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31. 发明申请

WO99051278A1 INORGANIC MATERIAL FOR RADIOACTIVE DRUG DELIVERY 审中-公开
标题翻译：用于放射性药物递送的无机材料
公开(公告)号：WO99051278A1
公开(公告)日：1999-10-14
申请号：PCT/US1999/006823
申请日：1999-03-29
IPC分类号： A61K9/14 , A61K47/02 , A61K51/00 , A61K51/12 , A61P35/00 , A61K51/02
CPC分类号： A61K51/1241 , A61K51/1251
摘要： Radiotherapy agents which are solid or porous particles are described. The particles are of an inorganic material containing a suitable radionuclide and having an average particle diameter of about 0.05 to 5000 microns.
摘要翻译：描述了作为固体或多孔颗粒的放射治疗剂。颗粒是含有合适的放射性核素并且平均粒径为约0.05至5000微米的无机材料。

32. 发明申请

WO1999004826A1 METHOD FOR DETECTION OF FIBRIN CLOTS 审中-公开
标题翻译：检测纤维素的方法
公开(公告)号：WO1999004826A1
公开(公告)日：1999-02-04
申请号：PCT/AU1997000467
申请日：1997-07-24
申请人： THE AUSTRALIAN NATIONAL UNIVERSITY , BURCH, William, Martin , BROWITT, Rodney, James , NAIR, Chenicheri, Hariharan , SHATS, Elena, Alexandra
发明人： THE AUSTRALIAN NATIONAL UNIVERSITY
IPC分类号： A61K51/02
CPC分类号： A61K51/1251
摘要： The invention relates to a method for labelling macromolecules with a detectable marker which is encompassed in a layer of carbon, and a method for labelling biological macromolecules with such a marker. Disclosed is a method for labelling proteins in vivo with this marker, and a method for detecting fibrin clots using radionuclides contained inside a carbon cage. Preferably the radiolabel is Tc encapsulated inside the carbon in the form of a nano-encapsulate.
摘要翻译：本发明涉及用包含在一层碳中的可检测标记物标记大分子的方法，以及用这种标记物标记生物大分子的方法。本发明公开了一种使用该标记体内标记蛋白质的方法，以及使用包含在碳笼内的放射性核素检测纤维蛋白凝块的方法。放射性标记优选以纳米封装形式封装在碳内。

33. 发明申请

WO9205866A3 EFFICIENT MICROCAPSULE PREPARATION AND METHOD OF USE 审中-公开
标题翻译：有效的微胶囊制备和使用方法
公开(公告)号：WO9205866A3
公开(公告)日：1992-05-29
申请号：PCT/US9107366
申请日：1991-10-02
申请人： UNIV TEXAS
发明人： WALLACE SIDNEY , YANG DAVID J , WALLACE MICHAEL , KUANG LI-REN , LI CHUN
IPC分类号： A61K9/50 , A61K9/16 , A61K47/48 , A61K49/04 , A61K51/12 , B01J13/12 , B01J13/20 , B01J13/06
CPC分类号： A61K49/048 , A61K9/1641 , A61K9/1647 , A61K9/1652 , A61K9/167 , A61K9/1694 , A61K47/645 , A61K51/1251 , A61K2123/00 , B01J13/125 , B01J13/20
摘要： The present invention relates to a highly efficient method of preparing microcapsules suitable for encapsulation or surface attachment of therapeutic and diagnostic agents. In one aspect of the invention, surface charge of the polymeric material is altered by conjugation of an amino acid ester to the polymer, providing improved targeting of encapsulated agents to specific tissue cells. Examples include encapsulation of hydrophilic radiodiagnostic agents in 1 νm capsules to provide improved opacification and encapsulation of cytotoxic agents in 100 νm capsules for chemo embolization procedures. The microcapsules are suitable for attachment of a wide range of targeting agents, including antibodies, steroids and drugs, which may be attached to the microcapsule polymer before or after formation of suitably sized microcapsules.
摘要翻译：本发明涉及一种制备适合包封治疗剂和诊断剂的微胶囊的方法。胶衣是由可生物降解的聚合物制成的。在本发明的一个特定方面，聚合物材料的表面电荷通过氨基酸酯与聚合物的缀合而改变，从而为特定的组织细胞提供靶向。亲水性放射诊断剂在1微米胶囊中的包封提供了改善的不透明性。细胞毒性剂在100微米胶囊中的包封可用于化学栓塞过程。

34. 发明申请

WO2016191247A1 RADIOACTIVE NANOPARTICLES AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：放射性纳米粒子及其制备方法和使用方法
公开(公告)号：WO2016191247A1
公开(公告)日：2016-12-01
申请号：PCT/US2016/033432
申请日：2016-05-20
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： SUN, Xiankai , HAO, Yaowu , MOEENDARBARI, Sina
IPC分类号： A61K51/12 , A61K49/18 , A61K103/00 , A61K103/32 , A61P35/00 , B82Y15/00
CPC分类号： A61K51/1244 , A61K49/183 , A61K49/186 , A61K51/1251 , B82Y15/00
摘要： In one aspect, radioactive nanoparticles are described herein. In some embodiments, a radioactive nanoparticle described herein comprises a metal nanoparticle core, an outer metal shell disposed over the metal nanoparticle core, and a metallic radioisotope disposed within the metal nanoparticle core or within the outer metal shell. In some cases, the radioactive nanoparticle has a size of about 30-500 ran in three dimensions. In addition, in some embodiments, the radioactive nanoparticle further comprises an inner metal shell disposed between the metal nanoparticle core and the outer metal shell. The metal nanoparticle core, outer metal shell, and inner metal shell of the radioactive nanoparticle can have various metallic compositions.
摘要翻译：在一个方面，本文描述了放射性纳米颗粒。在一些实施方案中，本文所述的放射性纳米颗粒包含金属纳米颗粒芯，设置在金属纳米颗粒芯上的外金属壳和设置在金属纳米颗粒芯内或外金属壳内的金属放射性同位素。在一些情况下，放射性纳米颗粒在三维中具有约30-500的尺寸。此外，在一些实施例中，放射性纳米颗粒还包括设置在金属纳米颗粒芯和外部金属壳之间的内部金属壳。放射性纳米颗粒的金属纳米颗粒芯，外金属壳和内金属壳可以具有各种金属组成。

35. 发明申请

WO2016161129A1 SELF ASSEMBLING MOLECULES FOR TARGETED DRUG DELIVERY 审中-公开
标题翻译：自主组装用于定向药物递送的分子
公开(公告)号：WO2016161129A1
公开(公告)日：2016-10-06
申请号：PCT/US2016/025290
申请日：2016-03-31
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： ELMALEH, David, R. , TAKAHASHI, Kazue
IPC分类号： A61K9/51 , A61K47/48 , A61P35/00
CPC分类号： A61K47/6949 , A61K9/5052 , A61K9/5169 , A61K31/337 , A61K31/473 , A61K31/7068 , A61K39/39 , A61K47/62 , A61K47/6849 , A61K47/6925 , A61K49/0069 , A61K49/0091 , A61K49/1821 , A61K49/189 , A61K51/1251 , A61K51/1268 , A61P35/00
摘要： Described herein are self-assembling protein molecules for delivering a payload, for example, a toxic anti-cancer agent, a cancer immunotherapy, a toxic anti-cancer agent and a cancer immunotherapy, or an imaging agent, to specific tissues. Examples of self-assembled proteins include clathrin and derivatives of clathrin.
摘要翻译：本文描述了用于向特定组织递送有效负载（例如有毒抗癌剂，癌症免疫治疗，有毒抗癌剂和癌症免疫治疗或显像剂）的自组装蛋白质分子。自组装蛋白质的实例包括网格蛋白和网格蛋白的衍生物。

36. 发明申请

WO2015144891A1 NANOSTRUCTURES AND APPLICATIONS THEREOF 审中-公开
标题翻译：纳米结构及其应用
公开(公告)号：WO2015144891A1
公开(公告)日：2015-10-01
申请号：PCT/EP2015/056739
申请日：2015-03-27
申请人： SPAGO NANOMEDICAL AB
发明人： AXELSSON, Oskar , BÄCKSTRÖM, Sania , PETORAL JR, Rodrigo
IPC分类号： A61K51/12 , A61P35/00
CPC分类号： A61K51/065 , A61K51/1251 , C08G77/30
摘要： Disclosed herein are globular nanostructures having a hydrodynamic diameter (D h ) of 8-100 nm comprising a central part and a peripheral part, wherein said central part has a calculated diameter (D c ) of 6-90 nm and said peripheral part has an estimated thickness (T p ) so that D h =D c +2T p , wherein said central part comprises: (i) a crosslinked polymeric framework comprising monomer residues wherein at least 30 % by number of the monomer residues have crosslinked thereby forming the crosslinked polymeric framework and/or (ii) a branched polymeric framework comprising monomer residues wherein the number of branch points is at least 30 % of the number of monomer residues, wherein said central part comprises chelating groups of which at least 4 allow chelation of at least one multiply charged cation, wherein said chelating groups are independently selected from the group consisting of -COOR 1 , -P=O(OR 1 )(OR 2 ), and -S(=O) 2 OR 1 , wherein R 1 and R 2 are independently selected from the group consisting of a negative charge, H, and lower alkyls, and wherein said peripheral part comprises a synthetic polymer material covalently attached to the central part, wherein the synthetic polymer material is hydrophilic and bioinert, and electrically neutral or zwitterionic. Also disclosed are compositions comprising such nanoparticles, and optionally also a radionuclide, use of such compositions, kits containing such compositions and methods for obtaining such compositions.
摘要翻译：本文公开了具有8-100nm的流体动力学直径（Dh）的球状纳米结构，其包括中心部分和周边部分，其中所述中心部分具有6-90nm的计算直径（Dc），并且所述周边部分具有估计的厚度（Tp），使得Dh = Dc + 2Tp，其中所述中心部分包含：（i）包含单体残基的交联聚合物骨架，其中至少30％数量的单体残基已经交联从而形成交联的聚合物骨架和/或 ii）包含单体残基的支化聚合物框架，其中分支数目为单体残基数量的至少30％，其中所述中心部分包含螯合基团，其至少4个允许螯合至少一个多电荷阳离子，其中所述螯合基团独立地选自-COOR1，-P = O（OR1）（OR2）和-S（= O）2OR1，其中R1和R2独立地选自：负电荷，H和低级烷基，并且其中所述外围部分包括共价连接到中心部分的合成聚合物材料，其中合成聚合物材料是亲水的和生物惰性的，并且是电中性的或两性离子的。还公开了包含这样的纳米颗粒，任选地还有放射性核素的组合物，这种组合物的使用，含有这些组合物的试剂盒和获得这种组合物的方法。

37. 发明申请

WO2014118815A2 INTRAOPERATIVE DETECTION OF TUMOR RESIDUES USING BETA- RADIATION AND CORRESPONDING PROBES 审中-公开
标题翻译：使用辐照和相关探针进行肿瘤残留的内窥镜检测
公开(公告)号：WO2014118815A2
公开(公告)日：2014-08-07
申请号：PCT/IT2014000025
申请日：2014-01-29
申请人： UNIV ROMA , ISTITUTO NAZ DI FISICA NUCLEARE , MUSEO STORICO DELLA FISICA E CT STUDI E RICHERCHE E FERMI
发明人： FACCINI RICCARDO , BELLINI FABIO , COLLAMATI FRANCESCO , DI DOMENICO ANTONIO , DE LUCIA ERIKA , FERRONI FERNANDO , FIORE SALVATORE , MARAFINI MICHELA , MATTEI ILARIA , PATERA VINCENZO , PIERSANTI LUCA , SARTI ALESSIO , SCIUBBA ADALBERTO , VOENA CECILIA
CPC分类号： A61B6/481 , A61B6/4216 , A61B6/4258 , A61B6/4405 , A61K51/04 , A61K51/0489 , A61K51/088 , A61K51/1096 , A61K51/1251 , G01T1/161
摘要： The invention relates to the use of &bgr;- emitting radiolabeled tracers for administration to a patient prior to radio-guided surgery, and to the corresponding probes designed to intraoperatively detect &bgr;- decays from cancerous tissues so as to locate even small cancerous remnants still present after resection of the main cancerous lesions. The &bgr;- emitting radiolabeled tracer for use according to the invention is labeled with a radioisotope undergoing exclusively &bgr;- decays or a radioisotope undergoing &bgr;- decays and having no more than 10-11 % of γ rays decays, ptrgrtsbly no more than 5% of γ rays decays. The corresponding probe for use in combination with the &bgr;- emitting tracer proposed has an extension direction along a longitudinal axis and comprises one or more blocks of scintillating material, each one having a main extension parallel to the longitudinal axis and transversal dimensions smaller than 3 mm, each of said one or more blocks being partially shielded by a material that is inactive with respect to &bgr;- radiation.
摘要翻译：本发明涉及放射性标记的示踪剂在放射性引导手术之前用于给予患者的用途，以及设计用于术中检测并从癌组织衰变的相应探针的用途，以便甚至定位甚至小的癌性残余物存在切除主要癌性病变后。根据本发明使用的发射放射性标记的示踪剂用经历独特的衰变或放射性同位素经历衰变并且具有不超过10-11％的γ射线衰变的放射性同位素标记，ptrgrbb不超过 5％的γ射线衰变。与发射示踪剂组合使用的相应探针具有沿纵向轴线的延伸方向，并且包括一个或多个闪烁材料块，每个块具有平行于纵向轴线的主延伸部分和小于3的横向尺寸所述一个或多个块中的每一个被相对于辐射无效的材料部分屏蔽。

38. 发明申请

WO2014040143A1 METHOD OF TREATING CANCER 审中-公开
标题翻译：治疗癌症的方法
公开(公告)号：WO2014040143A1
公开(公告)日：2014-03-20
申请号：PCT/AU2013/001059
申请日：2013-09-17
申请人： GRAY, Bruce N.
发明人： GRAY, Bruce N.
IPC分类号： A61K51/12 , A61K103/32 , A61K103/00 , A61K103/30 , A61P35/00
CPC分类号： A61K51/1251 , A61K51/025 , A61K51/06 , Y10T428/2982
摘要： The present invention relates to small particles comprising a radionuclide and in particular to small particles comprising a radionuclide for implantation in organs or tissues or tumours of subjects. Embodiments of the invention have been particularly developed for embolisation into the arterial system using a technique known as radioembolisation or Selective Internal Radiation Therapy (SIRT) and will be described hereinafter with reference to this application. However, it will be appreciated that the invention is not limited to this particular field of use. The small particles are preferably radioactive microspheres comprising a matrix and a radionuclide stably attached. These microspheres have a diameter ranging from 5 to 45 μπι and the radionuclide has a specific activity ranging from 100 to 2000 Bq per microsphere.
摘要翻译：本发明涉及包含放射性核素的小颗粒，特别涉及包含用于植入受试者的器官或组织或肿瘤中的放射性核素的小颗粒。本发明的实施例已经特别开发用于使用已知为放射栓塞或选择性内部放射治疗（SIRT）的技术栓塞入动脉系统，并且将在下文中参考本申请进行描述。然而，应当理解，本发明不限于该特定的使用领域。小粒子优选为包含基质和稳定连接的放射性核素的放射性微球。这些微球的直径范围为5至45μ，而每个微球的放射性核素的比活性为100至2000Bq。

39. 发明申请

WO2012074840A3 COMPOSITIONS AND METHODS FOR IN VIVO IMAGING 审中-公开
标题翻译：用于血管成像的组合物和方法
公开(公告)号：WO2012074840A3
公开(公告)日：2013-02-14
申请号：PCT/US2011061856
申请日：2011-11-22
申请人： GEN HOSPITAL CORP , REINER THOMAS , KELIHER EDMUND J , WEISSLEDER RALPH
发明人： REINER THOMAS , KELIHER EDMUND J , WEISSLEDER RALPH
IPC分类号： C07F5/02 , A61K49/06 , C07D403/14
CPC分类号： A61K51/0459 , A61K49/0021 , A61K51/1251
摘要： This document relates to compounds useful for targeting PARP1. Also provided herein are methods for using such compounds to detect and image cancer cells.
摘要翻译：本文件涉及可用于靶向PARP1的化合物。本文还提供了使用这些化合物来检测和成像癌细胞的方法。

40. 发明申请

WO2012074840A2 COMPOSITIONS AND METHODS FOR IN VIVO IMAGING 审中-公开
标题翻译：用于血管成像的组合物和方法
公开(公告)号：WO2012074840A2
公开(公告)日：2012-06-07
申请号：PCT/US2011/061856
申请日：2011-11-22
申请人： THE GENERAL HOSPITAL CORPORATION , REINER, Thomas , KELIHER, Edmund J. , WEISSLEDER, Ralph
发明人： REINER, Thomas , KELIHER, Edmund J. , WEISSLEDER, Ralph
CPC分类号： A61K51/0459 , A61K49/0021 , A61K51/1251
摘要： This document relates to compounds useful for targeting PARP1. Also provided herein are methods for using such compounds to detect and image cancer cells.
摘要翻译：本文件涉及可用于靶向PARP1的化合物。本文还提供了使用这些化合物来检测和成像癌细胞的方法。

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