CO., INC. , DETMERS, Patricia, A. , BANSAL, Vinay, S.
发明人： DETMERS, Patricia, A. , BANSAL, Vinay, S.
IPC分类号： C07K1/00
摘要： A method of identifying a protein that is involved in cholesterol uptake, trafficking or transport is disclosed which comprises contacting a mammalian cell, or a mammalian cellular or acellular component with photocholesterol, and characterizing any protein that is identified as containing, complexed or bound to the photocholesterol.

9. 发明申请

WO2008125928A3 STANDARDIZED BIOACTIVE EXTRACTS OF ANNONA SQUAMOSA 审中-公开
标题翻译： ANNONA SQUAMOSA的标准化生物提取物
公开(公告)号：WO2008125928A3
公开(公告)日：2009-09-11
申请号：PCT/IB2007055302
申请日：2007-12-21
申请人： RANBAXY LAB LTD , KATIYAR CHANDRA KANT , KANAUJIA ANIL , SINGH YOGENDRA , PANNAKAL STEVE THOMAS , DUGGAR RAJEEV , AGGARWAL MANJREE , SRINIVAS KONA , BANSAL VINAY S , SHARMA SUCHITRA , MITTRA SHIVANI , YADAV SATYAPAL SINGH , RAY ABHIJIT , LAKSHMI B S , SUJATHA SUNDARESAN , SHUKLA GYANESH
发明人： KATIYAR CHANDRA KANT , KANAUJIA ANIL , SINGH YOGENDRA , PANNAKAL STEVE THOMAS , DUGGAR RAJEEV , AGGARWAL MANJREE , SRINIVAS KONA , BANSAL VINAY S , SHARMA SUCHITRA , MITTRA SHIVANI , YADAV SATYAPAL SINGH , RAY ABHIJIT , LAKSHMI B S , SUJATHA SUNDARESAN , SHUKLA GYANESH
IPC分类号： A61K36/185 , A61P3/10
CPC分类号： A61K36/185 , C07B2200/09 , C07C59/42 , A61K2300/00
摘要： The invention relates to standardized extracts of aerial parts of plant Annona squamosa, a method of identifying, characterizing and isolating bioactive marker compounds of Formulae I and II from aerial parts of plant Annona squamosa and use thereof. The invention also relates to a method for the preparation of standardized extracts of Annona squamosa aerial parts.
摘要翻译：本发明涉及植物Annona squamosa的地上部分的标准化提取物，鉴定，表征和分离来自植物Annona squamosa的地上部分的式I和II的生物活性标记化合物的方法及其用途。本发明还涉及一种用于制备Annona squamosa空间部分的标准化提取物的方法。

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