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1. 发明申请

WO2012027566A2 NOVEL MEDICAL DEVICE COATINGS 审中-公开
标题翻译：新型医疗器械涂料
公开(公告)号：WO2012027566A2
公开(公告)日：2012-03-01
申请号：PCT/US2011049140
申请日：2011-08-25
申请人： TYRX INC , PULAPURA SATISH , GE QING
发明人： PULAPURA SATISH , GE QING
CPC分类号： A61L31/10 , A61K31/155 , A61K31/496 , A61K31/65 , A61K33/38 , A61L31/16 , A61L2300/204 , A61L2300/216 , A61L2300/404 , A61L2300/606 , A61L2420/06 , C09D5/14 , C09D171/02 , Y10T428/265 , Y10T428/31678 , C08L71/02 , C08L67/02
摘要： The present invention relates to coatings comprising polyethylene glycol and at least one polyphenolic polymer. In particular, the polyphenolic polymer could be selected from the group consisting of tyrosine-derived polyarylates, linear polyesteramides, dihydroxybenzoate polymers, and resorcinol-derived polymers. The coating of the present invention may also include a drug, such as an antibiotic. The coatings of the present invention are suitable for use as coatings for medical devices, such as orthopedic pins or stents.
摘要翻译：本发明涉及包含聚乙二醇和至少一种多酚聚合物的涂料。特别地，多酚聚合物可以选自酪氨酸衍生的多芳基化合物，线性聚酯酰胺，二羟基苯甲酸酯聚合物和间苯二酚衍生的聚合物。本发明的涂层还可以包括药物，例如抗生素。本发明的涂层适合用作医疗装置如矫形针或支架的涂层。

2. 发明申请

WO2007056134A3 RESORBABLE PHENOLIC POLYMERS 审中-公开
标题翻译：可分离的酚醛聚合物
公开(公告)号：WO2007056134A3
公开(公告)日：2009-04-23
申请号：PCT/US2006042944
申请日：2006-11-03
申请人： TYRX PHARMA INC , MOSES ARIKHA , PULAPURA SATISH , SCHWARTZ ARTHUR , GE QING , SHATOVA IRENE
发明人： MOSES ARIKHA , PULAPURA SATISH , SCHWARTZ ARTHUR , GE QING , SHATOVA IRENE
IPC分类号： C08G73/00 , A61M31/00 , C07C233/65 , C08F220/44 , C08G65/40 , C08G69/08
CPC分类号： C08G69/48 , C07C235/34 , C07C235/52 , C08G63/6856 , C08G64/12 , C08G73/028
摘要： The invention provides biocompatible resorbable polymers, comprising monomer units having formula (I), formula (II), formula (III) or formula (IV). The polymers degrade over time when implanted in the body, and are useful as components of implantable medical devices.
摘要翻译：本发明提供具有式（I），式（II），式（III）或式（IV））的单体单元的生物相容性可再吸收聚合物。当植入体内时，聚合物随时间降解，并且可用作可植入医疗装置的组件。

3. 发明申请

WO2006102461A3 INFLUENZA THERAPEUTIC 审中-公开
标题翻译：流感治疗
公开(公告)号：WO2006102461A3
公开(公告)日：2007-07-26
申请号：PCT/US2006010491
申请日：2006-03-22
申请人： MASSACHUSETTS INST TECHNOLOGY , CHEN JIANZHU , GE QING , EISEN HERMAN N
发明人： CHEN JIANZHU , GE QING , EISEN HERMAN N
IPC分类号： A61K38/00 , A61K48/00 , C12N15/11 , C12N15/113
CPC分类号： A61K9/5146 , A61K9/5153 , A61K38/00 , C12N15/111 , C12N15/1131 , C12N2310/111 , C12N2310/14 , C12N2310/321 , C12N2310/53 , C12N2320/11 , C12N2320/32 , C12N2799/021 , C12N2310/3521
摘要： The present invention provides compositions comprising an RNAi-inducing entity targeted to an influenza virus transcript and any of a variety of delivery agents. The invention further includes methods of use of the compositions for inhibiting a biological activity of an influenza virus and/or for treatment or prevention of influenza. The invention provides target portion sequences that are favorably conserved for RNAi across a plurality of influenza virus A strains isolated from human hosts and/or avian hosts and RNAi-inducing entities, e.g., siRNAs and shRNAs, targeted to such favorably conserved target portions. The invention provides a variety of nucleic acids comprising sequences identical or complementary to at least a portion of one or more of these favorably conserved target portion sequences. The invention further provides methods and compositions for delivering RNAi-inducing agents to an organ or tissue of a mammalian subject, e.g., to the lung. Methods of diagnosing influenza and determining the susceptibility of an influenza virus to inhibition by an RNAi-inducing agent are also provided. Transgenic animals that express an RNAi-inducing agent targeted to an influenza gene are another aspect of the invention.
摘要翻译：本发明提供了包含针对流感病毒转录物的RNAi诱导实体和各种递送试剂中的任一种的组合物。本发明还包括使用该组合物抑制流感病毒的生物活性和/或用于治疗或预防流感的方法。本发明提供了靶向部分序列，其针对分离自人宿主和/或禽类宿主和RNAi诱导实体（例如siRNA和shRNA）分离的多个流感病毒A的RNAi被有针对性地保守，靶向这些有利的保守靶部分。本发明提供了多种核酸，其包含与这些有利保守的靶部分序列中的一种或多种的至少一部分相同或互补的序列。本发明进一步提供了用于将RNAi诱导剂递送至哺乳动物受试者的器官或组织例如肺的方法和组合物。还提供了诊断流感并确定流感病毒对RNAi诱导剂抑制的易感性的方法。表达针对流感基因的RNAi诱导剂的转基因动物是本发明的另一方面。

4. 发明申请

WO2006102461A2 INFLUENZA THERAPEUTIC 审中-公开
标题翻译：流感治疗
公开(公告)号：WO2006102461A2
公开(公告)日：2006-09-28
申请号：PCT/US2006/010491
申请日：2006-03-22
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , CHEN, Jianzhu , GE, Qing , EISEN, Herman, N.
发明人： CHEN, Jianzhu , GE, Qing , EISEN, Herman, N.
IPC分类号： A61K38/00 , A61K48/00 , C12N15/11 , C12N15/113
CPC分类号： A61K9/5146 , A61K9/5153 , A61K38/00 , C12N15/111 , C12N15/1131 , C12N2310/111 , C12N2310/14 , C12N2310/321 , C12N2310/53 , C12N2320/11 , C12N2320/32 , C12N2799/021 , C12N2310/3521
摘要： The present invention provides compositions comprising an RNAi-inducing entity targeted to an influenza virus transcript and any of a variety of delivery agents. The invention further includes methods of use of the compositions for inhibiting a biological activity of an influenza virus and/or for treatment or prevention of influenza. The invention provides target portion sequences that are favorably conserved for RNAi across a plurality of influenza virus A strains isolated from human hosts and/or avian hosts and RNAi-inducing entities, e.g., siRNAs and shRNAs, targeted to such favorably conserved target portions. The invention provides a variety of nucleic acids comprising sequences identical or complementary to at least a portion of one or more of these favorably conserved target portion sequences. The invention further provides methods and compositions for delivering RNAi-inducing agents to an organ or tissue of a mammalian subject, e.g., to the lung. Methods of diagnosing influenza and determining the susceptibility of an influenza virus to inhibition by an RNAi-inducing agent are also provided. Transgenic animals that express an RNAi-inducing agent targeted to an influenza gene are another aspect of the invention.
摘要翻译：本发明提供了包含针对流感病毒转录物的RNAi诱导实体和各种递送试剂中的任一种的组合物。本发明还包括使用该组合物抑制流感病毒的生物活性和/或用于治疗或预防流感的方法。本发明提供了针对分离自人宿主和/或禽类宿主和RNAi诱导实体（例如siRNA和shRNA）的多个流感病毒A菌株的RNAi有利地保守的靶标部分序列，靶向这些有利的保守靶部分。本发明提供了多种核酸，其包含与这些有利保守的靶部分序列中的一种或多种的至少一部分相同或互补的序列。本发明进一步提供了用于将RNAi诱导剂递送至哺乳动物受试者的器官或组织例如肺的方法和组合物。还提供了诊断流感并确定流感病毒对RNAi诱导剂抑制的易感性的方法。表达针对流感基因的RNAi诱导剂的转基因动物是本发明的另一方面。

5. 发明申请

WO2006047683A3 ANTISENSE ANTIVIRAL COMPOUND AND METHOD FOR TREATING INFLUENZA VIRAL INFECTION 审中-公开
公开(公告)号：WO2006047683A3
公开(公告)日：2006-05-04
申请号：PCT/US2005/038780
申请日：2005-10-26
申请人： AVI BIOPHARMA, INC. , STEIN, David, A. , GE, Qing , CHEN, Jianzhu , IVERSEN, Patrick, L.
发明人： STEIN, David, A. , GE, Qing , CHEN, Jianzhu , IVERSEN, Patrick, L.
IPC分类号： C07H21/04
摘要： The invention provides antisense antiviral compounds and methods of their use and production in inhibition of growth of viruses of the Orthomyxoviridae family and in the treatment of a viral infection. The compounds are particularly useful in the treatment of influenza virus infection in a mammal. The antisense antiviral compounds are substantially uncharged morpholino oligonucleotides having 1) a nuclease resistant backbone, 2) 12-40 nucleotide bases, and 3) a targeting sequence of at least 12 bases in length that hybridizes to a target region selected from the following: a) the 5' or 3' terminal 25 bases of the negative sense viral RNA segment of Influenzavirus A, Influenzavirus B and Influenzavirus C; b) the terminal 25 bases of the 3' terminus of the positive sense cRNA and; and c) the 50 bases surrounding the AUG start codon of an influenza viral mRNA.

6. 发明申请

WO2006047683A2 ANTISENSE ANTIVIRAL COMPOUND AND METHOD FOR TREATING INFLUENZA VIRAL INFECTION 审中-公开
标题翻译：反义抗病毒化合物和治疗流感病毒感染的方法
公开(公告)号：WO2006047683A2
公开(公告)日：2006-05-04
申请号：PCT/US2005038780
申请日：2005-10-26
申请人： AVI BIOPHARMA INC , STEIN DAVID A , GE QING , CHEN JIANZHU , IVERSEN PATRICK L
发明人： STEIN DAVID A , GE QING , CHEN JIANZHU , IVERSEN PATRICK L
IPC分类号： A61K48/00 , C12N15/113
CPC分类号： C12N15/1131 , C12N2310/3145 , C12N2310/3233 , C12N2310/3513
摘要： The invention provides antisense antiviral compounds and methods of their use and production in inhibition of growth of viruses of the Orthomyxoviridae family and in the treatment of a viral infection. The compounds are particularly useful in the treatment of influenza virus infection in a mammal. The antisense antiviral compounds are substantially uncharged morpholino oligonucleotides having 1) a nuclease resistant backbone, 2) 12-40 nucleotide bases, and 3) a targeting sequence of at least 12 bases in length that hybridizes to a target region selected from the following: a) the 5' or 3' terminal 25 bases of the negative sense viral RNA segment of Influenzavirus A, Influenzavirus B and Influenzavirus C; b) the terminal 25 bases of the 3' terminus of the positive sense cRNA and; and c) the 50 bases surrounding the AUG start codon of an influenza viral mRNA.
摘要翻译：本发明提供了反义抗病毒化合物及其在抑制正粘病毒科病毒生长和治疗病毒感染中的使用和生产方法。这些化合物特别适用于治疗哺乳动物的流感病毒感染。反义抗病毒化合物是基本上不带电的吗啉代寡核苷酸，具有1）核酸酶抗性骨架，2）12-40个核苷酸碱基，和3）至少12个碱基长度的靶向序列，其与选自以下的靶标区域杂交：a ）流感病毒A，流感病毒B和流感病毒C的负义病毒RNA片段的5'或3'末端25个碱基; b）正义cRNA的3'末端的末端25个碱基和; 和c）流感病毒mRNA的AUG起始密码子周围的50个碱基。

7. 发明申请

WO2010045384A3 SHORT HAIRPIN RNAS FOR INHIBITION OF GENE EXPRESSION 审中-公开
标题翻译：短发HAIRPIN RNAS用于抑制基因表达
公开(公告)号：WO2010045384A3
公开(公告)日：2010-06-10
申请号：PCT/US2009060712
申请日：2009-10-14
申请人： SOMAGENICS INC , GE QING , JOHNSTON BRIAN H , KAZAKOV SERGEI A , ILVES HEINI , DALLAS ANNE
发明人： GE QING , JOHNSTON BRIAN H , KAZAKOV SERGEI A , ILVES HEINI , DALLAS ANNE
IPC分类号： C07H21/04
CPC分类号： C12N15/111 , C12N15/1131 , C12N2310/14 , C12N2310/531 , C12N2310/533
摘要： Methods, compositions, and kits that include small hairpin RNA (shRNA) useful for inhibition of gene expression, such as viral-mediated gene expression, are described.
摘要翻译：描述了包括用于抑制基因表达的小发夹RNA（shRNA）的方法，组合物和试剂盒，例如病毒介导的基因表达。

8. 发明申请

WO2006047683B1 ANTISENSE ANTIVIRAL COMPOUND AND METHOD FOR TREATING INFLUENZA VIRAL INFECTION 审中-公开
标题翻译：抗真菌化合物和治疗流感病毒感染的方法
公开(公告)号：WO2006047683B1
公开(公告)日：2006-11-09
申请号：PCT/US2005038780
申请日：2005-10-26
申请人： AVI BIOPHARMA INC , STEIN DAVID A , GE QING , CHEN JIANZHU , IVERSEN PATRICK L
发明人： STEIN DAVID A , GE QING , CHEN JIANZHU , IVERSEN PATRICK L
IPC分类号： C07H21/04 , C12N15/113
CPC分类号： C12N15/1131 , C12N2310/3145 , C12N2310/3233 , C12N2310/3513
摘要： The invention provides antisense antiviral compounds and methods of their use and production in inhibition of growth of viruses of the Orthomyxoviridae family and in the treatment of a viral infection. The compounds are particularly useful in the treatment of influenza virus infection in a mammal. The antisense antiviral compounds are substantially uncharged morpholino oligonucleotides having 1) a nuclease resistant backbone, 2) 12-40 nucleotide bases, and 3) a targeting sequence of at least 12 bases in length that hybridizes to a target region selected from the following: a) the 5' or 3' terminal 25 bases of the negative sense viral RNA segment of Influenzavirus A, Influenzavirus B and Influenzavirus C; b) the terminal 25 bases of the 3' terminus of the positive sense cRNA and; and c) the 50 bases surrounding the AUG start codon of an influenza viral mRNA.
摘要翻译：本发明提供反义抗病毒化合物及其在抑制正粘病毒科的病毒生长和用于病毒感染治疗中的用途和生产方法。该化合物特别可用于治疗哺乳动物的流感病毒感染。反义抗病毒化合物是基本上不带电荷的吗啉代寡核苷酸，其具有1）核酸酶抗性主链，2）12-40个核苷酸碱基，和3）长度为至少12个碱基的靶向序列与选自以下的靶区域杂交：）流感病毒A，流感病毒B和流感病毒C的负义病毒RNA片段的5'或3'末端25个碱基; b）正义cRNA的3'末端的末端25个碱基; 和c）围绕流感病毒mRNA的AUG起始密码子的50个碱基。

9. 发明申请

WO2006115799A1 SHAPE MEMORY POLYMERS BASED ON SEMICRYSTALLINE THERMOPLASTIC POLYURETHANES BEARING NANOSTRUCTURED HARD SEGMENTS 审中-公开
标题翻译：基于半导体热塑性聚氨酯的形状记忆聚合物承载纳米硬化部分
公开(公告)号：WO2006115799A1
公开(公告)日：2006-11-02
申请号：PCT/US2006/013797
申请日：2006-04-11
申请人： UNIVERSITY OF CONNECTICUT , MATHER, Patrick, T. , LIU, Changdeng , GE, Qing
发明人： MATHER, Patrick, T. , LIU, Changdeng , GE, Qing
IPC分类号： C08G18/38 , C08G18/42 , C08G18/48
CPC分类号： C08G18/3893 , C08G18/4277 , C08G18/428 , C08G18/4833 , C08G18/61 , C08G61/08 , C08G2230/00 , C08G2280/00 , C08L65/00
摘要： Thermoplastic polyurethanes having an alternating sequence of hard and soft segments in which a nanostructured polyhedral oligosilsesquioxane diol is used as a chain extender to form a crystalline hard segment constituting SMPs. The polyurethanes are formed by reacting a polyol, a chain extender dihydroxyl-terminated polyhedral oligosilsesquioxane and a diisocyanate. The polyurethanes have multiple applications including for example, implants for human health care, drug delivery matrices, superabsorbant hydrogels, coatings, adhesives, temperature and moisture sensors, etc.
摘要翻译：具有硬链段和软链段的交替序列的热塑性聚氨酯，其中使用纳米结构多面体寡聚倍半硅氧烷二醇作为扩链剂以形成构成SMP的结晶硬链段。聚氨酯通过使多元醇，扩链剂二羟基封端的多面体寡聚倍半硅氧烷和二异氰酸酯反应而形成。聚氨酯具有多种应用，包括例如用于人体保健的植入物，药物递送基质，超吸收水凝胶，涂层，粘合剂，温度和湿度传感器等。

10. 发明申请

WO2004029213A3 COMPOSITIONS AND METHODS FOR DELIVERY OF SHORT INTERFERING RNA AND SHORT HAIRPIN RNA 审中-公开
标题翻译：用于递送短干扰RNA和短发夹RNA的组合物和方法
公开(公告)号：WO2004029213A3
公开(公告)日：2004-09-16
申请号：PCT/US0330508
申请日：2003-09-29
申请人： MASSACHUSETTS INST TECHNOLOGY , CHEN JIANZHU , EISEN HERMAN N , GE QING
发明人： CHEN JIANZHU , EISEN HERMAN N , GE QING
IPC分类号： A61K38/00 , A61K48/00 , C12N15/11 , C12N15/113 , C12N15/09 , C12N15/63
CPC分类号： C12N15/1131 , A61K9/5146 , A61K9/5153 , A61K38/00 , C12N15/111 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2320/32 , C12N2799/021
摘要： The present invention provides compositions comprising an RNAi-inducing entity any of a variety of different delivery agents. Preferred RNAi-inducing agents include siRNA, shRNA, and RNAi-inducing vectors. Preferred delivery agents include cationic polymers, modified cationic polymers, lipids, and surfactants suitable for introduction into the lung. The invention further provides methods of inhibiting expression of a target 10 transcript in a mammal and methods of treating or preventing a disease or condition in a mammal by administration of the compositions.
摘要翻译：本发明提供了包含RNAi诱导实体的组合物，所述组合物包含多种不同递送剂中的任一种。优选的RNAi诱导剂包括siRNA，shRNA和RNAi诱导载体。优选的递送剂包括阳离子聚合物，改性阳离子聚合物，脂质和适用于引入肺中的表面活性剂。本发明进一步提供了抑制哺乳动物中靶转录物表达的方法以及通过施用组合物治疗或预防哺乳动物的疾病或病症的方法。

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