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1. 发明申请

WO2011144985A1 PRE-ANALYTICAL MEDICAL DEVICE TO COLLECT A BIOLOGICAL SAMPLE OF FECES 审中-公开
标题翻译：预分析医疗器械收集FECES的生物样本
公开(公告)号：WO2011144985A1
公开(公告)日：2011-11-24
申请号：PCT/IB2011/001058
申请日：2011-05-17
申请人： ALIFAX HOLDING SPA , GALIANO, Paolo
发明人： GALIANO, Paolo
IPC分类号： A61B10/00
CPC分类号： A61B10/0038 , A61B10/0096 , A61B2017/00477
摘要： A pre-analytical medical device (10) to collect a biological sample of feces comprises a container (12) and at least a collection member (26) for the sample. The container (12) has inside a containing compartment (13) for the sample and is provided with an upper wall (14) having at least a first specialized aperture (16, 18, 20) with a shape and size mating with that of the collection member (26), for the introduction of the samples to be analyzed into the compartment (13). Said upper wall (14) also has at least a second specialized aperture (22), distinct from said first aperture (16, 18, 20), with a shape and size mating with that of a test tube (34) to transfer the sample outside the compartment (13) for subsequent analysis.
摘要翻译：用于收集粪便的生物样品的预分析医疗装置（10）包括用于样品的容器（12）和至少一个收集构件（26）。容器（12）在用于样品的容纳隔室（13）内部，并且设置有具有至少第一专用孔（16,18,20）的上壁（14），该第一专用孔（16,18,20）的形状和尺寸与收集构件（26），用于将要分析的样品引入隔室（13）。所述上壁（14）还具有与所述第一孔（16,18,20）不同的至少第二专用孔（22），其具有与试管（34）的形状和尺寸相配合的形状和尺寸，以将样品在隔室（13）之外用于随后的分析。

2. 发明申请

WO2010089659A3 MEDICAL DEVICE TO VERIFY THE PRESENCE OF MICROORGANISMS OR BACTERIA IN A SAMPLE OF AN ORGAN OR A BIOLOGICAL TISSUE, DIAGNOSTIC APPARATUS COMPRISING SAID MEDICAL DEVICE AND RELATIVE METHOD 审中-公开
标题翻译：用于验证微生物或细菌在一种或多种生物组织样品中的存在的医疗装置，包含所述医疗装置的诊断装置和相关方法
公开(公告)号：WO2010089659A3
公开(公告)日：2011-04-21
申请号：PCT/IB2010000228
申请日：2010-02-05
申请人： ALIFAX HOLDING SPA , GALIANO PAOLO
发明人： GALIANO PAOLO
IPC分类号： C12M1/24 , B01L3/14 , C12M1/34
CPC分类号： C12M23/08 , B01L3/50825 , B01L2300/046 , B01L2300/0609 , C12M23/38
摘要： Medical device (10) to verify the presence of microorganisms or bacteria in a sample (32) of an organ or biological tissue inside a container element (28), which is made of material transparent to the electromagnetic radiations that are emitted toward it along a path (P) and has at least an aperture (30) through which said sample (32) is inserted. Liquid culture means (34) are provided inside the container element (28) which are suitable to promote the growth of microorganisms or bacteria possibly present in the sample (32). The medical device (10) comprises a closing element (12) able to be located in correspondence with the aperture (30) and a support element (16) of the oblong type, which extends from the closing element (32) and is able to be introduced inside the container element (28). The support element (16) has an end portion (20) able to be associated stably with the sample (32) so as to keep the sample (32) suspended and at least partly immersed in the liquid culture means (34) inside the container element (28).
摘要翻译：用于验证在容器元件（28）内的器官或生物组织的样品（32）中的微生物或细菌的存在的医疗设备（10），所述容器元件（28）由对沿着其发射的电磁辐射透明的材料制成，路径（P）并且至少具有插入所述样品（32）的孔（30）。液体培养装置（34）设置在容器元件（28）的内部，其适于促进可能存在于样品（32）中的微生物或细菌的生长。医疗装置（10）包括能够与孔（30）对应定位的闭合元件（12）和从闭合元件（32）延伸的长方形的支撑元件（16），并且能够引入容器元件（28）内。支撑元件（16）具有能够与样品（32）稳定地相关联的端部（20），以便将样品（32）悬浮并且至少部分地浸入容器内部的液体培养装置（34）中元件（28）。

3. 发明申请

WO2014128629A1 METHOD TO IDENTIFY BACTERIAL SPECIES BY MEANS OF GAS CHROMATOGRAPHY/MASS SPECTROMETRY IN BIOLOGICAL SAMPLES 审中-公开
标题翻译：通过气相色谱/生物样品中的质谱鉴定鉴定细菌物种的方法
公开(公告)号：WO2014128629A1
公开(公告)日：2014-08-28
申请号：PCT/IB2014/059109
申请日：2014-02-20
申请人： ALIFAX HOLDING SPA
发明人： GALIANO, Paolo
IPC分类号： G01N33/497 , G01N33/68 , C12Q1/04
CPC分类号： C12Q1/04 , G01N33/493 , G01N33/497 , G01N33/6848 , G01N2033/4977
摘要： Method to identify bacterial classes in a biological sample, in particular a urine sample, that provides to carry out an analysis by means of Gas Chromatography- Mass Spectrometry (GC/MS) of the volatile components, such as metabolites and catabolites, of the sample in order to identify a graphic plot characteristic of a specific bacterial class.
摘要翻译：鉴定生物样品中的细菌类别的方法，特别是尿液样品，其通过气相色谱 - 质谱法（GC / MS）对样品中的挥发性组分如代谢物和分解代谢物进行分析以便识别特定细菌类别的图形特征。

4. 发明申请

WO2011086462A1 METHOD AND APPARATUS FOR DIAGNOSTIC ANALYSES 审中-公开
标题翻译：诊断分析方法和装置
公开(公告)号：WO2011086462A1
公开(公告)日：2011-07-21
申请号：PCT/IB2011/000056
申请日：2011-01-13
申请人： ALIFAX HOLDING SPA , GALIANO, Paolo
发明人： GALIANO, Paolo
IPC分类号： G01N21/51 , G01N33/68 , C12M1/34
CPC分类号： C12M41/36 , C12Q1/04 , G01N21/51 , G01N2021/4711 , G01N2333/31
摘要： A method for diagnostic analyses, in particular to identify pathogens, such as viruses, bacteria or other micro-organisms present in a biological sample, comprises a first step of measuring and continuously monitoring the turbidity and/or the concentration of the pathogens, by means of an instrumental reading technique, of a liquid culture medium into which the sample to be analyzed has been inoculated and in which the replication of the pathogens possibly present occurs, said measuring and monitoring being carried out dynamically during the replication of the pathogens growing in the culture medium; and a second step of identifying the pathogens, carried out by taking at least an aliquot of the liquid culture medium containing the biological sample directly obtained from the first step, which has reached a desired value of turbidity according to a standardized value scale, such as the McFarland turbidity scale, and/or of concentration of the pathogens, and using said aliquot directly in mass spectrophotometric identification means (15) in order to identify the pathogens, which means are calibrated in their functioning depending on the measurement results of the first step. The desired values of turbidity and/or of concentration of the pathogens are preliminarily selected, during the first step, on the basis of the specific needs which, on each occasion, are identified in order to carry out the second identification step
摘要翻译：用于诊断分析的方法，特别是鉴定存在于生物样品中的病原体，例如病毒，细菌或其他微生物的方法，包括测量和连续监测病原体的浊度和/或浓度的第一步骤仪器阅读技术的液体培养基，待分析样品已经接种到其中并且可能存在可能存在病原体复制的液体培养基，所述测量和监测在复制生长在培养基以及第二步骤，通过至少将含有直接从第一步获得的生物样品的液体培养基的等分试样按照标准化的标度值达到所需的浊度值来进行，例如麦克法兰浑浊度和/或病原体的浓度，并将所述等分试样直接用于质谱分析方法（15）中，以鉴定病原体，这意味着根据第一步骤的测量结果在其功能上进行校准。在第一步骤中，基于每次确定为了进行第二识别步骤的具体需要，预先选择所需病原体的浊度和/或浓度的所需值

5. 发明申请

WO2010097685A3 APPARATUS TO ANALYZE A BIOLOGICAL SAMPLE 审中-公开
标题翻译：分析生物样品的装置
公开(公告)号：WO2010097685A3
公开(公告)日：2010-11-04
申请号：PCT/IB2010000369
申请日：2010-02-24
申请人： ALIFAX HOLDING SPA , GALIANO PAOLO , MANSUTTI ALESSANDRO
发明人： GALIANO PAOLO , MANSUTTI ALESSANDRO
IPC分类号： C12M1/34 , G01N21/51
CPC分类号： G01N21/51 , C12Q1/04 , G01N2021/4707 , G01N2021/4709 , G01N2021/4711
摘要： Apparatus to analyze a biological sample (11) contained in a container (12), comprising an examining device (16) able to perform an optical measurement on the biological sample, based on light-scattering technology, at least of the bacterial growth in the biological sample. The examining device is provided with emitter means (20) able to emit a first light beam (BO) toward the container (12) of the biological sample and sensor means (22, 24) able to detect at least a light beam diffused from the container (12) of the biological sample and to transmit a relative signal, correlated to the light beam diffused, to a control unit (18) which is able to process, directly or indirectly, the signal in order to verify at least the possible bacterial growth in the biological sample (11). The container (12) is disposed along a determinate lying plane (P) and comprises at least a containing micro-element (14) able to contain at least a part of the biological sample and inside which a liquid culture ground is provided so as to allow bacterial growth in the biological sample. The emitter means (20) and sensor means (22, 24) are able to be located on each occasion in correspondence with the containing micro-element (14). The sensor means (22, 24) comprise first sensor means (22) disposed on the same side of the emitter means (20) with respect to the lying plane (P), and second sensor means (24) disposed on the opposite side of the emitter means (20) with respect to the lying plane (P). The first sensor means (22) are able to detect a back-scattering radiation coming from the determinate containing micro-element (14). The second sensor means (24) are able to detect a forward-scattering radiation coming from the determinate containing micro-element (14), from which back-scattering radiation (B2) and forward-scattering radiation (B4) derive respective first and second signals transmitted to the control unit.
摘要翻译：用于分析包含在容器（12）中的生物样品（11）的装置，包括能够基于光散射技术对生物样品进行光学测量的检查装置（16），至少在生物样品。检查装置设置有能够朝向生物样本的容器（12）发射第一光束（BO）的发射器装置（20），以及能够至少检测从所述生物样品扩散的光束的传感器装置（22,24）容器（12），并将与扩散的光束相关的相对信号传送到能够直接或间接处理信号的控制单元（18），以便至少验证可能的细菌生物样品中的生长（11）。容器（12）沿着确定的躺卧平面（P）设置，并且至少包括能容纳生物样品的至少一部分的容纳微量元件（14），并在其内设置液体培养地，从而允许生物样品中的细菌生长。发射器装置（20）和传感器装置（22,24）能够在每个场合下与容纳微元件（14）相对应地定位。所述传感器装置（22,24）包括相对于所述平躺面（P）设置在所述发射器装置（20）的相同侧上的第一传感器装置（22），以及设置在所述第二传感器装置所述发射装置（20）相对于所述平躺面（P）。第一传感器装置（22）能够检测来自确定的容纳微量元件（14）的反向散射辐射。第二传感器装置（24）能够检测来自确定的容纳微量元件（14）的前向散射辐射，反向散射辐射（B2）和前向散射辐射（B4）从该第一和第二发送到控制单元的信号。

6. 发明申请

WO2010097685A2 APPARATUS TO ANALYZE A BIOLOGICAL SAMPLE 审中-公开
标题翻译：用于分析生物样品的装置
公开(公告)号：WO2010097685A2
公开(公告)日：2010-09-02
申请号：PCT/IB2010/000369
申请日：2010-02-24
申请人： ALIFAX HOLDING SPA , GALIANO, Paolo , MANSUTTI, Alessandro
发明人： GALIANO, Paolo , MANSUTTI, Alessandro
IPC分类号： C12M1/34 , G01N21/51
CPC分类号： G01N21/51 , C12Q1/04 , G01N2021/4707 , G01N2021/4709 , G01N2021/4711
摘要： Apparatus to analyze a biological sample (11) contained in a container (12), comprising an examining device (16) able to perform an optical measurement on the biological sample, based on light-scattering technology, at least of the bacterial growth in the biological sample. The examining device is provided with emitter means (20) able to emit a first light beam (BO) toward the container (12) of the biological sample and sensor means (22, 24) able to detect at least a light beam diffused from the container (12) of the biological sample and to transmit a relative signal, correlated to the light beam diffused, to a control unit (18) which is able to process, directly or indirectly, the signal in order to verify at least the possible bacterial growth in the biological sample (11). The container (12) is disposed along a determinate lying plane (P) and comprises at least a containing micro-element (14) able to contain at least a part of the biological sample and inside which a liquid culture ground is provided so as to allow bacterial growth in the biological sample. The emitter means (20) and sensor means (22, 24) are able to be located on each occasion in correspondence with the containing micro-element (14). The sensor means (22, 24) comprise first sensor means (22) disposed on the same side of the emitter means (20) with respect to the lying plane (P), and second sensor means (24) disposed on the opposite side of the emitter means (20) with respect to the lying plane (P). The first sensor means (22) are able to detect a back-scattering radiation coming from the determinate containing micro-element (14). The second sensor means (24) are able to detect a forward-scattering radiation coming from the determinate containing micro-element (14), from which back-scattering radiation (B2) and forward-scattering radiation (B4) derive respective first and second signals transmitted to the control unit.
摘要翻译：用于分析包含在容器（12）中的生物样本（11）的装置，其包括能够基于光散射技术对生物样本执行光学测量的检查装置（16）至少是生物样品中的细菌生长。检查装置设置有能够朝着生物样本的容器（12）发射第一光束（BO）的发射器装置（20），并且传感器装置（22,24）能够检测从生物样本扩散的至少一束光束并且将与扩散的光束相关的相对信号传输到控制单元（18），该控制单元能够直接或间接处理信号以便至少验证可能的细菌生物样品中的生长（11）。容器（12）沿着确定的躺卧平面（P）布置并且包括至少一个容纳微生物元件（14），该容纳微生物元件能够容纳至少一部分生物样本并且在其内部提供液体培养基以便允许生物样品中的细菌生长。发射器装置（20）和传感器装置（22,24）能够每次与包含的微元件（14）相对应地定位。传感器装置（22,24）包括第一传感器装置（22）和第二传感器装置（24），第一传感器装置（22）相对于平躺平面（P）布置在发射器装置（20）的相同侧上，所述发射器装置（20）相对于所述平面（P）。第一传感器装置（22）能够检测来自含有确定物的微元件（14）的后向散射辐射。第二传感器装置（24）能够检测来自包含该确定物的微元件（14）的前向散射辐射，由该后向散射辐射（B2）和前向散射辐射（B4）从该微元件（14）导出相应的第一和第二信号传输到控制单元。

7. 发明申请

WO2014020392A3 APPARATUS AND METHOD TO DETERMINE THE BLOOD SEDIMENTATION RATE AND OTHER PARAMETERS CONNECTED THERETO 审中-公开
标题翻译：用于确定血液沉淀速率的装置和方法及其连接的其它参数
公开(公告)号：WO2014020392A3
公开(公告)日：2014-03-27
申请号：PCT/IB2013001565
申请日：2013-07-19
申请人： ALIFAX HOLDING SPA
发明人： GALIANO PAOLO
IPC分类号： G01N15/05 , G01N33/49
CPC分类号： G01N15/05
摘要： An apparatus to determine the blood sedimentation rate and other parameters connected thereto, carried out by emitting, by means of emitter means (16), a beam of radiations (60) which passes through a sample being examined, and by detecting, by means of receiver means (17), the beam of radiations after they have passed through said sample, comprising a reading chamber associated to at least a tube (12) connected to a feed (11; 21; 28) of the sample to be analyzed. Said reading chamber is at least partly transparent to radiations in a certain range of wavelengths, and has at least a substantially rectilinear segment of reduced size into which the sample to be analyzed is introduced. The reading chamber (50) consists of a tube (51) made of plastic material, or glass, defining a capillary channel coupled to said tube (12) in fluidic continuity.
摘要翻译：一种通过借助于发射器装置（16）发射穿过正被检查的样本的辐射束（60）并且通过借助于发射器装置（16）检测与其连接的其他参数来确定血液沉降率和其他参数的装置接收器装置（17），辐射束在它们已经通过所述样本之后，包括与至少一个连接到待分析样本的进料（11; 21; 28）的管（12）相关的读取室。所述读取室对于特定波长范围内的辐射至少部分是透明的，并且至少具有尺寸减小的基本上直线的部分，待分析的样品被引入其中。阅读室（50）包括由塑料材料或玻璃制成的管（51），其限定了以流体连续性连接到所述管（12）的毛细管通道。

8. 发明申请

WO2013021274A1 DEVICE FOR TAKING, PREPARING AND TRANSFERRING FECAL SAMPLES, AND CORRESPONDING METHOD 审中-公开
标题翻译：用于制作和传送FECAL样品的设备及相关方法
公开(公告)号：WO2013021274A1
公开(公告)日：2013-02-14
申请号：PCT/IB2012/001544
申请日：2012-08-10
申请人： ALIFAX HOLDING SPA , GALIANO, Paolo
发明人： GALIANO, Paolo
IPC分类号： A61B10/00 , C12M1/30 , B01L3/14 , B01L3/00
CPC分类号： A61B10/0038 , B01L3/5029 , B01L3/50825 , B01L2300/047 , B01L2300/0609 , B01L2300/0681 , B01L2400/0481
摘要： Device for taking, preparing and transferring fecal samples comprising at least a test tube (13) able to contain a diluting solution and the fecal sample taken so as to obtain a diluted solution (37) of the fecal sample, and a collection and transfer unit (12) for the fecal sample able to be inserted inside the test tube (13), in which the collection and transfer unit (12) comprises a first stopper (14) to close the test tube (13), a tubular transfer member (18) associated externally with the first stopper (14) through which the diluted solution (37) is picked up or transferred toward the outside, a hollow rod (15, 1 15) associated internally with the first stopper (14) and able to be inserted into the test tube (13), on one side fluidically connected to the tubular member (18) and on the other side having at least a collection terminal (17, 117) for the fecal sample, passage ways being provided to put the inside of the test tube (13) in communication with the inside of the hollow rod (15), so as to allow the diluted solution (37) to flow from the test tube (13) toward the tubular member (18), through the hollow rod (15).
摘要翻译：用于摄取，制备和转移粪便样品的装置，所述粪便样品至少包含能够含有稀释溶液的试管（13）和所述粪便样品，以获得粪便样品的稀释溶液（37），以及收集和转移单元（12），其中所述收集和转移单元（12）包括用于关闭所述试管（13）的第一止动件（14），所述管状转移构件（12） 18），与第一止动器（14）相连，稀释溶液（37）通过该第一止动件被拾取或转移到外部;空心杆（15,115），其与第一止动件（14）内部相关联并且能够插入到试管（13）中，一侧流体连接到管状构件（18），另一侧具有用于粪便样品的至少一个收集端（17,117），通道设置成将内部的测试管（13）与中空杆的内部连通（15），以使稀释溶液（37）通过中空棒（15）从试管（13）流向管状部件（18）。

9. 发明申请

WO2010004416A3 METHOD AND RELATIVE APPARATUS FOR CARRYING OUT DIAGNOSTIC ANALYSES 审中-公开
标题翻译：诊断分析的方法和相关装置
公开(公告)号：WO2010004416A3
公开(公告)日：2010-04-15
申请号：PCT/IB2009006201
申请日：2009-07-07
申请人： ALIFAX HOLDING SPA , GALIANO PAOLO , DI COLA GIOVANNI , FRAPPA FRANCESCO
发明人： GALIANO PAOLO , DI COLA GIOVANNI , FRAPPA FRANCESCO
IPC分类号： G01N33/557
CPC分类号： G01N33/557
摘要： Method for diagnostic analyses of a biological sample, comprising: - a step of preparing a mixture of a biological sample and one or more reactive agents, - a step of reaction of the antigen-antibody type, wherein the one or more reactive agents react in the mixture with one or more components of the biological sample according to a reaction kinetics. The method also comprises a step of measuring the initial speed at which the reaction occurs, and a step of comparing at least part of the reaction kinetics with standard kinetics having a known concentration, corresponding to a reaction of the same type as that to which the biological sample is subjected, so as verify if the initial concentration of antigen or antibody is greater than the concentration of the reference standard, in order to obtain an indication as to whether the biological sample is affected or not by the prozone effect.
摘要翻译：用于诊断分析生物样品的方法，其包括： - 制备生物样品和一种或多种反应剂的混合物的步骤; - 抗原 - 抗体类型的反应步骤，其中所述一种或多种反应剂在根据反应动力学与生物样品的一种或多种组分的混合物。该方法还包括测量反应发生的初始速度的步骤，以及将至少部分反应动力学与具有已知浓度的标准动力学进行比较的步骤，所述标准动力学对应于与所述反应对生物样品进行处理，以验证抗原或抗体的初始浓度是否大于参考标准的浓度，以获得关于生物样品是否受到前带效应影响的指示。

10. 发明申请

WO2010020863A2 METHOD FOR BACTERIOLOGICAL TESTING ON PLASMA 审中-公开
标题翻译：血浆细菌学检测方法
公开(公告)号：WO2010020863A2
公开(公告)日：2010-02-25
申请号：PCT/IB2009006588
申请日：2009-08-19
申请人： ALIFAX HOLDING SPA , GALIANO PAOLO
发明人： GALIANO PAOLO
IPC分类号： C12M1/32 , C12M1/34 , C12M1/36
CPC分类号： C12Q1/04 , G01N21/51
摘要： A method for bacteriological testing on plasma comprises the following steps: - a first step in which a blood sample (12) taken from a patient is dispensed in a first container (14); - a second step in which the sedimentation of the blood sample (12) is determined, so as to separate the corpuscular part (24), which sediments on the bottom of the first container (14), from the liquid part or plasma (26) which represents the surnatant; - a third step in which a determinate portion of the surnatant is taken, consisting of the liquid part or plasma (26) thus obtained; - a fourth step in which the portion of the liquid part or plasma (26) obtained in a culture ground is inoculated inside a second container (30) suitable to allow a bacterial culture and an instrument reading by means of an optical measurement machine (32); - a fifth step in which bacterial growth is allowed in the culture ground contained in the second container (30); - a sixth step in which, by means of the optical measurement machine (32), on the culture ground contained in the second container (30), an optical measurement is made in order to detect and/or quantify the presence of bacteria and microorganisms.
摘要翻译：血浆细菌试验方法包括以下步骤：第一步，将从患者取出的血液样品（12）分配到第一容器（14）中; - 确定血液样品（12）沉降的第二步骤，以将第一容器（14）底部沉淀的红细胞部分（24）从液体部分或等离子体（26 ）代表公民; - 第三步骤，其中取得所述污染物的确定部分，由如此获得的液体部分或等离子体（26）组成; - 第四步，将在培养基中获得的液体部分或等离子体（26）的部分接种在适于通过光学测量机（32）进行细菌培养和仪器读取的第二容器（30）内）; - 在包含在第二容器（30）中的培养基中允许细菌生长的第五步骤。 - 第六步，其中通过光学测量机（32）在包含在第二容器（30）中的培养地上进行光学测量，以便检测和/或定量细菌和微生物的存在。

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