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1. 发明申请

WO2012016024A3 CULTURE BOTTLES WITH INTERNAL SENSORS 审中-公开
标题翻译：文化瓶与内部传感器
公开(公告)号：WO2012016024A3
公开(公告)日：2013-08-08
申请号：PCT/US2011045698
申请日：2011-07-28
申请人： BIO MERIEUX INC , WILSON MARK S , ROBINSON RONNIE J , RONSICK CHRISTOPHER S , YERBIC PATRICK , FANNING MARK JOSEPH , PHILIPAK STANLEY M
发明人： WILSON MARK S , ROBINSON RONNIE J , RONSICK CHRISTOPHER S , YERBIC PATRICK , FANNING MARK JOSEPH , PHILIPAK STANLEY M
IPC分类号： C12M1/34 , B01L3/00 , C12M3/00
CPC分类号： G01N21/03 , G01N21/77 , G01N21/78 , G01N2021/0382 , G01N2021/7786
摘要： Specimen containers incorporating a sensor are provided with features for decreasing the volume of polymer matrix material required for the sensor. Such volume- reducing features can take the form of scallop-like indentations projecting inwards towards the interior of the container formed in the transition between the side wall of the container and the base of the container. Alternatively, the base of the container includes a raised rim extending upwards into the interior of the body inward of and spaced from the side wall. The rim defines a chamber for the sensor. Methods of manufacturing specimen containers with cured liquid phase sensor matrix materials are also disclosed.
摘要翻译：包含传感器的样品容器具有用于减小传感器所需的聚合物基质材料的体积的特征。这种减小体积的特征可以采取扇形状凹陷的形式向内突出，形成在容器的侧壁和容器的底部之间的过渡部分中的容器的内部。或者，容器的底部包括向上延伸到身体内部并且与侧壁间隔开的凸起边缘。轮缘限定了传感器的腔室。还公开了具有固化的液相传感器基质材料的样品容器的制造方法。

2. 发明申请

WO2010132829A2 COMBINED DETECTION INSTRUMENT FOR CULTURE SPECIMEN CONTAINERS AND INSTRUMENT FOR IDENTIFICATION AND/OR CHARACTERIZATION OF A MICROBIAL AGENT IN A SAMPLE 审中-公开
标题翻译：用于文化样本容器的组合检测仪器和用于在样品中鉴定和/或表征微生物剂的仪器
公开(公告)号：WO2010132829A2
公开(公告)日：2010-11-18
申请号：PCT/US2010034995
申请日：2010-05-14
申请人： BIO MERIEUX INC , ROBINSON RONNIE J , WILSON MARK S , RONSICK CHRISTOPHER S , WALSH JOHN D , HYMAN JONES , THORPE THURMAN , CLAY BRADFORD
发明人： ROBINSON RONNIE J , WILSON MARK S , RONSICK CHRISTOPHER S , WALSH JOHN D , HYMAN JONES , THORPE THURMAN , CLAY BRADFORD
IPC分类号： C12M1/26
CPC分类号： C12Q1/04 , C12M41/36 , C12Q1/02 , G01N35/00603 , G01N35/0099 , G01N2035/00148 , G01N2035/0406 , G01N2035/0453
摘要： A detection instrument determines whether a specimen container (e.g., blood culture bottle) is positive for presence of microbial agent growth therein. When the container is deemed positive it is made available (e.g, transferred or exposed to) to an automated instrument performing identification and/or characterization of the microbial agent. The identification and/or characterization instrument removes a portion of the sample from the specimen container and places it into a disposable separation and concentration device. The microbial agent is concentrated via optional selective lysis of non-microbial agent cellular material which may be present and centrifugation. A reading module reads the concentrated microbial agent using spectroscopic methods, e.g., measurements of intrinsic fluorescence. Such interrogation may occur while the microbial agent remains concentrated in the disposable device.
摘要翻译：检测仪器确定样品容器（例如血培养瓶）是否对其中存在微生物剂生长是阳性的。当容器被认为是正的时，它被提供（例如，转移或暴露于）到执行微生物剂的鉴定和/或表征的自动化仪器。识别和/或表征仪器将样品的一部分从样品容器中取出并将其放入一次性分离和浓缩装置中。微生物剂通过选择性裂解可能存在的和非离子的非微生物剂细胞材料而浓缩。阅读模块使用光谱方法读取浓缩的微生物剂，例如固有荧光的测量。当微生物剂保持集中在一次性装置中时，可能发生这种询问。

3. 发明申请

WO2010132823A3 SYSTEM AND METHODS FOR RAPID IDENTIFICATION AND/OR CHARACTERIZATION OF A MICROBIAL AGENT IN A SAMPLE 审中-公开
公开(公告)号：WO2010132823A3
公开(公告)日：2010-11-18
申请号：PCT/US2010/034987
申请日：2010-05-14
申请人： BIOMERIEUX, INC. , ROBINSON, Ronnie, J. , WILSON, Mark, S. , RONSICK, Christopher, S. , WALSH, John, D. , HYMAN, Jones , CLAY, Bradford
发明人： ROBINSON, Ronnie, J. , WILSON, Mark, S. , RONSICK, Christopher, S. , WALSH, John, D. , HYMAN, Jones , CLAY, Bradford
IPC分类号： G01N33/50
摘要： A method of testing a specimen sample contained within a sealed specimen container. A test sample is removed from the specimen container with a disposable sampling device. Non-microbial agent components of the test sample are lysed, thereby producing a lysed sample. The lysed sample is delivered to a disposable separation device. A microbial agent present in test sample is concentrated within the disposable separation device. The concentrated microbial agent is interrogated, e.g., spectroscopically.

4. 发明申请

WO2012083150A2 METHODS FOR THE ISOLATION, ACCUMULATION CHARACTERIZATION AND/OR IDENTIFICATION OF MICROORGANISMS USING A FILTRATION AND SAMPLE TRANSFER DEVICE 审中-公开
标题翻译：使用过滤和样品转移装置分离，累积和/或鉴定微生物的方法
公开(公告)号：WO2012083150A2
公开(公告)日：2012-06-21
申请号：PCT/US2011/065449
申请日：2011-12-16
申请人： BIOMERIEUX, INC. , WALSH, John , HYMAN, Jones , RONSICK, Christopher, S.
发明人： WALSH, John , HYMAN, Jones , RONSICK, Christopher, S.
IPC分类号： B01L3/00
CPC分类号： B01L3/50255 , B01L3/561 , B01L2300/0681
摘要： The present invention is directed to methods, devises and kits for separating, accumulating, characterizing and/or identifying microorganisms known to be present or that may be present in a test sample. The method of the invention comprises optional lysing non-microorganism cells and/or particulates that may be present in a test sample, followed by a subsequent filtration step for isolation and/or accumulation of microorganisms. In one embodiment, a filtration and sample transfer device is used for isolation and/or accumulation of microorganisms by filtration. Once the microorganisms have been filtered for isolation and/or accumulation microorganisms, the isolated and/or accumulated microorganisms can be analyzing to acquire measurements for the characterization and/or identification of said microorganisms.
摘要翻译：本发明涉及用于分离，积累，表征和/或鉴定已知存在或可能存在于测试样品中的微生物的方法，设计和试剂盒。本发明的方法包括任选地裂解可能存在于测试样品中的非微生物细胞和/或颗粒，随后进行用于分离和/或积累微生物的随后的过滤步骤。在一个实施方案中，过滤和样品转移装置用于通过过滤分离和/或积累微生物。一旦微生物已被过滤以分离和/或累积微生物，分离的和/或累积的微生物可以被分析以获得用于表征和/或鉴定所述微生物的测量。

5. 发明申请

WO2012016024A2 CULTURE BOTTLES WITH INTERNAL SENSORS 审中-公开
标题翻译：文化瓶与内部传感器
公开(公告)号：WO2012016024A2
公开(公告)日：2012-02-02
申请号：PCT/US2011/045698
申请日：2011-07-28
申请人： BIOMERIEUX, INC. , WILSON, Mark, S. , ROBINSON, Ronnie, J. , RONSICK, Christopher, S. , YERBIC, Patrick , FANNING, Mark, Joseph , PHILIPAK, Stanley, M.
发明人： WILSON, Mark, S. , ROBINSON, Ronnie, J. , RONSICK, Christopher, S. , YERBIC, Patrick , FANNING, Mark, Joseph , PHILIPAK, Stanley, M.
IPC分类号： C12M3/04
CPC分类号： G01N21/03 , G01N21/77 , G01N21/78 , G01N2021/0382 , G01N2021/7786
摘要： Specimen containers incorporating a sensor are provided with features for decreasing the volume of polymer matrix material required for the sensor. Such volume- reducing features can take the form of scallop-like indentations projecting inwards towards the interior of the container formed in the transition between the side wall of the container and the base of the container. Alternatively, the base of the container includes a raised rim extending upwards into the interior of the body inward of and spaced from the side wall. The rim defines a chamber for the sensor. Methods of manufacturing specimen containers with cured liquid phase sensor matrix materials are also disclosed.
摘要翻译：包含传感器的样品容器具有用于减小传感器所需的聚合物基体材料的体积的特征。这种减小体积的特征可以采取扇形状凹陷的形式向内突出，形成在容器的侧壁和容器的底部之间的过渡部分中的容器的内部。或者，容器的底部包括向上延伸到身体内部并且与侧壁间隔开的凸起边缘。轮缘限定了传感器的腔室。还公开了具有固化的液相传感器基质材料的样品容器的制造方法。

6. 发明申请

WO1996039533A1 DEVICE AND METHOD FOR DETECTING MICROORGANISMS 审中-公开
标题翻译：用于检测微生物的装置和方法
公开(公告)号：WO1996039533A1
公开(公告)日：1996-12-12
申请号：PCT/US1996008700
申请日：1996-06-04
申请人： AKZO NOBEL N.V. , READ, Karen, A. , TROGDON, David, E. , THORPE, Thurman, C. , RONSICK, Christopher, S. , JEFFREY, Scott, R.
发明人： AKZO NOBEL N.V.
IPC分类号： C12Q01/22
CPC分类号： G01N21/253 , C12M23/08 , C12M23/38 , C12M29/20 , C12M41/26 , C12M41/36 , C12Q1/04
摘要： A method and a sealable, sterilizable vessel (36) for detecting the presence of microorganisms in a specimen, the vessel containing a liquid culture medium and a sensor (37) with an indicator medium therein. A gas permeable membrane (31) with a gas impermeable removable seal (32) thereon are provided in a wall of the vessel. If the microorganism to be detected is an anaerobic organism, then the gas impermeable seal (32) is left in place. If the microorganism to be detected is an aerobic organism, then the gas impermeable seal (32) is removed so as to allow the passage of oxygen into the vessel. In a preferred embodiment, the gas permeable membrane (31) allows the passage of oxygen into the vessel while at least partly restricting the passage of carbon dioxide to outside of the vessel. Changes in the indicator medium resulting from a change in gas production (CO2, NH2, H2S, etc.), volatile acid production or pH concentration in the medium, are detected from outside the vessel.
摘要翻译：一种用于检测样品中微生物的存在的方法和可密封的可灭菌容器（36），所述容器含有液体培养基和其中具有指示剂介质的传感器（37）。在容器的壁上设置有其上具有气体不可渗透的可移除密封件（32）的透气膜（31）。如果要检测的微生物是厌氧生物，则将不透气密封件（32）留在原位。如果要检测的微生物是有氧生物体，则除去气体不可渗透的密封件（32），以允许氧气进入容器。在优选实施例中，气体可渗透膜（31）允许氧气进入容器，同时至少部分地限制二氧化碳通过容器的外部。从容器外部检测到由气体产生（CO2，NH2，H2S等）变化引起的指示剂介质的变化，介质中的挥发性酸产生或pH浓度的变化。

7. 发明申请

WO2010132829A3 COMBINED DETECTION INSTRUMENT FOR CULTURE SPECIMEN CONTAINERS AND INSTRUMENT FOR IDENTIFICATION AND/OR CHARACTERIZATION OF A MICROBIAL AGENT IN A SAMPLE 审中-公开
公开(公告)号：WO2010132829A3
公开(公告)日：2010-11-18
申请号：PCT/US2010/034995
申请日：2010-05-14
申请人： BIOMERIEUX, INC , ROBINSON, Ronnie, J. , WILSON, Mark, S. , RONSICK, Christopher, S. , WALSH, John, D. , HYMAN, Jones , THORPE, Thurman , CLAY, Bradford
发明人： ROBINSON, Ronnie, J. , WILSON, Mark, S. , RONSICK, Christopher, S. , WALSH, John, D. , HYMAN, Jones , THORPE, Thurman , CLAY, Bradford
IPC分类号： G01N35/04
摘要： A detection instrument determines whether a specimen container (e.g., blood culture bottle) is positive for presence of microbial agent growth therein. When the container is deemed positive it is made available (e.g, transferred or exposed to) to an automated instrument performing identification and/or characterization of the microbial agent. The identification and/or characterization instrument removes a portion of the sample from the specimen container and places it into a disposable separation and concentration device. The microbial agent is concentrated via optional selective lysis of non-microbial agent cellular material which may be present and centrifugation. A reading module reads the concentrated microbial agent using spectroscopic methods, e.g., measurements of intrinsic fluorescence. Such interrogation may occur while the microbial agent remains concentrated in the disposable device.

8. 发明申请

WO2004096081A3 TRANSFER NEEDLE SAFETY APPARATUS 审中-公开
标题翻译：转运针安全装置
公开(公告)号：WO2004096081A3
公开(公告)日：2005-08-11
申请号：PCT/US2004012603
申请日：2004-04-22
申请人： TYCO HEALTHCARE , BIO MERIEUX INC , SAMPSON ERIC , RONSICK CHRISTOPHER S
发明人： SAMPSON ERIC , RONSICK CHRISTOPHER S
IPC分类号： A61B5/15 , A61B5/00 , B65D81/00
CPC分类号： A61J1/2096 , A61B5/15003 , A61B5/150389 , A61B5/150503 , A61B5/150992 , A61B5/154 , A61B5/155 , A61J1/2055 , A61J1/2065 , Y10S604/905
摘要： A transfer needle safety apparatus (10) including a guide port adapted to fit a variety of body fluid receptacle sizes. A sleeve (30) substantially fills the cavity inside a needle shield.
摘要翻译：一种输送针安全装置（10），其包括适于装配各种体液容器尺寸的引导口。套管（30）基本上填充针护罩内的空腔。

9. 发明申请

WO2004096081A2 TRANSFER NEEDLE SAFETY APPARATUS 审中-公开
标题翻译：转运针安全装置
公开(公告)号：WO2004096081A2
公开(公告)日：2004-11-11
申请号：PCT/US2004/012603
申请日：2004-04-22
申请人： TYCO HEALTHCARE GROUP LP , BIOMERIEUX, INC. , SAMPSON, Eric , RONSICK, Christopher, S.
发明人： SAMPSON, Eric , RONSICK, Christopher, S.
IPC分类号： A61F
CPC分类号： A61J1/2096 , A61B5/15003 , A61B5/150389 , A61B5/150503 , A61B5/150992 , A61B5/154 , A61B5/155 , A61J1/2055 , A61J1/2065 , Y10S604/905
摘要： A transfer needle safety apparatus including a guide port adapted to fit a variety of body fluid receptacle sizes. A sleeve substantially fills the cavity inside a needle shield. The sleeve includes a robust external lead-in structure for aligning/assembling and centering the sleeve in the shield and a robust internal lead-in structure for aligning and centering a narrow body receptacle onto a needle. The sleeve engages a long section of the outer surface of a receptacle thereby preventing rocking or lateral motion of a receptacle septum relative to a needle tip. Streamlined gripping features allow removal of the sleeve from the shield.
摘要翻译：一种输送针安全装置，包括适于配合各种体液容器尺寸的引导口。套管基本上填充针护罩内的空腔。套筒包括坚固的外部引入结构，用于将套管对准/组装和定心在屏蔽中，并具有坚固的内部引入结构，用于将窄体插座对准和定心到针上。套筒接合容器的外表面的长部分，从而防止插座隔膜相对于针尖的摇摆或侧向运动。流线型的夹持特征允许从屏蔽层移除套筒。

10. 发明申请

WO2012083150A3 METHODS FOR THE ISOLATION, ACCUMULATION CHARACTERIZATION AND/OR IDENTIFICATION OF MICROORGANISMS USING A FILTRATION AND SAMPLE TRANSFER DEVICE 审中-公开
标题翻译：用过滤和样品转移装置分离，积累表征和/或鉴定微生物的方法
公开(公告)号：WO2012083150A3
公开(公告)日：2012-08-02
申请号：PCT/US2011065449
申请日：2011-12-16
申请人： BIO MERIEUX INC , WALSH JOHN , HYMAN JONES , RONSICK CHRISTOPHER S
发明人： WALSH JOHN , HYMAN JONES , RONSICK CHRISTOPHER S
IPC分类号： B01L3/00
CPC分类号： B01L3/50255 , B01L3/561 , B01L2300/0681
摘要： The present invention is directed to methods, devises and kits for separating, accumulating, characterizing and/or identifying microorganisms known to be present or that may be present in a test sample. The method of the invention comprises optional lysing non-microorganism cells and/or particulates that may be present in a test sample, followed by a subsequent filtration step for isolation and/or accumulation of microorganisms. In one embodiment, a filtration and sample transfer device is used for isolation and/or accumulation of microorganisms by filtration. Once the microorganisms have been filtered for isolation and/or accumulation microorganisms, the isolated and/or accumulated microorganisms can be analyzing to acquire measurements for the characterization and/or identification of said microorganisms.
摘要翻译：本发明涉及用于分离，积累，表征和/或鉴定已知存在或可能存在于测试样品中的微生物的方法，设备和试剂盒。本发明的方法包括任选的裂解非微生物细胞和/或可能存在于测试样品中的颗粒，接着是随后的用于分离和/或积聚微生物的过滤步骤。在一个实施方案中，过滤和样品转移装置用于通过过滤分离和/或积累微生物。一旦微生物已被过滤以分离和/或积累微生物，就可以分析分离的和/或积累的微生物以获得用于所述微生物的表征和/或鉴定的测量。

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