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41. 发明申请

WO2011133877A2 TELESCOPING CRYOCANE 审中-公开
标题翻译：推荐CRYOCANE
公开(公告)号：WO2011133877A2
公开(公告)日：2011-10-27
申请号：PCT/US2011/033599
申请日：2011-04-22
申请人： ST REPRODUCTIVE TECHNOLOGIES LLC , COGNARD, Eric , MORENO, Juan
发明人： COGNARD, Eric , MORENO, Juan
IPC分类号： A01M1/02 , A61J1/00 , C12M1/24 , B65D21/02 , B65D85/00
CPC分类号： A01N1/0268 , G01N1/42
摘要： A telescoping cryocane having a first container element and a second container element, where the first container element and the second container element are in a slidable telescoping relationship. One or more of the first and the second container elements being configured for suspending and retaining a continer for container materials which require storage at very low temperatures.
摘要翻译：具有第一容器元件和第二容器元件的伸缩式冷冻机，其中第一容器元件和第二容器元件处于可滑动的伸缩关系。第一和第二容器元件中的一个或多个被构造用于悬挂和保持用于在非常低的温度下储存的容器材料的连续件。

42. 发明申请

WO2011106384A1 APPARATUS AND METHODS FOR INTEGRATED SAMPLE PREPARATION, REACTION AND DETECTION 审中-公开
标题翻译：集成样品制备，反应和检测的装置和方法
公开(公告)号：WO2011106384A1
公开(公告)日：2011-09-01
申请号：PCT/US2011/025871
申请日：2011-02-23
申请人： GENTURADX, INC. , BIRD, Dylan, Hilmer , CHING, Jesus , JOHNSON, Bruce, A. , MORAVICK, Keith, E. , RICHARDSON, Bruce
发明人： BIRD, Dylan, Hilmer , CHING, Jesus , JOHNSON, Bruce, A. , MORAVICK, Keith, E. , RICHARDSON, Bruce
IPC分类号： C12M1/24
CPC分类号： B01L7/52 , B01F5/12 , B01F11/0071 , B01F15/0203 , B01F15/0237 , B01F2015/0221 , B01F2215/0037 , B01L3/502 , B01L3/502715 , B01L3/50851 , B01L3/523 , B01L3/527 , B01L7/00 , B01L2200/025 , B01L2200/026 , B01L2200/028 , B01L2200/0647 , B01L2200/10 , B01L2200/16 , B01L2300/042 , B01L2300/044 , B01L2300/0627 , B01L2300/0654 , B01L2300/0672 , B01L2300/0829 , B01L2300/0867 , B01L2300/087 , B01L2300/1805 , B01L2400/0406 , B01L2400/043 , B01L2400/0478 , B01L2400/0481 , B01L2400/0622 , B01L2400/0633 , B01L2400/0644 , B01L2400/0683 , C12Q1/6806 , C12Q1/686 , G01N1/38 , G01N35/1079 , G01N2035/0436 , Y10T436/118339 , Y10T436/25375 , Y10T436/255
摘要： Cartridges for the isolation of a biological sample and downstream biological assays on the sample are provided. In one embodiment, a nucleic acid sample is isolated from a biological sample and the nucleic acid sample is amplified, for example by the polymerase chain reaction. The cartridges provided herein can also be used for the isolation of non-nucleic acid samples, for example proteins, and to perform downstream reactions on the proteins, for example, binding assays. Instruments for carrying out the downstream biological assays and for detecting the results of the assays are also provided.
摘要翻译：提供用于分离生物样品的柱和样品上的下游生物测定。在一个实施方案中，从生物样品中分离核酸样品，并且例如通过聚合酶链式反应扩增核酸样品。本文提供的盒还可用于分离非核酸样品，例如蛋白质，并对蛋白质进行下游反应，例如结合测定。还提供了用于进行下游生物测定和检测测定结果的仪器。

43. 发明申请

WO2011106038A1 METHOD AND APPARATUS FOR PROVIDING A PHOTOBIOREACTOR 审中-公开
标题翻译：提供光电转换器的方法和装置
公开(公告)号：WO2011106038A1
公开(公告)日：2011-09-01
申请号：PCT/US2010/051971
申请日：2010-10-08
申请人： MENA, Jacinto , MARGALEF, Pere
发明人： MENA, Jacinto
IPC分类号： C12M3/02 , C12M1/24 , C12M1/04
CPC分类号： C12M21/02 , C12M23/28 , C12M27/00 , C12M29/00
摘要： The present invention provides for a photobioreactor for the cultivation of photosynthetic microorganisms and comprises a hydraulic circuit through which an aqueous solution containing culture of at least one type of photosynthetic organism circulates and gets exposed to a light source. The photobioreactor also comprises a means for feeding carbon dioxide into the system, a means for oxygen degasification, and a means for injecting nutrients into the system. The hydraulic circuit is comprised of two open receiving channels at the same relative elevation, a set of transparent or translucent tubes which connect receiving channels to each other, and at least one fluid moving device to move the fluid from the first to the second receiving channels through the tubes. Each receiving channel also comprises a directional dam which assists in maintaining two different surface levels of the aqueous solution within the upstream and downstream portions of each receiving channel.
摘要翻译：本发明提供了用于培养光合微生物的光生物反应器，并且包括液压回路，含有至少一种类型的光合生物的培养物的水溶液通过该回路循环并暴露于光源。光生物反应器还包括用于将二氧化碳进料到系统中的装置，用于氧气脱气的装置，以及用于将营养物质注入系统的装置。液压回路由相同相对高度的两个敞开的接收通道组成，一组将接收通道彼此连接的透明或半透明管，以及至少一个流体移动装置，用于将流体从第一接收通道移动到第二接收通道通过管子。每个接收通道还包括定向坝，其有助于维持每个接收通道的上游和下游部分内的水溶液的两个不同表面水平。

44. 发明申请

WO2011104612A2 DEVICE FOR CELL CULTURE AND ANALYSIS 审中-公开
标题翻译：细胞培养和分析装置
公开(公告)号：WO2011104612A2
公开(公告)日：2011-09-01
申请号：PCT/IB2011/000365
申请日：2011-02-23
申请人： UNIVERSITA' DEGLI STUDI DI VERONA , CHILOSI, Marco , KRAMPERO, Mauro , RICCIARDI, Mario
发明人： CHILOSI, Marco , KRAMPERO, Mauro , RICCIARDI, Mario
IPC分类号： C12M1/24
CPC分类号： C12Q1/04 , C12M23/08 , C12M23/22 , C12M25/02 , G01N1/06 , G01N1/36
摘要： The present invention relates to a device (1) for cell culture and analysis, comprising a first containing element (2), a second containing element (3) sealingly couplable to one another to define a culture chamber (4) and a flexible film (11) housable in said culture chamber (4) and available alternatively on one of said first element (2) or second element (3). The flexible film (11) can be made of a transparent material selected from the group consisting of polycarbonate, polystyrene and polyethylene. A method for cell analysis is also provided.
摘要翻译：本发明涉及用于细胞培养和分析的装置（1），其包括第一容纳元件（2），彼此密封地连接以限定培养室（4）和柔性膜（2）的第二容纳元件（3） 11），其可在所述培养室（4）中容纳，并且可替代地在所述第一元件（2）或第二元件（3）中的一个上可用。柔性膜（11）可以由选自聚碳酸酯，聚苯乙烯和聚乙烯的透明材料制成。还提供了一种细胞分析方法。

45. 发明申请

WO2011056230A1 SELF-CONTAINED BREATHING CLOSURE AND CONTAINER 审中-公开
标题翻译：自给式呼吸闭合和容器
公开(公告)号：WO2011056230A1
公开(公告)日：2011-05-12
申请号：PCT/US2010/002916
申请日：2010-11-05
申请人： MCADAMS, Todd, A. , HOWE, Harold, W. , DRAPER, Jeffrey, E. , FARRAR, Lawrence, C.
发明人： MCADAMS, Todd, A. , HOWE, Harold, W. , DRAPER, Jeffrey, E. , FARRAR, Lawrence, C.
IPC分类号： C12M1/24
CPC分类号： C12M23/38 , B01F11/0005 , B01F15/0203 , B01F15/0244 , C12M23/28 , C12M37/00 , Y10T137/0318
摘要： A self-contained breathing closure for flasks and other containers that require gas exchange. An illustrative embodiment of the closure is comprised of a splashguard, an adaptor for attaching the closure to the container, a bellows element and a gas-permeable barrier element. The splashguard is intended to keep liquid contents under vigorous agitation in the container without wetting the gas-permeable barrier. The adaptor couples the closure to the container in a secure fashion. The bellows element allows for repeated changes in the internal volume of the container-closure system. The gas-permeable barrier allows desired gases to enter and leave the container while excluding small particles and/or microorganisms. The technology may be used with existing glass flask technology, or coupled to a plastic flask that may be configured for either single-use, or multiple-use.
摘要翻译：用于需要气体交换的烧瓶和其他容器的独立呼吸闭合。闭合件的说明性实施例包括防溅板，用于将封闭件附接到容器的适配器，波纹管元件和透气性屏障元件。防溅板旨在将液体内容物剧烈搅拌在容器中，而不会润湿透气性屏障。转接器将闭合件以安全的方式连接到容器上。波纹管元件允许容器封闭系统的内部体积的重复变化。透气屏障允许所需气体进入和离开容器，同时排除小颗粒和/或微生物。该技术可以与现有的玻璃烧瓶技术一起使用，或者与可以配置为单次使用或多次使用的塑料烧瓶相结合。

46. 发明申请

WO2011052927A2 BIO-DEVICE FOR EXTRACTING HEMATOPOIETIC STEM CELLS AND MESENCHYMAL STEM CELLS IN PERIPHERAL BLOOD 审中-公开
标题翻译：用于在外周血中提取造血干细胞和间质干细胞的生物设备
公开(公告)号：WO2011052927A2
公开(公告)日：2011-05-05
申请号：PCT/KR2010007238
申请日：2010-10-21
申请人： TOZAIHOLDINGS INC , MOON SANG HO
发明人： MOON SANG HO
IPC分类号： C12M1/26 , C12M1/24
CPC分类号： C12M47/04 , A61M1/029 , A61M2202/0437 , B01D21/262 , B01D2221/10 , B01L3/5021 , B01L2200/141 , B01L2300/042 , B01L2300/049 , B01L2300/0832 , B01L2300/0858
摘要： Provided is a bio-device for extracting a buffy coat layer from peripheral blood, comprising: a device main body having an upper receiving space, a lower receiving space placed under the upper receiving space, and a bottleneck part which is a path connecting the upper receiving space and lower receiving space; an upper cover which is coupled to the upper portion of the device main body to be slidable on the device main body; and a lower cover which closes the lower receiving space by being coupled to the lower portion of the device main body to be slidable on the device main body. The bio-device of the present invention enables easy extraction of a buffy coat layer having a large amount of hematopoietic stem cells and mesenchymal stem cells.
摘要翻译：本发明提供一种从外周血中提取血沉棕黄层的生物设备，其包括：装置主体，其具有上容纳空间，位于上容纳空间下方的下容纳空间和作为连接上容纳空间的路径的瓶颈部分容纳空间和较低的容纳空间; 上盖，其与装置主体的上部结合以可在装置主体上滑动; 以及通过结合到装置主体的下部以能够在装置主体上滑动来封闭下容纳空间的下盖。本发明的生物设备能够容易地提取具有大量造血干细胞和间充质干细胞的血沉棕黄层。

47. 发明申请

WO2010089659A3 MEDICAL DEVICE TO VERIFY THE PRESENCE OF MICROORGANISMS OR BACTERIA IN A SAMPLE OF AN ORGAN OR A BIOLOGICAL TISSUE, DIAGNOSTIC APPARATUS COMPRISING SAID MEDICAL DEVICE AND RELATIVE METHOD 审中-公开
标题翻译：用于验证微生物或细菌在一种或多种生物组织样品中的存在的医疗装置，包含所述医疗装置的诊断装置和相关方法
公开(公告)号：WO2010089659A3
公开(公告)日：2011-04-21
申请号：PCT/IB2010000228
申请日：2010-02-05
申请人： ALIFAX HOLDING SPA , GALIANO PAOLO
发明人： GALIANO PAOLO
IPC分类号： C12M1/24 , B01L3/14 , C12M1/34
CPC分类号： C12M23/08 , B01L3/50825 , B01L2300/046 , B01L2300/0609 , C12M23/38
摘要： Medical device (10) to verify the presence of microorganisms or bacteria in a sample (32) of an organ or biological tissue inside a container element (28), which is made of material transparent to the electromagnetic radiations that are emitted toward it along a path (P) and has at least an aperture (30) through which said sample (32) is inserted. Liquid culture means (34) are provided inside the container element (28) which are suitable to promote the growth of microorganisms or bacteria possibly present in the sample (32). The medical device (10) comprises a closing element (12) able to be located in correspondence with the aperture (30) and a support element (16) of the oblong type, which extends from the closing element (32) and is able to be introduced inside the container element (28). The support element (16) has an end portion (20) able to be associated stably with the sample (32) so as to keep the sample (32) suspended and at least partly immersed in the liquid culture means (34) inside the container element (28).
摘要翻译：用于验证在容器元件（28）内的器官或生物组织的样品（32）中的微生物或细菌的存在的医疗设备（10），所述容器元件（28）由对沿着其发射的电磁辐射透明的材料制成，路径（P）并且至少具有插入所述样品（32）的孔（30）。液体培养装置（34）设置在容器元件（28）的内部，其适于促进可能存在于样品（32）中的微生物或细菌的生长。医疗装置（10）包括能够与孔（30）对应定位的闭合元件（12）和从闭合元件（32）延伸的长方形的支撑元件（16），并且能够引入容器元件（28）内。支撑元件（16）具有能够与样品（32）稳定地相关联的端部（20），以便将样品（32）悬浮并且至少部分地浸入容器内部的液体培养装置（34）中元件（28）。

48. 发明申请

WO2011041471A1 SINGLE LAYER PLASTIC TEST SAMPLE CULTURE BOTTLE 审中-公开
标题翻译：单层塑料试验样品文化瓶
公开(公告)号：WO2011041471A1
公开(公告)日：2011-04-07
申请号：PCT/US2010/050797
申请日：2010-09-30
申请人： BIOMERIEUX, INC. , ROBINSON, Ronnie, J. , RONSICK, Christopher, S. , WILSON, Mark, Steven
发明人： ROBINSON, Ronnie, J. , RONSICK, Christopher, S. , WILSON, Mark, Steven
IPC分类号： C12M1/24
CPC分类号： C12M23/08 , C12M23/20 , C12M23/28
摘要： A bottle for culturing a test sample, e.g., blood, includes a plastic vessel made from a single layer of plastic material. The bottle features a glass barrier coating applied to the bottle, such as a silica or glass coating. An alternative embodiment features a single layer plastic bottle and a gas barrier adhesive label covering the cylindrical side wall of the bottle. In another embodiment the gas barrier is in the form of a plastic shrink-wrap partially or alternatively completely enveloping the plastic vessel. Kits comprising two or more of such bottles and methods of manufacturing the bottles are also disclosed.
摘要翻译：用于培养测试样品例如血液的瓶子包括由单层塑料材料制成的塑料容器。该瓶具有施加到瓶子上的玻璃阻隔涂层，例如二氧化硅或玻璃涂层。替代实施例的特征在于单层塑料瓶和覆盖瓶的圆柱形侧壁的阻气粘合标签。在另一个实施方案中，气体阻隔层是部分或替代地完全包封塑料容器的塑料收缩包装的形式。还公开了包括这种瓶子中的两种或更多种的瓶子和制造瓶子的方法。

49. 发明申请

WO2010099264A3 CELL CULTURE SYSTEM WITH MANIFOLD 审中-公开
标题翻译：具有歧管的细胞培养系统
公开(公告)号：WO2010099264A3
公开(公告)日：2010-12-02
申请号：PCT/US2010025321
申请日：2010-02-25
申请人： CORNING INC , KENNEY DAVID A , MARTIN GREGORY R , WALL JOSEPH C
发明人： KENNEY DAVID A , MARTIN GREGORY R , WALL JOSEPH C
IPC分类号： C12M1/24 , B01L3/00
CPC分类号： C12M23/08 , C12M23/34 , C12M23/40 , C12M23/44 , Y10T29/49826
摘要： A cell culture apparatus includes cell culture units having cell culture chambers, each with at least one manifold. The manifold connects the cell culture unit to a fluid flow channel. The manifold has a dam which allows liquid to pool in the manifold and allows for the creation of an airspace in the manifold, which reduces hydrostatic pressure inside the apparatus and enables the stacking of multiple cell culture units. Embodiments include cascading manifolds, manifolds having reservoirs, and manifolds having valves.
摘要翻译：细胞培养装置包括具有细胞培养室的细胞培养装置，每个细胞培养装置具有至少一个歧管。歧管将细胞培养单元连接到流体流动通道。该歧管具有允许液体汇集在歧管中并且允许在歧管中产生空气空间的坝，其减小了设备内部的静水压力并且能够堆叠多个细胞培养单元。实施例包括级联歧管，具有储存器的歧管和具有阀的歧管。

50. 发明申请

WO2010124325A1 A CAPILLARY FLOW TEST ASSEMBLY 审中-公开
标题翻译：毛细管流量测试总成
公开(公告)号：WO2010124325A1
公开(公告)日：2010-11-04
申请号：PCT/AU2010/000483
申请日：2010-04-27
申请人： AXXIN PTY LTD , HOPPER, William, R
发明人： HOPPER, William, R
IPC分类号： G01N33/52 , C12M1/24 , G01N1/38 , B01L3/00 , G01N1/28
CPC分类号： B01L3/5082 , B01L3/5023 , B01L2200/026 , B01L2200/04 , B01L2200/16 , B01L2300/0636 , B01L2300/1816 , B01L2400/043
摘要： A capillary flow test assembly, including: a receptacle having an opening to receive a sample collection device including a sample to be tested using a capillary flow test, the receptacle containing: (i) one or more chemical entities to interact with the sample prior to performing the test, including one or more liquids contained in one or more packages; (ii) a release component configured to release the one or more liquids from the one or more packages to allow the one or more chemical entities to interact with the sample and thereby provide at least one interaction product for the test; (iii) a capillary flow test pad assembly configured to receive the at least one interaction product and to perform the capillary flow test thereon; and (iv) a delay component configured to delay or prevent transport of the one or more chemical entities and the sample to the capillary flow test pad assembly to allow time for the interaction to occur.
摘要翻译：一种毛细管流动测试组件，包括：容器，其具有用于接收包括使用毛细管流动测试的待测试样品的样品收集装置的开口，所述容器包含：（i）一个或多个化学实体，以在执行测试，包括一个或多个包装中包含的一种或多种液体; （ii）释放部件，其被配置为从所述一个或多个包装释放所述一种或多种液体，以允许所述一个或多个化学实体与所述样品相互作用，从而为所述测试提供至少一个相互作用产物; （iii）毛细管流动测试垫组件，其构造成接收所述至少一个相互作用产物并在其上进行毛细管流动测试; 以及（iv）延迟部件，其构造成延迟或防止将所述一个或多个化学实体和所述样品传送到所述毛细管流动测试垫组件以允许发生相互作用的时间。

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