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71. 发明申请

WO02075734A3 METHOD AND DEVICE FOR PRODUCING GEOMETRICALLY EXACT COPIES OF SUBSETS OF PUNCTIFORM LOCATIONS 审中-公开
标题翻译：方法和器具，用于产生审时度势点形体的几何精确副本
公开(公告)号：WO02075734A3
公开(公告)日：2003-02-13
申请号：PCT/EP0202941
申请日：2002-03-16
申请人： LIFEBITS AG , REXHAUSEN ULRICH , WICK MANFRED
发明人： REXHAUSEN ULRICH , WICK MANFRED
IPC分类号： B01L3/00 , B01L3/02 , C40B60/14 , G11B7/26 , G03F7/00
CPC分类号： B01L3/5085 , B01J2219/00382 , B01J2219/00441 , B01J2219/00536 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00617 , B01J2219/00621 , B01J2219/00637 , B01J2219/00659 , B01L3/0241 , C40B60/14
摘要： The invention relates to a method for producing a carrier for conducting a biochemical analysis. To this end, a carrier is produced with a large number of pits that are arranged along a spiral. Copies are produced starting from a master carrier and they contain subsets of the pits of said master carrier. When producing the copies, the pits of the master carrier are read, and the tracking of the laser is corrected according to the arrangement of the pits of the master carrier.
摘要翻译：一种生产用于生化分析的支撑方法表明，以产生具有大量沿着螺旋排列的凹坑的载体。从主载体拷贝的生产，包含主载波的凹坑的子集开始。在制备主载体的凹坑的拷贝被读取并根据所述主载波的凹坑的校正装置中激光的跟踪。

72. 发明申请

WO02075287A3 METHOD FOR DETECTING BIOCHEMICAL REACTIONS AND A MEASUREMENT CARRIER FOR CARRYING OUT THE METHOD 审中-公开
标题翻译：检测方法的生化反应和测量载体执行方法
公开(公告)号：WO02075287A3
公开(公告)日：2003-02-06
申请号：PCT/EP0202936
申请日：2002-03-16
申请人： LIFEBITS AG , REXHAUSEN ULRICH , WICK MANFRED
发明人： REXHAUSEN ULRICH , WICK MANFRED
IPC分类号： B01J19/00 , C12Q1/68 , G01N21/25
CPC分类号： G01N21/253 , B01J19/0046 , B01J2219/00497 , B01J2219/005 , B01J2219/00536 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00648 , B01J2219/00659 , B01J2219/00689 , B01J2219/00702 , B01J2219/0072 , C12Q1/6837 , C12Q2563/155
摘要： The aim of the invention is to detect biochemical reactions. To this end, specified detector molecules are applied to a measurement carrier, which corresponds to the shape and size of a CD or the like. These detector molecules can react with constituents of a sample to be examined. Afterwards, signal-emitting elements such as beads are bound to the reaction products, and the measurement carrier is post-metallized. The reflection properties of the signal emitting elements in comparison to the smooth metallized surfaces enable the number of the signal-emitting elements to be counted out according to the number of the punctiform locations with reactions. A CD / DVD player or another reading device is used for counting.
摘要翻译：为了检测生化反应，提出申请，其对应于一个CD或类似的特定检测器分子的形状和尺寸的测量载流子。这些可以与要被检查的样品的组分反应。随后，信号发射元件如珠结合到反应产物和测量载体nachverspiegelt。由于相比于平滑表面镜面的信号产生元件的反射特性中，对应于点状体的数量信号产生元件的数目可以与反应来算出来的。对于计数CD / DVD播放器或其他读者使用。

73. 发明申请

WO0241004A3 OPTICAL BIODISCS WITH REFLECTIVE LAYERS 审中-公开
标题翻译：具有反射层的光学生物学
公开(公告)号：WO0241004A3
公开(公告)日：2003-02-06
申请号：PCT/US0146157
申请日：2001-11-15
申请人： BURSTEIN TECHNOLOGIES INC
发明人： ZOVAL JIM V , KIDO HORACIO , VIRTANEN JORMA ANTERO
IPC分类号： B01J19/00 , B01L3/00 , B81B1/00 , C40B40/06 , C40B50/14 , C40B60/14 , G01N21/07 , G01N35/00
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00317 , B01J2219/005 , B01J2219/00536 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/00675 , B01J2219/00689 , B01J2219/00695 , B01J2219/00702 , B01J2219/00707 , B01J2219/00722 , B01L3/5025 , B01L3/5027 , B01L3/502753 , B01L2200/12 , B01L2300/021 , B01L2300/0636 , B01L2300/0806 , B01L2300/0887 , B01L2300/168 , B01L2400/0409 , C40B40/06 , C40B50/14 , C40B60/14 , G01N21/07 , G01N35/00069
摘要： An optical biodisc has a substrate, a first reflective layer over the substrate, an opening in the first reflective layer for receiving an investigational feature, and a second reflective layer over the opening for reflecting light transmitted through the substrate.
摘要翻译：光学生物二极管具有衬底，衬底上的第一反射层，用于接收研究特征的第一反射层中的开口和用于反射透射通过衬底的光的开口上的第二反射层。

74. 发明申请

WO2002068113A1 SYNTHESEVORRICHTUNG UND VERFAHREN ZU DEREN HERSTELLUNG 审中-公开
标题翻译：合成装置和方法及其
公开(公告)号：WO2002068113A1
公开(公告)日：2002-09-06
申请号：PCT/EP2002/001217
申请日：2002-02-06
申请人： GRAFFINITY PHARMACEUTICAL DESIGN GMBH , RAU, Harald , FRANK, Michael , SCHMIDT, Kristina , DICKOPF, Stefan , BURKERT, Klaus
发明人： RAU, Harald , FRANK, Michael , SCHMIDT, Kristina , DICKOPF, Stefan , BURKERT, Klaus
IPC分类号： B01J19/00
CPC分类号： B01L3/5085 , B01J19/0046 , B01J2219/00315 , B01J2219/00497 , B01J2219/00536 , B01J2219/00585 , B01J2219/00596 , C40B60/14
摘要： Die vorliegende Erfindung betrifft eine Synthesevorrichtung, insbesondere zur Verwendung in der kombinatorischen Chemie (z.B, Festphasensynthese), sowie ein Verfahren zu deren Herstellung. Die erfindungsgemäße Synthesevorrichtung weist im wesentlichen einen Behälter, wie z.B. eine Mikrotiterplatte, mit Wand- und/oder Bodenbereichen sowie einen Festphasenträger, beispielsweise Membranen, die zur Verwendung in der Festphasensynthese geeignet sind, auf. Durch thermische Einwiekung auf einen Bereich, vorzugsweise einen eng begrenzten Bereich, des Festphasenträgers erfolgt eine Fixierung des Trägers an mindestens einem der Behälterbereiche.
摘要翻译：本发明涉及一种合成装置，特别是用于在组合化学（例如，固相合成），以及它们的制备过程中使用。本发明的合成装置通常包括一个容器，如例如微量滴定板，用于壁和/或底部部分，以及一个固相支持物，例如膜，其适合用于固相合成中的用途。通过热Einwiekung到的区域中，优选的窄范围内，所述固相支持物上的槽部分中的至少一个固定在载体中进行。

75. 发明申请

WO02045845A2 APPARATUS FOR LIGHT DIRECTED CHEMICAL SYNTHESIS 审中-公开
标题翻译：用于轻型化学合成的装置
公开(公告)号：WO02045845A2
公开(公告)日：2002-06-13
申请号：PCT/US2001/051277
申请日：2001-10-25
IPC分类号： B01J19/00 , C07B61/00 , C07K1/04 , C40B40/06 , C40B40/10 , C40B40/12 , C40B70/00
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00317 , B01J2219/00351 , B01J2219/00441 , B01J2219/00536 , B01J2219/0054 , B01J2219/00565 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00617 , B01J2219/00621 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00659 , B01J2219/00689 , B01J2219/00704 , B01J2219/00711 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , C07B2200/11 , C07K1/045 , C07K1/047 , C40B40/06 , C40B40/10 , C40B40/12 , C40B70/00
摘要： The invention provides an apparatus for chemical synthesis comprising a light source, for example, a laser light source; a means for dispensing a chemical reagent onto the solid support; a means for splitting light emanating from the light source into two or more split beams of light; a means for polarizing the beams of light; a means for collimating the polarized light; a 1/4-wave plate disposed between the collimating means and the solid support; a means for focusing the polarized light onto the solid support; and a photodetector array.
摘要翻译：本发明提供了一种用于化学合成的装置，其包括光源，例如激光光源; 用于将化学试剂分配到固体支持物上的装置; 用于将从光源发出的光分解成两个或更多个分束光的装置; 用于偏振光束的装置; 用于准直偏振光的装置; 设置在准直装置和固体支撑体之间的1/4波片; 用于将偏振光聚焦到固体支持体上的装置; 和光电检测器阵列。

76. 发明申请

WO02044695A1 METHODS AND APPARATUS FOR DETECTING AND QUANTIFYING LYMPHOCYTES WITH OPTICAL BIODISCS 审中-公开
标题翻译：用光学生物学检测和定量淋巴细胞的方法和装置
公开(公告)号：WO02044695A1
公开(公告)日：2002-06-06
申请号：PCT/US2001/047055
申请日：2001-11-06
IPC分类号： B01J19/00 , B01L3/00 , C40B40/06 , C40B50/14 , C40B60/14 , G01N15/14 , G01N21/07 , G01N33/543 , G01N33/569 , G01N35/00
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00317 , B01J2219/00536 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00621 , B01J2219/0063 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/00675 , B01J2219/00689 , B01J2219/00695 , B01J2219/00702 , B01J2219/00707 , B01J2219/00722 , B01L3/5025 , B01L3/5027 , B01L3/502761 , B01L2300/0636 , B01L2300/0806 , B01L2300/168 , B01L2400/0409 , C40B40/06 , C40B50/14 , C40B60/14 , G01N15/1475 , G01N21/07 , G01N33/54306 , G01N33/54353 , G01N33/54386 , G01N33/56972 , G01N35/00069 , G01N2015/1486
摘要： A clinical diagnostic assay is performed on an optical bio disc and is read with a disc drive. A method for determining the quantity of a specific type of blood cell in a biological sample includes binding an antibody to a capture zone on the disc, providing a sample to the capture zone, remove portions of the sample that are not bound in the capture zone, and counting bound cells.
摘要翻译：在光学生物盘上进行临床诊断测定，并用盘驱动器读取。用于确定生物样品中特定类型的血细胞的量的方法包括将抗体结合到盘上的捕获区，向捕获区提供样品，除去未结合在捕获区中的样品部分，并计数结合的细胞。

77. 发明申请

WO02041004A2 OPTICAL BIODISCS WITH REFLECTIVE LAYERS 审中-公开
标题翻译：具有反射层的光学生物学
公开(公告)号：WO02041004A2
公开(公告)日：2002-05-23
申请号：PCT/US2001/046157
申请日：2001-11-15
IPC分类号： B01J19/00 , B01L3/00 , B81B1/00 , C40B40/06 , C40B50/14 , C40B60/14 , G01N21/07 , G01N35/00
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00317 , B01J2219/005 , B01J2219/00536 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/00675 , B01J2219/00689 , B01J2219/00695 , B01J2219/00702 , B01J2219/00707 , B01J2219/00722 , B01L3/5025 , B01L3/5027 , B01L3/502753 , B01L2200/12 , B01L2300/021 , B01L2300/0636 , B01L2300/0806 , B01L2300/0887 , B01L2300/168 , B01L2400/0409 , C40B40/06 , C40B50/14 , C40B60/14 , G01N21/07 , G01N35/00069
摘要： An optical biodisc has a substrate, a first reflective layer over the substrate, an opening in the first reflective layer for receiving an investigational feature, and a second reflective layer over the opening for reflecting light transmitted through the substrate.
摘要翻译：光学生物二极管具有衬底，衬底上的第一反射层，用于接收研究特征的第一反射层中的开口和用于反射透射通过衬底的光的开口上的第二反射层。

78. 发明申请

WO02005945A1 METHOD FOR PRODUCING MICROARRAY CHIPS WITH NUCLEIC ACIDS, PROTEINS OR OTHER TEST SUBSTRATES 审中-公开
标题翻译： WITH NUCLEIC，蛋白质或其他测试基板的方法HERSTELKUNG微阵列芯片
公开(公告)号：WO02005945A1
公开(公告)日：2002-01-24
申请号：PCT/DE2001/002559
申请日：2001-07-13
IPC分类号： B01J19/00 , C40B40/06 , C40B40/10 , G01N1/36
CPC分类号： G01N1/36 , B01J19/0046 , B01J2219/00457 , B01J2219/00513 , B01J2219/0052 , B01J2219/00524 , B01J2219/00531 , B01J2219/00533 , B01J2219/00536 , B01J2219/00538 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00659 , B01J2219/00664 , B01J2219/00673 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10
摘要： The invention relates to the production of microarray chips for analyzing a large number of individual values, especially DNA or protein microarray chips. According to said method, the substrate (e.g. DNA, protein or other test substances) is homogeneously distributed in a support substance. The support substance, together with the substrate content therein, is transformed into microscopically thin fibers and different fibers are arranged in a bundle. Alternatively, the support substance and the substrate are applied to each other in layers, the combination layer is cut into strips and different strips are combined to form a block. The bundle or block is cut into thin slices crosswise to the longitudinal axis, applied to a solid support and fixed. The support substance is removed and the substrate is immobilized on said support. This method enables microarray chips to be produced with as many substrates as required. The outstanding advantages of the method are as follows: 1. simple production of an almost unlimited number of chips (one bundle/block 10 cm in length produces 1000 slices = chips 100 micrometers thick); 2. very little variation among the chips in a series (the 1000 slices are almost identical in terms of substrate content). The invention hereby provides an efficient and economical means of producing microarray chips for the increasing demand in biomedical research and industry.
摘要翻译：本发明涉及制备微阵列芯片的用于大量单个值的调查，在特定的DNA或蛋白质的微阵列芯片。在该方法中，在基板（Z-B的DNA，蛋白质，或其它试验物质）均匀地分布在载体物质。具有包含在所述载体物质在其中使衬底在细微的薄纤维和不同的纤维的形式被捆扎。或者，载体物质被施加到以连续层的衬底，所述整体层切成条，并结合各个条带的块。束或块被切割横向于所述纵向轴线成薄片，放置在固体表面上并固定。该载体被去除并且衬底被固定在载体上。此过程允许制备微阵列芯片与任何数量的衬底制成。这种方法的突出优点是：1.简单的生产几乎无限数量的芯片（10厘米长的一串/块=得到1000个片材100微米厚度的分离芯片），2。低变化（一系列1000的芯片下片几乎是相同的）衬底的内容。这对于生物医学研究和工业需求的增加高效和经济生产的微阵列芯片是可能的。

79. 发明申请

WO01034765A1 METHODS AND APPARATUS FOR THE ELECTRONIC, HOMOGENEOUS ASSEMBLY AND FABRICATION OF DEVICES 审中-公开
标题翻译：电子，均质装置和装置的制造方法和装置
公开(公告)号：WO01034765A1
公开(公告)日：2001-05-17
申请号：PCT/US2000/030480
申请日：2000-11-03
IPC分类号： B81C99/00 , B01J19/00 , B01L3/00 , B01L9/00 , B82B3/00 , C07B61/00 , C07H21/00 , C07K1/04 , C12M3/00 , C12N15/00 , C12Q1/68 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , C40B70/00 , G01N33/543 , G02B6/122 , G06N3/00 , G06N3/06 , G06N3/12 , G11B7/0037 , G11B7/0045 , G11B7/005 , G11B7/24 , G11B7/244 , G11C13/02 , G11C19/00 , H01L21/336 , H01L21/98 , H01L29/78 , H01L51/00 , H01L51/30 , C12M1/34
CPC分类号： H01L24/95 , B01J19/0046 , B01J19/0093 , B01J2219/00315 , B01J2219/00317 , B01J2219/00432 , B01J2219/00497 , B01J2219/00527 , B01J2219/00529 , B01J2219/00536 , B01J2219/00545 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00614 , B01J2219/00626 , B01J2219/00637 , B01J2219/00653 , B01J2219/00659 , B01J2219/00677 , B01J2219/00686 , B01J2219/00689 , B01J2219/00707 , B01J2219/00711 , B01J2219/00713 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01L3/502707 , B01L3/502715 , B01L3/502761 , B01L9/52 , B01L2200/025 , B01L2200/028 , B01L2200/12 , B01L2300/0819 , B01L2400/0418 , B82B3/00 , B82Y5/00 , B82Y10/00 , B82Y20/00 , B82Y30/00 , B82Y40/00 , C07B2200/11 , C07H21/00 , C07K1/04 , C07K1/045 , C07K1/047 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , C40B70/00 , G01N33/54366 , G02B6/1225 , G06N3/002 , G06N3/061 , G06N3/123 , G11B7/00455 , G11B7/0052 , G11B7/244 , G11C13/0014 , G11C13/0019 , G11C13/04 , G11C19/00 , H01L25/50 , H01L29/6656 , H01L29/6659 , H01L29/66628 , H01L29/7834 , H01L51/0093 , H01L51/0595 , H01L2224/95085 , H01L2224/95145 , H01L2224/95147 , H01L2924/01005 , H01L2924/01006 , H01L2924/01011 , H01L2924/01013 , H01L2924/01015 , H01L2924/01018 , H01L2924/01019 , H01L2924/0102 , H01L2924/01023 , H01L2924/01027 , H01L2924/01033 , H01L2924/01039 , H01L2924/01044 , H01L2924/01047 , H01L2924/01049 , H01L2924/01052 , H01L2924/01072 , H01L2924/01074 , H01L2924/01075 , H01L2924/01078 , H01L2924/01079 , H01L2924/01082 , H01L2924/01322 , H01L2924/014 , H01L2924/10253 , H01L2924/10329 , H01L2924/12041 , H01L2924/12042 , H01L2924/14 , H01L2924/1461 , H01L2924/30105 , H01L2924/3025 , H01L2924/00
摘要： Methods and apparatus are provided for the fabrication of microscale, including micron and sub-micron scale, including nanoscale, devices. Electronic transport of movable component devices is utilized through a fluidic medium to effect transport to a desired target location on a substrate or motherboard. Forces include electrophoretic force, electroosmotic force, electrostatic force and/or dielectrophoretic force. In the preferred embodiment, free field electroosmotic forces are utilized either alone, or in conjunction with, other forces. These forces may be used singly or in combination, as well as in conjunction with yet other forces, such as fluidic forces, mechanical forces or thermal convective forces. In the preferred embodiment, devices of a size, weight and/or density which may not be effectively transported through electrophoretic transport may be transported on the surface of the target device or motherboard via electroosmotic fluid flow. Transport may be effected through the use of driving electrodes so as to transport the component device to yet other connection electrodes. In certain embodiments, the connection electrodes may also be utilized, either alone or in combination with driving electrodes, to electronically transport the component device to the connection electrodes. A driving electrode may be utilized to place the component device proximate to the connection electrodes, and then the connection electrodes be utilized to generate an electroosmotic flow so as to create a fluid pressure on the component device in a direction toward the connection electrodes. Serial movement or parallel movement of component devices may be achieved. In one aspect, the inventions contemplate methods to be practiced in a low gravity environment, such that modes of electronic transport may be utilized with component devices that could not be successfully effected in a normal gravitational environment.
摘要翻译：提供了用于制造微尺寸的方法和装置，包括微米级和亚微米级，包括纳米尺度的器件。通过流体介质利用可移动部件装置的电子传输，以实现传输到基板或主板上的期望的目标位置。力包括电泳力，电渗力，静电力和/或介电泳力。在优选实施例中，自由场电渗力单独使用或与其它力结合使用。这些力可以单独使用或组合使用，以及结合另外的力，例如流体力，机械力或热对流力。在优选实施例中，可以通过电泳输送不能有效输送的尺寸，重量和/或密度的装置可以经由电渗流体流在目标装置或母板的表面上运输。传输可以通过使用驱动电极来实现，以便将组件设备传送到另外的连接电极。在某些实施例中，连接电极也可单独使用或与驱动电极组合使用，以将组件装置电子传输到连接电极。可以使用驱动电极将部件装置靠近连接电极，然后使用连接电极产生电渗流，以便在朝向连接电极的方向上在部件装置上产生流体压力。可以实现组件设备的串行移动或平行移动。在一个方面，本发明考虑了在低重力环境中实施的方法，使得可以利用在正常重力环境中不能成功实现的部件装置的电子运输方式。

80. 发明申请

WO0073504A2 MICROARRAY CHIP AND METHOD FOR INDEXING THE SAME 审中-公开
标题翻译：微波芯片及其指引方法
公开(公告)号：WO0073504A2
公开(公告)日：2000-12-07
申请号：PCT/JP0003554
申请日：2000-06-01
申请人： HITACHI SOFTWARE ENG , TAMURA TAKURO , YAMAMOTO KENJI , WATANABE TOSHIMASA , YOSHII JYUNJI
发明人： TAMURA TAKURO , YAMAMOTO KENJI , WATANABE TOSHIMASA , YOSHII JYUNJI
IPC分类号： C12N15/09 , B01J19/00 , C12M1/00 , C12Q1/68 , C40B40/06 , C40B40/10 , G01N33/53 , G01N33/566 , G01N37/00
CPC分类号： C12Q1/6837 , B01J19/0046 , B01J2219/00527 , B01J2219/00529 , B01J2219/00536 , B01J2219/00542 , B01J2219/00545 , B01J2219/00547 , B01J2219/00572 , B01J2219/00576 , B01J2219/00596 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00659 , B01J2219/00707 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10
摘要： A method for specifying element information that should be used for a microarray chip in use. Some of element spots (15) arranged on a microarray chip (10) are used as an index (17). By doing so, the microarray chip can be specified and management of the element information and use of the experimental information can be done automatically.
摘要翻译：一种用于指定在使用中应用于微阵列芯片的元件信息的方法。使用布置在微阵列芯片（10）上的一些元件点（15）作为指标（17）。通过这样做，可以指定微阵列芯片，并且可以自动完成元素信息的管理和实验信息的使用。

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