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1. 发明申请

WO2013174754A3 COMPOSITION AND PROCESS FOR MAKING A POROUS INORGANIC OXIDE COATING 审中-公开
标题翻译：用于制造多孔无机氧化物涂料的组合物和方法
公开(公告)号：WO2013174754A3
公开(公告)日：2014-02-27
申请号：PCT/EP2013060276
申请日：2013-05-17
申请人： DSM IP ASSETS BV
发明人： ARFSTEN NANNING JOERG , DIJCK VAN MICHAEL ALPHONSUS CORNELIS JOHANNES , HABETS ROBERTO ARNOLDUS DOMINICUS MARIA
IPC分类号： C09D7/00
CPC分类号： B01J13/125 , B01J13/18 , B05D3/0254 , B05D5/061 , C01B33/143 , C01B33/145 , C01B33/149 , C01G23/047 , C01G25/02 , C01P2004/34 , C01P2004/64 , C03C17/007 , C03C2217/425 , C03C2217/732 , C08J3/128 , C09D5/006 , C09D7/1266 , C09D7/1291 , C09D7/67 , C09D7/70 , G02B1/11 , G02B1/111 , H01L31/02168 , H01L31/02325 , H01L31/02366 , Y02E10/50 , Y10T428/24997
摘要： The invention relates to acoating composition for making a porous inorganic oxide coating layer on a substrate, the composition comprising an inorganic oxide precursor as binder, a solvent, and a synthetic polyampholyte as pore forming agent. The size of the pores in the coating can be advantageously controlled by the comonomer composition of the polyampholyte, and/or by selecting conditions like temperature, pH, salt concentration, and solvent composition when making the composition. The invention also relates to a method of making such coating composition, to a process of applying a coating on a substrate using such composition, and to such coated substrate showing a specific combination of optical and mechanical properties.
摘要翻译：本发明涉及用于在基材上制备多孔无机氧化物涂层的赋型组合物，该组合物包含作为粘合剂的无机氧化物前体，溶剂和合成的聚阴离子作为成孔剂。通过聚阴离子的共聚单体组合物和/或通过在制备组合物时选择温度，pH，盐浓度和溶剂组成等条件，可以有利地控制涂层中的孔的尺寸。本发明还涉及制备这种涂料组合物的方法，使用这种组合物在基材上涂布涂料的方法，以及显示光学和机械性能的特定组合的涂布基材。

2. 发明申请

WO2014005402A1 一种具有多孔壳层的PLGA/碳酸钙复合微球及其制备方法审中-公开
公开(公告)号：WO2014005402A1
公开(公告)日：2014-01-09
申请号：PCT/CN2012/086491
申请日：2012-12-13
申请人：华南理工大学 , 王迎军 , 程德林 , 曹晓东
发明人：王迎军 , 程德林 , 曹晓东
IPC分类号： A61L27/46 , A61L27/18 , A61L27/02 , A61L27/50 , A61L27/56 , B01J13/04 , C08J9/26 , C08J3/12
CPC分类号： C08J3/212 , B01J13/125 , C08J3/12 , C08J2367/04
摘要：一种具有多孔壳层的PLGA/碳酸钙复合微球及其制备方法，包括以下步骤：a. 将PLGA溶解于二氯甲烷有机溶剂中，得到PLGA油相；将碳酸钙粉末添加到PLGA油相中，通过搅拌和超声处理后，得到有机/无机的均匀混合液；b. 将葡萄糖酸内酯溶解于PVA水溶液中，得到酸性PVA水溶液；c. 在搅拌条件下将步骤a得到的混合液分散到步骤b中的酸性PVA水溶液里，得到水包油的单乳液；d. 在减压条件下继续搅拌，使油相液滴中的二氯甲烷挥发，得到固化的复合微球；e. 收集步骤d中的微球，用去离子水洗涤，冷冻干燥即可。这种方法不引入成孔剂，制备的复合微球表面存在多孔结构，有利于细胞的生长。

3. 发明申请

WO2009093812A2 DOUBLE LAYERED POLYMER CAPSULES FOR THE STABILIZATION OF CAROTENOIDS, THE PROCESS FOR PREPARING THE SAME, AND THE COSMETIC COMPOSITION CONTAINING THE SAME 审中-公开
标题翻译：用于稳定卡介质的双层聚合物胶囊，其制备方法和含有它们的化妆品组合物
公开(公告)号：WO2009093812A2
公开(公告)日：2009-07-30
申请号：PCT/KR2008/007645
申请日：2008-12-24
申请人： AMOREPACIFIC CORPORATION , KIM, Yong Jin , AN, Ji Hye , PARK, Chang Hoon , CHO, Jun Cheol
发明人： KIM, Yong Jin , AN, Ji Hye , PARK, Chang Hoon , CHO, Jun Cheol
IPC分类号： C08J3/12
CPC分类号： A61Q19/08 , A61K8/11 , A61K8/8117 , A61K8/8147 , A61K8/8152 , A61K2800/412 , A61K2800/63 , B01J13/125 , B01J13/22
摘要： The present invention relates to a double-layered polymer capsule for stabilizing a carotenoid such as β- carotin and a method for preparing the same, and a cosmetic composition comprising the same, and more particularly, to a polymer capsule prepared by preparing a cationic polymer capsule containing a carotenoid and coating the surface of the capsule with an anionic polymer. The double-layered polymer capsule according to the present invention is a stabilizing system to preventing degeneration of an active material by the outside destructive environment and effective on materials susceptible to oxidation.
摘要翻译：本发明涉及用于稳定β-胡萝卜素类胡萝卜素的双层聚合物胶囊及其制备方法，以及包含其的化妆品组合物，更具体地涉及通过制备阳离子聚合物制备的聚合物胶囊胶囊含有类胡萝卜素，并用阴离子聚合物涂覆胶囊的表面。根据本发明的双层聚合物胶囊是一种稳定体系，用于防止外界破坏性环境对活性物质的退化，对于易氧化的材料有效。

4. 发明申请

WO0066087A8 EMULSION-BASED PROCESSES FOR MAKING MICROPARTICLES 审中-公开
公开(公告)号：WO0066087A8
公开(公告)日：2001-04-05
申请号：PCT/US0011781
申请日：2000-05-02
申请人： SOUTHERN BIOSYSTEMS INC , GIBSON JOHN W , HOLL RICHARD J , TIPTON ARTHUR J
发明人： GIBSON JOHN W , HOLL RICHARD J , TIPTON ARTHUR J
IPC分类号： A61K9/16 , B01J13/12
CPC分类号： B01J13/125 , A61K9/1647 , A61K9/1694 , Y10T428/2984 , Y10T428/2985
摘要： Processes for making microparticles, preferably containing an active agent, are provided. In a preferred embodiment, the process involves preparing (1) a dispersed phase containing an agent in a solution of polymer and a first solvent; (2) a continuous phase containing a surfactant, a second solvent that is totally or partially immiscible with the first solvent, and sufficient first solvent to saturate the continuous phase; and (3) an extraction phase that is a nonsolvent for the polymer, a solvent for the continuous phase components, and a solvent for the first solvent, wherein the first solvent has solubility in the extraction phase of between about 0,1 % and 25 % by weight. Then, the dispersed phase and the continuous phase are mixed to form an emulsion, and the emulsion is then briefly mixed with a suitable quantity of extraction phase to induce skin formation at the interface of the dispersed and continuous phases. Remaining solvent is removed by an evaporation process step. The emulsification and solvent removal steps are preferably conducted in a continuous process. The brief extraction step prior to evaporation minimizes the loss of active agent from the microparticles, and reduces the required volume of extraction phase as compared to other extraction-based processes. Alternate emulsification methods and solvent removal methods, such as incremental extraction, cryogenic extraction, or membrane separation, also are provided, and can be used in various combinations to make microparticles.

5. 发明申请

WO9205866A3 EFFICIENT MICROCAPSULE PREPARATION AND METHOD OF USE 审中-公开
标题翻译：有效的微胶囊制备和使用方法
公开(公告)号：WO9205866A3
公开(公告)日：1992-05-29
申请号：PCT/US9107366
申请日：1991-10-02
申请人： UNIV TEXAS
发明人： WALLACE SIDNEY , YANG DAVID J , WALLACE MICHAEL , KUANG LI-REN , LI CHUN
IPC分类号： A61K9/50 , A61K9/16 , A61K47/48 , A61K49/04 , A61K51/12 , B01J13/12 , B01J13/20 , B01J13/06
CPC分类号： A61K49/048 , A61K9/1641 , A61K9/1647 , A61K9/1652 , A61K9/167 , A61K9/1694 , A61K47/645 , A61K51/1251 , A61K2123/00 , B01J13/125 , B01J13/20
摘要： The present invention relates to a highly efficient method of preparing microcapsules suitable for encapsulation or surface attachment of therapeutic and diagnostic agents. In one aspect of the invention, surface charge of the polymeric material is altered by conjugation of an amino acid ester to the polymer, providing improved targeting of encapsulated agents to specific tissue cells. Examples include encapsulation of hydrophilic radiodiagnostic agents in 1 νm capsules to provide improved opacification and encapsulation of cytotoxic agents in 100 νm capsules for chemo embolization procedures. The microcapsules are suitable for attachment of a wide range of targeting agents, including antibodies, steroids and drugs, which may be attached to the microcapsule polymer before or after formation of suitably sized microcapsules.
摘要翻译：本发明涉及一种制备适合包封治疗剂和诊断剂的微胶囊的方法。胶衣是由可生物降解的聚合物制成的。在本发明的一个特定方面，聚合物材料的表面电荷通过氨基酸酯与聚合物的缀合而改变，从而为特定的组织细胞提供靶向。亲水性放射诊断剂在1微米胶囊中的包封提供了改善的不透明性。细胞毒性剂在100微米胶囊中的包封可用于化学栓塞过程。

6. 发明申请

WO2011127456A2 METHOD FOR FORMULATING LARGE DIAMETER SYNTHETIC MEMBRANE VESICLES 审中-公开
标题翻译：用于制备大直径合成膜的方法
公开(公告)号：WO2011127456A2
公开(公告)日：2011-10-13
申请号：PCT/US2011/031858
申请日：2011-04-08
申请人： PACIRA PHARMACEUTICALS, INC. , SCHUTT, Ernest, George , MCGUIRE, Ronald, Warren , WALTERS, Peter, Andrew , LOS, Kathleen, D.A.
发明人： SCHUTT, Ernest, George , MCGUIRE, Ronald, Warren , WALTERS, Peter, Andrew , LOS, Kathleen, D.A.
IPC分类号： A61K9/127 , F23D11/10 , B01F3/12 , B01D15/00 , A61K9/00 , A61K31/4458 , A61P23/00
CPC分类号： A61K9/1271 , A61K9/127 , A61K9/1277 , A61K9/4833 , A61K31/445 , A61K31/4458 , A61M11/00 , B01D1/16 , B01F3/04049 , B01F3/0807 , B01F3/088 , B01F5/104 , B01F7/0075 , B01F15/065 , B01F2015/061 , B01F2215/0032 , B01J13/043 , B01J13/125
摘要： The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.
摘要翻译：本发明一般涉及药学科学领域。更具体地，本发明包括用于制备含有大直径合成膜囊泡的药物制剂的装置和装置，例如多泡脂质体，用于制备这种制剂的方法，以及使用特定制剂用于治疗有需要的受试者。还考虑了通过使用用于治疗有需要的受试者的装置和装置产生的含有大直径合成膜囊泡的药物制剂的形成和使用。

7. 发明申请

WO2009142018A1 ベシクルの製造方法、この製造方法によって得られるベシクルおよびベシクルを製造するためのＷ／Ｏ／Ｗエマルション审中-公开
标题翻译：用于生产由生产方法获得的VESICLE，VESICLE的方法和用于生产VESICLE的W / O / W乳液
公开(公告)号：WO2009142018A1
公开(公告)日：2009-11-26
申请号：PCT/JP2009/002242
申请日：2009-05-21
申请人：国立大学法人筑波大学 , 市川創作 , 黒岩崇
发明人：市川創作 , 黒岩崇
IPC分类号： A61K9/127 , A23L1/035 , A61K8/06 , A61K8/14 , A61K9/113 , A61Q19/00 , B01J13/04
CPC分类号： B01J13/125 , A23L27/80 , A23P10/35 , A61K8/14 , A61K9/127 , A61K2800/412 , A61Q19/00
摘要：【課題】　有効成分の高い内包率と、粒子径の制御とを同時に達成することができるベシクルの製造方法を提供する。【解決手段】　内包させる物質を溶解あるいは懸濁状態で含む水溶液と、ベシクルを構成することができる乳化能を有する脂質を含む有機溶媒相とからＷ／Ｏエマルションを製造する工程と、前記Ｗ／Ｏエマルションと、ベシクル脂質膜を破壊しない水溶性乳化剤の外水相液からＷ／Ｏ／Ｗエマルションを製造する工程と、前記Ｗ／Ｏ／Ｗエマルションから有機溶媒相を除去してベシクルを形成させる工程とによってベシクルを製造する。
摘要翻译：公开了一种可以实现活性成分的高封闭速度和同时控制粒径的囊泡的制造方法。通过从包含待溶解或悬浮状态的物质的水溶液和含有能够形成囊泡的具有乳化能力的脂质的有机溶剂相生产W / O乳液的步骤来生产囊泡; 从W / O乳液和不破坏小泡脂质膜的水溶性乳化剂的外部水相液体制备W / O / W乳液的步骤; 以及通过从W / O / W乳液中除去有机溶剂相来形成囊泡的步骤。

8. 发明申请

WO2003106809A1 METHOD OF PREPARING MICROPARTICLES 审中-公开
标题翻译：制备微生物的方法
公开(公告)号：WO2003106809A1
公开(公告)日：2003-12-24
申请号：PCT/GB2003/002091
申请日：2003-05-15
申请人： BP EXPLORATION OPERATING COMPANY LIMITED , COLLINS, Ian, Ralph , DUNCUM, Simon, Neil
发明人： COLLINS, Ian, Ralph , DUNCUM, Simon, Neil
IPC分类号： E21B37/06
CPC分类号： C09K8/92 , B01J13/125 , C09K8/536 , C09K8/54
摘要： A method of preparing microparticles comprising an aqueous solution or dispersion of an oil or gas field production chemical encapsulated in a continuous polymeric phase comprising a degradable polymer, which method comprises: (a) preparing a water in oil in water double emulsion or a water in oil in oil double emulsion having an internal aqueous phase comprising an aqueous solution or dispersion of the production chemical and an internal oil phase comprising a solution of a degradable polymer dissolved in a volatile organic solvent wherein the internal aqueous phase is dispersed in the internal oil phase of the double emulsion in the form of droplets having a mean diameter of less than 10 microns; and (b) at least in part evaporating the volatile organic solvent from the double emulsion such that the degradable polymer accumulates around the droplets of the internal aqueous phase and hardens to form microparticles comprising a continuous polymeric phase encapsulating the internal aqueous phase having a mean particle diameter of less than 10 microns.
摘要翻译：一种制备微粒的方法，其包括包封在包含可降解聚合物的连续聚合物相中的油或气田生产化学品的水溶液或分散体，该方法包括：（a）在水中制备水包油双乳液或水油包水乳液，其具有包含生产化学品的水溶液或分散体的内部水相和包含溶解在挥发性有机溶剂中的可降解聚合物溶液的内部油相，其中内部水相分散在内部油相中的平均直径小于10微米的液滴形式的双重乳液; 和（b）至少部分地从双重乳液中蒸发挥发性有机溶剂，使得可降解聚合物在内部水相的液滴周围积聚并硬化以形成包含连续聚合物相的微粒，所述微粒包封具有平均粒子的内部水相直径小于10微米。

9. 发明申请

WO03082247A2 DRUG MICROPARTICLES 审中-公开
标题翻译：药物微量元素
公开(公告)号：WO03082247A2
公开(公告)日：2003-10-09
申请号：PCT/US0309327
申请日：2003-03-25
申请人： TEVA PHARMA , TEVA PHARMA , LERNER ITZHAK E , ROSENBERGER VERED , FLASHNER-BARAK MOSHE , DRABKIN ANNA , MOLDAVSKI NAOMI
发明人： LERNER ITZHAK E , ROSENBERGER VERED , FLASHNER-BARAK MOSHE , DRABKIN ANNA , MOLDAVSKI NAOMI
IPC分类号： A61K9/14 , A61K9/16 , A61K31/192 , A61K31/216 , A61K31/277 , A61K31/366 , A61K31/496 , A61K31/519 , A61K31/5513 , A61K31/60 , A61K31/7052 , A61K38/00 , A61K47/06 , A61K47/08 , A61K47/10 , A61K47/12 , A61K47/16 , A61K47/20 , A61K47/22 , A61K47/26 , A61K47/36 , A61K47/38
CPC分类号： A61K9/1682 , A61K9/167 , A61K9/1676 , A61K9/1694 , A61K31/519 , B01J13/02 , B01J13/125
摘要： Provided are microparticles of active pharmaceutical ingredients, drug delivery vehicles comprising same, and methods for making them.
摘要翻译：提供了活性药物成分的微粒，包含其的药物递送载体及其制备方法。

10. 发明申请

WO1992005866A2 EFFICIENT MICROCAPSULE PREPARATION AND METHOD OF USE 审中-公开
标题翻译：有效的微生物制备和使用方法
公开(公告)号：WO1992005866A2
公开(公告)日：1992-04-16
申请号：PCT/US1991007366
申请日：1991-10-02
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , WALLACE, Sidney , YANG, David, J. , WALLACE, Michael , KUANG, Li-Ren , LI, Chun
发明人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
IPC分类号： B01J13/06
CPC分类号： A61K49/048 , A61K9/1641 , A61K9/1647 , A61K9/1652 , A61K9/167 , A61K9/1694 , A61K47/645 , A61K51/1251 , A61K2123/00 , B01J13/125 , B01J13/20
摘要： The present invention relates to a highly efficient method of preparing microcapsules suitable for encapsulation or surface attachment of therapeutic and diagnostic agents. In one aspect of the invention, surface charge of the polymeric material is altered by conjugation of an amino acid ester to the polymer, providing improved targeting of encapsulated agents to specific tissue cells. Examples include encapsulation of hydrophilic radiodiagnostic agents in 1 νm capsules to provide improved opacification and encapsulation of cytotoxic agents in 100 νm capsules for chemo embolization procedures. The microcapsules are suitable for attachment of a wide range of targeting agents, including antibodies, steroids and drugs, which may be attached to the microcapsule polymer before or after formation of suitably sized microcapsules.

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