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1. 发明申请

WO2007011708A3 STENT WITH POLYMER COATING CONTAINING AMORPHOUS RAPAMYCIN 审中-公开
公开(公告)号：WO2007011708A3
公开(公告)日：2007-06-28
申请号：PCT/US2006027322
申请日：2006-07-14
申请人： MICELL TECHNOLOGIES INC , TAYLOR DOUG , DAYOUNG JAMES , MCCLAIN JIM
发明人： TAYLOR DOUG , DAYOUNG JAMES , MCCLAIN JIM
IPC分类号： A61F2/06 , A61L27/00 , B05D7/22
CPC分类号： A61F2/86 , A61F2/07 , A61F2002/821 , A61F2240/002 , A61F2250/0067 , A61L31/022 , A61L31/10 , A61L31/16 , A61L2300/216 , A61L2300/606 , A61L2420/08
摘要： A coated coronary stent, comprising: a stainless steel sent framework coated with a primer layer of Parylene C; and a rapamycin-polyrner coating having substantially uniform thickness disposed on the stent framework, wherein the rapamycin-polymer coating comprises polybutyl methacrylate (PBMA), polyethylene-co-vinyl acetate (PEVA) and rapamycin, wherein substantially all of the rapamycin in the coating is in amorphous form and substantially uniformly dispersed within the rapamycin-polymer coating.

2. 发明申请

WO2005001231A2 SUBMERSIBLE PUMP 审中-公开
标题翻译：潜水泵
公开(公告)号：WO2005001231A2
公开(公告)日：2005-01-06
申请号：PCT/US2004/017054
申请日：2004-05-28
申请人： MCCLAIN, Jim
发明人： MCCLAIN, Jim
IPC分类号： E21B
CPC分类号： F04B47/04 , E21B43/129 , F04B47/08
摘要： A submersible pump for attachment to the lower end of a well pipe discharge tube for insertion in liquid includes a stationary collecting tube for collecting the liquid and an upward and downward reciprocating pumping tube within the collecting tube for pushing and lifting the liquid into the discharge tube; source of pressurized gas, a casing assembly including a casing tube and a gas valve, and a piston assembly with the casing tube including a piston tube having a lower end connected to the pumping tube for reciprocating the pumping tube and an upper portion having pistons for moving in chambers with the inside of the casing tube. Preferably the same amount of liquid is pumped during the upward movement of the pumping tube as during the downward movement.
摘要翻译：用于连接到用于插入液体的井管放电管的下端的潜水泵包括用于收集液体的固定收集管和在收集管内的向上和向下往复泵送管，用于将液体推入和提升到排放管中 ; 加压气体源，包括套管和气阀的壳体组件以及具有套管的活塞组件，所述活塞组件包括活塞管，所述活塞管具有连接到泵管的下端，用于往复运动泵管和具有活塞的上部，在室内与套管的内部一起移动。优选地，在向下运动期间，在泵管的向上运动期间泵送相同量的液体。

3. 发明申请

WO2008042909A3 SURGICAL SUTURES HAVING INCREASED STRENGTH 审中-公开
标题翻译：具有增强强度的外科手术
公开(公告)号：WO2008042909A3
公开(公告)日：2008-08-07
申请号：PCT/US2007080213
申请日：2007-10-02
申请人： MICELL TECHNOLOGIES INC , MCCLAIN JIM
发明人： MCCLAIN JIM
IPC分类号： C08J3/205
CPC分类号： A61L17/145 , A61L17/005 , A61L17/12 , A61L2300/00
摘要： The invention relates to increasing the strength of bio-absorbable surgical sutures. The invention allows for delayed bioabsorption of suture materials to allow maintenance of mechanical strength of the suture for example in 'barbed' form.
摘要翻译：本发明涉及提高生物吸收性外科缝合线的强度。本发明允许缝合材料的延迟生物吸收以允许维持例如“倒刺”形式的缝合线的机械强度。

4. 发明申请

WO2008042909A2 SURGICAL SUTURES HAVING INCREASED STRENGTH 审中-公开
标题翻译：手术缝合具有增强的强度
公开(公告)号：WO2008042909A2
公开(公告)日：2008-04-10
申请号：PCT/US2007/080213
申请日：2007-10-02
申请人： MICELL TECHNOLOGIES INC. , MCCLAIN, Jim
发明人： MCCLAIN, Jim
IPC分类号： A61F2/02
CPC分类号： A61L17/145 , A61L17/005 , A61L17/12 , A61L2300/00
摘要： The invention relates to increasing the strength of bio-absorbable surgical sutures. The invention allows for delayed bioabsorption of suture materials to allow maintenance of mechanical strength of the suture for example in 'barbed' form.
摘要翻译：本发明涉及增加生物可吸收外科缝合线的强度。本发明允许缝合线材料的延迟生物吸收以允许维持缝合线的机械强度，例如以“倒钩”形式。

5. 发明申请

WO2007011707A3 POLYMER COATINGS CONTAINING DRUG POWDER OF CONTROLLED MORPHOLOGY 审中-公开
标题翻译：含控制形态药物粉末的聚合物涂层
公开(公告)号：WO2007011707A3
公开(公告)日：2007-12-27
申请号：PCT/US2006027321
申请日：2006-07-14
申请人： MICELL TECHNOLOGIES INC , TAYLOR DOUG , MCCLAIN JIM , SMOKE CLINT , COLE MIKE , DEYOUNG JAMES
发明人： TAYLOR DOUG , MCCLAIN JIM , SMOKE CLINT , COLE MIKE , DEYOUNG JAMES
IPC分类号： B05D3/00 , A61L2/00
CPC分类号： A61F2/82 , A61F2210/0076 , A61F2250/0067 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/426 , A61L2300/606 , A61L2300/63 , A61L2420/08 , Y10T428/264 , Y10T428/265 , Y10T428/31507 , Y10T428/31544 , Y10T428/31551 , Y10T428/31663 , Y10T428/31786 , Y10T428/31935 , Y10T428/31938
摘要： A method for depositing a coating comprising a polymer and pharmaceutical agent on a substrate, comprising the following steps: discharging at least one pharmaceutical agent in a therapeutically desirable morphology in dry powder form through a first orifice; discharging at least one polymer in dry powder form through a second orifice; depositing the polymer and/or pharmaceutical particles onto said substrate, wherein an electrical potential is maintained between the substrate and the pharmaceutical and/or polymer particles, thereby forming said coating; and sintering said coating under conditions that do not substantially modify the morphology of said pharmaceutical agent.
摘要翻译：一种用于在基底上沉积包含聚合物和药剂的涂层的方法，包括以下步骤：通过第一孔口以干粉形式释放治疗上理想的形态的至少一种药剂; 通过第二孔排出至少一种干粉形式的聚合物; 将聚合物和/或药物颗粒沉积到所述基底上，其中在基底和药物和/或聚合物颗粒之间保持电势，由此形成所述涂层; 和在不显着改变所述药剂的形态的条件下烧结所述涂层。

6. 发明申请

WO2007127363A2 COATINGS CONTAINING MULTIPLE DRUGS 审中-公开
标题翻译：包含多种药物的涂料
公开(公告)号：WO2007127363A2
公开(公告)日：2007-11-08
申请号：PCT/US2007/010227
申请日：2007-04-26
申请人： MICELL TECHNOLOGIES, INC. , DEYOUNG, James , TAYLOR, Doug , MCCLAIN, Jim , SMOKE, Clint , COLE, Mike
发明人： DEYOUNG, James , TAYLOR, Doug , MCCLAIN, Jim , SMOKE, Clint , COLE, Mike
IPC分类号： A61K9/14
CPC分类号： A61L31/16 , A61F2/90 , A61F2210/0004 , A61F2250/0067 , A61L31/06 , A61L31/10 , A61L31/148 , A61L2300/20 , A61L2300/216 , A61L2300/236 , A61L2300/416 , A61L2300/42 , A61L2300/426 , A61L2300/602 , A61L2300/608 , A61L2300/61 , A61L2420/02 , A61L2420/06 , A61L2420/08
摘要： A method for depositing a coating comprising a polymer and at least two pharmaceutical agents on a substrate, comprising the following steps: providing a stent framework; depositing on said stent framework a first layer comprising a first pharmaceutical agent; depositing a second layer comprising a second pharmaceutical agent; Wherein said first and second pharmaceutical agents are selected from two different classes of pharmaceutical agents.
摘要翻译：一种用于在基底上沉积包含聚合物和至少两种药剂的涂层的方法，包括以下步骤：提供支架框架; 在所述支架框架上沉积包含第一药剂的第一层; 沉积包含第二药剂的第二层; 其中所述第一和第二药剂选自两种不同类型的药剂。

7. 发明申请

WO2007002238A3 DRUG/POLYMER COMPOSITE MATERIALS AND METHODS OF MAKING THE SAME 审中-公开
标题翻译：药物/聚合物复合材料及其制备方法
公开(公告)号：WO2007002238A3
公开(公告)日：2007-05-10
申请号：PCT/US2006024221
申请日：2006-06-21
申请人： MICELL TECHNOLOGIES INC , MCCLAIN JIM , DEYOUNG JAMES
发明人： MCCLAIN JIM , DEYOUNG JAMES
IPC分类号： A61K9/00 , A61F13/00 , A61K9/20 , A61K9/48
CPC分类号： A61K47/32 , A61K9/0024 , A61K9/1635 , A61K9/1694
摘要： A method of forming a drug/polymer composite material is carried out by combining a drug material with a polymer material under pressure in the presence of a densified gas solvent (e.g., carbon dioxide) to form the drug/polymer composite material. Drug/polymer composite materials and shaped articles (e.g., subcutaneous drug depots) which may be produced by a process are also described, along with methods of use thereof.
摘要翻译：形成药物/聚合物复合材料的方法通过在致密化的气体溶剂（例如二氧化碳）的存在下将药物材料与聚合物材料在压力下组合以形成药物/聚合物复合材料来进行。还可以描述可以通过方法制备的药物/聚合物复合材料和成型制品（例如，皮下药物贮库）及其使用方法。

8. 发明申请

WO2005001231A3 SUBMERSIBLE PUMP 审中-公开
标题翻译：潜水泵
公开(公告)号：WO2005001231A3
公开(公告)日：2005-03-24
申请号：PCT/US2004017054
申请日：2004-05-28
申请人： MCCLAIN JIM
发明人： MCCLAIN JIM
IPC分类号： E21B20060101 , E21B43/00 , E21B43/12 , F04B47/04 , F04B47/08
CPC分类号： F04B47/04 , E21B43/129 , F04B47/08
摘要： A submersible pump (10) for attachment to the lower end of a well pipe discharge tube (100) for insertion in liquid includes a stationary collecting tube (20) for collecting the liquid and an upward and downward reciprocating pumping tube (30) within the collecting tube (20) for pushing and lifting the liquid into the discharge tube (100); source of pressurized gas (50), a casing assembly (41) including a casing tube (42) and a gas valve (60), and a piston assembly (88) with the casing tube (42) including a piston tube (81) having a lower end connected to the pumping tube (30) for reciprocating the pumping tube (30) and an upper portion having pistons (90) for moving in chambers with the inside of the casing tube (42). Preferably the same amount of liquid is pumped during the upward movement of the pumping tube (30) as during the downward movement.
摘要翻译：用于连接到用于插入液体的井管排放管（100）的下端的潜水泵（10）包括用于收集液体的固定收集管（20）和在其内部的向上和向下往复泵送管（30）收集管（20），用于将液体推入并提升到排放管（100）中; 加压气体源（50），包括套管（42）和气阀（60）的壳体组件（41）以及具有活塞管（81）的套管（42）的活塞组件（88）具有连接到泵送管（30）的下端，用于使泵管（30）往复运动;以及上部具有活塞（90），用于与套管（42）的内部一起移动。优选地，在向下运动期间，在泵管（30）的向上运动期间泵送相同量的液体。

9. 发明申请

WO2007002238A2 DRUG/POLYMER COMPOSITE MATERIALS AND METHODS OF MAKING THE SAME 审中-公开
标题翻译：药物/聚合物复合材料及其制备方法
公开(公告)号：WO2007002238A2
公开(公告)日：2007-01-04
申请号：PCT/US2006/024221
申请日：2006-06-21
申请人： MICELL TECHNOLOGIES INC. , MCCLAIN, Jim , DEYOUNG, James
发明人： MCCLAIN, Jim , DEYOUNG, James
IPC分类号： A61K9/14 , A61F2/02
CPC分类号： A61K47/32 , A61K9/0024 , A61K9/1635 , A61K9/1694
摘要： A method of forming a drug/polymer composite material is carried out by combining a drug material with a polymer material under pressure in the presence of a densified gas solvent (e.g., carbon dioxide) to form the drug/polymer composite material. Drug/polymer composite materials and shaped articles (e.g., subcutaneous drug depots) which may be produced by a process are also described, along with methods of use thereof.
摘要翻译：形成药物/聚合物复合材料的方法通过在压力下在致密气体溶剂（例如二氧化碳）存在下将药物材料与聚合物材料组合以形成药物 /高分子复合材料。还描述了可以通过方法生产的药物/聚合物复合材料和成形制品（例如，皮下药物贮存库）以及其使用方法。

10. 发明申请

WO2007127363A3 COATINGS CONTAINING MULTIPLE DRUGS 审中-公开
标题翻译：包含多种药物的涂料
公开(公告)号：WO2007127363A3
公开(公告)日：2008-10-16
申请号：PCT/US2007010227
申请日：2007-04-26
申请人： MICELL TECHNOLOGIES INC , DEYOUNG JAMES , TAYLOR DOUG , MCCLAIN JIM , SMOKE CLINT , COLE MIKE
发明人： DEYOUNG JAMES , TAYLOR DOUG , MCCLAIN JIM , SMOKE CLINT , COLE MIKE
IPC分类号： A61F13/00 , A61F2/00 , A61F2/06
CPC分类号： A61L31/16 , A61F2/90 , A61F2210/0004 , A61F2250/0067 , A61L31/06 , A61L31/10 , A61L31/148 , A61L2300/20 , A61L2300/216 , A61L2300/236 , A61L2300/416 , A61L2300/42 , A61L2300/426 , A61L2300/602 , A61L2300/608 , A61L2300/61 , A61L2420/02 , A61L2420/06 , A61L2420/08
摘要： A method for depositing a coating comprising a polymer and at least two pharmaceutical agents on a substrate, comprising the following steps: providing a stent framework; depositing on said stent framework a first layer comprising a first pharmaceutical agent; depositing a second layer comprising a second pharmaceutical agent; Wherein said first and second pharmaceutical agents are selected from two different classes of pharmaceutical agents.
摘要翻译：一种用于在基底上沉积包含聚合物和至少两种药剂的涂层的方法，包括以下步骤：提供支架框架; 在所述支架框架上沉积包含第一药剂的第一层; 沉积包含第二药剂的第二层; 其中所述第一和第二药剂选自两种不同类型的药剂。

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