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61. 发明申请

WO2008057578A1 NMR SYSTEMS FOR IN VIVO DETECTION OF ANALYTES 审中-公开
标题翻译：用于检测分析物的NMR系统
公开(公告)号：WO2008057578A1
公开(公告)日：2008-05-15
申请号：PCT/US2007/023516
申请日：2007-11-08
申请人： T2 BIOSYSTEMS, INC. , LEE, W., David , BERRY, David, A.
发明人： LEE, W., David , BERRY, David, A.
IPC分类号： G01R33/28 , G01R33/465
CPC分类号： G01R33/465 , A61B5/0075 , A61B5/055 , A61B5/062 , A61B5/076 , A61B5/14503 , A61B5/14507 , A61B5/14528 , A61B5/14532 , A61B5/14546 , A61B5/686 , A61B5/7257 , A61B5/7264 , A61B5/7278 , A61B6/12 , A61B8/0841 , A61B90/90 , A61B90/98 , A61B2576/00 , G01N24/08 , G01N24/088 , G01R33/285 , G01R33/287 , G01R33/30 , G01R33/34092 , G01R33/383 , G01R33/50 , G01R33/5601
摘要： This invention relates generally to NMR systems for in vivo detection of analytes. More particularly, in certain embodiments, the invention relates to systems in which superparamagnetic nanoparticles are exposed to a magnetic field and radio frequency (RF) excitation at or near the Larmor frequency, such that the aggregation and/or disaggregation of the nanoparticles caused by the presence and/or concentration of a given analyte in a biological fluid is detected in vivo from a monitored RF echo response.
摘要翻译：本发明一般涉及用于体内检测分析物的NMR系统。更具体地说，在某些实施方案中，本发明涉及其中超顺磁性纳米颗粒暴露于Larmor频率处或接近拉莫尔频率处的磁场和射频（RF）激发的系统，使得纳米粒子的聚集和/或解聚在生物流体中的给定分析物的存在和/或浓度是从所监测的RF回波响应体内检测的。

62. 发明申请

WO2007134160A2 TEMPERATURE-JUMP DYNAMIC NUCLEAR POLARIZATION 审中-公开
标题翻译：温度 - 跳动动态核极化
公开(公告)号：WO2007134160A2
公开(公告)日：2007-11-22
申请号：PCT/US2007/068654
申请日：2007-05-10
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , GRIFFIN, Robert, G. , HU, Kan-Nian , JOO, Chan, Gyu
发明人： GRIFFIN, Robert, G. , HU, Kan-Nian , JOO, Chan, Gyu
IPC分类号： G06Q30/00
CPC分类号： G01R33/62 , G01N24/08 , G01N24/087 , G01N24/10 , G01R33/282 , G01R33/30 , G01R33/46
摘要： In one aspect, the present invention provides a method for enhancing the sensitivity of liquid- state NMR or MRI experiments. In general, the method involves (a) providing a frozen sample in a magnetic field, wherein the frozen sample includes a polarizing agent with at least one unpaired electron and an analyte with at least one spin half nucleus; (b) polarizing the at least one spin half nucleus of the analyte by irradiating the frozen sample with radiation having a frequency that excites electron spin transitions in the at least one unpaired electron of the polarizing agent; (c) melting the frozen sample to produce a molten sample; and (d) detecting nuclear spin transitions in the at least one spin half nucleus of the analyte in the molten sample. In certain embodiments, the methods further comprise a step of freezing a sample in a magnetic field to provide the frozen sample in a magnetic field. The freezing, polarizing, melting and detecting steps may be repeated as many times as desired. In another aspect, the present invention provides systems for performing these methods.
摘要翻译：一方面，本发明提供了一种提高液态NMR或MRI实验灵敏度的方法。通常，该方法包括（a）在磁场中提供冷冻样品，其中冷冻样品包括具有至少一个不成对电子的偏振剂和具有至少一个旋转半核的分析物; （b）通过用具有激发所述至少一种不成对的电子中的电子自旋跃迁的频率的辐射照射所述冷冻样品来使所述分析物的所述至少一个旋转半核偏振; （c）熔化冷冻样品以产生熔融样品; 和（d）检测熔融样品中分析物的至少一个旋转半核中的核自旋跃迁。在某些实施方案中，所述方法还包括在磁场中冷冻样品以在磁场中提供冷冻样品的步骤。冷冻，极化，熔化和检测步骤可以根据需要重复多次。在另一方面，本发明提供了用于执行这些方法的系统。

63. 发明申请

WO2007081730A1 TWO- AND THREE- DIMENSIONAL MRI INVOLVING A FERROMAGNETIC SPHERE FIXEDLY ATTACHED TO THE SAMPLE 审中-公开
标题翻译：涉及固定在样本上的FERROMAGNETIC SPHERE的两维和三维MRI
公开(公告)号：WO2007081730A1
公开(公告)日：2007-07-19
申请号：PCT/US2007/000141
申请日：2007-01-04
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , BARBIC, Mladen , SCHERER, Axel
发明人： BARBIC, Mladen , SCHERER, Axel
IPC分类号： G01R33/48
CPC分类号： G01R33/48 , G01R33/30 , G01R33/3808 , G01R33/383
摘要： Systems and methods for obtaining two- and three-dimensional magnetic resonance images by using azimuthally symmetric dipolar magnetic fields from magnetic spheres . A complete two- or three- dimensional structured rendering of a sample can be obtained without the motion of the sample relative to the sphere. Magnetic spheres in the range of 100 μm and 100 nm are used with samples that are approximately one-tenth as large as the magnetic sphere . Sequential positioning of the integrated sample-sphere system in an external magnetic field being much larger than the magnetic field of the sphere (e.g. 10T) at various angular orientations provides all the required imaging slices for successful computerized tomographic image reconstruction. The requirement to scan the sample relative to the magnetic tip is eliminated. Resolutions approaching atomic dimensions are expected to be obtained.
摘要翻译：通过使用磁球的方位角对称偶极磁场获得二维和三维磁共振图像的系统和方法。可以获得样品的完整的二维或三维结构渲染，而不需要样品相对于球体的运动。使用范围为100μm和100 nm的磁性球体，其面积大约为磁球的十分之一。集成的样品球系统在外部磁场中的顺序定位比各种角度取向上的球体（例如10T）大得多，为成功的计算机断层图像重建提供了所有所需的成像切片。消除了相对于磁头扫描样品的要求。预计将获得接近原子尺寸的分辨率。

64. 发明申请

WO2005116677A1 SAMPLE CATCHER FOR NMR APPARATUS AND METHOD UTILIZING THEREOF 审中-公开
标题翻译： NMR装置的样品捕获器及其应用
公开(公告)号：WO2005116677A1
公开(公告)日：2005-12-08
申请号：PCT/US2005/015865
申请日：2005-05-05
申请人： VARIAN, INC. , LUKENS, Peter, C. , BAIC, Dusan
发明人： LUKENS, Peter, C. , BAIC, Dusan
IPC分类号： G01R33/30
CPC分类号： G01R33/30 , G01R33/307
摘要： An NMR apparatus, sample contained in a sample holder is ejected from an NMR probe to the top of the magnet region where a sample latching mechanism holds the sample in place without requiring a continuing flow of pressurized gas, electrical power or other outside force. The sample can then be removed and/or exchanged with another sample that is also held in place without the expenditure of gas. When ready the operator depresses a lever arm enabling the exchanged sample to move into the probe.
摘要翻译： NMR装置中，样本保持器中包含的样品从NMR探针喷射到磁体区域的顶部，其中样品闭锁机构将样品保持在适当位置，而不需要持续的加压气体，电力或其它外力流动。然后可以将样品除去和/或与另外的样品交换，而另一个样品也不用燃气就可以保持在原位。准备好后，操作员按下一个杠杆臂，使交换的样品移动到探头中。

65. 发明申请

WO2003102615A1 PROBEHEAD FOR NMR SPECTROMETER 审中-公开
标题翻译： NMR光谱仪的探针
公开(公告)号：WO2003102615A1
公开(公告)日：2003-12-11
申请号：PCT/EE2003/000002
申请日：2003-05-14
申请人： KEEMILISE JA BIOLOOGILISE FÜÜSIKA INSTITUUT , SAMOSON, Ago , TUHERM, Tiit , PAST, Jaan , REINHOLD, Andres , ANUPÕLD, Titt
发明人： SAMOSON, Ago , TUHERM, Tiit , PAST, Jaan , REINHOLD, Andres , ANUPÕLD, Titt
IPC分类号： G01R33/30
CPC分类号： G01R33/30
摘要： The invention relates to the probehead of nuclear magnetic resonance spectrometer comprising a frame, a radio frequency coil attached thereto and a rotor located inside the coil containing the examined sample, supported by bearings and provided with turbines at both ends, a source of compressed gas, an executive unit and a control unit. The innovative step involves using at least two turbines and providing the executive unit with at least to compressed gas channels for controlling rotor velocity, whereas the coil is connected to the inner surface of the frame with at least two, preferably four sheets of thin non-conductive and non-magnetic material. The rotation velocity of the probehead rotor can be controlled and the rotation direction reversed thereby obtaining additional information on the examined sample during the measuring process.
摘要翻译：本发明涉及核磁共振光谱仪的探针头，其包括框架，附接到其上的射频线圈和位于包含被检测样品的线圈内的转子，由轴承支撑并在两端设置有涡轮机，压缩气体源，执行单元和控制单元。创新的步骤包括使用至少两个涡轮机并且向执行单元提供至少一个用于控制转子速度的压缩气体通道，而线圈使用至少两个，优选四片薄非磁性连接到框架的内表面，导电和非磁性材料。可以控制探头转子的旋转速度并使旋转方向反转，从而在测量过程中获得关于被检样品的附加信息。

66. 发明申请

WO02082103A2 SOLVENT SUSCEPTIBILITY COMPENSATION FOR COUPLED LC-NMR 审中-公开
标题翻译：用于偶联LC-NMR的溶剂不溶性补偿
公开(公告)号：WO02082103A2
公开(公告)日：2002-10-17
申请号：PCT/US0211145
申请日：2002-04-09
申请人： WATERS INVESTMENTS LTD , DOURDEVILLE THEODORE A
发明人： DOURDEVILLE THEODORE A
IPC分类号： G01N30/84 , G01R33/30 , G01R33/565 , G01R
CPC分类号： G01N30/84 , G01N2030/8441 , G01R33/30 , G01R33/56536
摘要： A method and apparatus in which the limitation upon analysis caused by variation of the magnetic susceptibility of the solvent conveying a sample to an NMR spectrometer can be addressed. The solvent composition which is used to bring about elution of analyte from devices such as chromatography columns can be varied without causing a corresponding variation of the solvent composition used to transport the analyte to the NMR spectrometer. The decoupling is achieved by the summing into the chromatographic stream, post column, a solvent composition which is complementary to the instantaneous composition emerging from the column, such that the magnetic susceptibility of the summed streams remains constant.
摘要翻译：可以解决由将样品输送到NMR光谱仪的溶剂的磁化率变化引起的分析限制的方法和装置。用于使分析物从诸如色谱柱的装置洗脱的溶剂组合物可以变化，而不会导致用于将分析物输送到NMR光谱仪的溶剂组成的相应变化。通过将色谱流，柱后和与柱的瞬时成分互补的溶剂组成相加，使得相加的流的磁化率保持恒定，可实现去耦。

67. 发明申请

WO01096020A1 METHOD AND APPARATUS FOR PROVIDING A VARIABLE TEMPERATURE SAMPLE SPACE 审中-公开
标题翻译：提供可变温度样品空间的方法和装置
公开(公告)号：WO01096020A1
公开(公告)日：2001-12-20
申请号：PCT/GB2001/002669
申请日：2001-06-15
IPC分类号： F17C13/00 , G01R33/30 , G01R33/31 , B01L7/00 , B01L7/02
CPC分类号： F17C13/006 , F17C2205/0323 , F17C2223/0161 , F17C2227/0135 , F17C2227/0353 , F17C2250/043 , F17C2250/0631 , G01R33/30 , G01R33/31
摘要： A cryostat is provided with a sample space (12) in a chamber (10). A thermal syphon (18, 24, 28, 30) for controlling the temperature of a temperature regulating fluid is provided and forms a circuit together with the sample holder (12). A cryocooler (22) is located adjacent a condenser portion (24) of the thermal syphon for cooling the temperature regulating fluid and a heater (14) is provided to heat the fluid. A charcoal sorption pump is provided to reduce the pressure of the fluid and hence its temperature to reach temperatures of a few Kelvin and less.
摘要翻译：低温恒温器在室（10）中设置有样品空间（12）。提供用于控制温度调节流体的温度的热虹吸管（18,24,28,30），并与样品保持器（12）一起形成电路。低温冷却器（22）位于热虹吸管的冷凝器部分（24）附近，用于冷却温度调节流体，并且提供加热器（14）以加热流体。提供木炭吸附泵以降低流体的压力，并因此降低其温度达到几开氏度以下的温度。

68. 发明申请

WO1994028431A1 NMR SAMPLE HOLDER 审中-公开
标题翻译： NMR样品架
公开(公告)号：WO1994028431A1
公开(公告)日：1994-12-08
申请号：PCT/AU1994000258
申请日：1994-05-20
申请人： THE UNIVERSITY OF QUEENSLAND , FIELD, James , McKENNA, Ross, Thomas , ROSE, Stephen, Edward , BRERETON, Ian, Malcolm , ROFFMANN, Wolfgang , WILSON, Stephen, James , CROZIER, Stuart , DODDRELL, David, Michael
发明人： THE UNIVERSITY OF QUEENSLAND
IPC分类号： G01R33/30
CPC分类号： G01R33/30 , G01R33/285
摘要： A sample holder (10) for use with an NMR probe comprises a contoured element (11) in which a small animal or other sample is placed. The sample is fixed longitudinally and rotationally relative to the contoured element (11) by fixing means comprising a transverse bar (20) and callipers (24, 25), both of which can be adjusted from outside the sample holder. Anaesthetic gases are delivered by tube (17) while waste vapours are extracted by suction. The axial position of the sample holder relative to its associated probe resonator is adjustable via a knob (44) on the exterior of the resonator.
摘要翻译：与NMR探头一起使用的样品架（10）包括放置小动物或其他样品的轮廓元件（11）。样品通过包括横杆（20）和卡钳（24,25）的固定装置相对于轮廓元件（11）纵向和旋转地固定，两者都可以从样品架外部调节。麻醉气体由管（17）输送，而吸气抽取蒸气。样品保持器相对于其相关探头谐振器的轴向位置可通过谐振器外部的旋钮（44）来调节。

69. 发明申请

WO2017148805A1 A PERFUSION PHANTOM FOR MRI AND AN APPARATUS, SYSTEM AND METHOD FOR VALIDATING MR IMAGES OF A PHANTOM 审中-公开
标题翻译：一种用于MRI的灌注模型以及用于验证图像的MR图像的装置，系统和方法
公开(公告)号：WO2017148805A1
公开(公告)日：2017-09-08
申请号：PCT/EP2017/054254
申请日：2017-02-23
申请人： GOLD STANDARD PHANTOMS LIMITED
发明人： GOLAY, Xavier , OLIVER-TAYLOR, Aaron , HAMPSHIRE, Tom
IPC分类号： G01R33/563 , G01R33/58 , G09B23/30 , G01R33/28 , G01R33/30 , F04B43/04 , A61L2/10 , C02F1/32 , H01L41/04
CPC分类号： G01R33/58 , A61L2/10 , C02F1/325 , C02F2201/3222 , C02F2303/04 , F04B17/03 , F04B43/04 , F04B43/046 , F04B49/06 , F04B2205/09 , G01R33/288 , G01R33/30 , G01R33/307 , G01R33/563 , G01R33/56366 , G09B23/303 , H01L41/042
摘要： The invention provides a perfusion chamber for use in a phantom comprising a waterproof housing containing a porous material, the porous material defining fluid paths between pores and tubular channels within the porous material. The invention further provides a reservoir for use in a phantom, a pump mechanism for use within the bore of an MRI scanner, a phantom for use in an MRI scanner, and a method for calibrating a scanning device. The invention also provides an apparatus for validating images of a phantom, the apparatus comprising: one or more sensors for coupling to a phantom to be imaged, the sensors being configured to measure parameters associated with the operating state of the phantom; a control/logging system configured to: collect sensor data during imaging of the phantom by the imaging system and pass this as input to a computer model; compare the image data with reference image data produced using the computer model; and return a pass score in dependence on the comparison. The invention also provides a system for verifying images of a phantom and a method for verifying images of a phantom.
摘要翻译：本发明提供了一种用于体模的灌注室，该灌注室包括含有多孔材料的防水外壳，多孔材料限定了多孔材料内的孔和管状通道之间的流体路径。本发明进一步提供了用于体模中的储存器，用于MRI扫描仪的孔内的泵机构，用于MRI扫描仪的模体以及用于校准扫描装置的方法。本发明还提供了一种用于验证体模图像的设备，该设备包括：一个或多个传感器，用于耦合到要成像的体模，传感器被配置为测量与体模的操作状态相关联的参数; 控制/记录系统，其被配置为：在成像系统对幻像进行成像期间收集传感器数据，并将其作为输入传递给计算机模型; 将图像数据与使用计算机模型产生的参考图像数据进行比较; 并根据比较结果返回合格分数。本发明还提供了一种用于验证幻像图像的系统和一种验证幻像图像的方法。

70. 发明申请

WO2017111719A1 A PROTECTIVE COVER FOR PROBES OF NUCLEAR MAGNETIC RESONANCE SPECTROMETER 审中-公开
标题翻译：核磁共振谱仪探测器的保护罩
公开(公告)号：WO2017111719A1
公开(公告)日：2017-06-29
申请号：PCT/TR2015/050296
申请日：2015-12-30
申请人： GEBZE TEKNIK UNIVERSITESI
发明人： AHSEN, Vefa
IPC分类号： G01R33/30
CPC分类号： G01R33/30 , G01R33/307
摘要： The invention is related to a protective cover (1) to prevent possible problems that may arise if the air flow is forgotten to be opened when the sample tube is being positioned into the device. The protective cover (1) subject to the invention comprises a clamp (2) which is mounted to the opening of the barrel (10), enabling to position the sample tube into the barrel (10) after the cover opens by means of the air flow that is created, and seals off the opening of the barrel (10) by closing on its own when said air flow is shut off.
摘要翻译：本发明涉及一种防护罩（1），用于防止在将样品管定位到装置中时气流忘记打开时可能出现的问题。本发明的保护罩（1）包括安装到筒体（10）的开口的夹具（2），其能够在通过空气打开盖子后将样品管定位到筒体（10）中并且当所述气流被切断时通过自行关闭而封闭筒（10）的开口。

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