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1. 发明申请

WO2016161189A1 IMPLANTED ELECTRICAL LEAD FOR PACEMAKER 审中-公开
标题翻译：外置电气导线
公开(公告)号：WO2016161189A1
公开(公告)日：2016-10-06
申请号：PCT/US2016/025387
申请日：2016-03-31
申请人： CHILDREN'S HOSPITAL LOS ANGELES , UNIVERSITY OF SOUTHERN CALIFORNIA
发明人： BAR-COHEN, Yaniv , LOEB, Gerald , ZHOU, Li , YUN, Xiao
IPC分类号： A61N1/00 , A61N1/365
CPC分类号： A61N1/059 , A61L31/022 , A61L31/10 , A61N1/0587 , A61N1/37205 , A61N1/375 , A61N1/37512
摘要： An open coiled pacemaker lead is provided that has improved structural stability and functional life in vivo . The open coiled lead includes an electrically conductive material that is coated or covered by a thin layer of electrically insulative material. The coated coiled lead has adequate spacing between adjacent coils, and has a lumen of sufficient diameter, to allow for infiltration of biological connective tissue onto the surface of the coated coil when maintained in vivo for a sufficient amount of time. Infiltration of the connective tissue essentially uniformly along the entire coiled lead strengthens and lengthens the functional life of the coated coil lead.
摘要翻译：提供一种开放式卷曲的起搏器引线，其具有改善的体内结构稳定性和功能寿命。开放卷绕的引线包括被电绝缘材料薄层涂覆或覆盖的导电材料。涂覆的盘绕引线在相邻线圈之间具有足够的间隔，并且具有足够直径的内腔，以在体内维持足够的时间时允许生物结缔组织渗透到涂覆线圈的表面上。连续组织沿着整个盘绕的铅基本均匀地渗透，增强并延长涂层线圈引线的功能寿命。

2. 发明申请

WO2014182948A2 EPICARDIAL LEAD DESIGN 审中-公开
公开(公告)号：WO2014182948A2
公开(公告)日：2014-11-13
申请号：PCT/US2014/037366
申请日：2014-05-08
申请人： CHILDREN'S HOSPITAL LOS ANGELES , UNIVERSITY OF SOUTHERN CALIFORNIA
发明人： BAR-COHEN, Yaniv , LOEB, Gerald , ZHOU, Li , PECK, Raymond , NUTT, Stephen
IPC分类号： A61N1/365
CPC分类号： A61N1/375 , A61N1/0587 , A61N1/059 , A61N1/362 , A61N1/37205 , A61N1/37288 , A61N1/3756 , A61N1/3787
摘要： The present invention provides an advancement in the art of cardiac pacemakers. The invention provides a novel and unobvious pacemaker system that comprises at least one pacemaker and that is, to a large extent, self-controlled, allows for long-term implantation in a patient, and minimizes current inconveniences and problems associated with battery life. The invention further includes a mechanism in which at least two pacemakers are implanted in a patient, and in which the pacemakers communicate with each other at the time of a given pacing or respiratory event, without any required external input, and adjust pacing parameters to respond to the patient's need for blood flow. The invention further provides a novel design for a pacemaker in which the pacemaker electrode is connected to the pacemaker body by a lead that is configured to allow the pacemaker to lie parallel to the epicardial surface and to reduce stress on the pacemaker and heart tissue.
摘要翻译：本发明提供了心脏起搏器领域的进步。本发明提供了一种新颖且不显眼的起搏器系统，其包括至少一个起搏器，并且在很大程度上是自我控制的，允许在患者中长期植入，并且最小化与电池寿命相关的当前不便和问题。本发明还包括一种机构，其中至少两个起搏器被植入患者体内，并且其中起搏器在给定的起搏或呼吸事件时彼此通信，而没有任何需要的外部输入，并且调整起搏参数以响应对患者的血液流动需求。本发明还提供了一种用于起搏器的新颖设计，其中起搏器电极通过引线连接到起搏器主体，该引线被配置为允许起搏器平行于心外膜表面平行并且减小起搏器和心脏组织的应力。

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