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1. 发明申请

WO2022082229A1 REPETITIVE ELEMENT DNAS AND USES THEREOF 审中-公开
公开(公告)号：WO2022082229A1
公开(公告)日：2022-04-21
申请号：PCT/US2021/071910
申请日：2021-10-16
申请人： CHILDREN'S HOSPITAL LOS ANGELES
发明人： COBRINIK, David , CAMBIER, Linda
IPC分类号： C12Q1/6806 , C12Q1/6886
摘要： Provided herein is a blood test for the detection of a marker of osteosarcoma and other cancers.

2. 发明申请

WO2022016119A1 CHIMERIC MYD88 RECEPTORS FOR REDIRECTING IMMUNOSUPPRESSIVE SIGNALING AND RELATED COMPOSITIONS AND METHODS 审中-公开
公开(公告)号：WO2022016119A1
公开(公告)日：2022-01-20
申请号：PCT/US2021/042091
申请日：2021-07-16
申请人： SIMURX, INC. , CHILDREN'S HOSPITAL LOS ANGELES
发明人： ASGHARZADEH, Shahab , MOGHIMI, Babak , HADJIDANIEL, Michael , SHIRINBAK, Soheila
IPC分类号： C07K14/705 , A61P35/00 , C07K14/19
摘要： The present disclosure relates in some aspects to chimeric signaling receptors containing an extracellular domain capable of binding a molecule, such as an immunosuppressive cytokine, and a MyD88-containing intracellular domain capable of engaging a signaling pathway to activate an immune cell. In some aspects, the disclosure further relates to engineered cells, such as T cells, and compositions comprising the chimeric signaling receptors or engineered cells, and methods and uses thereof. In some embodiments, the cells may further express a genetically engineered recombinant antigen receptor directed against an antigen, such as a chimeric antigen receptor (CAR) or recombinant T cell receptor (TCR) and, in some cases, secrete a recombinant molecule, for example, a bispecific antibody.

3. 发明申请

WO2020264019A1 BCL11B OVEREXPRESSION TO ENHANCE HUMAN THYMOPOIESIS AND T CELL FUNCTION 审中-公开
公开(公告)号：WO2020264019A1
公开(公告)日：2020-12-30
申请号：PCT/US2020/039414
申请日：2020-06-24
申请人： CHILDREN'S HOSPITAL LOS ANGELES , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： PAREKH, Chintan , CROOKS, Gay , SEET, Christopher , MONTEL-HAGEN, Amelie
IPC分类号： A61K35/14 , A61P37/00
摘要： Methods of treating a subject using a T cell therapy are disclosed herein. The methods include increasing BCL11B expression in hematopoietic stem and progenitor cells (HSPCs), pluripotent stem cells, or mature T cells to form modified cells and administering a therapeutically effective amount of the modified cells to the subject for the T cell therapy. BCL11B expression in the HSPCs, pluripotent stem cells, or mature T cells increases production and/or proliferation of T cells from the HSPCs and/or the pluripotent stem cells, and/or increases proliferation of the T cells.

4. 发明申请

WO2017075670A1 "MOBILIZING LEUKEMIA CELLS" 审中-公开
标题翻译： “动员白血病细胞”
公开(公告)号：WO2017075670A1
公开(公告)日：2017-05-11
申请号：PCT/AU2016/051059
申请日：2016-11-04
申请人： CHILDREN'S HOSPITAL LOS ANGELES , ANTISENSE THERAPEUTICS LTD
发明人： TACHAS, George , KIM, Yong-Mi
IPC分类号： A61K31/7125 , C12N15/113 , A61P35/02
CPC分类号： A61K31/7125 , A61K45/06 , C12N15/1138 , C12N2310/11 , C12N2320/30
摘要： A method for mobilizing leukemia cells which are α4 integrin positive to the peripheral blood of a human subject, the method comprising administering to the human subject an effective amount of an antisense compound to α4 integrin. The cells may be mobilized from bone marrow. The antisense compound is: 5' - Me C Me UG AGT Me CTG TTT Me U Me CMeC A Me U Me U Me C Me U - 3' wherein, (a) each of the 19 internucleotide linkages of the oligonucleotide is an O,O-linked phosphorothioate diester; (b) the nucleotides at the positions 1 to 3 from the 5' end are 2'-O-(2-methoxyethyl) modified ribonucleosides; (c) the nucleotides at the positions 4 to 12 from the 5' end are 2'- deoxyribonucleosides; (d) the nucleotides at the positions 13 to 20 from the 5' end are 2'-O-(2-methoxyethyl) modified ribonucleosides; and (e) all cytosines are 5- methylcytosines ( Me C), or a pharmaceutically acceptable salt thereof.
摘要翻译：一种用于动员人类受试者外周血呈阳性的α4整联蛋白的白血病细胞的方法，所述方法包括向所述人类受试者施用有效量的针对α4整联蛋白的反义化合物。细胞可以从骨髓移动。反义化合物是：5'-Me-C Me UG AGT CTG TTT Me U （a）其中，（a）是式（II）的化合物：其中，寡核苷酸的19个核苷酸间键中的每一个都是O，O-连接的硫代磷酸二酯; （b）5'末端的1至3位核苷酸为2'-O-（2-甲氧基乙基）修饰的核糖核苷; （c）5'末端4至12位的核苷酸是2'-脱氧核糖核苷; （d）5'末端13〜20位的核苷酸为2'-O-（2-甲氧基乙基）修饰的核糖核苷; 和（e）所有的胞嘧啶是5-甲基胞嘧啶（MeC），或其药学上可接受的盐。

5. 发明申请

WO2017058828A1 METHODS FOR TREATING DISEASES MEDIATED BY ERBB4-POSITIVE PRO-INFLAMMATORY MACROPHAGES 审中-公开
标题翻译：治疗由ERBB4阳性炎症反应引起的疾病的方法
公开(公告)号：WO2017058828A1
公开(公告)日：2017-04-06
申请号：PCT/US2016/054027
申请日：2016-09-27
申请人： CHILDREN'S HOSPITAL LOS ANGELES
发明人： FREY, Mark R. , SCHUMACHER, Michael
IPC分类号： A61K38/18
CPC分类号： A61K38/1883
摘要： Provided herein are methods and compositions for treating disease-states associated with presence of increased number of ErbB4+ pro-inflammatory macrophages in a subject in need thereof. The methods include providing an activator of ErbB4 and administering a therapeutically effective amount of the activator to the subject. The compositions include an activator of ErbB4. In one embodiment, the activation of ErbB4 is Neuregulin-4.
摘要翻译：本文提供了用于治疗与有需要的受试者中存在增加数目的ErbB4 +促炎性巨噬细胞相关的疾病状态的方法和组合物。所述方法包括提供ErbB4的活化剂并向受试者施用治疗有效量的活化剂。组合物包括ErbB4的活化剂。在一个实施方案中，ErbB4的活化是神经调节蛋白-4。

6. 发明申请

WO2016161189A1 IMPLANTED ELECTRICAL LEAD FOR PACEMAKER 审中-公开
标题翻译：外置电气导线
公开(公告)号：WO2016161189A1
公开(公告)日：2016-10-06
申请号：PCT/US2016/025387
申请日：2016-03-31
申请人： CHILDREN'S HOSPITAL LOS ANGELES , UNIVERSITY OF SOUTHERN CALIFORNIA
发明人： BAR-COHEN, Yaniv , LOEB, Gerald , ZHOU, Li , YUN, Xiao
IPC分类号： A61N1/00 , A61N1/365
CPC分类号： A61N1/059 , A61L31/022 , A61L31/10 , A61N1/0587 , A61N1/37205 , A61N1/375 , A61N1/37512
摘要： An open coiled pacemaker lead is provided that has improved structural stability and functional life in vivo . The open coiled lead includes an electrically conductive material that is coated or covered by a thin layer of electrically insulative material. The coated coiled lead has adequate spacing between adjacent coils, and has a lumen of sufficient diameter, to allow for infiltration of biological connective tissue onto the surface of the coated coil when maintained in vivo for a sufficient amount of time. Infiltration of the connective tissue essentially uniformly along the entire coiled lead strengthens and lengthens the functional life of the coated coil lead.
摘要翻译：提供一种开放式卷曲的起搏器引线，其具有改善的体内结构稳定性和功能寿命。开放卷绕的引线包括被电绝缘材料薄层涂覆或覆盖的导电材料。涂覆的盘绕引线在相邻线圈之间具有足够的间隔，并且具有足够直径的内腔，以在体内维持足够的时间时允许生物结缔组织渗透到涂覆线圈的表面上。连续组织沿着整个盘绕的铅基本均匀地渗透，增强并延长涂层线圈引线的功能寿命。

7. 发明申请

WO2015070179A1 METHODS FOR TREATING HEMATOLOGICAL MALIGNANCIES 审中-公开
标题翻译：治疗血液恶性肿瘤的方法
公开(公告)号：WO2015070179A1
公开(公告)日：2015-05-14
申请号：PCT/US2014/064881
申请日：2014-11-10
申请人： CHILDREN'S HOSPITAL LOS ANGELES , FRED HUTCHINSON CANCER RESEARCH CENTER
发明人： KIM, Yong-mi , WAYNER, Elizabeth
IPC分类号： A61K38/00 , A01N45/00 , C07K1/00
CPC分类号： C07K16/2839 , A61K39/39575 , A61K45/06 , A61K2039/505 , C07K2317/24 , C07K2317/622 , C07K2317/73 , C07K2317/76 , G01N33/57426 , G01N2333/70546
摘要： Described herein are methods for treating hematological malignancies and/or solid tumors in a subject using inhibitors of integrin alpha 6. In some embodiments, the inhibitors are monoclonal antibodies. The antibodies may be conjugated to additional therapeutic agents. The antibodies may be co-administered sequentially or simultaneously with additional therapeutic agents.
摘要翻译：本文描述的是使用整联蛋白α6抑制剂治疗受试者的血液恶性肿瘤和/或实体瘤的方法。在一些实施方案中，抑制剂是单克隆抗体。抗体可以与另外的治疗剂缀合。抗体可以与其它治疗剂相继或同时共施用。

8. 发明申请

WO2015058148A1 ANTIBODY DEPENDENT EXOSOME THERAPY 审中-公开
标题翻译：抗体依赖性排除治疗
公开(公告)号：WO2015058148A1
公开(公告)日：2015-04-23
申请号：PCT/US2014/061245
申请日：2014-10-17
申请人： CHILDREN'S HOSPITAL LOS ANGELES
发明人： SEEGER, Robert, C. , FABBRI, Muller , JONG, Ambrose , WAYNE, Alan, S.
IPC分类号： A61P35/00
CPC分类号： A61K38/177 , A61K31/00 , A61K31/167 , A61K31/4745 , A61K31/675 , A61K31/704 , A61K31/7048 , A61K35/12 , A61K35/17 , A61K38/193 , A61K39/0011 , A61K39/39558 , A61K45/06 , A61K2039/5156 , C07K16/3053 , C07K16/3061 , C07K16/3084 , C07K2317/622 , C07K2319/03 , C07K2319/33 , A61K2300/00
摘要： Described herein are methods, pharmaceutical compositions and kits for treating cancer in a subject in need thereof by administering an effective amount of a composition comprising exosomes that comprise Fc receptors. In some embodiments, the exosomes in the pharmaceutical compositions described herein comprise Fc receptors including Fcgammal (CD64), Fcgamma2 (CD32), Fcgamma3 (CD16) or combinations thereof.
摘要翻译：本文描述的是通过施用有效量的包含Fc受体的外来体的组合物来治疗有需要的受试者的癌症的方法，药物组合物和试剂盒。在一些实施方案中，本文所述药物组合物中的外来体包含Fc受体，包括Fcgammal（CD64），Fcγ2（CD32），Fcγ3（CD16）或其组合。

9. 发明申请

WO2014182725A1 MATCHING DATA FROM VARIANT DATABASES 审中-公开
标题翻译：从不同的数据库匹配数据
公开(公告)号：WO2014182725A1
公开(公告)日：2014-11-13
申请号：PCT/US2014/037006
申请日：2014-05-06
申请人： CHILDREN'S HOSPITAL LOS ANGELES
发明人： NGUYEN, Ricky , JOHN, Sheryl , CAI, Francisco , PELED, Yael , WETZEL, Randall, C.
IPC分类号： G06F17/30
CPC分类号： G06F17/30657
摘要： A system for collaborative, data-driven translation of nomenclatures for data integration is described. Translation of observational data leverages both language and mathematics. Innovative scoring algorithms and interactive user interfaces aid in the discovery of matches. A process of sharing and approval enables collaboration despite multi-institutional barriers. While this system was developed with the intention of integrating clinical electronic health record data across multiple hospitals, it can be applied to a wide variety of data from any domain, due to its guiding principles and flexible design.
摘要翻译：描述了用于协作，数据驱动的用于数据集成的术语翻译的系统。观测数据的翻译利用语言和数学。创新的评分算法和交互式用户界面有助于发现比赛。共享和批准的过程使得协作尽管存在多种机制障碍。虽然该系统的开发是为了整合多家医院的临床电子健康记录数据，但由于其指导原则和灵活的设计，可以将其应用于任何领域的各种数据。

10. 发明申请

WO2022031881A1 PEDIATRIC LONG BONE FIXATION DEVICE 审中-公开
公开(公告)号：WO2022031881A1
公开(公告)日：2022-02-10
申请号：PCT/US2021/044592
申请日：2021-08-05
申请人： CHILDREN'S HOSPITAL LOS ANGELES
发明人： SKAGGS, David
IPC分类号： A61B17/80 , A61B17/74 , A61B17/68
摘要： Methods and devices for applying a compressive force to a growth plate in a long bone of a pediatric patient. A dynamically compressive bone plate is provided for applying the compressive force to the growth plate of the long bone. By applying compressive force to the growth plate in the long bone, the activity of the growth plate is suppressed, inactivated, or otherwise shut down.

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