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51. 发明申请

WO2012009684A3 DRUG DELIVERY MEDICAL DEVICE 审中-公开
标题翻译：药物递送医疗设备
公开(公告)号：WO2012009684A3
公开(公告)日：2012-04-19
申请号：PCT/US2011044263
申请日：2011-07-15
申请人： MICELL TECHNOLOGIES INC , MCCLAIN JAMES B , TAYLOR DOUGLAS , ZANI BRETT G , NEET JOHN , KIORPES TIMOTHY CHARLES
发明人： MCCLAIN JAMES B , TAYLOR DOUGLAS , ZANI BRETT G , NEET JOHN , KIORPES TIMOTHY CHARLES
IPC分类号： A61F2/06
CPC分类号： A61M25/10 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61M25/1011
摘要： Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on the substrate, wherein the coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within the coating and on the substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of the medical device in the body of the subject a portion of the pharmaceutical agent and/or active biological agent is delivered at the intervention site along with at least a portion of the polymer and/or a at least a portion of the pharmaceutical carrying agents.
摘要翻译：提供一种涂覆的可植入医疗装置，包括：基底; 以及涂层，其设置在所述基底上，其中所述涂层包含至少一种聚合物和至少一种治疗期望形态的药剂和/或至少一种活性生物剂和任选的一种或多种药物载体; 其中基本上所有的药剂和/或活性生物制剂都保留在涂层内和衬底上，直到可植入装置部署在受试者身体内部的介入部位，并且其中在将医疗装置部署在受试者的身体中时一部分药剂和/或活性生物剂在干预部位与至少一部分聚合物和/或药物载体的至少一部分一起递送。

52. 发明申请

WO2010111232A3 DRUG DELIVERY MEDICAL DEVICE 审中-公开
标题翻译：药物递送医疗设备
公开(公告)号：WO2010111232A3
公开(公告)日：2011-04-21
申请号：PCT/US2010028253
申请日：2010-03-23
申请人： MICELL TECHNOLOGIES INC , NEET JOHN , TAYLOR DOUGLAS , MCCLAIN JAMES B
发明人： NEET JOHN , TAYLOR DOUGLAS , MCCLAIN JAMES B
IPC分类号： A61M37/00 , A61F2/06 , A61L27/34 , A61L27/54
CPC分类号： A61L31/16 , A61L27/16 , A61L27/34 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/602 , A61L2300/608 , A61L2300/63 , A61L2420/08 , A61M25/0045
摘要： Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on said substrate, wherein said coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within said coating and on said substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of said medical device in the body of said subject a portion of said pharmaceutical agent and/or active biological agent is delivered at said intervention site along with at least a portion of said polymer and/or a at least a portion of said pharmaceutical carrying agents.
摘要翻译：提供一种涂覆的可植入医疗装置，包括：基底; 以及设置在所述基底上的涂层，其中所述涂层包含至少一种聚合物和至少一种治疗上需要的形态和/或至少一种活性生物试剂和任选的一种或多种药物载体的药剂; 其中基本上所有的药剂和/或活性生物制剂都保留在所述涂层内和所述衬底上，直到所述可植入装置部署在受试者身体内部的介入部位，并且其中在将所述医疗装置部署在所述受试者的身体中时所述药剂和/或活性生物剂的一部分与所述聚合物的至少一部分和/或所述药物载体的至少一部分在所述介入部位递送。

53. 发明申请

WO2010111232A9 DRUG DELIVERY MEDICAL DEVICE 审中-公开
公开(公告)号：WO2010111232A9
公开(公告)日：2010-09-30
申请号：PCT/US2010/028253
申请日：2010-03-23
申请人： MICELL TECHNOLOGIES, INC. , NEET, John , TAYLOR, Douglas , MCCLAIN, James, B.
发明人： NEET, John , TAYLOR, Douglas , MCCLAIN, James, B.
IPC分类号： A61M37/00 , A61L27/54 , A61L27/34 , A61F2/06
摘要： Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on said substrate, wherein said coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within said coating and on said substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of said medical device in the body of said subject a portion of said pharmaceutical agent and/or active biological agent is delivered at said intervention site along with at least a portion of said polymer and/or a at least a portion of said pharmaceutical carrying agents.

54. 发明申请

WO2010009335A1 DRUG DELIVERY MEDICAL DEVICE 审中-公开
标题翻译：药物交付医疗设备
公开(公告)号：WO2010009335A1
公开(公告)日：2010-01-21
申请号：PCT/US2009/050883
申请日：2009-07-16
申请人： MICELL TECHNOLOGIES, INC. , MCCLAIN, James, B. , TAYLOR, Douglas , NEET, John
发明人： MCCLAIN, James, B. , TAYLOR, Douglas , NEET, John
IPC分类号： A61L33/00
CPC分类号： A61L29/16 , A61F2002/30535 , A61F2250/0058 , A61K9/0024 , A61K9/0034 , A61K31/20 , A61K31/7088 , A61K31/7105 , A61K31/715 , A61K38/00 , A61L17/005 , A61L17/145 , A61L27/34 , A61L27/50 , A61L27/54 , A61L29/08 , A61L29/085 , A61L29/14 , A61L29/148 , A61L31/08 , A61L31/10 , A61L31/14 , A61L31/16 , A61L2300/406 , A61L2300/416 , A61L2300/426 , A61L2300/602 , A61L2300/608 , A61L2300/63 , A61L2420/08 , A61M2025/105
摘要： Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on said substrate, wherein said coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within said coating and on said substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of said medical device in the body of said subject a portion of said pharmaceutical agent and/or active biological agent is delivered at said intervention site along with at least a portion of said polymer and/or a at least a portion of said pharmaceutical carrying agents.
摘要翻译：提供一种涂覆的可植入医疗装置，其包括：基底; 和设置在所述基底上的涂层，其中所述涂层包含至少一种聚合物和至少一种处于治疗上所需形态的药剂和/或至少一种活性生物制剂和任选的一种或多种药用载剂; 其中基本上所有药剂和/或活性生物药剂保留在所述涂层内并且在所述基底上，直到所述可植入装置布置在受试者身体内的介入部位处，并且其中当所述医疗装置在所述受试者的身体内展开时所述药剂和/或活性生物制剂的一部分与所述聚合物的至少一部分和/或至少一部分所述药用承载剂一起在所述介入部位递送。

55. 发明申请

WO2009051780A1 DRUG COATED STENTS 审中-公开
标题翻译：药物包衣
公开(公告)号：WO2009051780A1
公开(公告)日：2009-04-23
申请号：PCT/US2008/011852
申请日：2008-10-17
申请人： MICELL TECHNOLOGIES, INC. , MCCLAIN, James, B. , TAYLOR, Douglas
发明人： MCCLAIN, James, B. , TAYLOR, Douglas
IPC分类号： A61F2/06
CPC分类号： A61L31/16 , A61L31/022 , A61L31/042 , A61L31/10 , A61L31/148 , A61L2300/236 , A61L2300/416 , A61L2300/42 , A61L2300/426 , A61L2300/602 , A61L2300/63 , A61L2420/02 , A61L2420/06 , A61L2420/08 , C08L67/04
摘要： Provided herein is a coated coronary stent, comprising: a stent framework; heparin molecules attached to the stent framework; and a rapamycin-polymer coating wherein at least part of rapamycin is in crystalline form. In one embodiment, the rapamycin-polymer coating comprises one or more resorbable polymers.
摘要翻译：本文提供了一种涂覆的冠状动脉支架，包括：支架框架; 肝素分子附着在支架框架上; 和雷帕霉素聚合物涂层，其中至少部分雷帕霉素是结晶形式。在一个实施方案中，雷帕霉素聚合物涂层包含一种或多种可再吸收的聚合物。

56. 发明申请

WO2008148013A1 POLYMER FILMS FOR MEDICAL DEVICE COATING 审中-公开
标题翻译：用于医疗器械涂层的聚合物膜
公开(公告)号：WO2008148013A1
公开(公告)日：2008-12-04
申请号：PCT/US2008/064732
申请日：2008-05-23
申请人： MICELL TECHNOLOGIES, INC. , TAYLOR, Douglas , MCCLAIN, James
发明人： TAYLOR, Douglas , MCCLAIN, James
IPC分类号： A61L27/04 , B05D1/04
CPC分类号： B05D1/025 , A61L27/34 , A61L31/10 , A61L2420/02 , B05D1/04 , B05D5/08 , B05D5/083 , B05D2401/90
摘要： A method for depositing a coating comprising a polymer and impermeable dispersed solid on a substrate, comprising the following steps: discharging at least one impermeable dispersed solid in dry powder form through a first orifice; discharging at least one polymer in dry powder form through a second orifice; depositing the polymer and/or impermeable dispersed solid particles onto said substrate, wherein an electrical potential is maintained between the substrate and the impermeable dispersed solid and/or polymer particles, thereby forming said coating; and sintering said coating under conditions that do not disrupt the activity and/or function of the substrate. A similar method is provided for depositing a coating comprising a hydrophobic polymer and a water-vapor-trapping material on a substrate.
摘要翻译：一种用于将包含聚合物和不渗透分散固体的涂层沉积在基材上的方法，包括以下步骤：通过第一孔排出至少一种干燥粉末形式的不可渗透的分散固体; 通过第二孔排出至少一种干粉形式的聚合物; 将聚合物和/或不可渗透的分散的固体颗粒沉积到所述基底上，其中在基底和不可渗透的分散的固体和/或聚合物颗粒之间保持电势，从而形成所述涂层; 并且在不破坏基材的活性和/或功能的条件下烧结所述涂层。提供了一种类似的方法，用于在衬底上沉积包含疏水性聚合物和水蒸汽捕获材料的涂层。

57. 发明申请

WO2007002238A2 DRUG/POLYMER COMPOSITE MATERIALS AND METHODS OF MAKING THE SAME 审中-公开
标题翻译：药物/聚合物复合材料及其制备方法
公开(公告)号：WO2007002238A2
公开(公告)日：2007-01-04
申请号：PCT/US2006/024221
申请日：2006-06-21
申请人： MICELL TECHNOLOGIES INC. , MCCLAIN, Jim , DEYOUNG, James
发明人： MCCLAIN, Jim , DEYOUNG, James
IPC分类号： A61K9/14 , A61F2/02
CPC分类号： A61K47/32 , A61K9/0024 , A61K9/1635 , A61K9/1694
摘要： A method of forming a drug/polymer composite material is carried out by combining a drug material with a polymer material under pressure in the presence of a densified gas solvent (e.g., carbon dioxide) to form the drug/polymer composite material. Drug/polymer composite materials and shaped articles (e.g., subcutaneous drug depots) which may be produced by a process are also described, along with methods of use thereof.
摘要翻译：形成药物/聚合物复合材料的方法通过在压力下在致密气体溶剂（例如二氧化碳）存在下将药物材料与聚合物材料组合以形成药物 /高分子复合材料。还描述了可以通过方法生产的药物/聚合物复合材料和成形制品（例如，皮下药物贮存库）以及其使用方法。

58. 发明申请

WO2004070071A2 METHOD OF COATING MICROELECTRONIC SUBSTRATES 审中-公开
标题翻译：涂布微电子基板的方法
公开(公告)号：WO2004070071A2
公开(公告)日：2004-08-19
申请号：PCT/US2003/038324
申请日：2003-12-02
申请人： MICELL TECHNOLOGIES, INC. , DEYOUNG, James, P. , MCCLAIN, James, B. , GROSS, Stephen, M. , TAYLOR, Doug , WAGNER, Mark, I. , BRAINARD, David, E.
发明人： DEYOUNG, James, P. , MCCLAIN, James, B. , GROSS, Stephen, M. , TAYLOR, Doug , WAGNER, Mark, I. , BRAINARD, David, E.
IPC分类号： C23C
CPC分类号： H01L21/283 , B05D1/18 , B05D2401/90 , H01L21/28556 , H01L21/288 , H01L21/67028 , H01L28/65
摘要： A method of coating a substrate comprises the steps of: (a) providing a substrate in an enclosed vessel, the substrate having a surface portion; (b) at least partially filling the enclosed vessel with a first supercritical fluid so that said first supercritical fluid contacts the surface portion, with the first supercritical fluid carrying or containing a coating component; then (c) adding a separate compressed gas atmosphere to the reaction vessel so that a boundary is formed between the first supercritical fluid and the separate compressed gas atmosphere, said separate compressed gas atmosphere having a density less than said first supercritical fluid; and then (d) displacing said first supercritical fluid from said vessel by continuing adding said separate compressed gas atmosphere to said vessel so that said boundary moves across said surface portion and a thin film of coating component is deposited on said microelectronic substrate.
摘要翻译：涂覆基材的方法包括以下步骤：（a）在密封容器中提供基材，所述基材具有表面部分; （b）用第一超临界流体至少部分地填充封闭的容器，使得所述第一超临界流体接触表面部分，第一超临界流体携带或包含涂层组分; 然后（c）向所述反应容器中加入单独的压缩气体气氛，使得在所述第一超临界流体和所述单独的压缩气体气氛之间形成边界，所述单独的压缩气体气氛的密度小于所述第一超临界流体; 然后（d）通过将所述单独的压缩气体气氛继续加入到所述容器中，使所述边界移动穿过所述表面部分并且将涂层组分的薄膜沉积在所述微电子衬底上，从而使所述第一超临界流体从所述容器移位。

59. 发明申请

WO2004046826A2 POSITIVE TONE LITHOGRAPHY IN CARBON DIOXIDE SOLVENTS 审中-公开
标题翻译：二氧化碳溶液中的积极色调
公开(公告)号：WO2004046826A2
公开(公告)日：2004-06-03
申请号：PCT/US0336670
申请日：2003-11-12
申请人： MICELL TECHNOLOGIES INC , MCCLAIN JAMES B , DEYOUNG JAMES P
发明人： MCCLAIN JAMES B , DEYOUNG JAMES P
IPC分类号： G03F20060101 , G03F7/00 , G03F7/32 , G03F7/36 , G03F
CPC分类号： G03F7/36 , G03F7/32 , G03F7/325 , G03F7/327
摘要： A method for carrying out positive tone lithography with a carbon dioxide solvent system is carried out by (a) providing a substrate having a polymer resist layer formed thereon; (b) exposing at least one portion of the polymer resist layer to radiant energy to form at least one light field region in the polymer resist layer; and then (c) contacting the polymer resist layer to a carbon dioxide solvent system, the solvent system preferably comprising a polar group, under conditions in which the at least one light field region is preferentially removed.
摘要翻译：通过（a）提供其上形成有聚合物抗蚀剂层的基材，进行用二氧化碳溶剂系统进行正色调光刻的方法; （b）将聚合物抗蚀剂层的至少一部分暴露于辐射能以在聚合物抗蚀剂层中形成至少一个光场区域; 然后（c）在其中优选除去所述至少一个光场区域的条件下，使所述聚合物抗蚀剂层与二氧化碳溶剂体系接触，所述溶剂体系优选包含极性基团。

60. 发明申请

WO2003084680A1 ENHANCED PROCESSING OF PERFORMANCE FILMS USING HIGH-DIFFUSIVITY PENETRANTS 审中-公开
标题翻译：使用高分辨率渗透剂对性能膜进行加强处理
公开(公告)号：WO2003084680A1
公开(公告)日：2003-10-16
申请号：PCT/US2003/009245
申请日：2003-03-26
申请人： MICELL TECHNOLOGIES, INC. , CARBONELL, Ruben , DESIMONE, Joseph, M. , MCCLAIN, James, B. , DEYOUNG, James, P.
发明人： CARBONELL, Ruben , DESIMONE, Joseph, M. , MCCLAIN, James, B. , DEYOUNG, James, P.
IPC分类号： B05D3/04
CPC分类号： H01L21/3105 , G03F7/168 , G03F7/265 , G03F7/38 , H01L21/31058
摘要： A method of reducing undesired topographic features, increasing film density, and/or increasing adhesion to an underlying substrate in a polymer film formed on a microelectronic substrate, comprises: (a) providing a microelectronic substrate, the substrate having a polymer film deposited thereon; (b) contacting the substrate to carbon dioxide (optionally containing additional ingredients such as cosolvents or chemical intermediates); and (c) elevating the pressure of the carbon dioxide to plasticize the polymer film and reduce undesired topographic features, increase film density, and/or increase adhesion of the film to the underlying substrate.
摘要翻译：包括：（a）提供微电子衬底，所述衬底具有沉积在其上的聚合物膜;以及（c）提供微电子衬底，所述衬底具有沉积在其上的聚合物膜; （b）将底物与二氧化碳接触（任选地含有另外的成分，例如助溶剂或化学中间体）; 和（c）提高二氧化碳的压力以塑化聚合物膜并减少不期望的形貌特征，增加膜密度和/或增加膜与下面的基底的粘附。

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