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1. 发明申请

WO2015144891A1 NANOSTRUCTURES AND APPLICATIONS THEREOF 审中-公开
标题翻译：纳米结构及其应用
公开(公告)号：WO2015144891A1
公开(公告)日：2015-10-01
申请号：PCT/EP2015/056739
申请日：2015-03-27
申请人： SPAGO NANOMEDICAL AB
发明人： AXELSSON, Oskar , BÄCKSTRÖM, Sania , PETORAL JR, Rodrigo
IPC分类号： A61K51/12 , A61P35/00
CPC分类号： A61K51/065 , A61K51/1251 , C08G77/30
摘要： Disclosed herein are globular nanostructures having a hydrodynamic diameter (D h ) of 8-100 nm comprising a central part and a peripheral part, wherein said central part has a calculated diameter (D c ) of 6-90 nm and said peripheral part has an estimated thickness (T p ) so that D h =D c +2T p , wherein said central part comprises: (i) a crosslinked polymeric framework comprising monomer residues wherein at least 30 % by number of the monomer residues have crosslinked thereby forming the crosslinked polymeric framework and/or (ii) a branched polymeric framework comprising monomer residues wherein the number of branch points is at least 30 % of the number of monomer residues, wherein said central part comprises chelating groups of which at least 4 allow chelation of at least one multiply charged cation, wherein said chelating groups are independently selected from the group consisting of -COOR 1 , -P=O(OR 1 )(OR 2 ), and -S(=O) 2 OR 1 , wherein R 1 and R 2 are independently selected from the group consisting of a negative charge, H, and lower alkyls, and wherein said peripheral part comprises a synthetic polymer material covalently attached to the central part, wherein the synthetic polymer material is hydrophilic and bioinert, and electrically neutral or zwitterionic. Also disclosed are compositions comprising such nanoparticles, and optionally also a radionuclide, use of such compositions, kits containing such compositions and methods for obtaining such compositions.
摘要翻译：本文公开了具有8-100nm的流体动力学直径（Dh）的球状纳米结构，其包括中心部分和周边部分，其中所述中心部分具有6-90nm的计算直径（Dc），并且所述周边部分具有估计的厚度（Tp），使得Dh = Dc + 2Tp，其中所述中心部分包含：（i）包含单体残基的交联聚合物骨架，其中至少30％数量的单体残基已经交联从而形成交联的聚合物骨架和/或 ii）包含单体残基的支化聚合物框架，其中分支数目为单体残基数量的至少30％，其中所述中心部分包含螯合基团，其至少4个允许螯合至少一个多电荷阳离子，其中所述螯合基团独立地选自-COOR1，-P = O（OR1）（OR2）和-S（= O）2OR1，其中R1和R2独立地选自：负电荷，H和低级烷基，并且其中所述外围部分包括共价连接到中心部分的合成聚合物材料，其中合成聚合物材料是亲水的和生物惰性的，并且是电中性的或两性离子的。还公开了包含这样的纳米颗粒，任选地还有放射性核素的组合物，这种组合物的使用，含有这些组合物的试剂盒和获得这种组合物的方法。

2. 发明申请

WO2021122859A1 IMMOBILIZATION OF PHENOLIC COMPOUNDS 审中-公开
公开(公告)号：WO2021122859A1
公开(公告)日：2021-06-24
申请号：PCT/EP2020/086591
申请日：2020-12-16
申请人： SPAGO NANOMEDICAL AB
发明人： GRAM, Andreas , AXELSSON, Oskar , LARSSON, Rikard
IPC分类号： C08G65/30 , C08G65/336
摘要： The present disclosure relates to a method of immobilizing a phenolic compound having a Mw ≥ 500 g/mol, wherein the method comprises the steps of ionizing the phenolic compound by subjecting it to a base; and contacting, under agitation, the ionized phenolic compound with a cross-linked resin comprising the functionality of -C(=0)- CHXCH2R, wherein X is chosen from the group consisting of Br, Cl, I, CN, OMs, OTs, or OTf, and R is H, CH3 or an branched or unbranched alkyl having 1 to 8 carbon atoms, in the presence of a base and a solvent. The present disclosure also relates to a method of removing phenolic compounds having a Mw ≥ 500 g/mol from a composition comprising compounds having at least one alkoxy silane group. The present disclosure also relates to the use of a method according to the present disclosure as well as to a product, from which at least one phenolic compound having a Mw ≥ 500 g/mol has been removed by a method according to the present disclosure.

3. 发明申请

WO2018130713A1 CHEMICAL COMPOUNDS FOR COATING OF NANOSTRUCTURES 审中-公开
公开(公告)号：WO2018130713A1
公开(公告)日：2018-07-19
申请号：PCT/EP2018/050975
申请日：2018-01-16
申请人： SPAGO NANOMEDICAL AB
发明人： AXELSSON, Oskar , SANZONE, Angelo
IPC分类号： C07F7/18 , B82Y5/00 , B82Y15/00 , C08G73/00
摘要： The present application relates to a chemical compound comprising an aromatic core, or a carbocyclic, non-aromatic, core, wherein the aromatic core is a benzene ring or a biphenyl; the carbocyclic, non-aromatic core is a 5 to 7 membered ring. The core has covalently attached thereto: at least two anchoring groups, each anchoring group comprising an activated silane group, wherein the anchoring groups have the following general formula –A-(CH 2 )nSiY3 wherein A is a covalent bond or O, "n" is an integer from 1 to 3, and Y is independently a methoxy group or an ethoxy group; and at least one hydrophilic group extending from the core, the hydrophilic group comprising one or more hydrophilic polymer residues with a molecular composition of (aO+bN)/(cC+dS+eSi+fP) > 0.3 where a, b, c, d, e and f are the mol percentage of oxygen (O), nitrogen (N), carbon (C), sulfur (S), silicon (Si) and phosphorus (P), respectively; wherein the hydrophilic polymer residue(s) is(are) selected, independently of each other if more than one hydrophilic group is present, from –(O-CH 2 -CH 2 ) m -OX, wherein X is CH 3 or H, and "m" is an integer from 6 to 25; and the number of hydrophilic groups extending from the core is from one to the number of ring structures in the core. The present invention also relates to compositions comprising the chemical compound and nanostructures comprising residues of the chemical compound as well as the use of such nanostructures. Furthermore, the invention relates to methods for obtaining the chemical compounds and the nanostructures.

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