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1. 发明申请

WO2019104439A1 MODIFIED NOROVIRUS VP1 PROTEINS AND VLPS COMPRISING MODIFIED NOROVIRUS VP1 PROTEINS 审中-公开
公开(公告)号：WO2019104439A1
公开(公告)日：2019-06-06
申请号：PCT/CA2018/051530
申请日：2018-11-30
申请人： MEDICAGO INC.
发明人： LAVOIE, Pierre-Olivier , D'AOUST, Marc-Andre
IPC分类号： C12N15/40 , A01H5/00 , A61K39/12 , A61P31/14 , A61P37/04 , C07K14/08 , C07K16/10 , C12N15/82 , C12N5/10 , C12N7/01 , C12P21/02
摘要： Nucleic acids encoding modified norovirus VP1 proteins, and VLPs comprising one or more of the modified norovirus VP1 proteins are provided. Methods for modified norovirus VP1 protein, and norovirus VLP, production in plants, portions of the plant or a plant cell, are also described.

2. 发明申请

WO2017127941A1 DEVICE AND METHOD FOR DETECTING FLATUS 审中-公开
标题翻译：用于检测平坦的装置和方法
公开(公告)号：WO2017127941A1
公开(公告)日：2017-08-03
申请号：PCT/CA2017/050100
申请日：2017-01-27
申请人： BURKE, Bradley
发明人： BURKE, Bradley
IPC分类号： A61B5/00 , A61B90/00 , A61F13/84 , G01N33/497
CPC分类号： A61B5/4255 , A61B5/0002 , A61B5/073 , A61B5/4848 , A61B5/6804 , A61B5/6808 , A61B5/6861 , A61B5/74
摘要： A device and methods for using a device, for determining a passing of flatus is described. The device comprises a sleeve comprising a first porous gas-permeable surface, a second surface attached to the first porous gas-permeable surface defining a pocket within the sleeve, and a flatus detector inserted within the pocket of the sleeve and positioned between the first porous gas-permeable surface and the second surface. The flatus detector may be a dry- surface carbon dioxide detector that irreversibly changes colour upon contact with increased concentrations of CO 2 gas, a chemiresistor, or a near field communication tag. The chemiresistor or near field communication tag may be modified for detecting target gases. The device may be a patch that is affixed to a patient or attached to a garment that is worn by the patient, or a capsule, with a detector disposed therein.
摘要翻译：描述了用于使用装置来确定肠胃胀气的传递的装置和方法。该装置包括一个套筒，该套筒包括一个第一多孔透气表面，一个连接到第一多孔透气表面的第二表面，在该套筒内限定一个凹穴，以及一个插入探测器的凹穴内并位于第一多孔透气表面和第二表面。气流探测器可以是干表面二氧化碳探测器，其在与增加浓度的CO 2气体，化学催化剂或近场通信标签接触时不可逆地改变颜色。化学电阻或近场通信标签可以修改用于检测目标气体。该装置可以是贴在患者身上的贴片，或贴附在患者佩戴的衣服上的贴片，或贴有检测器的胶囊。

3. 发明申请

WO2017091905A1 SINGLE VARIABLE DOMAIN T-CELL RECEPTORS 审中-公开
标题翻译：单个可变域T细胞受体
公开(公告)号：WO2017091905A1
公开(公告)日：2017-06-08
申请号：PCT/CA2016/051421
申请日：2016-12-02
申请人： INNOVATIVE TARGETING SOLUTIONS INC.
发明人： GALLO, Michael Lajos , KANG, Jaspal Singh , PIGOTT, Craig Robin , LIN, Abby , CHAI, Falene
IPC分类号： C07K14/725 , A61K38/17 , A61K47/66 , A61K47/68 , A61K51/08 , C07K19/00 , A61K47/48 , C12N5/10 , G01N33/567
CPC分类号： C07K16/2833 , A61K38/00 , C07K14/7051 , C07K19/00 , C07K2317/32 , C07K2317/569 , C07K2319/00 , C07K2319/03 , C07K2319/30 , C12N5/0636 , C12N2510/00 , G01N33/505 , G01N2333/7051
摘要： There is provided a single variable domain T-cell receptor (svd-TCR) comprising a first TCR variable domain, the first TCR variable domain specifically binding to an epitope, that is not a superantigen, in the absence of a second TCR variable domain. Also provided are compositions and cells comprising the svd-TCR as well as methods of identifying the svd-TCR.
摘要翻译：提供了单个可变区T细胞受体（svd-TCR），其包含第一TCR可变区，第一TCR可变区特异性结合至非超抗原缺少第二个TCR可变域。还提供了包含svd-TCR的组合物和细胞以及鉴定svd-TCR的方法。

4. 发明申请

WO2016004536A1 MODIFYING PROTEIN PRODUCTION IN PLANTS 审中-公开
标题翻译：修改植物中的蛋白质生产
公开(公告)号：WO2016004536A1
公开(公告)日：2016-01-14
申请号：PCT/CA2015/050644
申请日：2015-07-10
申请人： MEDICAGO INC. , UNIVERSITE LAVAL
发明人： MICHAUD, Dominique , PEPIN, Steeve , ETHIER, Gilbert , GOULET, Marie-Claire , GAUDREAU, Linda , GAGNE, Marielle , MARTEL, Michele , BECHTOLD, Nicole , D'AOUST, Marc-Andre , GOSSELIN, Andre
IPC分类号： C12N15/00 , A01H3/00 , A01H5/00 , C12N15/82 , C12P21/00
CPC分类号： C12N15/8251 , A01H3/00 , A01H3/02 , A01H3/04 , C12N15/8258
摘要： A method for synthesizing a protein of interest within a plant or a portion of a plant is provided. The method involves treating the plant to increase secondary leaf biomass production, followed by introducing one or more than one nucleic acid sequence encoding a protein of interest operatively linked with a regulatory region that is active in the plant, into the plant. The plant is then maintained under conditions that permit the nucleic acid sequence encoding the protein of interest to be expressed in the plant or the portion of the plant. Optionally, the plant or portion of the plant may be harvested and the protein of interest extracted.
摘要翻译：提供了在植物或植物的一部分内合成感兴趣的蛋白质的方法。该方法包括处理植物以增加次生叶生物量的产生，随后将编码目的蛋白质的一种或多于一种的核酸序列与在植物中具有活性的调节区域可操作地连接到植物中。然后将植物保持在允许编码目的蛋白质的核酸序列在植物或植物部分中表达的条件下。任选地，可以收获植物或植物的一部分，并提取目的蛋白质。

5. 发明申请

WO2015081439A1 PROCESS FOR HYDROLYZING A PRETREATED FEEDSTOCK AND RECOVERING LIGNIN 审中-公开
标题翻译：水解原料进料和回收提取物的方法
公开(公告)号：WO2015081439A1
公开(公告)日：2015-06-11
申请号：PCT/CA2014/051166
申请日：2014-12-04
申请人： IOGEN CORPORATION
发明人： FOODY, Brian E. , MARTENS, Kirsten , FOODY, Patrick J. , TOLAN, Jeffrey S.
IPC分类号： C12P19/14 , B01D35/02 , C07G1/00 , C08H7/00 , C08H8/00 , C12P19/02 , C12P7/10 , D21C1/02
CPC分类号： C12P19/14 , C07G1/00 , C08H6/00 , C08H8/00 , C12P7/04 , C12P7/10 , C12P19/02 , C12P2201/00 , D21C1/02 , D21C3/04 , D21C11/0007 , Y02E50/16
摘要： The present invention relates to a process for hydrolyzing a pretreated lignocellulosic feedstock. The process comprises hydrolyzing the pretreated lignocellulosic feedstock with an enzyme mixture comprising at least cellulase enzymes to produce a hydrolyzed slurry comprising glucose and lignin solids. The hydrolyzing is conducted in the presence of a polymer, such as for example an aliphatic polyether. A solids-liquid separation is conducted to recover lignin solids from a process stream comprising the lignin solids and the polymer. A process stream is then obtained comprising recovered lignin solids resulting from the solids-liquid separation. Also provided are processes for recovering the polymer from the lignin solids and/or from solution.
摘要翻译：本发明涉及一种水解预处理的木质纤维素原料的方法。该方法包括用至少包含纤维素酶的酶混合物水解预处理的木质纤维素原料，以产生包含葡萄糖和木质素固体的水解浆料。水解在聚合物如脂族聚醚存在下进行。进行固体 - 液体分离以从包含木质素固体和聚合物的工艺流中回收木质素固体。然后获得包含由固体 - 液体分离产生的回收的木质素固体的工艺流。还提供了从木质素固体和/或从溶液中回收聚合物的方法。

6. 发明申请

WO2015077874A1 CAPACITANCE-TYPE SENSOR PROBE 审中-公开
标题翻译：电容式传感器探头
公开(公告)号：WO2015077874A1
公开(公告)日：2015-06-04
申请号：PCT/CA2014/051092
申请日：2014-11-14
申请人： WESTPORT POWER INC.
发明人： HARPER, Gregory, C.
IPC分类号： G01F23/26
CPC分类号： G01F23/268
摘要： Sensor probes for capacitance-type liquid level sensors do not comprise an acceptable balance between cost, performance and durability for mobile applications. An improved sensor probe is provided. A first electrode comprises two or more first plate sections arranged in angular relationship with respect to each other. A second electrode comprises two or more second plate sections arranged in angular relationship with respect to each other. Spacers are located between the first and second electrodes such that each first plate section is spaced apart in parallel and substantially overlapping relationship with respective second plate sections. Fasteners securely fix the first and second electrodes in position.
摘要翻译：用于电容式液位传感器的传感器探头在移动应用的成本，性能和耐久性之间不能包含可接受的平衡。提供了一种改进的传感器探头。第一电极包括相对于彼此成角度关系布置的两个或更多个第一板部分。第二电极包括相对于彼此成角度关系布置的两个或更多个第二板部分。间隔件位于第一和第二电极之间，使得每个第一板部分平行间隔开并且与相应的第二板部分基本上重叠。紧固件将第一和第二电极牢固地固定就位。

7. 发明申请

WO2015027335A1 DIRECT EXHAUST GAS RECIRCULATION SYSTEM 审中-公开
标题翻译：直接排气回送系统
公开(公告)号：WO2015027335A1
公开(公告)日：2015-03-05
申请号：PCT/CA2014/050817
申请日：2014-08-26
申请人： WESTPORT POWER INC.
发明人： MILLWARD, Philip C.
IPC分类号： F02M25/07 , F02D21/08
CPC分类号： F02M26/43 , F01N13/107 , F02B29/0406 , F02B37/025 , F02B37/16 , F02B37/18 , F02M26/05 , F02M26/06 , F02M26/09 , F02M26/14 , F02M26/23 , F02M26/36 , F02M26/41 , F02M35/10222 , Y02T10/144
摘要： An improved exhaust gas recirculation (EGR) system comprises combustion chambers divided into a first portion and a second portion. An intake valve and an exhaust valve are associated with each combustion chamber. An intake manifold is in fluid communication with the combustion chambers through respective intake valves. A first exhaust manifold is in fluid communication with said first portion of combustion chambers through respective exhaust valves. A second exhaust manifold is in fluid communication with said second portion of combustion chambers through respective exhaust valves. An EGR exhaust valve is associated with each combustion chamber in said second portion. An EGR manifold is in fluid communication with each combustion chamber in said second portion through respective EGR exhaust valves and with said at least one intake manifold.
摘要翻译：改进的废气再循环（EGR）系统包括分为第一部分和第二部分的燃烧室。进气阀和排气阀与每个燃烧室相关联。进气歧管通过相应的进气阀与燃烧室流体连通。第一排气歧管通过相应的排气阀与燃烧室的所述第一部分流体连通。第二排气歧管通过相应的排气阀与燃烧室的第二部分流体连通。 EGR排气阀与所述第二部分中的每个燃烧室相关联。 EGR歧管通过相应的EGR排气阀和所述至少一个进气歧管与所述第二部分中的每个燃烧室流体连通。

8. 发明申请

WO2014205566A1 MODULE FOR CONTROLLING FUEL PRESSURE IN AN INTERNAL COMBUSTION ENGINE 审中-公开
标题翻译：用于控制内燃机中的燃油压力的模块
公开(公告)号：WO2014205566A1
公开(公告)日：2014-12-31
申请号：PCT/CA2014/050583
申请日：2014-06-20
申请人： WESTPORT POWER INC.
发明人： MARK, Randall, T. , WALKER, James, D.
IPC分类号： F02D41/38 , F02D19/10 , F02M21/02 , F02M25/00 , F02M43/02 , F02M43/04
CPC分类号： F02D41/3863 , F02D41/0025 , F02D41/0027 , F02D41/3845 , F02D2041/3881 , F02D2250/31 , F02M21/023 , F02M21/0245 , F02M43/02 , F02M43/04 , F02M55/02 , F02M55/025 , Y02T10/32
摘要： A module for controlling a first fuel rail pressure in an internal combustion engine and maintaining a predetermined pressure bias with a second fuel rail pressure comprises a manifold body and several components that are mounted on the manifold body to form an unitary and independent structure that is fluidly connected to a first fuel supply and to a first fuel rail. The components that are mounted on the manifold body are a pressure regulator, a shut-off valve and a check valve and can further comprise, for example, a service valve for venting the fuel from the module and/or a sensor for measuring the pressure in the first fuel rail.
摘要翻译：用于控制内燃机中的第一燃料轨压力并且利用第二燃料轨压力保持预定压力偏压的模块包括歧管主体和安装在歧管主体上的几个部件，以形成流体性的整体和独立的结构连接到第一燃料供应和第一燃料轨道。安装在歧管主体上的部件是压力调节器，截止阀和止回阀，并且还可以包括例如用于从模块排出燃料的维修阀和/或用于测量压力的传感器在第一个燃油轨。

9. 发明申请

WO2014186893A1 FUEL INJECTOR 审中-公开
标题翻译：喷油器
公开(公告)号：WO2014186893A1
公开(公告)日：2014-11-27
申请号：PCT/CA2014/050470
申请日：2014-05-21
申请人： WESTPORT POWER INC. , DELPHI INTERNATIONAL OPERATIONS LUXEMBOURG S.À.R.L.
发明人： MEEK, George A. , PANESAR, Lukhbir
IPC分类号： F02M43/04 , F02D19/08 , F02D41/38 , F02M25/00 , F02M43/00 , F02M61/04
CPC分类号： F02M43/04 , F02D19/0694 , F02D19/10 , F02M45/086 , F02M47/027 , F02M55/025 , F02M61/10 , F02M61/14 , F02M61/16 , F02M63/0015 , F02M63/0064 , F02M2200/40 , F02M2200/857 , Y02T10/36
摘要： A fuel injector (200) for an internal combustion engine is disclosed. The fuel injector is installable in a cylinder head bore of a cylinder head of the engine and comprises a body region (B) arranged to be received within the cylinder head bore, and a head region (H) arranged to extend outside the cylinder head bore to protrude from the cylinder head when the injector is installed in the cylinder head bore, a first valve needle (116) arranged to control the injection of a gaseous fuel from a first outlet, a second valve needle (120) arranged to control the injection of a liquid fuel from a second outlet, a gaseous fuel inlet (130) for admitting the gaseous fuel to the injector, and a liquid fuel inlet (156) for admitting the liquid fuel to the injector. The gaseous fuel inlet (130) is disposed in the body region (B) of the injector, and wherein the liquid fuel inlet (156) is disposed in the head region (H) of the injector. Preferably, the injector includes an internal accumulator volume (270) so that an external fuel rail is not necessary.
摘要翻译：公开了一种用于内燃机的燃料喷射器（200）。燃料喷射器可安装在发动机的气缸盖的气缸盖孔中，并且包括布置成容纳在气缸盖孔内的主体区域（B）和布置成延伸到气缸盖孔外侧的头部区域（H）当所述喷射器安装在所述气缸盖孔中时，从所述气缸盖突出;布置成控制从第一出口喷射气态燃料的第一阀针（116），布置成控制所述喷射的第二阀针来自第二出口的液体燃料，用于将气体燃料引入喷射器的气体燃料入口（130）和用于将液体燃料引入喷射器的液体燃料入口（156）。气体燃料入口（130）设置在喷射器的主体区域（B）中，并且其中液体燃料入口（156）设置在喷射器的头部区域（H）中。优选地，喷射器包括内部蓄能器容积（270），使得不需要外部燃料轨。

10. 发明申请

WO2014153674A1 INFLUENZA VIRUS-LIKE PARTICLE PRODUCTION IN PLANTS 审中-公开
标题翻译：在植物中的流感病毒样颗粒生产
公开(公告)号：WO2014153674A1
公开(公告)日：2014-10-02
申请号：PCT/CA2014/050326
申请日：2014-03-28
申请人： MEDICAGO INC.
发明人： COUTURE, Manon , D'AOUST, Marc-Andre , VEZINA, Louis-Philippe
IPC分类号： C12N15/82 , A01H5/00 , A61K39/145 , A61P31/16 , A61P37/04 , C07K14/11 , C12N15/44 , C12N7/01 , C12N7/04
CPC分类号： C12N15/8258 , A61K39/12 , A61K39/145 , A61K2039/5258 , A61K2039/54 , C07K14/005 , C07K2319/02 , C12N7/00 , C12N15/8257 , C12N2760/16122 , C12N2760/16123 , C12N2760/16134 , C12N2760/16151 , C12N2760/16171 , C12N2760/16222 , C12N2760/16223 , C12N2760/16234 , C12N2760/16251 , C12N2760/16271
摘要： A method of producing a virus like particle (VLP) in a plant comprising modified hemagglutinin is provided. The method comprises introducing a nucleic acid comprising a regulatory region active in the plant and operatively linked to a nucleotide sequence encoding a modified influenza hemagglutinin (HA) protein into the plant, or portion of the plant, the modified HA protein comprises a modified proteolytic loop. Followed by incubating the plant or portion of the plant under conditions that permit the expression of the nucleic acids, thereby producing the VLP. The modified proteolytic loop may comprise one or more protease cleavage sites exhibiting reduced or abolished cleavage by a protease. The nucleotide sequence encoding the HA may be selected from the group consisting of B HA, C, H1, H2, H3, H4, H5, H6, H7, H8, H9, H10, H11, H12, H13, H14, H15, and H16. Also described is a virus like particle (VLP) produced by the method, and plants expressing the VLP. The virus like particle (VLP) may comprise plant-specific N-glycans, or modified N- glycans.
摘要翻译：提供了在包含改良血凝素的植物中生产病毒样颗粒（VLP）的方法。该方法包括将包含在植物中具有活性的调节区的核酸引入植物或植物的一部分中并与编码经修饰的流感血凝素（HA）蛋白的核苷酸序列有效连接），所述修饰的HA蛋白包含修饰的蛋白水解环。随后在允许核酸表达的条件下温育植物或植物的部分，从而产生VLP。修饰的蛋白水解环可以包含一个或多个蛋白酶切割位点，其表现出由蛋白酶减少或消除的切割。编码HA的核苷酸序列可以选自B HA，C，H1，H2，H3，H4，H5，H6，H7，H8，H9，H10，H11，H12，H13，H14，H15和 H16。还描述了通过该方法产生的病毒样颗粒（VLP）和表达VLP的植物。病毒样颗粒（VLP）可以包含植物特异性N-聚糖或修饰的N-聚糖。

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