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41. 发明申请

WO2014210155A2 Anchor Deployment for Implantable Medical Devices 审中-公开
标题翻译：可植入医疗器械的锚定部署
公开(公告)号：WO2014210155A2
公开(公告)日：2014-12-31
申请号：PCT/US2014/044096
申请日：2014-06-25
申请人： MEDTRONIC, INC.
发明人： KERN, Michael, J. , BEHYMER, Bruce, A.
IPC分类号： A61M25/02
CPC分类号： A61N1/05 , A61M25/02 , A61M2025/028 , A61M2025/0286 , A61N1/0558 , A61N1/059 , A61N2001/0582
摘要： A tool for deploying an anchor sleeve onto one or more implantable medical device bodies includes a holding element, on which the sleeve is mounted, and a base member having a channel, which receives the element in sliding engagement. A conduit of the holding element receives the one or more elongate bodies in sliding engagement. A deployment tip forms an opening of the channel, through which the holding element extends in sliding engagement, and which engages the mounted anchor sleeve for deployment thereof. The deployment tip may be provided as a separate component, wherein a distal segment of the base member is configured for attachment therewith; as such, the tip may be part of a deployment assembly that also includes the holding element. The deployment assembly may be selected from a plurality thereof included in a kit along with the base member.
摘要翻译：用于将锚定套筒部署到一个或多个可植入医疗装置主体上的工具包括：保持套筒，其上安装有套筒;以及基部构件，其具有通道，该基部构件以滑动接合方式容纳元件。保持元件的导管以滑动接合的方式接纳一个或多个细长体。展开尖端形成通道的开口，保持元件通过该开口以滑动接合方式延伸，并且与所安装的锚固套接合以进行展开。部署尖端可以被提供为单独的部件，其中，所述基部部件的远侧部分构造成用于与其一起附着; 因此，尖端可以是也包括保持元件的展开组件的一部分。部署组件可以与基座构件一起从包括在套件中的多个中选择。

42. 发明申请

WO2014182948A2 EPICARDIAL LEAD DESIGN 审中-公开
公开(公告)号：WO2014182948A2
公开(公告)日：2014-11-13
申请号：PCT/US2014/037366
申请日：2014-05-08
申请人： CHILDREN'S HOSPITAL LOS ANGELES , UNIVERSITY OF SOUTHERN CALIFORNIA
发明人： BAR-COHEN, Yaniv , LOEB, Gerald , ZHOU, Li , PECK, Raymond , NUTT, Stephen
IPC分类号： A61N1/365
CPC分类号： A61N1/375 , A61N1/0587 , A61N1/059 , A61N1/362 , A61N1/37205 , A61N1/37288 , A61N1/3756 , A61N1/3787
摘要： The present invention provides an advancement in the art of cardiac pacemakers. The invention provides a novel and unobvious pacemaker system that comprises at least one pacemaker and that is, to a large extent, self-controlled, allows for long-term implantation in a patient, and minimizes current inconveniences and problems associated with battery life. The invention further includes a mechanism in which at least two pacemakers are implanted in a patient, and in which the pacemakers communicate with each other at the time of a given pacing or respiratory event, without any required external input, and adjust pacing parameters to respond to the patient's need for blood flow. The invention further provides a novel design for a pacemaker in which the pacemaker electrode is connected to the pacemaker body by a lead that is configured to allow the pacemaker to lie parallel to the epicardial surface and to reduce stress on the pacemaker and heart tissue.
摘要翻译：本发明提供了心脏起搏器领域的进步。本发明提供了一种新颖且不显眼的起搏器系统，其包括至少一个起搏器，并且在很大程度上是自我控制的，允许在患者中长期植入，并且最小化与电池寿命相关的当前不便和问题。本发明还包括一种机构，其中至少两个起搏器被植入患者体内，并且其中起搏器在给定的起搏或呼吸事件时彼此通信，而没有任何需要的外部输入，并且调整起搏参数以响应对患者的血液流动需求。本发明还提供了一种用于起搏器的新颖设计，其中起搏器电极通过引线连接到起搏器主体，该引线被配置为允许起搏器平行于心外膜表面平行并且减小起搏器和心脏组织的应力。

43. 发明申请

WO2014062547A1 TERMINAL RING CONFIGURATION TO PREVENT IMPROPER IS4 LEAD CONNECTOR ELECTRICAL CONTACT WITH DF4 CONNECTOR PORT 审中-公开
标题翻译：端子环配置以防止不正确的IS4导线连接器与DF4连接器端口的电气接触
公开(公告)号：WO2014062547A1
公开(公告)日：2014-04-24
申请号：PCT/US2013/064789
申请日：2013-10-14
申请人： CARDIAC PACEMAKERS, INC.
发明人： FUHS, Christopher A. , RIVARD, Adam J. , HOECKE, Kyle , COOKE, Daniel J. , CLARK, Bryan A.
IPC分类号： A61N1/375 , A61N1/39
CPC分类号： A61N1/059 , A61N1/3752 , A61N1/3925 , A61N1/3962 , A61N1/3968 , H01R13/17 , H01R13/642 , H01R24/58 , H01R2201/12
摘要： An implantable lead includes a flexible lead body, a plurality of conductor wires and a plurality of electrodes. The implantable lead also includes a terminal connector assembly coupled with a proximal end of the lead body. The terminal connector assembly is sized to be inserted into and received by a connector port of a pulse generator header. The terminal connector assembly includes a plurality of axially spaced terminal ring elements each electrically coupled to at least one of the conductor wires. The terminal ring elements are separated from one another by an electrically insulating material. Each of the terminal ring elements includes an outer surface having a first portion and a second portion, the first portion being electrically conductive and the second portion being electrically non-conductive.
摘要翻译：可植入引线包括柔性引线体，多根导线和多个电极。可植入引线还包括与引线主体的近端耦合的端子连接器组件。端子连接器组件的尺寸设置成插入脉冲发生器接头的连接器端口并由其接收。端子连接器组件包括多个轴向间隔开的端子环元件，每个端子环元件电耦合到至少一个导线。端子环元件通过电绝缘材料彼此分离。每个端子环元件包括具有第一部分和第二部分的外表面，第一部分是导电的，而第二部分是非导电的。

44. 发明申请

WO2013136312A3 MECHANISM, SYSTEM, METHOD FOR IN VIVO LEAD FIXATION 审中-公开
标题翻译：机构，系统，体内铅固定方法
公开(公告)号：WO2013136312A3
公开(公告)日：2014-03-13
申请号：PCT/IB2013052101
申请日：2013-03-15
申请人： KRISHNAN SUBRAMANIAM CHITOOR
发明人： KRISHNAN SUBRAMANIAM CHITOOR , PATIL NITIN
IPC分类号： A61N1/37 , A61N1/05
CPC分类号： A61N1/059 , A61N1/05 , A61N1/057 , A61N1/3706 , A61N1/371 , A61N2001/0585
摘要： A lead for in vivo procedures for stimulation of a tissue is provided that has stimulating electrodes and a fixation mechanism disposed at a distal end of the lead. The fixation mechanism includes a fixation component disposed on an opposite side with respect to an active surface of the stimulation electrodes. The lead fixation mechanism when deployed disposes the active surface of stimulation electrodes onto a tissue region opposite to the fixation component. A system and a method for optimally positioning the lead for stimulation of the tissue are also provided.
摘要翻译：提供用于刺激组织的体内程序的引导件，其具有设置在引线的远端处的刺激电极和固定机构。固定机构包括相对于刺激电极的有效表面设置在相对侧的固定部件。引导固定机构在部署时将刺激电极的活性表面配置到与固定部件相对的组织区域上。还提供了用于最佳地定位用于刺激组织的引线的系统和方法。

45. 发明申请

WO2014036317A2 HIS BUNDLE LEAD DELIVERY SYSTEM 审中-公开
标题翻译：他的铅笔交货系统
公开(公告)号：WO2014036317A2
公开(公告)日：2014-03-06
申请号：PCT/US2013057381
申请日：2013-08-29
申请人： CARDIAC PACEMAKERS INC
发明人： SHUROS ALLAN C , TOCKMAN BRUCE A , REDDY G SHANTANU
IPC分类号： A61N1/05 , A61M25/00
CPC分类号： A61N1/059 , A61N1/0565 , A61N1/0573 , A61N1/362 , A61N1/372
摘要： Various embodiments concern implanting a lead to directly stimulate the bundle of His. Various embodiments can include introducing a curve of an outer guide catheter into the right ventricle, extending a curve of an inner guide catheter from a lumen of the outer guide catheter, extending a fixation element on a distal tip of an anchor wire from a lumen the inner guide catheter, and anchoring the anchor wire to target tissue within the right ventricle, the target tissue along the septal wall and proximate the tricuspid valve and the bundle of His. A distal tip of an implantable lead with a lumen can then be advanced over the anchor wire to the target tissue as the anchor wire guides the distal tip of the lead to the target tissue.
摘要翻译：各种实施例涉及植入铅直接刺激His束。各种实施例可以包括将外引导导管的曲线引入右心室，将内引导导管的曲线从外引导导管的内腔延伸，将固定丝的远侧末端上的固定元件从内腔延伸内导向导管，并将锚线锚定在右心室内的靶组织上，沿着隔膜壁和靠近三尖瓣和His束的靶组织。然后随着锚线将引线的远侧末端引导到目标组织，可以将具有内腔的可植入引线的远侧末端推进到锚定线上到目标组织。

46. 发明申请

WO2012082755A1 PACEMAKER RETRIEVAL SYSTEMS AND METHODS 审中-公开
标题翻译： PACEMAKER检索系统和方法
公开(公告)号：WO2012082755A1
公开(公告)日：2012-06-21
申请号：PCT/US2011/064671
申请日：2011-12-13
申请人： NANOSTIM, INC. , KHAIRKHAHAN, Alexander , KLENK, Alan , EBY, Thomas
发明人： KHAIRKHAHAN, Alexander , KLENK, Alan , EBY, Thomas
IPC分类号： A61N1/05
CPC分类号： A61N1/0573 , A61B2017/22035 , A61M25/0082 , A61N1/059 , A61N1/362 , A61N1/37205 , A61N1/3756 , A61N2001/0578
摘要： A catheter system for retrieving a leadless cardiac pacemaker from a patient is provided. The cardiac pacemaker can include a docking or retrieval feature configured to be grasped by the catheter system. In some embodiments, the retrieval catheter can include a snare configured to engage the retrieval feature of the pacemaker. The retrieval catheter can include a torque shaft selectively connectable to a docking cap and be configured to apply rotational torque to a pacemaker to be retrieved. Methods of delivering the leadless cardiac pacemaker with the delivery system are also provided.
摘要翻译：提供了一种用于从患者检索无引线心脏起搏器的导管系统。心脏起搏器可以包括构造成被导管系统抓住的对接或检索特征。在一些实施例中，回收导管可以包括构造成接合起搏器的检索特征的圈套。回收导管可以包括可选择性地连接到对接盖的扭矩轴，并且被构造成将旋转扭矩施加到要起重器的起搏器。还提供了使用输送系统递送无引线心脏起搏器的方法。

47. 发明申请

WO2012064963A1 ANCHORAGE DEVICES COMPRISING AN ACTIVE PHARMACEUTICAL INGREDIENT 审中-公开
标题翻译：包含活性药物成分的安装装置
公开(公告)号：WO2012064963A1
公开(公告)日：2012-05-18
申请号：PCT/US2011/060197
申请日：2011-11-10
申请人： TYRX, INC. , MCJAMES, William , DO, Frank , GE, Qing , PULAPURA, Satish
发明人： MCJAMES, William , DO, Frank , GE, Qing , PULAPURA, Satish
IPC分类号： A61L31/10 , A61L31/16
CPC分类号： A61L31/08 , A61L31/10 , A61L31/16 , A61L2300/602 , A61N1/059
摘要： An anchorage device 100 comprising a mesh substrate 124 coupled to an implantable medical device 120 is disclosed, where the mesh substrate has a coating 120 comprising a polymer, and the mesh further comprises at least one active pharmaceutical ingredient. The active pharmaceutical agent is designed to elute from the device over time. The mesh substrate can be configured to reduce the mass of the anchorage device such that tissue in-growth and/or scar tissue formation at the treatment site is reduced. In some embodiments, the mesh substrate can be formed with a mesh having a low areal density. In some embodiments, the mesh substrate can include one or more apertures or pores to reduce the mass of the substrate.
摘要翻译：公开了一种锚固装置100，其包括耦合到可植入医疗装置120的网状基底124，其中网状基底具有包含聚合物的涂层120，并且网格还包含至少一种活性药物成分。活性药剂被设计成随着时间从该装置中洗脱。网状基底可以被配置为减小锚固装置的质量，使得在治疗部位的组织生长和/或瘢痕组织形成减少。在一些实施例中，网状基底可以形成有具有低面密度的网。在一些实施例中，网状基底可以包括一个或多个孔或孔以减小基底的质量。

48. 发明申请

WO2011038330A1 MRI COMPATIBLE LEADLESS CARDIAC PACEMAKER 审中-公开
标题翻译： MRI兼容无铅CARDIAC PACEMAKER
公开(公告)号：WO2011038330A1
公开(公告)日：2011-03-31
申请号：PCT/US2010/050367
申请日：2010-09-27
申请人： NANOSTIM, INC. , OSTROFF, Alan
发明人： OSTROFF, Alan
IPC分类号： A61N1/372
CPC分类号： A61N1/059 , A61N1/0573 , A61N1/3718 , A61N1/37205 , A61N1/3756
摘要： An implantable battery powered leadless pacemaker or biostimulator is provided that may include any of a number of features. One feature of the biostimulator is that it safely operates under a wide range of MRI conditions. One feature of the biostimulator is that it has a total volume small enough to avoid excessive image artifacts during a MRI procedure. Another feature of the biostimulator is that it has reduced path lengths between electrodes to minimize tissue heating at the site of the biostimulator. Yet another feature of the biostimulator is that a current loop area within the biostimulator is small enough to reduce an induced current and voltage in the biostimulator during MRI procedures. Methods associated with use of the biostimulator are also covered.
摘要翻译：提供可植入电池供电的无引线起搏器或生物刺激器，其可以包括多个特征中的任何一个。生物刺激仪的一个特点是它可以在广泛的MRI条件下安全运行。生物刺激仪的一个特点是它具有足够小的总体积，以避免MRI过程中过多的图像伪影。生物刺激器的另一个特征是它减少了电极之间的路径长度，以最小化生物刺激器部位的组织加热。生物刺激器的另一个特征是生物刺激器内的电流回路区域足够小以在MRI过程期间减少生物刺激器中的感应电流和电压。还涉及与使用生物刺激仪有关的方法。

49. 发明申请

WO2008034005A3 CARDIAC STIMULATION USING LEADLESS ELECTRODE ASSEMBLIES 审中-公开
标题翻译：使用无铅电极组件进行心脏刺激
公开(公告)号：WO2008034005A3
公开(公告)日：2008-07-10
申请号：PCT/US2007078405
申请日：2007-09-13
申请人： BOSTON SCIENT SCIMED INC , HASTINGS ROGER N , LAFONTAINE DANIEL M , PIKUS MICHAEL J , WILLARD MARTIN R
发明人： HASTINGS ROGER N , LAFONTAINE DANIEL M , PIKUS MICHAEL J , WILLARD MARTIN R
IPC分类号： A61N1/362 , A61N1/05 , A61N1/372 , A61N1/378
CPC分类号： A61N1/059 , A61N1/365 , A61N1/372 , A61N1/37205 , A61N1/37288 , A61N1/375 , A61N1/3756
摘要： An implantable cardiac tissue excitation system includes an implantable pacing controller unit with a pulse generation circuit. The system also includes a lead with a lead body extending between a proximal lead end attachable to the pacing controller unit and a distal lead end configured to be implanted within a heart. A lead conductor extends within the lead body. The system also includes a transmitter assembly located near the distal lead end that is electrically connected to the pulse generation circuit through the lead conductor to wirelessly transmit pacing control information and pacing energy. The system also includes a leadless electrode assembly configured to be implanted within the heart that includes a receiver to receive the wireless transmission, a charge storage unit to store the charge energy, and an electrical stimulation circuit to deliver an electrical stimulus to cardiac tissue using the pacing control information and the charge energy.
摘要翻译：可植入心脏组织激励系统包括具有脉冲发生电路的可植入起搏控制器单元。该系统还包括引线，引线本体在可附接到起搏控制器单元的近端引导端与构造成植入心脏内的远端引线端之间延伸。引线导体在引线体内延伸。该系统还包括位于远端引导端附近的发射器组件，其通过引线导体电连接到脉冲发生电路，以无线地发送起搏控制信息和起搏能量。该系统还包括被配置为植入在心脏内的无引线电极组件，其包括用于接收无线传输的接收器，用于存储充电能量的电荷存储单元，以及电刺激电路，以使用起搏控制信息和充电能量。

50. 发明申请

WO2007047681A2 LEADLESS CARDIAC PACEMAKER AND SYSTEM 审中-公开
标题翻译：无铅CARDIAC PACEMAKER和系统
公开(公告)号：WO2007047681A2
公开(公告)日：2007-04-26
申请号：PCT/US2006/040564
申请日：2006-10-13
申请人： NANOSTIM, INC. , JACOBSON, Peter, M.
发明人： JACOBSON, Peter, M.
IPC分类号： A61N1/05
CPC分类号： A61N1/3962 , A61M25/0662 , A61N1/056 , A61N1/0573 , A61N1/0587 , A61N1/059 , A61N1/3621 , A61N1/3627 , A61N1/36514 , A61N1/36542 , A61N1/368 , A61N1/3684 , A61N1/3704 , A61N1/3706 , A61N1/3708 , A61N1/372 , A61N1/37205 , A61N1/37217 , A61N1/37252 , A61N1/3727 , A61N1/37288 , A61N1/375 , A61N1/3756 , A61N1/3925 , A61N1/3956 , A61N2001/058 , H04B13/005
摘要： In a cardiac pacing system, a leadless cardiac pacemaker is configured for implantation in electrical contact with a cardiac chamber and configured for leadless pacing.
摘要翻译：在心脏起搏系统中，无引线心脏起搏器被配置用于植入与心室的电接触并被配置用于无引线起搏。

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